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    • 3. 发明申请
    • EVALUATING THE EFFICACY OF LEAVE-ON COSMETIC COMPOSITIONS TO PROTECT FROM POLLUTANTS
    • WO2019219393A1
    • 2019-11-21
    • PCT/EP2019/061200
    • 2019-05-02
    • UNILEVER N.V.UNILEVER PLCCONOPCO, INC., D/B/A UNILEVER
    • CHEN, GuoqiangFANG, YiHUANG, NanJI, ChengdongMENG, ShengYI, ShangchunYUAN, Caigen
    • G01N15/04G01N21/62
    • Disclosed is an in vitro method to determine efficacy of a cosmetic composition or an active ingredient comprised therein to inhibit an atmospheric pollutant from contacting skin, comprising the steps of: (i) filling a sample holder of known dimensions with a known amount of said composition to form a layer of defined thickness therein; (ii) depositing, on said layer, a known amount of a model fine particulate matter which resembles a particulate atmospheric pollutant and is responsive to a spectroscopic or microscopic chemical imaging technique; (iii) performing said chemical imaging; (iv) for a defined period, recording and analyzing the interaction of said model fine particulate matter with and within said layer by the imaging technique, where interaction indicates the penetration speed of said model fine particulate matter in the layer; and, (v) ascertaining said efficacy from the information of step (iv) wherein the slope of a plot of data obtained from said imaging technique against time in the range of 1 to 100 minutes is indicative of short-term efficacy of said composition and the nature of the plot beyond 100 minutes is indicative of long- term efficacy and wherein long-term inhibition factor of said composition is calculated as follows: Long term inhibition factor = Formula (1) where, x is the distance between the bottom of the chamber and the assumed centre of the Gaussian distribution of the model fine particulate model in the layer, σ is the width of the Gaussian distribution and μ is the mean of the Gaussian distribution, where it is assumed that distribution of the model fine particulate matter in said layer follows Gaussian distribution.