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1. 发明申请

WO2010023512A8 NOVEL VANILLOID RECEPTOR MODULATORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新颖的香草素受体调节剂，其制备方法和含有它们的药物组合物
公开(公告)号：WO2010023512A8
公开(公告)日：2010-08-05
申请号：PCT/IB2009000097
申请日：2009-01-15
申请人： MATRIX LAB LTD , GOPALAN BALASUBRAMANIAN , MANOJIT PAL , ARUMUGAM KODIMUTHALI , NIDHI DHINGRA
发明人： GOPALAN BALASUBRAMANIAN , MANOJIT PAL , ARUMUGAM KODIMUTHALI , NIDHI DHINGRA
IPC分类号： C07D311/68 , A61K31/47 , A61P25/00 , C07D401/12 , C07D405/12
CPC分类号： C07D405/12 , C07D311/68 , C07D401/12
摘要： The present invention pertains to novel vanilloid receptor modulators of general formula I, process for their preparation, and pharmaceutical compositions containing them. These novel vanilloid receptor modulators are valuable agents for preventing, ameliorating, or treating vanilloid receptor mediated diseases and are useful, e.g., for the treatment of acute pain, chronic pain, nociceptive pain, neuropathic pain, post¬ operative pain, dental pain, cancer pain, or pain due to retinopathy, stroke, urinary incontinence, inflammatory bowel disease, irritation of skin, dermatitis and muscle spasms. (I) General Formula(I)
摘要翻译：本发明涉及通式I的新型香草素受体调节剂，其制备方法和含有它们的药物组合物。这些新颖的香草素受体调节剂是用于预防，改善或治疗类香草素受体介导的疾病的有价值的药剂，并且可用于例如治疗急性疼痛，慢性疼痛，伤害性疼痛，神经性疼痛，手术后疼痛，牙齿疼痛，癌症疼痛或由于视网膜病，中风，尿失禁，炎症性肠病，皮肤刺激，皮炎和肌肉痉挛引起的疼痛。（I）通式（I）

2. 发明申请

WO2009147476A1 NOVEL PDE INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译：新型PDE抑制剂，含有它们的药物组合物及其制备方法
公开(公告)号：WO2009147476A1
公开(公告)日：2009-12-10
申请号：PCT/IB2009/000186
申请日：2009-01-29
申请人： MATRIX LABORATORIES LTD. , SUGIN, Lal Jabaris Sobhana George , RAJESH VIDYAWANT, Gupta , NARENDRA KUMAR, Manne , VANJIVAKA, Sreelatha , MANOJIT, Pal , SANTOSH KUMAR, Singh , SHRIKANT HANUMAMTAPPA, Havale , ARUMUGAM, Kodimuthali , LAXMI KISHORE PARSA, Venkata
发明人： SUGIN, Lal Jabaris Sobhana George , RAJESH VIDYAWANT, Gupta , NARENDRA KUMAR, Manne , VANJIVAKA, Sreelatha , MANOJIT, Pal , SANTOSH KUMAR, Singh , SHRIKANT HANUMAMTAPPA, Havale , ARUMUGAM, Kodimuthali , LAXMI KISHORE PARSA, Venkata
IPC分类号： C07D471/04 , A61K31/437 , A61P11/00
CPC分类号： C07D471/04
摘要： The present invention relates to novel heterocyclic compounds of general formula (I), which are phosphodiesterase inhibitors (PDEs), in particular phosphodiesterase type 4 inhibitors, pharmaceutical compositions containing them, and processes for their preparation. These novel PDEs are useful in treating allergic and inflammatory diseases (such as asthma, COPD, allergic rhinitis, allergic conjunctivitis, respiratory distress syndrome, chronic bronchitis, nephritis, rheumatoid spondylitis, osteoarthritis, atopic dermatitis, eosinophilic granuloma, psoriasis, rheumatoid septic shock, ulcerative colitis, multiple sclerosis, chronic inflammation, Crohn's syndrome and central nervous system(CNS) disorders) and for inhibiting the production of Tumor Necrosis Factor(TNF-α).
摘要翻译：本发明涉及通式（I）的新型杂环化合物，其是磷酸二酯酶抑制剂（PDE），特别是磷酸二酯酶4型抑制剂，含有它们的药物组合物及其制备方法。这些新型PDE可用于治疗过敏性和炎性疾病（例如哮喘，COPD，过敏性鼻炎，过敏性结膜炎，呼吸窘迫综合征，慢性支气管炎，肾炎，类风湿性脊柱炎，骨关节炎，特应性皮炎，嗜酸性肉芽肿，银屑病，类风湿性脓毒性休克，溃疡性结肠炎，多发性硬化症，慢性炎症，克罗恩综合征和中枢神经系统（CNS）病症）和抑制肿瘤坏死因子（TNF-α）的产生。

3. 发明申请

WO2010023512A1 NOVEL VANILLOID RECEPTOR MODULATORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：新型VANILLOID受体调节剂，其制备方法和含有它们的药物组合物
公开(公告)号：WO2010023512A1
公开(公告)日：2010-03-04
申请号：PCT/IB2009/000097
申请日：2009-01-15
申请人： MATRIX LABORATORIES LTD. , GOPALAN, Balasubramanian , MANOJIT, Pal , ARUMUGAM, Kodimuthali , NIDHI, Dhingra
发明人： GOPALAN, Balasubramanian , MANOJIT, Pal , ARUMUGAM, Kodimuthali , NIDHI, Dhingra
IPC分类号： C07D311/68 , C07D401/12 , C07D405/12 , A61K31/47 , A61P25/00
CPC分类号： C07D405/12 , C07D311/68 , C07D401/12
摘要： The present invention pertains to novel vanilloid receptor modulators of general formula I, process for their preparation, and pharmaceutical compositions containing them. These novel vanilloid receptor modulators are valuable agents for preventing, ameliorating, or treating vanilloid receptor mediated diseases and are useful, e.g., for the treatment of acute pain, chronic pain, nociceptive pain, neuropathic pain, post¬ operative pain, dental pain, cancer pain, or pain due to retinopathy, stroke, urinary incontinence, inflammatory bowel disease, irritation of skin, dermatitis and muscle spasms. (I) General Formula(I)
摘要翻译：本发明涉及通式I的新型香草酸受体调节剂，其制备方法和含有它们的药物组合物。这些新型香草素受体调节剂是预防，改善或治疗香草素受体介导的疾病的有价值的药剂，可用于治疗急性疼痛，慢性疼痛，伤害性疼痛，神经性疼痛，手术后疼痛，牙痛，癌症疼痛或由于视网膜病变，中风，尿失禁，炎性肠病，皮肤刺激，皮炎和肌肉痉挛引起的疼痛。（I）通式（I）

4. 发明授权

US07335656B2 Medical devices employing triazine compounds and compositions thereof 失效
标题翻译：使用三嗪化合物的医疗装置及其组合物
公开(公告)号：US07335656B2
公开(公告)日：2008-02-26
申请号：US11512863
申请日：2006-08-30
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Sridevi Alluri , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Potlapally Rajender Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Sridevi Alluri , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Potlapally Rajender Kumar , Gaddam Om Reddy
IPC分类号： A61M31/00 , A61F2/86 , C07D251/70 , C07D251/52 , C07D251/30 , A61P35/00
CPC分类号： A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods, compounds, and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses, and is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention also relates to compounds that inhibit smooth muscle proliferation, for example, by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis. This invention also relates to medical devices, such as a stent, comprising a compound or composition of this invention disposed on or within the medical device.
摘要翻译：本发明涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法，化合物和组合物，并且涉及抑制或阻断糖基化蛋白质产生内皮细胞中信号传导相关炎症反应诱导的化合物。本发明还涉及抑制平滑肌增殖的化合物，例如通过调节HSPG如Perlecan。本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞症状，例如再狭窄和动脉粥样硬化。本发明还涉及包括设置在医疗装置上或内部的本发明的化合物或组合物的医疗装置，例如支架。

5. 发明授权

US07112587B2 Methods and compositions of novel triazine compounds 失效
公开(公告)号：US07112587B2
公开(公告)日：2006-09-26
申请号：US10400134
申请日：2003-03-26
申请人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Bhatlapenumarthy Sesha Sridevi , Potlapally Rajendar Kumar , Gaddam Om Reddy
发明人： Richard T. Timmer , Christopher W. Alexander , Sivaram Pillarisetti , Uday Saxena , Koteswar Rao Yeleswarapu , Manojit Pal , Jangalgar Tirupathy Reddy , Velagala Venkata Rama Murali Krishna Reddy , Bhatlapenumarthy Sesha Sridevi , Potlapally Rajendar Kumar , Gaddam Om Reddy
IPC分类号： C07D251/30 , C07D251/46 , C07D251/48 , A61K31/53 , A61P35/00
CPC分类号： A61K31/53 , C04B35/632 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/6521 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

6. 发明申请

US20060128729A1 Novel bicyclic heterocyclic compounds, process for their preparation and compositions containing them 审中-公开
标题翻译：新型双环杂环化合物，其制备方法和含有它们的组合物
公开(公告)号：US20060128729A1
公开(公告)日：2006-06-15
申请号：US11285982
申请日：2005-11-23
申请人： Manojit Pal , Yeleswarapu Rao , Ish Khanna , Nalivela Swamy , Venkataraman Subramanian , Venkateswara Batchu , Javed Iqbal , Sivaram Pillarisetti
发明人： Manojit Pal , Yeleswarapu Rao , Ish Khanna , Nalivela Swamy , Venkataraman Subramanian , Venkateswara Batchu , Javed Iqbal , Sivaram Pillarisetti
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.
摘要翻译：本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法增殖，炎症，糖苷酶表达或Perlecan的低表达。

7. 发明申请

US20050227983A1 Triazine compounds and their analogs, compositions, and methods 失效
标题翻译：三嗪化合物及其类似物，组合物和方法
公开(公告)号：US20050227983A1
公开(公告)日：2005-10-13
申请号：US10808210
申请日：2004-03-24
申请人： Richard Timmer , Christopher Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Alluri , Velagala Venkata Krishna Reddy , Manojit Pal , Jangalgar Reddy , Koteswar Yeleswarapu , Gaddam Reddy , Potlapally Kumar
发明人： Richard Timmer , Christopher Alexander , Sivaram Pillarisetti , Uday Saxena , Sesha Alluri , Velagala Venkata Krishna Reddy , Manojit Pal , Jangalgar Reddy , Koteswar Yeleswarapu , Gaddam Reddy , Potlapally Kumar
IPC分类号： A61K31/53 , A61P19/02 , A61P29/00 , A61P35/00 , C07D251/46 , C07D251/52 , C12M1/34 , C07D43/02
CPC分类号： C07D251/46
摘要： The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.
摘要翻译：本发明涉及三嗪化合物及其类似物和衍生物，以及包含这些化合物的方法和组合物。本发明的化合物和组合物尤其可用于治疗由炎症反应引起的病理生理学病症，抑制或阻断糖基化蛋白产生内皮细胞中信号传导相关炎症反应的诱导，抑制平滑肌增生，治疗血管闭塞症状其特征在于平滑肌增生如再狭窄和动脉粥样硬化等。

8. 发明申请

WO2009115874A3 NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译：新型杂环化合物，含有它们的药物组合物及其制备方法
公开(公告)号：WO2009115874A3
公开(公告)日：2009-11-12
申请号：PCT/IB2009000190
申请日：2009-01-29
申请人： MATRIX LAB LTD , GOPALAN BALASUBRAMANIAN , MANOJIT PAL , SHRIKANT HANUMANTAPPA HAVALE , ARUMUGAM KODIMUTHALI , SANTOSH KUMAR SINGH , RAJESH VIDYAWANT GUPTA , RANJEET KUMAR TOKALA , ANITHA MUNGARA , BATHOJU CHANDRA CHARY , SUGIN LAL JABARIS SOBHANA GEOR
发明人： GOPALAN BALASUBRAMANIAN , MANOJIT PAL , SHRIKANT HANUMANTAPPA HAVALE , ARUMUGAM KODIMUTHALI , SANTOSH KUMAR SINGH , RAJESH VIDYAWANT GUPTA , RANJEET KUMAR TOKALA , ANITHA MUNGARA , BATHOJU CHANDRA CHARY , SUGIN LAL JABARIS SOBHANA GEORGE
IPC分类号： C07D209/08 , A61K31/343 , A61K31/403 , A61K31/404 , A61P29/00 , C07D209/88 , C07D307/91 , C07D403/04 , C07D405/04 , C07D413/04
CPC分类号： C07D403/04 , C07D209/08 , C07D209/88 , C07D307/91 , C07D405/04 , C07D413/04
摘要： The present invention relates to novel heterocyclic compounds of general formula (I) that are phosphodiesterase inhibitors (PDEs), in particular phosphodiesterase type 4 inhibitors. These novel PDEs are useful in the treatment of inflammatory diseases (such as asthma, COPD, allergic rhinitis, allergic conjunctivitis, respiratory distress syndrome, chronic bronchitis, nephritis, rheumatoid spondylitis, osteoarthritis, atopic dermatitis, eosinophilic granuloma, psoriasis, rheumatoid septic shock, ulcerative colitis, multiple sclerosis, chronic inflammation, Crohn's syndrome and central nervous system(CNS) disorders) as well as disorders or conditions generally characterized by or associated with an excessive secretion of TNF-a and Phosphodiesterase 4 (PDE IV).
摘要翻译：本发明涉及通式（I）的新型杂环化合物，其为磷酸二酯酶抑制剂（PDE），特别是磷酸二酯酶4型抑制剂。这些新型PDE可用于治疗炎性疾病（如哮喘，COPD，变应性鼻炎，过敏性结膜炎，呼吸窘迫综合征，慢性支气管炎，肾炎，类风湿性脊椎炎，骨关节炎，特应性皮炎，嗜酸性肉芽肿，牛皮癣，类风湿性脓毒性休克，溃疡性结肠炎，多发性硬化症，慢性炎症，克罗恩氏综合征和中枢神经系统（CNS）病症）以及通常特征在于或与TNF-α和磷酸二酯酶4（PDE IV）的过度分泌相关的病症或病症。

9. 发明申请

WO2009115874A2 NOVEL HETEROCYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译：新型杂环化合物，含有它们的药物组合物及其制备方法
公开(公告)号：WO2009115874A2
公开(公告)日：2009-09-24
申请号：PCT/IB2009/000190
申请日：2009-01-29
申请人： MATRIX LABORATORIES LTD. , GOPALAN, Balasubramanian , MANOJIT, Pal , SHRIKANT, Hanumantappa, Havale , ARUMUGAM, Kodimuthali , SANTOSH, Kumar Singh , RAJESH, Vidyawant Gupta , RANJEET, Kumar, Tokala , ANITHA, Mungara , BATHOJU, Chandra Chary , SUGIN, Lal Jabaris Sobhana George
发明人： GOPALAN, Balasubramanian , MANOJIT, Pal , SHRIKANT, Hanumantappa, Havale , ARUMUGAM, Kodimuthali , SANTOSH, Kumar Singh , RAJESH, Vidyawant Gupta , RANJEET, Kumar, Tokala , ANITHA, Mungara , BATHOJU, Chandra Chary , SUGIN, Lal Jabaris Sobhana George
IPC分类号： C07D209/08 , C07D209/88 , C07D307/91 , C07D403/04 , C07D405/04 , C07D413/04 , A61K31/403 , A61K31/404 , A61K31/343 , A61P29/00
CPC分类号： C07D403/04 , C07D209/08 , C07D209/88 , C07D307/91 , C07D405/04 , C07D413/04
摘要： The present invention relates to novel heterocyclic compounds of general formula (I) that are phosphodiesterase inhibitors (PDEs), in particular phosphodiesterase type 4 inhibitors. These novel PDEs are useful in the treatment of inflammatory diseases (such as asthma, COPD, allergic rhinitis, allergic conjunctivitis, respiratory distress syndrome, chronic bronchitis, nephritis, rheumatoid spondylitis, osteoarthritis, atopic dermatitis, eosinophilic granuloma, psoriasis, rheumatoid septic shock, ulcerative colitis, multiple sclerosis, chronic inflammation, Crohn's syndrome and central nervous system(CNS) disorders) as well as disorders or conditions generally characterized by or associated with an excessive secretion of TNF-α and Phosphodiesterase 4 (PDE IV).
摘要翻译：本发明涉及通式（I）的新型杂环化合物，其是磷酸二酯酶抑制剂（PDE），特别是磷酸二酯酶4型抑制剂。这些新型PDE可用于治疗炎性疾病（例如哮喘，COPD，过敏性鼻炎，过敏性结膜炎，呼吸窘迫综合征，慢性支气管炎，肾炎，类风湿性脊椎炎，骨关节炎，特应性皮炎，嗜酸性肉芽肿，牛皮癣，类风湿性脓毒性休克，溃疡性结肠炎，多发性硬化症，慢性炎症，克罗恩综合征和中枢神经系统（CNS）疾病）以及通常以TNF-α和磷酸二酯酶4（PDE IV）的过度分泌为特征或相关的病症或病症。

10. 发明申请

WO2005040163A1 HETEROCYCLIC COMPOUNDS THAT BLOCK THE EFFECTS OF ADVANCED GLYCATION END PRODUCTS (AGE) 审中-公开
标题翻译：阻止高级糖果终产物（年龄）的影响的杂环化合物
公开(公告)号：WO2005040163A1
公开(公告)日：2005-05-06
申请号：PCT/IB2004/003430
申请日：2004-10-20
申请人： DR. REDDY'S LABORATORIES LTD , YELESWARAPU, Koteswar, Rao , MANOJIT, Pal , VEDULA MANOHAR, Sharma , AKELLA, Venkateswarlu , PILLARISETTI, Sivaram , PADAKANTI, Srinivas , KALLEDA, Srinivasa, Rao
发明人： YELESWARAPU, Koteswar, Rao , MANOJIT, Pal , VEDULA MANOHAR, Sharma , AKELLA, Venkateswarlu , PILLARISETTI, Sivaram , PADAKANTI, Srinivas , KALLEDA, Srinivasa, Rao
IPC分类号： C07D417/12
CPC分类号： C04B35/632 , A61K31/427 , C07D215/56 , C07D239/88 , C07D239/90 , C07D311/30 , C07D401/12 , C07D417/12 , C07D417/14 , C07D487/04
摘要： The present invention relates to novel compounds of Formula (Ia) or (Ib), their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. Formula (Ia), or Formula (Ib) in the above formulae L represents Formula (I), Formula (II) or -(CH 2 ) 1 - Q represents Formula (III), or Formula (IV). The present invention also relates to a process for the preparation of the above said novel compounds, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory responses in tissues, including endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. The present invention also relates to compounds that act as modulators of Perlecan activity and expression. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating heparan sulfate proteoglycans (HSPG) such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as stenosis, restenosis, neointimal hyperplasia, and atherosclerosis. The compounds of Formula (I) are also useful for the treatment and/or prevention of cancer. The types of cancers include melanoma, prostate, leukemia, lymphoma, non-small lung cancers, cancer of the central nervous system, breast, colon, ovarian or renal cancer.
摘要翻译：本发明涉及式（Ia）或（Ib）的新化合物，其药学上可接受的盐和含有它们的药学上可接受的组合物。上式L中的式（Ia）或式（Ib）表示式（I），式（II）或 - （CH 2）1 -Q表示式（III）或式（IV）。本发明还涉及制备上述新化合物，其药学上可接受的盐和含有它们的药物组合物的方法。本发明还涉及包含治疗由炎性反应引起的病理生理状况的化合物的方法和组合物。特别地，本发明涉及抑制或阻断糖化蛋白质在组织（包括内皮细胞）中产生信号传导相关炎症反应的诱导的化合物。本发明涉及抑制平滑肌增殖的化合物。本发明还涉及作为Perlecan活性和表达调节剂的化合物。特别地，本发明涉及通过调节硫酸乙酰肝素蛋白聚糖（HSPG）如Perlecan来抑制平滑肌细胞增殖的化合物。本发明还涉及化合物用于治疗以平滑肌增生为特征的血管闭塞状态，例如狭窄，再狭窄，新内膜增生和动脉粥样硬化。式（I）的化合物也可用于治疗和/或预防癌症。癌症的类型包括黑素瘤，前列腺癌，白血病，淋巴瘤，非小细胞肺癌，中枢神经系统癌症，乳腺癌，结肠癌，卵巢癌或肾癌。

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