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1. 发明授权

US5885619A Large area submucosal tissue graft constructs and method for making the same 失效
标题翻译：大面积粘膜下组织移植物构建及其制备方法
公开(公告)号：US5885619A
公开(公告)日：1999-03-23
申请号：US931299
申请日：1997-09-16
申请人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
发明人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
IPC分类号： A61L27/00 , A61F2/00 , A61F2/10 , A61K35/38 , A61L27/36 , A61P43/00
CPC分类号： A61L27/3691 , A61F2/0063 , A61K35/38 , A61L27/3629
摘要： A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.
摘要翻译：通过融合部分重叠的粘膜下层组织片或片材来制备单一的异构层状组织移植物构建体。通过在允许或促进压缩的粘膜下层片的脱水的条件下，通过在两个表面之间至少压缩所述条的重叠位置来熔化粘膜下层组分。可以通过使用互补的非平面压缩表面来制备三维移植物构建体。

2. 发明授权

US5711969A Large area submucosal tissue graft constructs 失效
标题翻译：大面积粘膜下组织移植物构建体
公开(公告)号：US5711969A
公开(公告)日：1998-01-27
申请号：US418515
申请日：1995-04-07
申请人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
发明人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
IPC分类号： A61L27/00 , A61F2/00 , A61F2/10 , A61K35/38 , A61L27/36 , A61P43/00
CPC分类号： A61L27/3691 , A61F2/0063 , A61K35/38 , A61L27/3629
摘要： A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.
摘要翻译：通过融合部分重叠的粘膜下层组织片或片材来制备单一的异构层状组织移植物构建体。通过在允许或促进压缩的粘膜下层片的脱水的条件下，通过在两个表面之间至少压缩所述条的重叠位置来熔化粘膜下层组分。可以通过使用互补的非平面压缩表面来制备三维移植物构建体。

3. 发明授权

US5955110A Multilayered submucosal graft constructs and method for making the same 失效
标题翻译：多层粘膜下移植物构建体及其制备方法
公开(公告)号：US5955110A
公开(公告)日：1999-09-21
申请号：US776490
申请日：1996-11-12
申请人： Umesh H. Patel , Michael C. Hiles , Bryan A. Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
发明人： Umesh H. Patel , Michael C. Hiles , Bryan A. Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
IPC分类号： A61L27/00 , A61F2/00 , A61F2/10 , A61K35/38 , A61L27/36 , A61P43/00
CPC分类号： A61L27/3691 , A61F2/0063 , A61K35/38 , A61L27/3629
摘要： Multi-laminar tissue graft constructs, pseudoisotropic graft constructs and a method of preparing such constructs are described. Multi-laminar tissue graft constructs are prepared by fusing partially overlapped strips of submucosa tissue into a unitary graft construct by compressing the tissue under dehydrating conditions. Pseudoisotropic tissue graft constructs are prepared by overlapping a first strip of submucosa tissue with at least two strips of submucosa tissue orientated so that the longitudinal axis of each strip formts an angle of about 180.degree./N with the longitudinal axes of at least two other strips of submucosal tissue.
摘要翻译： PCT No.PCT / US96 / 04721 Sec。 371日期：1996年11月12日 102（e）日期1996年11月12日PCT 1996年4月5日PCT公布。公开号WO96 / 31226 PCT 日期1996年10月10日描述了多层组织移植物构建体，伪各向异性移植物构建体和制备这种构建体的方法。通过在脱水条件下压缩组织将部分重叠的粘膜下层组织融合成单一移植物构建体来制备多层组织移植物构建体。通过将粘膜下层组织的第一条带与定向的至少两条粘膜下层组织重叠来制备假性别组织移植物构建体，使得每个条带的纵向轴线与至少两个其它条带的纵向轴线形成约180°/ N的角度的粘膜下组织。

4. 发明授权

US06187039B1 Tubular submucosal graft constructs 有权
标题翻译：管状粘膜下移植物构建体
公开(公告)号：US06187039B1
公开(公告)日：2001-02-13
申请号：US09297620
申请日：1999-05-04
申请人： Michael C. Hiles , Umesh H. Patel , Leslie A. Geddes , Stephen F. Badylak
发明人： Michael C. Hiles , Umesh H. Patel , Leslie A. Geddes , Stephen F. Badylak
IPC分类号： A60F206
CPC分类号： A61L27/3604 , A61F2/06 , A61F2310/00365 , A61L27/24 , A61L27/3629 , A61L27/3687
摘要： An easy-to-produce and mechanically strong tube of an implantable submucosal tissue has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the submucosal tissue prosthesis generally involves wrapping a first sheet of submucosal tissue (60) and a second sheet of submucosal tissue (70) around a mandrel (50), wherein the first end (74) and the second opposite end (76) of the second sheet of submucosal tissue (70) are sutured together with sutures (78). The submucosal tissue is compressed and dried on the mandrel (50) before removing the construct by pulling on a first end (54) and a second end (56) of a water permeable tape to unwind the tape and thus release the construct for eventual use.
摘要翻译：已经开发了可植入的粘膜下组织的容易制造和机械强度的管，其以任何期望的长度，壁厚或直径制造。通过本发明的方法生产的构造体可以用作动脉，静脉，输尿管，尿道，分流器的移植物，或者在需要顺应的组织相容管的任何应用中。粘膜下组织假体的制造通常包括围绕心轴（50）缠绕第一片粘膜下组织（60）和第二片粘膜下组织（70），其中第一端（74）和第二相对端（76））的第二片粘膜下组织（70）与缝合线（78）缝合在一起。在通过拉动透水性带的第一端（54）和第二端（56）去除构造物之前，在心轴（50）上压缩并干燥粘膜下组织以展开带，并因此释放结构以最终使用。

5. 发明授权

US5968096A Method of repairing perforated submucosal tissue graft constructs 失效
标题翻译：修复穿孔粘膜下组织移植物构建体的方法
公开(公告)号：US5968096A
公开(公告)日：1999-10-19
申请号：US908151
申请日：1997-08-06
申请人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
发明人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
IPC分类号： A61F2/00 , A61F2/02 , A61L27/36 , A61F2/10 , A61K35/38
CPC分类号： A61L27/3683 , A61F2/02 , A61L27/3629 , A61F2240/001
摘要： A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.
摘要翻译：描述了一种穿孔单层多层组织移植物构建体及其制备方法。该方法包括将粘膜下层组织与其它粘膜下组织条带重叠，在允许或促进压缩粘膜下层片脱水的条件下至少压缩两个表面的两个表面的重叠部分，并对所得的单一组织移植物构件进行穿孔。穿孔组织移植组合物相对于非穿孔粘膜下组织移植物具有增强的机械和重塑性能。

6. 发明授权

US5755791A Perforated submucosal tissue graft constructs 失效
公开(公告)号：US5755791A
公开(公告)日：1998-05-26
申请号：US628789
申请日：1996-04-05
申请人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
发明人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
IPC分类号： A61F2/00 , A61F2/02 , A61L27/36 , A61F2/10
CPC分类号： A61L27/3683 , A61F2/02 , A61L27/3629 , A61F2240/001
摘要： A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.

7. 发明授权

US05997575A Perforated submucosal tissue graft constructs 失效
标题翻译：穿孔粘膜下组织移植物构建体
公开(公告)号：US05997575A
公开(公告)日：1999-12-07
申请号：US932868
申请日：1997-09-18
申请人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
发明人： Bryan Whitson , Boyle Cheng , Stephen F. Badylak
IPC分类号： A61F2/00 , A61F2/02 , A61L27/36 , A61F2/10
CPC分类号： A61L27/3683 , A61F2/02 , A61L27/3629 , A61F2240/001
摘要： A perforated unitary multi-laminar tissue graft construct and method for preparing such construct is described. The method comprises overlapping strips of submucosa tissue with other strips of submucosal tissue, compressing at least the overlapped portions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets, and perforating the resulting unitary tissue graft construct. The perforated tissue graft compositions have enhanced mechanical and remodeling properties relative to non-perforated submucosal tissue grafts.
摘要翻译：描述了一种穿孔单层多层组织移植物构建体及其制备方法。该方法包括将粘膜下层组织与其它粘膜下组织条带重叠，在允许或促进压缩粘膜下层片脱水的条件下至少压缩两个表面的两个表面的重叠部分，并对所得的单一组织移植物构件进行穿孔。穿孔组织移植组合物相对于非穿孔粘膜下组织移植物具有增强的机械和重塑性能。

8. 发明授权

US6126686A Artificial vascular valves 失效
标题翻译：人造血管瓣
公开(公告)号：US6126686A
公开(公告)日：2000-10-03
申请号：US319653
申请日：1999-06-10
申请人： Stephen F. Badylak , Arthur C. Coffey , Leslie A. Geddes , Michael C. Hiles , James Hong , Rebecca Roeder
发明人： Stephen F. Badylak , Arthur C. Coffey , Leslie A. Geddes , Michael C. Hiles , James Hong , Rebecca Roeder
IPC分类号： A61L27/00 , A61F2/06 , A61F2/24 , A61L27/36
CPC分类号： A61F2/2412 , A61F2/2415 , A61L27/3604 , A61L27/3629 , A61L27/3641 , A61L27/3645 , A61L27/3691 , A61L27/3886 , A61L27/507 , A61F2/06 , A61F2/2409 , A61F2220/0075 , Y10S623/91 , Y10S623/918 , Y10S623/925
摘要： A method for preparing vascular valves from submucosal tissue is described. Both bicuspid and tricuspid valve constructs are described. The bicuspid constructs can be formed with or without a supporting stent. The tricuspid constructs are formed by fixing submucosal tissue to a supporting stent, folding the submucosal tissue, and forming the valve commissures from the folded submucosal tissue by cutting along the folds. The artificial vascular valves are useful for replacing damaged or diseased valves of a warm-blooded vertebrate.
摘要翻译： PCT No.PCT / US97 / 22728 Sec。 371日期1999年6月10日第 102（e）1999年6月10日PCT 1997年12月10日PCT公布。第WO98 / 25549号公报日期：1998年6月18日描述了从粘膜下组织制备血管瓣膜的方法。描述了双尖瓣和三尖瓣构造。二尖瓣构建体可以形成有或不具有支撑支架。通过将粘膜下组织固定到支撑支架，折叠粘膜下组织以及通过沿着折痕切割从折叠的粘膜下组织形成瓣膜连合而形成三尖瓣构造。人造血管瓣可用于更换温血脊椎动物的受损或患病瓣膜。

9. 发明授权

US06475232B1 Stent with reduced thrombogenicity 有权
标题翻译：支架具有降低的血栓形成
公开(公告)号：US06475232B1
公开(公告)日：2002-11-05
申请号：US09319718
申请日：1999-06-10
申请人： Charles F. Babbs , Neal F. Fearnot , Stephen F. Badylak , Leslie A Geddes , Michael C. Hiles , Joe D. Bourland
发明人： Charles F. Babbs , Neal F. Fearnot , Stephen F. Badylak , Leslie A Geddes , Michael C. Hiles , Joe D. Bourland
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/07 , A61F2/86 , A61F2/885 , A61F2/90 , A61F2/91 , A61F2/95 , A61F2/958 , A61F2002/072 , A61F2002/075 , A61F2002/9583 , A61F2220/0008 , A61F2220/005 , A61F2220/0075 , A61F2240/001 , A61F2250/0067 , A61L31/005 , A61L31/10 , A61L33/18 , A61M25/0045 , A61M29/02 , C08L89/06
摘要： A tissue graft construct and method for repairing the inner linings of damaged or diseased vertebrate vessels is described. The method comprises the steps of positioning a tissue graft construct within a blood vessel at a site in need of repair. The tissue graft construct comprises a stent (3) covered with submucosal tissue (4) wherein the stent (3) is formed for receiving the distal end of a catheter (1) having an inflatable balloon (2).
摘要翻译：描述了用于修复受损或患病的脊椎动物血管的内衬的组织移植物构建体和方法。该方法包括以下步骤：将组织移植物构建体定位在需要修复的部位的血管内。组织移植物构件包括覆盖有粘膜下组织（4）的支架（3），其中支架（3）被形成用于接纳具有可膨胀气囊（2）的导管（1）的远端。

10. 发明授权

US08927003B2 Extracellular matrix based gastroesophageal junction reinforcement device 有权
标题翻译：基于细胞外基质的胃食管结合加强装置
公开(公告)号：US08927003B2
公开(公告)日：2015-01-06
申请号：US13108074
申请日：2011-05-16
申请人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
发明人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
IPC分类号： A61L27/36 , A61K35/38 , A61L27/38
CPC分类号： A61L27/3679 , A61F2/04 , A61F2002/044 , A61K35/38 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3882 , A61L2430/22
摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
摘要翻译：提供用于植入患有至少部分食管的患者的医疗装置。医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。在本文中还描述了用于制造医疗装置的模具和装置的使用方法。

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