专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2010104819A2 HOLLOW GOLD NANOSPHERES (HAUNSS) AND HAUNSS-LOADED MICROSPHERES USEFUL IN DRUG DELIVERY 审中-公开
标题翻译：中性黄金纳米颗粒（HAUNSS）和HAUNSS负载的微生物用于药物递送
公开(公告)号：WO2010104819A2
公开(公告)日：2010-09-16
申请号：PCT/US2010/026605
申请日：2010-03-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LI, Chun , YOU, Jian
发明人： LI, Chun , YOU, Jian
IPC分类号： A61K9/127 , A61K9/16 , A61K49/00 , A61K47/02 , A61P35/00
CPC分类号： A61K9/5031 , A61K9/5115 , A61K31/704 , A61K41/0028 , A61K41/0052 , A61K47/6923
摘要： A near-infrared mediated drug delivery system comprising a plurality of microspheres made of polymeric material, each sphere containing a plurality of hollow gold nanospheres together with drug product, wherein upon NIR irradiation, the drug product is released from the microsphere.
摘要翻译：一种近红外介导的药物递送系统，包括由聚合物材料制成的多个微球体，每个球体与药物产品一起包含多个中空金纳米球体，其中在NIR照射下，药物产物从微球体释放。

2. 发明申请

WO2007134229A3 FUNGUS-SPECIFIC IMAGING AGENTS 审中-公开
公开(公告)号：WO2007134229A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/068766
申请日：2007-05-11
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LI, Chun , KONTOYIANNIS, Dimitrios P.
发明人： LI, Chun , KONTOYIANNIS, Dimitrios P.
IPC分类号： A01N37/18 , A61K38/00
摘要： The disclosure relates to an imaging composition including a fungus-specific peptide and an imaging material. Another imaging composition includes a fungus-specific peptide and a chelator able to chelate a radionuclide. The disclosure also provides to a method of detecting a fungal infection. The method includes administering an imaging agent to a patient. The imaging agent comprises a fungus-specific peptide and an imaging material. Then one may detect the imaging agent in the patient. Detecting retained imaging agent in a tissue or organ indicates fungal infection of the tissue or organ.

3. 发明申请

WO2010028156A3 DUAL MODALITY DETECTION OF APOPTOSIS 审中-公开
公开(公告)号：WO2010028156A3
公开(公告)日：2010-03-11
申请号：PCT/US2009/055899
申请日：2009-09-03
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LI, Chun , XIONG, Chiyi
发明人： LI, Chun , XIONG, Chiyi
IPC分类号： A61K49/00 , A61P35/00
摘要： To image apoptosis in vivo , small, membrane-permeable probes comprising a caspase 3 substrate, a fluorogenic dye and a radionuclide is provided. This dual-modality probe can be cleaved by caspase upon exposure to apoptotic cells, allowing imaging of caspase 3 and 7 activities using both optical and nuclear imaging techniques. The combined use of these methods provides the opportunity for a direct correlation between in vitro and in vivo biological activities and a viable method to treat disease

4. 发明申请

WO2012138379A2 MULTIFUNCTIONAL CHELATOR-FREE RADIOACTIVE NANOPARTICLES FOR IMAGING AND THERAPY 审中-公开
标题翻译：用于成像和治疗的多功能免疫放射性纳米粒子
公开(公告)号：WO2012138379A2
公开(公告)日：2012-10-11
申请号：PCT/US2011/056928
申请日：2011-10-19
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LI, Chun , ZHOU, Min , ZHANG, Rui
发明人： LI, Chun , ZHOU, Min , ZHANG, Rui
CPC分类号： A61K41/0052 , A61K33/34 , A61K47/60 , A61K51/1244 , A61K51/1251
摘要： Methods and composition for improving therapeutic and imaging potential of radioactive nanoparticles are provided. For example, in certain aspects methods for preparing a composition containing a nanoparticle having an integrated metal radioisotope and uses thereof are described. Furthermore, the invention provides such a composition.
摘要翻译：提供了用于改善放射性纳米颗粒的治疗和成像潜力的方法和组合物。例如，在某些方面，描述了制备含有具有整合的金属放射性同位素的纳米颗粒的组合物的方法及其用途。此外，本发明提供了这种组合物。

5. 发明申请

WO2007134236A2 IMAGING AGENTS AND METHODS 审中-公开
标题翻译：成像剂和方法
公开(公告)号：WO2007134236A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068783
申请日：2007-05-11
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LI, Chun , WANG, Wei , WEN, Xiaoxia , MELANCON, Marites P. , WANG, Yuetang , BANKSON, Jim , STEPHENS, Clifton , JASSER, Samar , GELOVANI, Juri , MYERS, Jeffrey
发明人： LI, Chun , WANG, Wei , WEN, Xiaoxia , MELANCON, Marites P. , WANG, Yuetang , BANKSON, Jim , STEPHENS, Clifton , JASSER, Samar , GELOVANI, Juri , MYERS, Jeffrey
IPC分类号： A61K51/00
CPC分类号： A61K49/0032 , A61K31/404 , A61K49/0056 , A61K49/146 , C07D209/14 , C09B23/0033 , C09B23/0066 , C09B23/086
摘要： The disclosure includes a composition including a poly(L-glutamic acid) and a NIRF dye. It also includes a method including providing to a plurality of cells an imaging agent including poly(L-glutamic acid), a NIRF dye and then imaging the cells to detect the imaging agent. It further includes a dual functional contrast agent including an MRI agent conjugated with an optical imaging agent. A method of detecting cancer is provided including injecting a dual functional contrast agent into a patient and performing both an MRI and an optical scan. The presence of the agent may indicate cancer. A method of detecting cancer by injecting PG-DTPA-Gd-NIR813 into a patient, then detecting the presence or absence of Gd in a cell or tissue of the patient and detecting the presence or absence of NIR813 in a cell or tissue of the patient is provided. The presence of Gd and NIR813 may indicate cancer.
摘要翻译：本公开内容包括包含聚（L-谷氨酸）和NIRF染料的组合物。它还包括一种方法，包括向多个细胞提供包括聚（L-谷氨酸），NIRF染料的成像剂，然后对细胞成像以检测成像剂。其还包括双功能造影剂，其包括与光学成像剂共轭的MRI剂。提供了一种检测癌症的方法，包括将双功能造影剂注射到患者体内并执行MRI和光学扫描。药剂的存在可能表明癌症。通过将PG-DTPA-Gd-NIR813注入患者体内检测癌症的方法，然后检测患者细胞或组织中Gd的存在或不存在，并检测患者的细胞或组织中是否存在NIR813 被提供。 Gd和NIR813的存在可能表明癌症。

6. 发明申请

WO2007134127A2 AGENTS FOR IMAGING APOPTOSIS 审中-公开
标题翻译：用于成像疫苗的药剂
公开(公告)号：WO2007134127A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/068596
申请日：2007-05-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , GELOVANI, Juri , TONG, William , NAJJAR, Amer , LI, Chun
发明人： GELOVANI, Juri , TONG, William , NAJJAR, Amer , LI, Chun
IPC分类号： G06F12/06
CPC分类号： C12Q1/37 , A61K47/556 , A61K51/04 , G01N2333/96466 , G01N2510/00
摘要： Compositions, and methods of using such compositions, having the following Formula (I) or salt, ester, or hydrate thereof, wherein R 1 is Asp-Glu peptide, tert -butyloxycarbonyl, methoxyphenylacetyl, bromomethoxyphenylacetyl, fluoromethoxyphenylacetyl, (methylmethoxyphenyl)acetyl, or iodomethoxyphenylacetyl; R 2 is valine (with or without protecting groups), aspartate (with or without protecting groups), t-Butyl, hydrogen, aniline, aromatic molecules, tert -butyloxycarbonyl, or fluorenyl-methoxy-carbonyl; and R 3 is p- nitroaniline, 7-amino-4-methylcoumarin, fluoroethylamine, l-amino-4-fluoromethyl- cyclohexane, l-amino-4-fluoroethyl-cyclohexane, aniline, p-fluoroaniline, p- fluoromethylaniline, p-fluorobenzylamine, p-fluoromethylbenzylamine, 4-aminopiperidine, 4-amino- 1 -fluoroethylpiperidine, or 4-amino- 1 -fluoropropylpiperidine.
摘要翻译：组成和使用具有下式（I）或其盐，酯或水合物的组合物的方法，其中R 1是Asp-Glu肽，叔丁氧基羰基，甲氧基苯乙酰基，溴甲氧基苯乙酰基，氟甲氧基苯乙酰基，（甲基甲氧基苯基）乙酰基或碘代甲氧基苯乙酰基; R 2是缬氨酸（具有或不具有保护基团），天冬氨酸（具有或不具有保护基团），叔丁基，氢，苯胺，芳族分子，叔丁氧基羰基或芴基 - 甲氧基 - 羰基; 和R 3是对硝基苯胺，7-氨基-4-甲基香豆素，氟乙胺，1-氨基-4-氟甲基 - 环己烷，1-氨基-4-氟乙基 - 环己烷，苯胺，对氟苯胺对氟甲基苯胺，对氟苄胺，对氟甲基苄胺，4-氨基哌啶，4-氨基-1-氟乙基哌啶或4-氨基-1-氟丙基哌啶。

7. 发明申请

WO2005019247A2 CYCLIC PEPTIDE AND IMAGING COMPOUND COMPOSITIONS AND USES FOR TARGETED IMAGING AND THERAPY 审中-公开
标题翻译：循环肽和成像组合物及其用于靶向成像和治疗的用途
公开(公告)号：WO2005019247A2
公开(公告)日：2005-03-03
申请号：PCT/US2004/026220
申请日：2004-08-13
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , LI, Chun , KE, Shi , WANG, Wei
发明人： LI, Chun , KE, Shi , WANG, Wei
IPC分类号： C07K7/64
CPC分类号： A61K49/0032 , A61K49/0034 , A61K49/0056 , A61K51/08 , A61K51/082 , A61K51/088 , C07K7/56 , C07K14/8146
摘要： The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf) NIR imaging compositions and novel cyclic HWGFTL polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.
摘要翻译：本发明涉及可与成像剂（包括新成像剂）缀合的新型环肽。具体而言，它包括c（KRGDf）NIR成像组合物和新颖的环状HWGFTL多肽，其可以尤其用于NIR，MRI和核成像以及治疗中。另外，本发明包括新型成像剂，例如TS-ICG衍生物。本发明还涉及制造和使用这种化合物的方法。这种用途包括术前和术中检测肿瘤细胞和治疗监测。

8. 发明申请

WO2017100533A1 POLYMERIC DRUG DELIVERY SYSTEMS FOR TREATMENT OF DISEASE 审中-公开
标题翻译：用于治疗疾病的聚合物药物递送系统
公开(公告)号：WO2017100533A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/065763
申请日：2016-12-09
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： LI, Chun , ZHAO, Jun , FLEMING, Jason
IPC分类号： A61K47/48 , A61P35/00 , C08F8/42
CPC分类号： C08F8/42
摘要： Provided are compositions and nanoparticle formulations that may be used, e.g., to deliver a therapeutic compound to a subject. In some embodiments, the nanoparticles may be used to deliver one or more chemotherapeutic agents to treat a cancer such, e.g., as a pancreatic ductal adenocarcinoma.
摘要翻译：提供了可用于例如将治疗性化合物递送至受试者的组合物和纳米颗粒制剂。在一些实施方案中，纳米颗粒可用于递送一种或多种化学治疗剂以治疗癌症，例如胰腺导管腺癌。

9. 发明申请

WO1994002106A1 THERAPEUTIC AND DIAGNOSTIC USE OF MODIFIED POLYMERIC MICROCAPSULES 审中-公开
标题翻译：改性聚合物微胶囊的治疗和诊断用途
公开(公告)号：WO1994002106A1
公开(公告)日：1994-02-03
申请号：PCT/US1993006675
申请日：1993-07-16
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , WALLACE, Sidney , YANG, David , WALLACE, Michael , LI, Chun , LI-REN, Kuang
IPC分类号： A61K09/50
CPC分类号： A61K9/1647 , A61K9/1641 , A61K9/1652 , A61K9/167 , A61K9/1694 , A61K47/6925 , A61K49/048 , A61K51/1251 , A61K2123/00 , B01J13/125 , B01J13/20 , Y10T428/2985
摘要： The present invention relates to a highly efficient method of preparing modified microcapsules exhibiting selective targeting. These microcapsules are suitable for encapsulation or surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of hydrophilic radiodiagnostic agents in 1 (my)m capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 (my)m capsules for chemoembolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules. The invention also includes hydrophilic microcapsules surface modified with hydroxyl groups. Various agents such as estrone may be attached to the microcapsules and effectively targeted to selected organs.
摘要翻译：本发明涉及一种制备显示出选择性靶向的改性微胶囊的高效方法。这些微胶囊适用于治疗和诊断剂的包封或表面附着。在本发明的一个方面，通过将氨基酸酯与聚合物缀合来改变聚合物材料的表面电荷，从而提供封装剂对特定组织细胞的改进靶向。实例包括将亲水性放射性诊断剂包封在1（my）m胶囊中，以提供改进的不透明化和包封细胞毒性剂在100（my）m胶囊中用于化疗栓塞过程。微胶囊适合于连接广泛范围的靶向剂，包括抗体，类固醇和药物，其可在形成适当大小的微胶囊之前或之后附着于微胶囊聚合物。本发明还包括用羟基表面改性的亲水性微胶囊。可以将诸如雌酮的各种试剂连接到微胶囊上并且有效地靶向选定的器官。

10. 发明申请

WO2003055935A1 DENDRITIC POLY (AMINO ACID) CARRIERS AND METHODS OF USE 审中-公开
标题翻译： DENDRITIC POLY AMINO ACID CARRIERS AND METHODS OF USE
公开(公告)号：WO2003055935A1
公开(公告)日：2003-07-10
申请号：PCT/US2002/040937
申请日：2002-12-23
申请人： BOARD OF REGENTS - THE UNIVERSITY OF TEXAS SYSTEM
发明人： LI, Chun , VEGA, Javier , WALLACE, Sidney , TANSEY, Wayne , CHARNSANGAVEJ, Chusilp
IPC分类号： C08G69/10
CPC分类号： B82Y5/00 , A61K47/6855 , A61K47/6885 , A61K51/1268 , C08G69/10 , C08G83/003
摘要： The present invention concerns a design for dendritic poly (amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly (amino acid) carriers have multiple functional groups at the polymer surface. In addition, they have heterofunctional groups on the poly (amino acid) side chains for drug or diagnostic agent attachement. They are designed to allow sufficient preservation of the binding affinity of the targeting ligand while conjugating therapeutic or diagnostic agents to the polymers. The present invention also describes methods of production of the polymer carriers and methods for the treatment or diagnosis of diseases employing the polymer carriers. The present invention also includes methods to introduce targeting moieties site-specifically to the end of polymer chains.
摘要翻译：本发明涉及树突状聚（氨基酸）聚合物载体的设计，也称为非线性聚合物及其应用。这些树枝状聚（氨基酸）载体在聚合物表面具有多个官能团。此外，它们在聚（氨基酸）侧链上具有用于药物或诊断剂附着的异官能团。它们被设计成允许充分保留靶向配体的结合亲和力，同时将治疗剂或诊断剂与聚合物共轭。本发明还描述了生产聚合物载体的方法和用于治疗或诊断使用聚合物载体的疾病的方法。本发明还包括将靶向部位特异性引入到聚合物链的末端的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式