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1. 发明申请

WO2008048231A2 BIOSENSOR METHOD AND SYSTEM BASED ON FEATURE VECTOR EXTRACTION 审中-公开
标题翻译：基于特征向量提取的生物传感器方法和系统
公开(公告)号：WO2008048231A2
公开(公告)日：2008-04-24
申请号：PCT/US2006/032772
申请日：2006-08-18
申请人： UT-BATTELLE, LLC , GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , QI, Hairong , WANG, Xiaoling
发明人： GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , QI, Hairong , WANG, Xiaoling
IPC分类号： G01N33/50
CPC分类号： C12Q1/025
摘要： A method of biosensor-based detection of toxins includes the steps of providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a time-dependent biosensor signal from the biosensor in the gas or liquid medium to be monitored or analyzed for the presence of one or more toxins selected from chemical, biological or radiological agents. The time-dependent biosensor signal is processed to obtain a plurality of feature vectors using at least one of amplitude statistics and a time- frequency analysis. At least one parameter relating to toxicity of the gas or liquid medium is then determined from the feature vectors based on reference to the control signal. A water or air quality sensor system 10 includes photosynthetic organisms as a biosensor in an air or water medium to be monitored or analyzed for the presence of one or more toxins, a detector 12 proximate to the biosensor for measuring a time-dependent biosensor signal from said biosensor, and a processor 30 for analyzing the time-dependent biosensor signal to obtain a plurality of feature vectors using amplitude statistics or time-frequency analysis, wherein the processor determines at least one parameter relating to toxicity of the medium from the feature vectors.
摘要翻译：基于生物传感器的毒素检测方法包括以下步骤：在气体或液体介质中提供由生物传感器产生的至少一个时间依赖性控制信号，并从时间依赖性生物传感器信号获得来自气体或液体介质中的生物传感器将被监测或分析选自化学，生物或放射性试剂的一种或多种毒素的存在。使用幅度统计和时间 - 频率分析中的至少一个处理时间相关生物传感器信号以获得多个特征向量。然后基于参考控制信号从特征向量确定至少一个与气体或液体介质的毒性有关的参数。水或空气质量传感器系统10包括作为生物传感器的光合生物体，其在待监测或分析一种或多种毒素的存在的空气或水介质中;靠近生物传感器的检测器12，用于测量来自生物传感器的时间依赖性生物传感器信号所述生物传感器和处理器30，用于使用幅度统计或时间 - 频率分析来分析时间相关生物传感器信号以获得多个特征向量，其中处理器根据特征向量确定与介质的毒性有关的至少一个参数。

2. 发明申请

WO2008054394A3 METHOD AND APPARATUS FOR DETECTION OF TOXIC AGENTS USING PHOTOSYNTHETIC ORGANISMS 审中-公开
公开(公告)号：WO2008054394A3
公开(公告)日：2008-05-08
申请号：PCT/US2006/042984
申请日：2006-11-03
申请人： UT-BATTELLE, LLC , GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , WU, Jie, Jayne , QI, Hairong
发明人： GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , WU, Jie, Jayne , QI, Hairong
IPC分类号： C12Q1/02 , G01N33/53
摘要： A water quality analyzer for real-time detection according to the invention (100) comprises a biased AC electro-osmosis (ACEO) cell (154) for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector (157) is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region responses to incident light from light source (105), wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package (158) analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.

3. 发明授权

EP1957663B1 METHOD AND APPARATUS FOR ENHANCED DETECTION OF TOXIC AGENTS 有权
标题翻译：方法和装置有毒物质完善的检测
公开(公告)号：EP1957663B1
公开(公告)日：2009-09-02
申请号：EP06851909.9
申请日：2006-11-03
申请人： UT-BATTELLE, LLC
发明人： GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , WU, Jie, Jayne , QI, Hairong
IPC分类号： C12Q1/02 , G01N33/53
CPC分类号： C12Q1/025
摘要： A water quality analyzer for real-time detection according to the invention (100) comprises a biased AC electro-osmosis (ACEO) cell (154) for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector (157) is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region responses to incident light from light source (105), wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package (158) analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.

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