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    • 1. 发明申请
    • LOCKING SYRINGE WITH INTEGRATED BIAS MEMBER
    • 具有集成的偏置构件的锁定注入
    • WO2011032513A1
    • 2011-03-24
    • PCT/CN2010/077083
    • 2010-09-17
    • United Medical Innovations, Inc.LIU, YunxingLI, Chun
    • LIU, YunxingLI, Chun
    • A61M5/20A61M5/315A61M5/178
    • A61M5/31501A61B6/481A61B6/504A61M5/007A61M5/20A61M5/3129A61M5/3148A61M5/31505A61M5/31511A61M2005/3139A61M2005/31508
    • A locking syringe with an integrated bias member, for delivering medical fluids at high pressure, can include a housing, a shaft, a piston, a cap assembly, a bias member, and a locking member. A distal end of the housing can interface with a patient delivery apparatus. The housing includes an internal cavity into which a distal end of the shaft can be inserted. The piston can be connected to the distal end of the shaft and can include a peripheral sealing surface that can slidably engage the inside surface of the housing to form a movable seal. The cap assembly at the proximal end of the housing can engage the shaft. A base cap can secure the piston within the housing. The bias member can have a distal end coupled to the piston and a proximal end restrained, such as to help pressurize the internal cavity. The user- actuatable locking member can user-selectively engage and inhibit unwanted movement of the shaft.
    • 具有用于在高压下输送医疗流体的集成偏压构件的锁定注射器可以包括壳体,轴,活塞,帽组件,偏置构件和锁定构件。 壳体的远端可以与患者输送装置接合。 壳体包括内腔,轴的远端可以插入其中。 活塞可以连接到轴的远端并且可以包括周边密封表面,其可滑动地接合壳体的内表面以形成可移动的密封。 在壳体的近端处的帽组件可以接合轴。 底盖可以将活塞固定在壳体内。 偏置构件可以具有联接到活塞的远端和约束的近端,例如帮助加压内部空腔。 用户可致动的锁定构件可以用户选择性地接合并阻止轴的不期望的运动。
    • 5. 发明申请
    • WIND FARM AND METHOD AND CONTROLLER FOR FEEDING THE SAME
    • 风力农场和用于饲喂它的方法和控制器
    • WO2018076236A1
    • 2018-05-03
    • PCT/CN2016/103578
    • 2016-10-27
    • ABB SCHWEIZ AGYU, RongrongYAO, DaweiLI, ChunCHEN, NiyaZHANG, Yan
    • YU, RongrongYAO, DaweiLI, ChunCHEN, NiyaZHANG, Yan
    • H02J3/46
    • A method for feeding a grid by a group of wind turbines (WT1, WT2, WT3, WT4, WT5) in a wind farm and controller (10) and wind farm using the same is provided. The method includes: (a) obtaining first real-time SCADA data and first real-time constant variables concerning each of the wind turbines (WT1, WT2, WT3, WT4, WT5) in the group for a first time point, and first calculating fatigue degree of the wind turbine using the obtained first real-time SCADA data and the first real-time constant variables thereof; and (b) first distributing the grid load among the wind turbines (WT1, WT2, WT3, WT4, WT5) in the group using the calculated fatigue degrees thereof. By having the solutions as mention above, during the operation period of "Crack Generation", it provides output data indicative of a load distribution among the wind turbines (WT1, WT2, WT3, WT4, WT5) of the wind farm in relation to the fatigue degrees of the wind turbines (WT1, WT2, WT3, WT4, WT5). This allows achieving an optimal load distribution among the wind turbines from time to time (i.e. at each execution cycle thereof) always taking into account the fatigue degrees of the wind turbines (WT1, WT2, WT3, WT4, WT5), which represent the operating conditions of the wind turbine prior to occurrence of defect. During "crack generation" operation period of wind turbines, this is helpful for controlling in a mode designed based on fatigue minimization so as to postpone defect occurrence as much as possible which is able to extend lifetime of wind farm with fixed capital cost.
    • 提供了一种由风力农场和控制器(10)中的一组风力涡轮机(WT1,WT2,WT3,WT4,WT5)馈送电网的方法以及使用该方法的风力发电场。 该方法包括:(a)在第一时间点获得关于该组中的每个风力涡轮机(WT1,WT2,WT3,WT4,WT5)的第一实时SCADA数据和第一实时常数变量,并且第一计算 使用所获得的第一实时SCADA数据及其第一实时常数变量来计算风力涡轮机的疲劳程度; (b)首先使用计算出的疲劳度来分配组中的风力涡轮机(WT1,WT2,WT3,WT4,WT5)之中的电网负载。 通过具有上述解决方案,在“裂纹产生”的操作期间,其提供指示风力发电场的风力涡轮机(WT1,WT2,WT3,WT4,WT5)中的负载分布的输出数据, 风力涡轮机的疲劳度(WT1,WT2,WT3,WT4,WT5)。 这允许总是考虑风力涡轮机(WT1,WT2,WT3,WT4,WT5)的疲劳程度来实现风力涡轮机之间不时的最佳负载分配(即,在其每个执行周期) 在发生缺陷之前风力涡轮机的状况。 在“裂缝产生”期间, 这有助于在基于疲劳最小化设计的模式下进行控制,从而尽可能延迟缺陷的发生,从而能够延长固定资本成本的风电场寿命。
    • 9. 发明申请
    • NANOPARTICLE FORMULATED GLYCOLIPID ANTIGENS FOR IMMUNOTHERAPY
    • 用于免疫治疗的纳米颗粒配方甘露聚糖抗体
    • WO2010083728A1
    • 2010-07-29
    • PCT/CN2010/000100
    • 2010-01-22
    • ZHOU, DapengLI, Chun
    • ZHOU, DapengLI, Chun
    • A61K39/385A61P35/00A61P31/12A61P37/00
    • A61K39/39A61K2039/55511A61K2039/55555A61K2039/57
    • A nanoparticle formulated glycolipid antigen contains 2 components: 1). Nanoparticles at size of 10 to 2000 nm, composed by biodegradable polymers, such as poly(lactic acid), poly(glycolic acid), polycaprolactone, and other polyester species; polyothoesters species; polyanhydrides species and polyphosphazene species, as well as any copolymers composed by 2 or more than 2 polymers as mentioned. 2) 6-aminoethoxy-6-deoxy-alpha-galactosylceramide. The key technology applied to this invention is, component 2 is chemically conjugated to the surface of component 1, through amide linkage. The objection of this invention is to provide a novel surface conjugated formulation to a glycolipid antigen, which can stimulate immune system repeatedly in long term treatment of cancer and chronic viral infection status. The glycolipid conjugated to surface of nanoparticles can repeatedly stimulate NKT cells to produce IFN-g, a cytokine with potent anticancer and antiviral activities. This novel drug has been found to have anticancer effect in a mouse model of tumor metastasis.
    • 配制的糖脂抗原含有2种成分:1)。 尺寸为10〜2000nm的纳米粒子,由聚(乳酸),聚(乙醇酸),聚己酸内酯等多种生物降解性聚合物构成; 多聚酯种; 聚酐类和聚磷腈类,以及由2或2个以上提及的聚合物组成的任何共聚物。 2)6-氨基乙氧基-6-脱氧-α-半乳糖神经酰胺。 应用于本发明的关键技术是组分2通过酰胺键与组分1的表面化学偶联。 本发明的目的是提供一种与糖脂抗原的新型表面缀合制剂,其可以在长期治疗癌症和慢性病毒感染状态中反复刺激免疫系统。 与纳米颗粒表面缀合的糖脂可以反复刺激NKT细胞产生IFN-g,这是具有强力抗癌和抗病毒活性的细胞因子。 已经发现这种新型药物在肿瘤转移的小鼠模型中具有抗癌作用。