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1. 发明公开

EP3973271A1 EVALUATING THE EFFICACY OF LEAVE-ON COSMETIC COMPOSITIONS TO PROTECT SKIN FROM POLLUTANTS 审中-实审
公开(公告)号：EP3973271A1
公开(公告)日：2022-03-30
申请号：EP19759420.3
申请日：2019-09-02
申请人： Unilever IP Holdings B.V. , UNILEVER GLOBAL IP LIMITED , Conopco, Inc., D/B/A Unilever
发明人： FANG, Yi , MENG, Sheng , YI, Shangchun
IPC分类号： G01N21/64 , A61Q17/00 , A61Q19/00 , G01N33/52

2. 发明申请

WO2019219393A1 EVALUATING THE EFFICACY OF LEAVE-ON COSMETIC COMPOSITIONS TO PROTECT FROM POLLUTANTS 审中-公开
公开(公告)号：WO2019219393A1
公开(公告)日：2019-11-21
申请号：PCT/EP2019/061200
申请日：2019-05-02
申请人： UNILEVER N.V. , UNILEVER PLC , CONOPCO, INC., D/B/A UNILEVER
发明人： CHEN, Guoqiang , FANG, Yi , HUANG, Nan , JI, Chengdong , MENG, Sheng , YI, Shangchun , YUAN, Caigen
IPC分类号： G01N15/04 , G01N21/62
摘要： Disclosed is an in vitro method to determine efficacy of a cosmetic composition or an active ingredient comprised therein to inhibit an atmospheric pollutant from contacting skin, comprising the steps of: (i) filling a sample holder of known dimensions with a known amount of said composition to form a layer of defined thickness therein; (ii) depositing, on said layer, a known amount of a model fine particulate matter which resembles a particulate atmospheric pollutant and is responsive to a spectroscopic or microscopic chemical imaging technique; (iii) performing said chemical imaging; (iv) for a defined period, recording and analyzing the interaction of said model fine particulate matter with and within said layer by the imaging technique, where interaction indicates the penetration speed of said model fine particulate matter in the layer; and, (v) ascertaining said efficacy from the information of step (iv) wherein the slope of a plot of data obtained from said imaging technique against time in the range of 1 to 100 minutes is indicative of short-term efficacy of said composition and the nature of the plot beyond 100 minutes is indicative of long- term efficacy and wherein long-term inhibition factor of said composition is calculated as follows: Long term inhibition factor = Formula (1) where, x is the distance between the bottom of the chamber and the assumed centre of the Gaussian distribution of the model fine particulate model in the layer, σ is the width of the Gaussian distribution and μ is the mean of the Gaussian distribution, where it is assumed that distribution of the model fine particulate matter in said layer follows Gaussian distribution.

3. 发明申请

WO2020053019A1 EVALUATING THE EFFICACY OF LEAVE-ON COSMETIC COMPOSITIONS TO PROTECT SKIN FROM POLLUTANTS 审中-公开
公开(公告)号：WO2020053019A1
公开(公告)日：2020-03-19
申请号：PCT/EP2019/073351
申请日：2019-09-02
申请人： UNILEVER N.V. , UNILEVER PLC , CONOPCO, INC., d/b/a UNILEVER
发明人： FANG, Yi , MENG, Sheng , YI, Shangchun
IPC分类号： G01N21/64 , A61Q17/00 , A61Q19/00 , G01N33/52
摘要： Disclosed is a method of determining efficacy of a cosmetic composition to inhibit an atmospheric pollutant from contacting skin, comprising the steps of: (i) filling a sample holder of known dimensions with known amount of said composition to form a layer of defined thickness therein, where said sample holder is amenable to fluorescence-based assay; (ii) depositing, on said layer, a known amount of a model fine particulate matter which resembles an atmospheric pollutant at least in size and which comprises a material responsive to fluorescence microscopy which is excitable by a wavelength (ʎ ex ) and which emits radiation (ʎ em ) where (ʎ ex ) ≠ (ʎ em ); (iii) irradiating said composition and said model fine particulate matter by said ʎ ex and recording intensity of fluorescence at ʎ em a plurality of times for a defined period during which said model fine particulate matter interacts with said layer; and, (iv) determining, corrected intensity of fluorescence at ʎ em by the following equation; corrected Intensity = recorded intensity / average transmittance where said average transmittance is the average of the transmittance of the composition measured at ʎ ex and ʎ em determined by Beer-Lambert law by measuring the absorbance at ʎ ex and ʎ em , where the corrected intensity is inversely proportional to said efficacy of said composition.

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