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1. 发明授权

US07314449B2 Apparatus for determining cardiovascular parameters 失效
标题翻译：用于确定心血管参数的装置
公开(公告)号：US07314449B2
公开(公告)日：2008-01-01
申请号：US10743515
申请日：2003-12-22
申请人： Ulrich J. Pfeiffer , Thorsten Burger
发明人： Ulrich J. Pfeiffer , Thorsten Burger
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/02108 , A61B5/02152 , A61B5/1135
摘要： An apparatus that continuously monitors the arterial pressure measured by a pressure sensor in an artery, which pressure is regarded as the reading Pao that approximately corresponds to the aortal pressure. In principle, the arterial pressure can be measured in the aorta, near the aorta, or in the arterial tree. To provide a second reading, the apparatus, via the input channel, continuously monitors the central venous pressure (CVP), which is regarded as the reading PIT that approximately corresponds to the intrathoracic pressure (ITP). The third reading is provided via the input channel as a reading Z which expresses the thoracic compliance. Via known algorithms of the pulse contour analysis, the apparatus calculates the stroke volume variation, using as the determining pressure the transmural pressure which is calculated according to the formula Ptransmural=Pao−f(C)*PIT The cardiac volume responsiveness indicator (CVRI) is calculated for mechanical positive respiration according to the formula CVRI=k*(SVV/ΔCVP) or for spontaneous breathing according to the formula CVRI=l−m*(ΔCVP/SVV).
摘要翻译：一种连续监测动脉压力传感器测量的动脉压的装置，该压力被认为是大致对应于主动脉压的读数Pao。原则上，可以在主动脉，主动脉附近或动脉树中测量动脉压。为了提供二读，该装置经由输入通道连续监测中心静脉压（CVP），其被认为是大致对应于胸内压（ITP）的读数PIT。通过输入通道提供三读作为表达胸部顺应性的读数Z。通过脉冲轮廓分析的已知算法，该装置计算行程体积变化，使用根据公式<？in-line-formula description =“In-line Formulas”end =“ 铅“？> Ptransmural = Pao-f（C）* PIT <？in-line-formula description =”In-line Formulas“end =”tail“？>计算心脏体积反应性指标（CVRI），用于机械正呼吸根据公式<？in-line-formula description =“In-line Formulas”end =“lead”？> CVRI = k *（SVV / DeltaCVP）<？in-line-formula description =“In-line Formulas” end =“tail”？>或用于根据公式的自发呼吸<？in-line-formula description =“In-line Formulas”end =“lead”？> CVRI = lm *（DeltaCVP / SVV）<？in -line-formula description =“内联公式”end =“tail”？>

2. 发明授权

US07209780B2 System and a computer program for the determination of quantities relating to the circulatory system of a patient 失效
标题翻译：系统和用于确定与患者的循环系统相关的量的计算机程序
公开(公告)号：US07209780B2
公开(公告)日：2007-04-24
申请号：US10222973
申请日：2002-08-19
申请人： Ulrich J. Pfeiffer , Thorsten Burger
发明人： Ulrich J. Pfeiffer , Thorsten Burger
IPC分类号： A61B6/00
CPC分类号： A61B5/028 , A61B5/029
摘要： A system for the determination of quantifies relating to the circulatory system of a patient including a device for the non-invasive measurement of the qualitative variation over time of the local concentration of an indicator injected into the blood circulation system at a first position, the measurement taking place at a second position of the blood circulation system. An evaluating unit is provided, in which there is implemented an evaluating algorithm which transforms the qualitative variation into a quantitative variation over time of the local concentration of the indicator injected into the blood circulation system. For the purposes of the transformation, the condition is fulfilled that the cardiac output COdye calculable from the quantitative variation over time of the local concentration in accordance with a predetermined relationship is equal to an input value of the cardiac output COe, which has been determined by thermodilution measurement.
摘要翻译：一种用于确定与患者的循环系统有关的量化的系统，包括用于非侵入式测量在第一位置处注入到血液循环系统中的指示剂的局部浓度随时间的定性变化的装置，所述测量发生在血液循环系统的第二位置。提供了一种评估单元，其中实施了一种评估算法，其将定性变化变换为随着时间的定量变化，注入到血液循环系统中的指示剂的局部浓度。为了转化的目的，满足以下条件：根据预定关系，根据局部浓度随时间的定量变化可计算出的心输出量COdye等于心输出量COe的输入值，其由热稀释测量。

3. 发明授权

US06736782B2 Apparatus, computer program, central venous catheter assembly and method for hemodynamic monitoring 失效
标题翻译：装置，计算机程序，中心静脉导管组装及血液动力学监测方法
公开(公告)号：US06736782B2
公开(公告)日：2004-05-18
申请号：US10083108
申请日：2002-02-27
申请人： Ulrich J. Pfeiffer , Thorsten Burger
发明人： Ulrich J. Pfeiffer , Thorsten Burger
IPC分类号： A61B502
CPC分类号： A61B5/028 , A61B5/029 , A61M2025/004
摘要： A central venous cather (1) is placed in the vena cava superior (2) and equipped with a heating coil (3) for emitting heat pulses in the immediate proximity of the distal end (5) of the catheter (1) in order to introduce travelling temperature deviations to the patient's circulation. The power transferred to the blood stream during emission of each heat pulse represents an input signal for modified thermodilution measurements. Each travelling temperature deviation is detected as a system response corresponding to an input signal, when it reaches an arterial catheter (14) which additionally comprises a pressure sensor (17) for measuring the local blood pressure in the arteria femoralis (16) as a function of time. The computer (18) has stored thereon an executable computer program for repeatedly determining a reference cardiac output value from a plurality of input signals and corresponding system responses by thermodilution curve evaluation methods and for determining from the blood pressure function hemodynamic parameters by pulse contour analysis methods using the most recent respective reference cardiac output value for quasi-continuous recalibration.
摘要翻译：将中心静脉吻合器（1）放置在腔静脉上部（2）中，并配备有用于在紧邻导管（1）的远端（5）处发射热脉冲的加热线圈（3），以便引入患者血液循环的温度偏差。在每个加热脉冲的发射期间转移到血流的功率代表用于改进的热稀释测量的输入信号。每个行驶温度偏差被检测为对应于输入信号的系统响应，当其到达动脉导管（14）时，其另外包括用于测量股动脉（16）中的局部血压的压力传感器（17）作为功能的时间。计算机（18）在其上存储有可执行的计算机程序，用于通过热稀释曲线评估方法从多个输入信号和相应的系统响应中重复地确定参考心输出量，并且通过脉搏轮廓分析方法从血压函数测定血液动力学参数使用最近的相应参考心输出量进行准连续重新校准。

4. 发明授权

US06631286B2 Device for the determination of tissue perfusion and operative use thereof 有权
公开(公告)号：US06631286B2
公开(公告)日：2003-10-07
申请号：US09993901
申请日：2001-11-27
申请人： Ulrich J. Pfeiffer , Andreas Becker , Norbert Eder , Thorsten Burger , Christian Töns
发明人： Ulrich J. Pfeiffer , Andreas Becker , Norbert Eder , Thorsten Burger , Christian Töns
IPC分类号： A61B600
CPC分类号： H04N5/2256 , A61B5/0059 , A61B5/0261 , A61B5/0275 , H04N5/33
摘要： A safety housing, into which an infrared laser light source is integrated together with the CCD camera, forms a compact unit for the determination of tissue perfusion. Rays from the infrared laser light source radiate the area of operation and indocyanin green, previously injected intravenously into the patient, is excited to fluorescence by the radiation, which is detected by the CCD camera.

5. 发明授权

US06537230B1 Apparatus, computer system and computer program for determining a cardio-vascular parameter of a patient 失效
标题翻译：用于确定患者心血管参数的装置，计算机系统和计算机程序
公开(公告)号：US06537230B1
公开(公告)日：2003-03-25
申请号：US09869354
申请日：2001-10-01
申请人： Ulrich J. Pfeiffer , Thorsten Burger
发明人： Ulrich J. Pfeiffer , Thorsten Burger
IPC分类号： A61B502
CPC分类号： A61B5/028 , A61B5/029
摘要： A computer system (104) is connected to an injection means (107) to inject at a first place (101 ) a bolus warmer or colder than patient's blood. The travelling temperature deviation thus introduced to the patient's vascular system (103) passes the pulmonary circulation (111), where an extravascular thermovolume (112) may be present. When the temperature deviation reaches the second place (102), where blood temperature is measured by a sensor device (117) connected to the computer system (104), it is recorded as Thermodilution Curve (15), from which the computer system (104) determines an extravascular thermovolume estimate. Depending on that result the computer system (104) calculates a new amount of bolus to be injected by the injection means (107). The higher the extravascular thermovolume estimate, the higher the new amount of bolus. The new travelling temperature deviation thus introduced to patient's vascular system (103) eventually reaches the second place (102), where it is recorded as an improved Thermodilution Curve (17) from which cardio-vascular parameters of improved accuracy are derived by the computer system (104).
摘要翻译：计算机系统（104）连接到注射装置（107）以在第一位置（101）注射比患者血液更快或更冷的注射装置。由此引入患者血管系统（103）的行进温度偏差通过肺循环（111），其中可存在血管外热血泡（112）。当温度偏差达到第二位置（102）时，通过与计算机系统（104）连接的传感器装置（117）测量血液温度，将其记录为热模量曲线（15），计算机系统（104））确定血管外热血机估计。根据该结果，计算机系统（104）计算由喷射装置（107）喷射的新的推注量。血管外温度估计值越高，推注剂量越高。由此引入患者血管系统（103）的新的行进温度偏差最终达到第二位（102），在那里将其记录为改进的热调节曲线（17），计算机系统可从该温度曲线（17）导出改进精度的心血管参数（104）。

6. 发明授权

US06853857B2 Method, device and computer program for determining the blood flow in a tissue or organ region 有权
标题翻译：用于确定组织或器官区域中的血流的方法，装置和计算机程序
公开(公告)号：US06853857B2
公开(公告)日：2005-02-08
申请号：US10134650
申请日：2002-04-30
申请人： Ulrich J. Pfeiffer , Thorsten Burger , Andreas Becker
发明人： Ulrich J. Pfeiffer , Thorsten Burger , Andreas Becker
IPC分类号： A61B5/00 , A61B5/026 , A61B5/0275 , A61B6/00
CPC分类号： A61B5/0275 , A61B5/0059 , A61B5/0261
摘要： In a method, a device and a computer program for determining the blood flow in a tissue or organ region, the fluorescence intensity of an exogenous chromophore is measured as a function of time in the tissue region to be examined and from this the permeation rate of the chromophore is calculated, from which the blood flow can be derived.
摘要翻译：在一种用于确定组织或器官区域中的血液流动的装置和计算机程序中，测量外源发色团的荧光强度作为待检查组织区域中时间的函数，并且从该渗透速率计算发色团，从中可以导出血流。

7. 发明授权

US06394961B1 Method to increase transpulmonary thermodilution cardiac output accuracy by use of extravascular thermovolume to control the amount of thermal indicator 有权
标题翻译：通过使用血管外热血流量来控制热指示剂的量来增加肺内热稀释心输出量的方法
公开(公告)号：US06394961B1
公开(公告)日：2002-05-28
申请号：US09697600
申请日：2000-10-27
申请人： Ulrich J. Pfeiffer , Thorsten Burger
发明人： Ulrich J. Pfeiffer , Thorsten Burger
IPC分类号： A61B502
CPC分类号： A61B5/028 , A61B5/029
摘要： The present invention relates to a method for determining the cardiac output of a subject by thermodilution measurements by providing a predetermined amount of thermal indicator in a blood vessel with the thermal indicator having a temperature different from the temperature of subject's blood, thus exhibiting an indicator temperature difference. By measuring the temperature of subject's blood at a second place downstream the cardiac output (CO) and the extravascular thermovolume can be determined as a function of the time for the thermodilution curve. As a function of the thermodilution curve the measurements of the amount of thermal indicator and/or thermal indicator volume temperature difference are adjusted to provide a more accurate determination of cardiac output.
摘要翻译：本发明涉及通过在血管中提供预定量的热指示剂来测定受试者的心输出量的方法，所述热指示器的温度不同于受试者血液的温度，因此显示指示剂温度区别。通过测量心输出量（CO）下游第二个位置处的受试者血液的温度，并且可以将血管外热血流量确定为热稀释曲线的时间的函数。作为热稀释曲线的函数，调节热指示剂量和/或热指示器体积温度差的测量值以提供更准确的心输出量测定。

8. 发明申请

US20120271613A1 INTRA-OPERATIVE SURGICAL PLAN CHANGING 有权
标题翻译：手术方案改变
公开(公告)号：US20120271613A1
公开(公告)日：2012-10-25
申请号：US13503253
申请日：2010-10-20
申请人： Alan Ashby , Harald Bornfleth , Thorsten Burger
发明人： Alan Ashby , Harald Bornfleth , Thorsten Burger
IPC分类号： G06G7/60
CPC分类号： G06F19/321 , G06F19/00
摘要： A system and computer implemented method for use in determining the deviation-of an intra-operative position of an orthopaedic implant from a planned position is described. The position of the orthopaedic implant in the bone is defined by a plurality of implant position parameters. The distance of a plurality of anatomical features in a three dimensional model of the surface of the bone relative to a model of the implant at a first position is calculated. The first position corresponds to a first set of values for the implant position parameters. The distance of the plurality of anatomical features to a model of the implant at a second position in the bone is calculated. The second position corresponds to a second set of values for the implant position parameters, and the second position is different to the first position.
摘要翻译：描述了一种用于确定整形外科植入物的术中位置与计划位置的偏差的系统和计算机实现的方法。骨骼植入物在骨骼中的位置由多个植入位置参数限定。计算骨骼表面的三维模型中的多个解剖特征相对于在第一位置处的植入物的模型的距离。第一位置对应于植入位置参数的第一组值。计算多个解剖特征与在骨骼中的第二位置处的植入物的模型的距离。第二位置对应于植入位置参数的第二组值，而第二位置与第一位置不同。

9. 发明申请

US20060084890A1 Method and apparatus for performing a computer-assisted orthopaedic procedure 有权
公开(公告)号：US20060084890A1
公开(公告)日：2006-04-20
申请号：US10956181
申请日：2004-09-30
申请人： D. Block , Thorsten Burger , Francois Urvoy , Magnus Flett , Michal Slomczykowski , Marcellino Maheson , Roger Oakeshott , Alec Birkbeck
发明人： D. Block , Thorsten Burger , Francois Urvoy , Magnus Flett , Michal Slomczykowski , Marcellino Maheson , Roger Oakeshott , Alec Birkbeck
IPC分类号： A61B5/103
CPC分类号： A61B17/864 , A61B17/1742 , A61B34/20 , A61B2010/0258 , A61B2034/2055 , A61B2090/3916 , A61B2090/3983
摘要： A method of performing a computer-assisted orthopaedic procedure includes securing a sensor support instrument to the patient's bone. A number of sensors are secured to the support instrument. A computer-assisted orthopaedic surgical instrument is also disclosed.

10. 发明授权

US09737369B2 Surgical apparatus and procedure 有权
公开(公告)号：US09737369B2
公开(公告)日：2017-08-22
申请号：US12919839
申请日：2009-02-26
申请人： Thorsten Burger , Frank Foley , Michal Slomczykowski
发明人： Thorsten Burger , Frank Foley , Michal Slomczykowski
IPC分类号： A61B5/103 , A61B34/10 , A61B34/20 , A61B90/00
CPC分类号： A61B34/10 , A61B34/20 , A61B2090/061
摘要： A computer assisted surgery method and apparatus for determining a change in a property of a joint of a patient caused by an arthroplasty procedure is described. The relative position of a first bone and a second bone of the joint is determined with the joint in a first position. The position of a pre-operative center of motion of the joint relative to the first bone is determined. The position of the second bone relative to the pre-operative center of motion is determined using the relative position of the first and second bones. The position of a post-operative center of motion resulting from a prosthetic component to be used in the joint is determined. The position of the second bone relative to the post-operative center of motion is determined. Any change in the property of the joint. is determined from the difference between the position of the second bone relative to the pre-operative center of motion and the position of the second bone relative to the post-operative center of motion.

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