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1. 发明申请

WO2011029064A1 HAND-HELD PORTABLE FUNDUS CAMERA FOR SCREENING PHOTOGRAPHY 审中-公开
标题翻译：手持式便携式摄像机用于屏幕摄影
公开(公告)号：WO2011029064A1
公开(公告)日：2011-03-10
申请号：PCT/US2010/047909
申请日：2010-09-03
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , YATES, Paul, Andrew , TRAN, Kenneth
发明人： YATES, Paul, Andrew , TRAN, Kenneth
IPC分类号： A61B3/14
CPC分类号： A61B3/156 , A61B3/12 , A61B3/1208 , A61B3/14 , G06K9/00604
摘要： System and Method pertaining to the modification and integration of an existing consumer digital camera, for example, with an optical imaging module to enable point and shoot fundus photography of the eye. The auto-focus macro capability of existing consumer cameras is adapted to photograph the retina over an extended diopter range, eliminating the need for manual diopter focus adjustment. The thru-the-lens (TTL) auto-exposure flash capability of existing consumer cameras is adapted to photograph the retina with automatic flash exposure eliminating the need for manual flash adjustment. The consumer camera imaging sensor and flash are modified to allow the camera sensor to perform both non-mydriatic focusing of the retina using infrared illumination and standard color flash photography of the retina without the need for additional imaging sensors or mechanical filters. These modifications and integration of existing consumer cameras for fundus photography of the eye significantly improve ease of manufacture and usability over existing fundus cameras.
摘要翻译：关于现有消费者数码相机的修改和整合的系统和方法，例如，具有光学成像模块，以实现眼睛的点和拍摄眼底摄影。现有消费类相机的自动聚焦宏功能适用于在延长屈光度范围内拍摄视网膜，无需手动屈光度调焦。现有消费类相机的透镜（TTL）自动曝光闪光灯功能适用于使用自动闪光曝光拍摄视网膜，无需手动闪光调节。消费者相机成像传感器和闪光灯被修改以允许相机传感器使用红外照明和视网膜的标准彩色闪光拍摄来执行视网膜的非散瞳聚焦，而不需要附加的成像传感器或机械滤光器。现有消费者相机对眼底眼镜摄影的这些修改和整合显着提高了现有眼底照相机的易于制造和可用性。

2. 发明申请

WO2020198634A1 COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED MACULAR DEGENERATION 审中-公开
公开(公告)号：WO2020198634A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/025354
申请日：2020-03-27
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , YATES, Paul, Andrew , REICHEL, Elias , LEONE, Ashton
发明人： YATES, Paul, Andrew , REICHEL, Elias , LEONE, Ashton
IPC分类号： A61K38/06 , A61K38/07 , A61K45/06
摘要： Provided are chemically modified tetracycline (CMT) derivatives for the treatment of non-exudative macular degeneration. The CMT derivatives lack antimicrobial activity, include a phenol ring, and a chemical structure sufficient to chelate Zn2+. Methods of inhibiting and/or minimizing inflammation in a subject, including administering to the subject a dose of a CMT derivative, are also provided. Methods of treating non-exudative age-related macular degeneration (AMD) are provided.

3. 发明申请

WO2010129775A1 SELF-ILLUMINATED HANDHELD LENS FOR RETINAL EXAMINATION AND PHOTOGRAPHY AND RELATED METHOD THEREOF 审中-公开
标题翻译：用于离子检测和摄影的自发光手持镜片及其相关方法
公开(公告)号：WO2010129775A1
公开(公告)日：2010-11-11
申请号：PCT/US2010/033875
申请日：2010-05-06
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , YATES, Paul, Andrew
发明人： YATES, Paul, Andrew
IPC分类号： A61B3/14
CPC分类号： A61B3/0008 , A61B3/12 , A61B3/1208 , A61B3/125 , A61B3/14 , A61B3/156 , G06K9/00604 , H04N5/2251 , H04N5/2256
摘要： System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.
摘要翻译：系统和方法旨在通过集成到手持眼底透镜中的照明来提供对患者视网膜的全面和均匀照明。通过整合照明，方法和系统减少甚至消除许多镜头伪影和反射。通过增加在视网膜临床检查期间提供的准确性，质量和视野，该方法和系统将允许从业者进行更准确的诊断并且将增加视网膜外科手术中的安全性。

4. 发明申请

WO2018035239A1 EYE MODEL FOR WIDE FIELD FUNDUS IMAGING 审中-公开
标题翻译：宽视场基焦成像的眼球模型
公开(公告)号：WO2018035239A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047169
申请日：2017-08-16
申请人： YATES, Paul, Andrew , LAI, Ming , YI, Ta-Wei
发明人： YATES, Paul, Andrew , LAI, Ming , YI, Ta-Wei
IPC分类号： G09B23/28
CPC分类号： G09B23/30 , A61B3/1173 , A61B3/14
摘要： The present invention contemplates an infant eye model for wide field retinal imaging by implementing nominal physical parameters and optical characteristics found in scientific literature and by simulating retinal features and details found in real eye images. The present invention also contemplates implementing a corneal model with a translucent plastic to mimic image haze and 1st Purkinje reflection. The present invention also contemplates implementing a birefringent layer to the lens posterior surface to simulate 4th Purkinje reflection and its brightness variation. The present invention further contemplates implementing a photo-realistic retinal hemisphere shell to provide retinal details and demonstrate retinopathy associated with retinal diseases.
摘要翻译：通过实施在科学文献中发现的标称物理参数和光学特性并且通过模拟在真实眼睛图像中发现的视网膜特征和细节，本发明设想了用于宽视野视网膜成像的婴儿眼模型。本发明还考虑实施具有半透明塑料的角膜模型以模拟图像模糊和第一浦肯野反射。本发明还考虑在透镜后表面上实施双折射层以模拟第四浦肯野反射及其亮度变化。本发明进一步考虑实施照片般逼真的视网膜半球壳以提供视网膜细节并展示与视网膜疾病相关的视网膜病。

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