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1. 发明申请

US20080119571A1 COMPOSITIONS AND METHODS TO ENHANCE REVERSE CHOLESTEROL TRANSPORT 审中-公开
标题翻译：组合物和方法来增强反向胆固醇运输
公开(公告)号：US20080119571A1
公开(公告)日：2008-05-22
申请号：US11759713
申请日：2007-06-07
申请人： Ish Khanna , Sivaram Pillarisetti , Uday Saxena
发明人： Ish Khanna , Sivaram Pillarisetti , Uday Saxena
IPC分类号： A61K45/00 , A61P3/00 , A61P9/00 , C12N5/00
CPC分类号： A61K31/506 , C07D401/04
摘要： The present invention shows that pharmacological up regulation of SRB-1, ABC-A1 and LCAT genes collectively can be used to promote reverse cholesterol transport and increase circulating HDL cholesterol as treatment for atherosclerosis and related cardiovascular disorders.
摘要翻译：本发明显示，SRB-1，ABC-A1和LCAT基因的药理学上调可以统一用于促进逆转胆固醇转运，并增加循环HDL胆固醇作为动脉粥样硬化和相关心血管疾病的治疗。

2. 发明授权

US08008328B2 Methods for the treatment of diabetes-associated dyslipdemia 失效
标题翻译：治疗糖尿病相关性血脂异常的方法
公开(公告)号：US08008328B2
公开(公告)日：2011-08-30
申请号：US12005887
申请日：2007-12-28
申请人： Uday Saxena , Sivaram Pillarisetti , Ish Khanna
发明人： Uday Saxena , Sivaram Pillarisetti , Ish Khanna
IPC分类号： A61K31/44 , A61K31/70 , A61K31/54 , A61K31/505 , A61K31/445 , A61K31/40 , A61K31/195 , A61K31/155
CPC分类号： A61K31/445 , A61K31/5415 , Y10S514/866 , A61K2300/00
摘要： Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed.
摘要翻译：公开了通过施用烟酸和美洛昔康治疗胰岛素抵抗，糖尿病和/或糖尿病相关血脂异常的方法。

3. 发明申请

US20080275049A1 Methods and Compositions for Upregulation of GATA Activity 审中-公开
标题翻译：用于上调GATA活性的方法和组成
公开(公告)号：US20080275049A1
公开(公告)日：2008-11-06
申请号：US12113426
申请日：2008-05-01
申请人： John Anastasios Polikandriotis , Sivaram Pillarisetti , Ish Khanna , Uday Saxena
发明人： John Anastasios Polikandriotis , Sivaram Pillarisetti , Ish Khanna , Uday Saxena
IPC分类号： A61K31/53 , C12Q1/02 , A61P9/10 , C12Q1/66
CPC分类号： G01N33/5067 , A61K31/53 , G01N2333/4703
摘要： A novel method of identifying compounds capable of upregulating GATA activity is disclosed. The method includes providing a sample of cells that express GATA, providing a sample of a candidate compound, contacting the cell sample and the compound sample, and measuring a quantitative indicator of GATA activity within the cell sample after the contacting step. GATA inducers identified by the method and uses therefore to upregulate GATA activity in subjects and to prevent or treat atherosclerosis or diabetes in subjects are also described.
摘要翻译：公开了鉴定能够上调GATA活性的化合物的新方法。该方法包括提供表达GATA的细胞样品，提供候选化合物样品，接触细胞样品和化合物样品，以及在接触步骤之后测量细胞样品内GATA活性的定量指标。还描述了通过该方法鉴定的GATA诱导物并因此用于上调受试者中的GATA活性并预防或治疗受试者的动脉粥样硬化或糖尿病。

4. 发明申请

US20080214531A1 Methods and compositions for the treatment of insulin resistance, diabetes, and diabetes-associated dyslipdemia 失效
标题翻译：用于治疗胰岛素抵抗，糖尿病和糖尿病相关性血脂异常的方法和组合物
公开(公告)号：US20080214531A1
公开(公告)日：2008-09-04
申请号：US12005887
申请日：2007-12-28
申请人： Uday Saxena , Sivaram Pillarisetti , Ish Khanna
发明人： Uday Saxena , Sivaram Pillarisetti , Ish Khanna
IPC分类号： A61K31/5415 , A61P3/10 , A61P3/06
CPC分类号： A61K31/445 , A61K31/5415 , Y10S514/866 , A61K2300/00
摘要： Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed.
摘要翻译：公开了通过施用烟酸和美洛昔康治疗胰岛素抵抗，糖尿病和/或糖尿病相关血脂异常的方法。

5. 发明申请

US20060128729A1 Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them 审中-公开
标题翻译：新型双环杂环化合物，其制备方法和含有它们的组合物
公开(公告)号：US20060128729A1
公开(公告)日：2006-06-15
申请号：US11285982
申请日：2005-11-23
申请人： Manojit Pal , Yeleswarapu Rao , Ish Khanna , Nalivela Swamy , Venkataraman Subramanian , Venkateswara Batchu , Javed Iqbal , Sivaram Pillarisetti
发明人： Manojit Pal , Yeleswarapu Rao , Ish Khanna , Nalivela Swamy , Venkataraman Subramanian , Venkateswara Batchu , Javed Iqbal , Sivaram Pillarisetti
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
摘要翻译：本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法增殖，炎症，糖苷酶表达或Perlecan的低表达。

6. 发明授权

US07820654B2 Pyrimidine compounds, process for their preparation and compositions containing them 失效
标题翻译：嘧啶化合物，其制备方法和含有它们的组合物
公开(公告)号：US07820654B2
公开(公告)日：2010-10-26
申请号：US11234695
申请日：2005-09-23
申请人： Manojit Pal , Srinivas Kalleda , Srinivas Padakanti , Nalivela Kumara Swamy , Koteswar Rao Yeleswarapu , Christopher W. Alexander , Ish Khanna , Javed Iqbal , Sivaram Pillarisetti , Deepak Barange
发明人： Manojit Pal , Srinivas Kalleda , Srinivas Padakanti , Nalivela Kumara Swamy , Koteswar Rao Yeleswarapu , Christopher W. Alexander , Ish Khanna , Javed Iqbal , Sivaram Pillarisetti , Deepak Barange
IPC分类号： A61K31/54 , A61K31/535 , A61K31/497 , A61K31/505 , C07D417/00 , C07D413/00 , C07D403/00 , C07D239/02
CPC分类号： C07D405/14 , C07D239/30 , C07D239/40 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/48 , C07D239/50 , C07D239/54 , C07D401/04 , C07D403/12 , C07D405/12
摘要： The present invention is directed to a compounds, methods and compositions for making the compounds and methods of treating a variety of diseases and disease states including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan, comprising the administration of new heterocyclic compounds, particularly substituted pyrimidines. The present invention is directed to novel compounds represented by the general formula:
摘要翻译：本发明涉及用于制备化合物的化合物，方法和组合物以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或由Perlecan低表达介导的疾病包括施用新的杂环化合物，特别是取代的嘧啶。本发明涉及由以下通式表示的新化合物：

7. 发明申请

US20060128702A1 Heterocyclic and bicyclic compounds, compositions and methods 审中-公开
标题翻译：杂环和双环化合物，组合物和方法
公开(公告)号：US20060128702A1
公开(公告)日：2006-06-15
申请号：US11286006
申请日：2005-11-23
申请人： Manojit Pal , Ish Khanna , Venkataraman Subramanian , Srinivas Padakanti , Sivaram Pillarisetti
发明人： Manojit Pal , Ish Khanna , Venkataraman Subramanian , Srinivas Padakanti , Sivaram Pillarisetti
IPC分类号： A61K31/5377 , A61K31/4709 , A61K31/4706 , C07D413/02 , C07D401/02 , C07D215/38
CPC分类号： C07D215/38 , C07D215/44 , C07D401/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/02
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
摘要翻译：本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法增殖，炎症，糖苷酶表达或Perlecan的低表达。

8. 发明申请

US20140142178A1 METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES AND DYSLIPIDEMIA 审中-公开
标题翻译：用于治疗糖尿病和DYSLIPIDEMIA的方法和组合物
公开(公告)号：US20140142178A1
公开(公告)日：2014-05-22
申请号：US14148580
申请日：2014-01-06
申请人： Ish Khanna , Sivaram Pillarisetti
发明人： Ish Khanna , Sivaram Pillarisetti
IPC分类号： C07C311/51
CPC分类号： C07C311/51 , C07C31/27 , C07C43/115 , C07C53/132 , C07C61/12 , C07C61/15 , C07C69/608 , C07C69/74 , C07C233/58 , C07C233/60 , C07C255/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D257/04
摘要： Novel compounds of Formula I are provided: its stereoisomers and/or pharmaceutically acceptable salts for the treatment of diabetes and diabetes-associated dyslipidemia, wherein R1 is selected from a group consisting of hydroxy, alkoxy, amine, alkyl, haloalkyl, NHSO2R, or NHCOR wherein R is selected from alkyl or cycloalkyl, NHR′ wherein R′ is alkyl or cycloalkyl optionally substituted by hydroxy or alkoxy; and n1 and n2 are independently selected from 0, 1, and 2. At least one of R3 and R4 and/or R5 and R6 form a cyclic ring of 3-8 carbon atoms optionally containing alkyl groups, hetero atoms, or functional groups such as O, N, SO2. Additionally, when R3 and R4 or R5 and R6 do not form a cyclic ring, then they may be independently selected from hydrogen, alkyl, branched alkyl, and cycloalkyl. L1 is a linear aliphatic chain optionally containing from 4 to 16 carbon atoms. The chain may optionally be substituted one or more times by alkyl, branched alkyl, cycloalkyl, or aryl. R2 is independently selected from hydrogen, alkoxy, hydroxy, alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, heteroaryl, cyano, or COR7, wherein R7 is selected from hydroxy, alkyl, alkoxy, or amine, NHR′, NHSO2R, or NHCOR. Y1 is oxygen or hydrogen. Y2 is optional, wherein when Y2 is present, Y1 and Y2 are hydrogen. When Y2 is not present, Y1 is a carbonyl group.
摘要翻译：提供式I的新型化合物：其用于治疗糖尿病和糖尿病相关血脂异常的其立体异构体和/或药学上可接受的盐，其中R 1选自羟基，烷氧基，胺，烷基，卤代烷基，NHSO 2 R或NHCOR 其中R选自烷基或环烷基，NHR'，其中R'是任选被羟基或烷氧基取代的烷基或环烷基; 并且n1和n2独立地选自0,1和2. R3和R4和/或R5和R6中的至少一个形成3-8个碳原子的环状环，任选地含有烷基，杂原子或官能团，例如作为O，N，SO 2。此外，当R3和R4或R5和R6不形成环时，它们可以独立地选自氢，烷基，支链烷基和环烷基。 L1是任选含有4至16个碳原子的直链脂族链。该链可以任选地被烷基，支链烷基，环烷基或芳基取代一次或多次。 R 2独立地选自氢，烷氧基，羟基，烷基，卤代烷基，环烷基，杂环烷基，杂芳基，氰基或COR 7，其中R 7选自羟基，烷基，烷氧基或胺，NHR'，NHSO 2 R或NHCOR。 Y1是氧或氢。 Y2是任选的，其中当存在Y2时，Y1和Y2是氢。当不存在Y2时，Y1是羰基。

9. 发明授权

US07700774B2 Heterocyclic compounds and their pharmaceutical compositions 失效
标题翻译：杂环化合物及其药物组合物
公开(公告)号：US07700774B2
公开(公告)日：2010-04-20
申请号：US11314299
申请日：2005-12-20
申请人： Anima Baruah , Ish Khanna , Sivaram Pillarisetti
发明人： Anima Baruah , Ish Khanna , Sivaram Pillarisetti
IPC分类号： C07D215/38
CPC分类号： C07D471/04
摘要： The present invention provides, among other things, new bicyclic heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译：本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗或预防与脂蛋白代谢相关的多种病症或疾病的方法。

10. 发明申请

US20060178514A1 Novel benzylamine derivatives as CETP inhibitors 有权
标题翻译：新型苄胺衍生物作为CETP抑制剂
公开(公告)号：US20060178514A1
公开(公告)日：2006-08-10
申请号：US11320120
申请日：2005-12-28
申请人： Anima Baruah , Dibyendu De , Ish Khanna , Sivaram Pillarisetti , Santanu Maitra , Christopher Alexander , Jennepalli Sreenu
发明人： Anima Baruah , Dibyendu De , Ish Khanna , Sivaram Pillarisetti , Santanu Maitra , Christopher Alexander , Jennepalli Sreenu
IPC分类号： A61K31/4965 , A61K31/4745 , A61K31/4706 , C07D491/02 , C07D471/02 , C07D215/38
CPC分类号： A61K31/506 , A61K31/437 , A61K31/438 , A61K31/47 , A61K31/4709 , A61K31/496 , C07D213/73 , C07D213/74 , C07D215/38 , C07D221/04 , C07D239/78 , C07D241/20 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04
摘要： The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.
摘要翻译：本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。

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