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1. 发明专利

JP2009133868A Sampling probe for microarray read out using electrospray mass spectrometry 有权
标题翻译：采用电喷雾质谱法测定微量的采样探针
公开(公告)号：JP2009133868A
公开(公告)日：2009-06-18
申请号：JP2009053183
申请日：2009-03-06
申请人： Ut Battelle Llc , ユーティ―バテルエルエルシー
发明人： VAN BERKEL GARY J
IPC分类号： G01N1/00 , G01N27/62 , G01N1/28 , G01N13/24 , G01N33/53 , G01N35/00 , G01N37/00 , H01J49/04 , H01J49/26
CPC分类号： H01J49/0404 , G01N1/22 , G01N2035/00158 , H01J49/0463 , H01J49/165
摘要： PROBLEM TO BE SOLVED: To obtain samples from surface array spots having analytes by the automated sampling system and a method of analysis using an electronic spray. SOLUTION: The system includes at least one probe, the probe including an inlet for flowing at least one kind of eluting solvent to respective ones of a plurality of spots and an outlet for delivering the analyte away from the spots. An automatic positioning system is provided for translating the probe relative to the spot to permit sampling of any spot. An electrospray ion source having an input connected by fluidity to the probe receives the analyte and generates ions from the analyte. The ion source provides the generated ions to a structure for analysis to identify the analyte, preferably being a mass spectrometer. The probe can be a surface contact probe, where the probe forms an enclosing seal along the periphery of the array spot surface. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：通过自动采样系统从具有分析物的表面阵列点获得样品和使用电子喷雾的分析方法。解决方案：该系统包括至少一个探针，该探针包括用于将至少一种洗脱溶剂流到多个斑点中的相应的一个点的出口和用于将分析物远离斑点的出口。提供了一种自动定位系统，用于将探头相对于该点转换以允许对任何点进行采样。具有通过流动性连接到探针的输入的电喷雾离子源接收分析物并从分析物产生离子。离子源将生成的离子提供到用于分析的结构以鉴定分析物，优选为质谱仪。探针可以是表面接触探针，其中探针沿着阵列光斑表面的周边形成封闭的密封。版权所有（C）2009，JPO＆INPIT

2. 发明专利

CA2453523C THIN-CHANNEL ELECTROSPRAY EMITTER 未知
公开(公告)号：CA2453523C
公开(公告)日：2010-11-23
申请号：CA2453523
申请日：2002-07-19
申请人： UT BATTELLE LLC
发明人： VAN BERKEL GARY J
IPC分类号： H01J37/00 , H01J49/04
摘要： An electrospray device having an inlet (115), a high voltage electrode chamber (110), and a planar electrode (102) where a fluid is passed over the planar electrode to impart a charge to the fluid for the creation of charged droplets.

3. 发明专利

CA2453523A1 THIN-CHANNEL ELECTROSPRAY EMITTER 未知
公开(公告)号：CA2453523A1
公开(公告)日：2003-01-30
申请号：CA2453523
申请日：2002-07-19
申请人： UT BATTELLE LLC
发明人： VAN BERKEL GARY J
IPC分类号： H01J49/04 , H01J37/00
摘要： An electrospray device having an inlet (115), a high voltage electrode chamb er (110), and a planar electrode (102) where a fluid is passed over the planar electrode to impart a charge to the fluid for the creation of charged drople ts.

4. 发明专利

CA2754363C METHOD OF AND SYSTEM FOR FORMATION AND WITHDRAWAL OF A SAMPLE FROM A SURFACE TO BE ANALYZED 未知
公开(公告)号：CA2754363C
公开(公告)日：2018-05-29
申请号：CA2754363
申请日：2010-03-04
申请人： UT BATTELLE LLC
发明人： VAN BERKEL GARY J , KERTESZ VILMOS
IPC分类号： H01J49/04 , H01J49/16
摘要： A method and system (20) for formation and withdrawal of a sample from a surface (22) to be analyzed utilizes a collection instrument (24) having a port (37) through which a liquid solution is conducted onto the surface to be analyzed. The port is positioned adjacent the surface to be analyzed, and the liquid solution is conducted onto the surface through the port so that the liquid solution conducted onto the surface interacts with material comprising the surface. An amount (52) of material is thereafter withdrawn from the surface. Pressure control can be utilized to manipulate the solution balance at the surface to thereby control the withdrawal of the amount of material from the surface. Furthermore, such pressure control can be coordinated with the movement of the surface relative to the port of the collection instrument within the X-Y plane.

5. 发明专利

CA2729699A1 CONTROL OF THE POSITIONAL RELATIONSHIP BETWEEN A SAMPLE COLLECTION INSTRUMENT AND A SURFACE TO BE ANALYZED DURING A SAMPLING PROCEDURE WITH IMAGE ANALYSIS 未知
公开(公告)号：CA2729699A1
公开(公告)日：2010-01-07
申请号：CA2729699
申请日：2009-06-02
申请人： UT BATTELLE LLC
发明人： VAN BERKEL GARY J , KERTESKZ VILMOS
IPC分类号： B01L3/00
摘要： A system (20) and method utilizes an image analysis approach for controlling the collection instrument-to-surface distance in a sampling system for use, for example, with mass spectrometric detection. Such an approach involves the capturing of an image of the collection instrument (23) or the shadow thereof cast across the surface (22) and the utilization of line average brightness (LAB) techniques to determine the actual distance between the collection instrument and the surface. The actual distance is subsequently compared to a target distance for re-optimization, as necessary, of the collection instrument-to-surface during an automated surface sampling operation.

6. 发明公开

EP2567395A4 SYSTEM AND METHOD FOR EXTRACTING A SAMPLE FROM A SURFACE 有权
公开(公告)号：EP2567395A4
公开(公告)日：2017-12-27
申请号：EP11778447
申请日：2011-05-06
申请人： UT-BATTELLE LLC , DH TECH DEVELOPMENT PTE LTD
发明人： VAN BERKEL GARY J , COVEY THOMAS
IPC分类号： H01J49/00 , B01L3/00 , G01N1/02 , G01N1/40
CPC分类号： G01N1/4055 , B01L3/502715 , G01N2001/028 , H01J49/00
摘要： A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface.

7. 发明专利

CA2729701C CONTROL OF THE POSITIONAL RELATIONSHIP BETWEEN A SAMPLE COLLECTION INSTRUMENT AND A SURFACE TO BE ANALYZED DURING A SAMPLING PROCEDURE USING A LASER SENSOR 未知
公开(公告)号：CA2729701C
公开(公告)日：2015-11-03
申请号：CA2729701
申请日：2009-06-02
申请人： UT BATTELLE LLC
发明人： VAN BERKEL GARY J , KERTESZ VILMOS
IPC分类号： B01L3/00
摘要： A system (20) and method utilizes distance- measuring equipment (40) including a laser sensor (42) for controlling the collection instrument-to-surface distance during a sample collection process for use, for example, with mass spectrometric detection. The laser sensor is arranged in a fixed positional relationship with the collection instrument (23), and a signal is generated by way of the laser sensor which corresponds to the actual distance between the laser sensor and the surface (22). The actual distance between the laser sensor and the surface is compared to a target distance between the laser sensor and the surface when the collection instrument is arranged at a desired distance from the surface for sample collecting purposes, and adjustments are made, if necessary, so that the actual distance approaches the target distance.

8. 发明专利

CA2798638A1 SYSTEM AND METHOD FOR EXTRACTING A SAMPLE FROM A SURFACE 未知
公开(公告)号：CA2798638A1
公开(公告)日：2011-11-10
申请号：CA2798638
申请日：2011-05-06
申请人： UT BATTELLE LLC , DH TECHNOLOGIES DEV PTE LTD
发明人： VAN BERKEL GARY J , COVEY THOMAS
IPC分类号： H01J49/00 , B01L3/02 , H01J27/02
摘要： A system and method is disclosed for extracting a sample from a sample surface. A sample is provided and a sample surface receives the sample which is deposited on the sample surface. A hydrophobic material is applied to the sample surface, and one or more devices are configured to dispense a liquid on the sample, the liquid dissolving the sample to form a dissolved sample material, and the one or more devices are configured to extract the dissolved sample material from the sample surface.

9. 发明专利

CA2754363A1 METHOD OF AND SYSTEM FOR FORMATION AND WITHDRAWAL OF A SAMPLE FROM A SURFACE TO BE ANALYZED 未知
公开(公告)号：CA2754363A1
公开(公告)日：2010-09-10
申请号：CA2754363
申请日：2010-03-04
申请人： UT BATTELLE LLC
发明人： VAN BERKEL GARY J , KERTESZ VILMOS
IPC分类号： H01J49/04 , H01J49/16
摘要： A method and system (20) for formation and withdrawal of a sample from a surface (22) to be analyzed utilizes a collection instrument (24) having a port (37) through which a liquid solution is conducted onto the surface to be analyzed. The port is positioned adjacent the surface to be analyzed, and the liquid solution is conducted onto the surface through the port so that the liquid solution conducted onto the surface interacts with material comprising the surface. An amount (52) of material is thereafter withdrawn from the surface. Pressure control can be utilized to manipulate the solution balance at the surface to thereby control the withdrawal of the amount of material from the surface. Furthermore, such pressure control can be coordinated with the movement of the surface relative to the port of the collection instrument within the X-Y plane.

10. 发明专利

CA2496392A1 PLANAR FLOW-BY-ELECTRODE CAPACITIVE ELECTROSPRAY ION SOURCE 未知
公开(公告)号：CA2496392A1
公开(公告)日：2004-03-11
申请号：CA2496392
申请日：2003-08-28
申请人： UT BATTELLE LLC
发明人： VAN BERKEL GARY J
IPC分类号： B01D17/06 , H01J49/04
摘要： An electrospray ion source includes a chamber including a channel region therein, the channel including at least one inlet for directing a solution into the channel and at least a first and a second outlet for transmitting t he solution or derivatives therefrom out from channel. Structure for separating ions in the solution is provided from separating the solution into at least a first and a second flow stream portion. The first flow stream portion is enriched in negative ions and the second flow stream portion is enriched in positive ions. The first flow stream portion is adapted to exit the chamber through the first outlet while the second flow stream portion is adapted to exit the chamber through the second outlet. A method of charge separation ca n include the step of simultaneously providing at least two gas phase ion stre am portions having opposite polarity.

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