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1. 发明授权

US06462345B1 Process and arrangement for confocal microscopy 有权
标题翻译：共焦显微镜的工艺和布置
公开(公告)号：US06462345B1
公开(公告)日：2002-10-08
申请号：US09295556
申请日：1999-04-21
申请人： Ulrich Simon , Sebastian Tille , Gunter Moehler , Stefan Wilhelm , Ulrich Meisel , Ernst Hans Karl Stelzer
发明人： Ulrich Simon , Sebastian Tille , Gunter Moehler , Stefan Wilhelm , Ulrich Meisel , Ernst Hans Karl Stelzer
IPC分类号： G01N2164
CPC分类号： G02B21/0056 , G01N21/645 , G02B21/0064 , G02B21/0076 , G02B21/0084
摘要： A process for confocal microscopy is disclosed in which laser light is coupled into a microscope beam path, directed successively with respect to time onto different locations of a specimen, and an image of the scanned plane is generated from the light reflected and emitted by the irradiated locations. A change in the spectral composition and in the intensity of light is carried out during the deflection of the laser beam from location to location, while the deflection continues in an uninterrupted manner. In this way, at least two locations of the specimen located next to one another are acted upon by light with different spectral characteristics and by laser radiation of different intensity. By periodically interrupting the coupling in of the laser light during the deflection of the microscope beam path, it is made possible that only selected portions of the image field are acted upon by the laser radiation. A laser scanning microscope for carrying out this process is also disclosed.
摘要翻译：公开了一种用于共焦显微镜的方法，其中将激光耦合到相对于时间相对于样本的不同位置的显微镜光束路径中，并且从被照射的反射和发射的光产生扫描平面的图像位置。在激光束从位置到位置的偏转期间进行光谱组成和光强度的变化，而偏转以不间断的方式继续。以这种方式，彼此相邻的样本的至少两个位置由具有不同光谱特性的光和不同强度的激光辐射作用。通过在显微镜光束路径的偏转期间周期性地中断激光的耦合，使得只有图像场的选定部分被激光辐射作用才有可能。还公开了用于进行该方法的激光扫描显微镜。

2. 再颁专利

USRE41666E1 Process and arrangement for confocal microscopy 有权
标题翻译：共焦显微镜的工艺和布置
公开(公告)号：USRE41666E1
公开(公告)日：2010-09-14
申请号：US10959949
申请日：2004-10-07
申请人： Ulrich Simon , Sebastian Tille , Gunter Moehler , Stefan Wilhelm , Ulrich Meisel , Ernst Stelzer
发明人： Ulrich Simon , Sebastian Tille , Gunter Moehler , Stefan Wilhelm , Ulrich Meisel , Ernst Stelzer
IPC分类号： G01N21/64 , G01J3/30
CPC分类号： G02B21/0056 , G01N21/645 , G02B21/0064 , G02B21/0076 , G02B21/0084
摘要： A process for confocal microscopy is disclosed in which laser light is coupled into a microscope beam path, directed successively with respect to time onto different locations of a specimen, and an image of the scanned plane is generated from the light reflected and emitted by the irradiated locations. A change in the spectral composition and in the intensity of light is are carried out during the deflection of the laser beam from location to location, while the deflection continues in an uninterrupted manner. In this way , so that at least two adjacent locations of the specimen located next to one another are acted upon by light with different spectral characteristics and by laser radiation of different intensity. By periodically interrupting the coupling in of the laser light during the deflection of the microscope beam path, it is made possible that only selected portions of the image field are acted upon by the laser radiation. A laser scanning microscope for carrying out this process is also disclosed. A laser scanning microscope for carrying out this process is also disclosed.
摘要翻译：公开了一种用于共焦显微镜的方法，其中将激光耦合到相对于时间相对于样本的不同位置的显微镜光束路径中，并且从被照射的反射和发射的光产生扫描平面的图像位置。在激光束从位置到位置的偏转期间，进行光谱组成和光强度的变化，同时偏转以不间断的方式继续。以这种方式，使得彼此相邻的样本的至少两个相邻位置由具有不同光谱特性的光和不同强度的激光辐射作用。通过在显微镜光束路径的偏转期间周期性地中断激光的耦合，使得只有图像场的选定部分被激光辐射作用才有可能。还公开了用于进行该方法的激光扫描显微镜。还公开了用于进行该方法的激光扫描显微镜。

3. 发明授权

US07498561B2 Arrangement for the detection of illumination radiation in a laser scanning microscope 有权
标题翻译：在激光扫描显微镜中检测照射辐射的布置
公开(公告)号：US07498561B2
公开(公告)日：2009-03-03
申请号：US11487936
申请日：2006-07-17
申请人： Thomas Mehner , Stefan Wilhelm , Ulrich Meisel , Mirko Liedtke
发明人： Thomas Mehner , Stefan Wilhelm , Ulrich Meisel , Mirko Liedtke
IPC分类号： G01J3/50
CPC分类号： G02B21/0032 , G02B21/008
摘要： An arrangement for the detection of the illumination radiation in a laser scanning microscope, wherein a portion of the illumination radiation is coupled out and detected at the main color splitter, wherein light transmitted through the main color splitter is advantageously detected and/or a portion of the illumination radiation is coupled out and detected before coupling into a light-conducting fiber and/or a portion of the illumination radiation is coupled out and detected at a beam splitter arranged downstream of a light-conducting fiber.
摘要翻译：一种用于在激光扫描显微镜中检测照射辐射的装置，其中照射辐射的一部分耦合到主分色器并在主分色器处被检测，其中有利地检测透过主分色器的光和/或一部分照射辐射在耦合到导光纤维之前被耦合出来并被检测，并且/或者一部分照射辐射被耦合出来，并在布置在导光纤维下游的分束器处被检测。

4. 发明申请

US20060011858A1 Process for the observation of at least one sample region with a light raster microscope 审中-公开
标题翻译：用光栅显微镜观察至少一个样品区域的方法
公开(公告)号：US20060011858A1
公开(公告)日：2006-01-19
申请号：US10967328
申请日：2004-10-19
申请人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
发明人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
IPC分类号： G01N21/64
CPC分类号： G02B21/0076 , G02B21/0048
摘要： Process for the observation of at least one sample region with a light raster microscope by a relative movement between the illumination light and sample via first scanning means along at least one scanning axis essentially perpendicular to the illumination axis wherein at an angle to the plane of the relative movement, preferably perpendicular thereto, second scanning means are moved and an image acquisition takes place by the movement of the first and second scanning means being coupled and a three-dimensional sampling movement being done by the illumination of the sample wherein the second scanning means are coupled to the movement of the first scanning means in such a manner that straight and/or curved lines and/or plane and/or curved surfaces are scanned which are extended along at least one scanning direction of the first scanning means as well as along the scanning direction of the second scanning means.
摘要翻译：用于通过第一扫描装置沿着基本上垂直于照明轴线的至少一个扫描轴的照明光和样品之间的相对运动用光栅显微镜观察至少一个样品区域的方法，其中与至少一个样品区域的平面成角度相对运动，优选地与其垂直，第二扫描装置被移动，并且通过被耦合的第一和第二扫描装置的运动而进行图像采集，并且三维采样运动是通过样品的照射完成的，其中第二扫描装置耦合到第一扫描装置的运动，使得沿着第一扫描装置的至少一个扫描方向延伸的直线和/或曲线和/或平面和/或曲面被扫描，以及沿着第二扫描装置的扫描方向。

5. 发明申请

US20070131875A1 Process for the observation of at least one sample region with a light raster microscope 有权
标题翻译：用光栅显微镜观察至少一个样品区域的方法
公开(公告)号：US20070131875A1
公开(公告)日：2007-06-14
申请号：US11590851
申请日：2006-11-01
申请人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
发明人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
IPC分类号： G01N21/64
CPC分类号： G02B21/0076 , G02B21/0048
摘要： Process for the observation of at least one sample region with a light raster microscope by a relative movement between the illumination light and sample via first scanning means along at least one scanning axis essentially perpendicular to the illumination axis wherein at an angle to the plane of the relative movement, preferably perpendicular thereto, second scanning means are moved and an image acquisition takes place by the movement of the first and second scanning means being coupled and a three-dimensional sampling movement being done by the illumination of the sample wherein the second scamming means are coupled to the movement of the first scanning means in such a manner that straight and/or curved lines and/or plane and/or curved surfaces are scanned which are extended along at least one scanning direction of the first scanning means as well as along the scanning direction of the second scanning means.
摘要翻译：用于通过第一扫描装置沿着基本上垂直于照明轴线的至少一个扫描轴的照明光和样品之间的相对运动用光栅显微镜观察至少一个样品区域的方法，其中与至少一个样品区域的平面成角度相对运动，优选地与其垂直，第二扫描装置被移动，并且通过所耦合的第一和第二扫描装置的移动进行图像采集，并且通过样品的照射进行三维采样运动，其中第二打扫装置耦合到第一扫描装置的运动，使得沿着第一扫描装置的至少一个扫描方向延伸的直线和/或曲线和/或平面和/或曲面被扫描，以及沿着第二扫描装置的扫描方向。

6. 发明授权

US07649683B2 Process for the observation of at least one sample region with a light raster microscope with linear sampling 有权
标题翻译：用线性采样的光栅显微镜观察至少一个样品区域的方法
公开(公告)号：US07649683B2
公开(公告)日：2010-01-19
申请号：US10967341
申请日：2004-10-19
申请人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
发明人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
IPC分类号： G02B21/06
CPC分类号： G02B21/008 , G02B21/0036 , Y10S359/90
摘要： Process for observing at least one sample region with a light raster microscope by a relative movement between the illumination light and sample via a first scanner along at least one scanning axis essentially perpendicular to the illumination axis wherein several illuminated sample points lie on a line and are detected simultaneously with a spatially resolving detector. At an angle to the plane of the relative movement, a second scanner is moved and an image acquisition takes place by coupling the movement of the first and second scanners and a three-dimensional sampling movement being done by the illumination of the sample. The second scanner is coupled to the movement of the first scanner such that straight and/or curved lines and/or plane and/or curved surfaces are scanned which are extended along at least one scanning direction of the first scanner as well as along the scanning direction of the second scanner.
摘要翻译：使用光栅显微镜通过第一扫描仪沿着基本上垂直于照明轴的至少一个扫描轴的照射光和样本之间的相对运动来观察至少一个样本区域的过程，其中几个照亮的采样点位于一条线上，并且是与空间分辨检测器同时检测。与相对运动的平面成一角度，第二扫描器被移动，并且通过耦合第一和第二扫描器的运动以及通过样本的照明来完成三维采样运动来进行图像采集。第二扫描器耦合到第一扫描仪的运动，使得扫描直线和/或曲线和/或平面和/或曲面，其沿着第一扫描器的至少一个扫描方向以及沿着扫描第二扫描仪的方向。

7. 发明授权

US07271382B2 Process for the observation of at least one sample region with a light raster microscope with light distribution in the form of a point 失效
标题翻译：用光斑显微镜观察至少一个样品区域的过程，该光栅显微镜具有点状形式的光分布
公开(公告)号：US07271382B2
公开(公告)日：2007-09-18
申请号：US10967636
申请日：2004-10-19
申请人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
发明人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
IPC分类号： H01J3/14 , H01J5/16 , H01J40/14 , G06K9/00
CPC分类号： G02B21/002 , G02B21/0044 , G02B21/0064 , G02B21/008 , G02B21/248
摘要： Process for the observation of at least one sample region with a light raster microscope by a relative movement between the illumination light and sample via first scanning means along at least one scanning axis essentially perpendicular to the illumination axis wherein the illumination light illuminates the sample in parallel at several points or regions and several points or regions are detected simultaneously wherein at an angle to the plane of the relative movement, preferably perpendicular thereto, second scanning means are moved and an image acquisition takes place by the movement of the first and second scanning means being coupled and a three-dimensional sampling movement being done by the illumination of the sample wherein the second scanning means are coupled to the movement of the first scanning means in such a manner that straight and/or curved lines and/or plane and/or curved surfaces are scanned which are extended along at least one scanning direction of the first scanning means as well as along the scanning direction of the second scanning means.
摘要翻译：用于通过第一扫描装置沿着基本上垂直于照明轴的至少一个扫描轴的照明光和样品之间的相对运动用光栅显微镜观察至少一个样本区域的过程，其中照明光平行照射样本在多个点或区域处，同时检测多个点或区域，其中相对于相对运动的平面成一角度，优选垂直于其，第二扫描装置被移动，并且通过第一和第二扫描装置被耦合，并且通过样品的照射来完成三维采样运动，其中第二扫描装置以这样的方式耦合到第一扫描装置的运动，使得直线和/或曲线和/或平面和/或扫描沿着第一扫描线的至少一个扫描方向延伸的曲面 g装置以及沿着第二扫描装置的扫描方向。

8. 发明申请

US20050046932A1 Arrangement in the illumination beam path of a laser scanning microscope 有权
标题翻译：激光扫描显微镜的照明光束路径的布置
公开(公告)号：US20050046932A1
公开(公告)日：2005-03-03
申请号：US10888098
申请日：2004-07-09
申请人： Ralph Lange , Stefan Wilhelm , Ulrich Meisel , Matthias Reich
发明人： Ralph Lange , Stefan Wilhelm , Ulrich Meisel , Matthias Reich
IPC分类号： G02B26/08 , G02B21/00 , G02B21/06
CPC分类号： G02B21/002
摘要： An arrangement in the illumination beam path of a laser scanning microscope, comprising a mirror which can be introduced into the beam path for coupling in at least one additional wavelength, and a method for the operation of a laser scanning microscope with a mirror which can be swiveled in rapidly for coupling at least one additional wavelength into the illumination beam path, wherein the swiveling process is synchronized with the illumination control by a control unit in such a way that at least one additional wavelength is coupled into the illumination beam path when the mirror is swiveled out.
摘要翻译：激光扫描显微镜的照明光束路径中的布置，包括可以被引入到光束路径中用于耦合到至少一个附加波长的反射镜，以及用于具有镜子的激光扫描显微镜的操作方法，所述反射镜可以是快速旋转以将至少一个附加波长耦合到照明光束路径中，其中旋转过程与控制单元的照明控制同步，使得当镜子耦合至少一个附加波长到照明光束路径时被旋转出来

9. 发明授权

US07459698B2 Process for the observation of at least one sample region with a light raster microscope 有权
标题翻译：用光栅显微镜观察至少一个样品区域的方法
公开(公告)号：US07459698B2
公开(公告)日：2008-12-02
申请号：US11590851
申请日：2006-11-01
申请人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
发明人： Ralf Engelmann , Joerg-Michael Funk , Joerg Steinert , Bernhard Zimmermann , Stefan Wilhelm , Joerg Engel , Ulrich Meisel
IPC分类号： G01N21/64
CPC分类号： G02B21/0076 , G02B21/0048
摘要： Process for the observation of at least one sample region with a light raster microscope by a relative movement between the illumination light and sample via a first scanner along at least one scanning axis essentially perpendicular to the illumination axis wherein at an angle to the plane of the relative movement, preferably perpendicular thereto a second scanner is moved and an image acquisition takes place by the movement of the first and second scanners being coupled and a three-dimensional sampling movement being done by the illumination of the sample wherein the second scanner is coupled to the movement of the first scanner in such a manner that straight and/or curved lines and/or plane and/or curved surfaces are scanned which are extended along at least one scanning direction of the first scanner as well as along the scanning direction of the second scanner.
摘要翻译：用于利用光栅显微镜通过第一扫描器沿着基本上垂直于照明轴的至少一个扫描轴的照明光和样本之间的相对运动来观察至少一个样本区域的过程，其中，相对运动，优选地垂直于其，第二扫描器被移动，并且通过被耦合的第一和第二扫描器的运动而进行图像采集，并且三维采样运动是通过样本的照射进行的，其中第二扫描器耦合到第一扫描器的运动以这样的方式扫描直线和/或曲线和/或平面和/或曲面，其沿着第一扫描仪的至少一个扫描方向以及沿着第一扫描仪的扫描方向延伸第二台扫描仪

10. 发明授权

US07212337B2 Arrangement in the illumination beam path of a laser scanning microscope 有权
标题翻译：激光扫描显微镜的照明光束路径的布置
公开(公告)号：US07212337B2
公开(公告)日：2007-05-01
申请号：US10888098
申请日：2004-07-09
申请人： Ralph Lange , Stefan Wilhelm , Ulrich Meisel , Matthias Reich
发明人： Ralph Lange , Stefan Wilhelm , Ulrich Meisel , Matthias Reich
IPC分类号： G02B21/06
CPC分类号： G02B21/002
摘要： An arrangement in the illumination beam path of a laser scanning microscope, comprising a mirror which can be introduced into the beam path for coupling in at least one additional wavelength, and a method for the operation of a laser scanning microscope with a mirror which can be swiveled in rapidly for coupling at least one additional wavelength into the illumination beam path, wherein the swiveling process is synchronized with the illumination control by a control unit in such a way that at least one additional wavelength is coupled into the illumination beam path when the mirror is swiveled out.
摘要翻译：激光扫描显微镜的照明光束路径中的布置，包括可以被引入到光束路径中用于耦合到至少一个附加波长的反射镜，以及用于具有镜子的激光扫描显微镜的操作方法，所述反射镜可以是快速旋转以将至少一个附加波长耦合到照明光束路径中，其中旋转过程与控制单元的照明控制同步，使得当镜子耦合至少一个附加波长到照明光束路径时被旋转出来

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