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1. 发明授权

EP1957663B1 METHOD AND APPARATUS FOR ENHANCED DETECTION OF TOXIC AGENTS 有权
标题翻译：方法和装置有毒物质完善的检测
公开(公告)号：EP1957663B1
公开(公告)日：2009-09-02
申请号：EP06851909.9
申请日：2006-11-03
申请人： UT-BATTELLE, LLC
发明人： GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , WU, Jie, Jayne , QI, Hairong
IPC分类号： C12Q1/02 , G01N33/53
CPC分类号： C12Q1/025
摘要： A water quality analyzer for real-time detection according to the invention (100) comprises a biased AC electro-osmosis (ACEO) cell (154) for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector (157) is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region responses to incident light from light source (105), wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package (158) analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.

2. 发明申请

WO2003001249A3 MODULATING PHOTOREACTIVITY IN A CELL 审中-公开
公开(公告)号：WO2003001249A3
公开(公告)日：2003-01-03
申请号：PCT/US2002/019880
申请日：2002-06-24
申请人： UT-BATTELLE, LLC
发明人： GREENBAUM, Elias , HUMAYUN, Mark, S. , KURITZ, Tanya, C.
IPC分类号： A61F3/00
摘要： Photoreactivity in a cell is modulated by incorporating an isolated optical trigger on the surface or in the membrane of the cell. Exposure of a cell bearing incorporated optical triggers causes the generation of a measurable physiological signal.

3. 发明授权

EP1963519B1 METHOD AND SYSTEM FOR REAL-TIME ANALYSIS OF BIOSENSOR DATA 有权
标题翻译：方法和系统生物传感器的实时分析
公开(公告)号：EP1963519B1
公开(公告)日：2009-07-08
申请号：EP06840233.8
申请日：2006-12-13
申请人： UT-BATTELLE, LLC
发明人： GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr.
IPC分类号： C12Q1/02 , C12Q1/22
CPC分类号： G06F19/00 , C12Q1/02 , C12Q1/22 , G01N2333/405
摘要： A water or air quality analysis system (10) and related method is biosensor-based for detecting toxins. The water or air to be analyzed includes a plurality of photosynthetic organisms therein, wherein toxins including chemical, biological or radiological agents alter a nominal photosynthetic activity of the photosynthetic organisms. A photodetector (12) is for measuring photosynthetic activity of the plurality of photosynthetic organisms. An electronics package (30) includes a processor coupled to the photodetector for analyzing the photosynthetic activity to indicate a presence of a toxin in the water or air. The analysis includes obtaining at a first time a measured photosynthetic activity curve for the photosynthetic organisms, and comparing the measured curve to a reference photosynthetic activity curve to determine differences therebetween. The presence of specific toxins, or precursors thereof, are then identified if present in the air or water using the differences.

4. 发明申请

WO2002079763A2 TISSUE-BASED STANDOFF BIOSENSORS FOR DETECTING CHEMICAL WARFARE AGENTS 审中-公开
标题翻译：用于检测化学品保护剂的基于组织的生物传感器
公开(公告)号：WO2002079763A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/002941
申请日：2002-01-31
申请人： UT-BATTELLE, LLC
发明人： GREENBAUM, Elias , SANDERS, Charlene, A.
IPC分类号： G01N21/64
CPC分类号： G01N33/5097 , G01N33/5014 , Y10S435/808 , Y10T436/163333 , Y10T436/25875
摘要： A tissue-based, deployable, standoff air quality sensor (10) for detecting the presence of at least one chemical or biological warfare agent, includes: a cell (14) containing entrapped photosynthetic tissue, the cell adapted for analyzing photosynthetic activity of the entrapped photosynthetic tissue; means (20) for introducing an air sample into the cell and contacting the air sample with the entrapped photosynthetic tissue; a fluorometer (12) in operable relationship with the cell for measuring photosynthetic activity of the entrapped photosynthetic tissue; and transmitting means (30) for transmitting analytical data generated by the fluorometer relating to the presence of at least one chemical or biological warfare agent in the air sample, the sensor (10) adapted for deployment into a selected area.
摘要翻译：用于检测至少一种化学或生物战剂的存在的基于组织的可部署的支架空气质量传感器（10）包括：包含夹带的光合组织的细胞（14），所述细胞适于分析被捕获的光合作用光合组织; 用于将空气样品引入细胞并使空气样品与夹带的光合组织接触的装置（20）; 荧光计（12），其与所述细胞处于可操作的关系，用于测量包埋的光合组织的光合活性; 以及发送装置（30），用于发送由所述荧光计产生的关于所述空气样本中至少一种化学或生物战剂的存在的分析数据，所述传感器（10）适于部署到选定区域。

5. 发明公开

EP1356280A2 TISSUE-BASED WATER QUALITY BIOSENSORS FOR DETECTING CHEMICAL WARFARE AGENTS 审中-公开
标题翻译：方法为化学战剂在水检测
公开(公告)号：EP1356280A2
公开(公告)日：2003-10-29
申请号：EP02724900.2
申请日：2002-01-31
申请人： UT-Battelle, LLC
发明人： GREENBAUM, Elias , SANDERS, Charlene, A.
IPC分类号： G01N33/18
CPC分类号： G01N33/5097 , C12Q1/02 , G01N2021/635 , G01N2520/00
摘要： A method of testing water to detect the presence of at least one chemical or biological warfare agent includes the steps of: a) exposing water to a measuring means for measuring photosynthetic activity of free-living indigenous photosynthetic organisms; b) measuring photosynthetic activity of indigenous photosynthetic organisms occurring naturally in the water to detect the presence of at least one chemical or biological warfare agent in the water.

6. 发明公开

EP1399385A2 CATALYST-INDUCED GROWTH OF CARBON NANOTUBES ON TIPS OF CANTILEVERS AND NANOWIRES 审中-公开
标题翻译： ON繁荣和纳米线的峰值碳纳米管催化剂的影响增长
公开(公告)号：EP1399385A2
公开(公告)日：2004-03-24
申请号：EP02799546.3
申请日：2002-06-03
申请人： UT-Battelle, LLC , University of Tennessee Research Foundation
发明人： LEE, Ida , LEE, James, Weifu , LOWNDES, Douglas, H. , MERKULOV, Vladimir, I. , ERES, Gyula , WEI, Yayi , GREENBAUM, Elias
IPC分类号： C01B31/02
CPC分类号： C25D21/12 , C01B32/162 , C01B32/18 , C01B2202/02 , C01B2202/06 , C25D1/02 , C25D5/18 , C25D7/00 , C25D7/0607 , G01Q70/12 , Y10S977/762 , Y10S977/843 , Y10S977/873 , Y10S977/876 , Y10T428/31504
摘要： A method is described for catalyst-induced growth of carbon nanotubes, nanofibers, and other nanostructures on the tips of nanowires, cantilevers, conductive micro/nanometer structures, wafers and the like. The method can be used for production of carbon nanotube-anchored cantilevers that can significantly improve the performance of scanning probe microscopy (AFM, EFM, etc.). The invention can also be used in many other processes of micro and/or nanofabrication with carbon nanotubes/fibers. Key elements of this invention include: (1) proper selection of a metal catalyst and programmable pulsed electrolytic deposition of the desired specific catalyst precisely at the tip of a substrate; (2) catalyst-induced growth of carbon nanotubes/fibers at the catalyst-deposited tips; (3) control of carbon nanotube/fiber growth pattern by manipulation of tip shape and growth conditions; and (4) automation for mass production.

7. 发明申请

WO2007070828A1 METHOD AND SYSTEM FOR REAL-TIME ANALYSIS OF BIOSENSOR DATA 审中-公开
标题翻译：生物传感器数据实时分析的方法和系统
公开(公告)号：WO2007070828A1
公开(公告)日：2007-06-21
申请号：PCT/US2006/062009
申请日：2006-12-13
申请人： UT-BATTELLE, LLC , GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr.
发明人： GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr.
IPC分类号： C12Q1/02 , C12Q1/22
CPC分类号： G06F19/00 , C12Q1/02 , C12Q1/22 , G01N2333/405
摘要： A water or air quality analysis system (10) and related method is biosensor-based for detecting toxins. The water or air to be analyzed includes a plurality of photosynthetic organisms therein, wherein toxins including chemical, biological or radiological agents alter a nominal photosynthetic activity of the photosynthetic organisms. A photodetector (12) is for measuring photosynthetic activity of the plurality of photosynthetic organisms. An electronics package (30) includes a processor coupled to the photodetector for analyzing the photosynthetic activity to indicate a presence of a toxin in the water or air. The analysis includes obtaining at a first time a measured photosynthetic activity curve for the photosynthetic organisms, and comparing the measured curve to a reference photosynthetic activity curve to determine differences therebetween. The presence of specific toxins, or precursors thereof, are then identified if present in the air or water using the differences.
摘要翻译：水或空气质量分析系统（10）和相关方法是基于生物传感器的检测毒素。待分析的水或空气包括其中的多种光合生物，其中包括化学，生物或放射性试剂的毒素改变光合生物的标称光合活性。光电检测器（12）用于测量多个光合生物的光合活性。电子封装（30）包括耦合到光电检测器的处理器，用于分析光合作用以指示毒素在水或空气中的存在。分析包括首次获得光合生物的测量光合活性曲线，并将测量曲线与参考光合活性曲线进行比较，以确定它们之间的差异。然后如果存在于空气或水中，则使用差异鉴定特定毒素或其前体的存在。

8. 发明申请

WO2008054394A3 METHOD AND APPARATUS FOR DETECTION OF TOXIC AGENTS USING PHOTOSYNTHETIC ORGANISMS 审中-公开
公开(公告)号：WO2008054394A3
公开(公告)日：2008-05-08
申请号：PCT/US2006/042984
申请日：2006-11-03
申请人： UT-BATTELLE, LLC , GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , WU, Jie, Jayne , QI, Hairong
发明人： GREENBAUM, Elias , RODRIGUEZ, Miguel, Jr. , WU, Jie, Jayne , QI, Hairong
IPC分类号： C12Q1/02 , G01N33/53
摘要： A water quality analyzer for real-time detection according to the invention (100) comprises a biased AC electro-osmosis (ACEO) cell (154) for receiving a fluid to be analyzed having a plurality photosynthetic organisms therein, and concentrating the plurality photosynthetic organisms into at least one concentrated region. A photodetector (157) is provided for obtaining a measured photosynthetic activity of the plurality of photosynthetic organisms in the concentrated region responses to incident light from light source (105), wherein chemical, biological or radiological agents reduce a nominal photosynthetic activity of the photosynthetic organisms. An electronics package (158) analyzes the measured photosynthetic activity to indicate a presence of the chemical, biological or radiological agents in the fluid.

9. 发明申请

WO2003027011A3 CATALYST-INDUCED GROWTH OF CARBON NANOTUBES ON TIPS OF CANTILEVERS AND NANOWIRES 审中-公开
公开(公告)号：WO2003027011A3
公开(公告)日：2003-04-03
申请号：PCT/US2002/017237
申请日：2002-06-03
申请人： UT-BATTELLE, LLC , UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
发明人： LEE, Ida , LEE, James, Weifu , LOWNDES, Douglas, H. , MERKULOV, Vladimir, I. , ERES, Gyula , WEI, Yayi , GREENBAUM, Elias
IPC分类号： C01B31/02
摘要： A method is described for catalyst-induced growth of carbon nanotubes, nanofibers, and other nanostructures on the tips of nanowires, cantilevers, conductive micro/nanometer structures, wafers and the like. The method can be used for production of carbon nanotube-anchored cantilevers that can significantly improve the performance of scanning probe microscopy (AFM, EFM, etc.). The invention can also be used in many other processes of micro and/or nanofabrication with carbon nanotubes/fibers. Key elements of this invention include: (1) proper selection of a metal catalyst and programmable pulsed electrolytic deposition of the desired specific catalyst precisely at the tip of a substrate; (2) catalyst-induced growth of carbon nanotubes/fibers at the catalyst-deposited tips; (3) control of carbon nanotube/fiber growth pattern by manipulation of tip shape and growth conditions; and (4) automation for mass production.

10. 发明申请

WO2002066975A2 TISSUE-BASED WATER QUALITY BIOSENSORS FOR DETECTING CHEMICAL WARFARE AGENTS 审中-公开
标题翻译：用于检测化学品保护剂的基于组织的水质生物传感器
公开(公告)号：WO2002066975A2
公开(公告)日：2002-08-29
申请号：PCT/US2002/002940
申请日：2002-01-31
申请人： UT-BATTELLE, LLC
发明人： GREENBAUM, Elias , SANDERS, Charlene, A.
IPC分类号： G01N33/18
CPC分类号： G01N33/5097 , C12Q1/02 , G01N2021/635 , G01N2520/00
摘要： A method of testing water to detect the presence of at least one chemical or biological warfare agent includes the steps of: a) exposing water to a measuring means for measuring photosynthetic activity of free-living indigenous photosynthetic organisms; b) measuring photosynthetic activity of indigenous photosynthetic organisms occurring naturally in the water to detect the presence of at least one chemical or biological warfare agent in the water.
摘要翻译：测试水以检测至少一种化学或生物战剂的存在的方法包括以下步骤：a）将水暴露于用于测量自由生活的土着光合生物的光合作用的测量装置; b）测量水中天然存在的土着光合生物的光合活性，以检测水中至少一种化学或生物战剂的存在。

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