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1. 发明申请

WO2008014036A1 AQUEOUS GEL FORMULATION AND METHOD FOR INDUCING TOPICAL ANESTHESIA 审中-公开
标题翻译：凝胶凝胶配方及诱发局部麻醉方法
公开(公告)号：WO2008014036A1
公开(公告)日：2008-01-31
申请号：PCT/US2007/068358
申请日：2007-05-07
申请人： AKORN, INC. , ALAM, Abu , REICHEL, Elias , BUSBEE, Brandon
发明人： ALAM, Abu , REICHEL, Elias , BUSBEE, Brandon
IPC分类号： A61K9/00 , A61K9/06 , A61K47/38
CPC分类号： A61K9/0048 , A61K9/06 , A61K31/167 , A61K47/38
摘要： Disclosed is a stable aqueous gel formulation suitable for topical use comprising water, an anesthetic (e.g., lidocaine hydrochloride), a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile and has low particulate count. Also disclosed is a method of inducing topical anesthesia on a tissue or organ, e.g., the eye, of an animal comprising providing a stable aqueous gel formulation comprising water, an anesthetic, a viscoelastic polymer, and a tonicity modifier, wherein the aqueous gel formulation is free of preservatives and phosphate buffer, is isotonic with physiological fluids, and is sterile, and topically administering an effective amount of the aqueous gel formulation to the tissue or organ of the animal.
摘要翻译：公开了适用于局部使用的稳定的水性凝胶制剂，其包括水，麻醉剂（例如盐酸利多卡因），粘弹性聚合物和张力调节剂，其中所述水性凝胶制剂不含防腐剂和磷酸盐缓冲液，与生理液体等渗并且是无菌的并且具有低的颗粒计数。还公开了一种在动物的组织或器官（例如眼睛）上诱导局部麻醉的方法，包括提供包含水，麻醉剂，粘弹性聚合物和张力调节剂的稳定的水性凝胶制剂，其中所述水性凝胶制剂没有防腐剂和磷酸盐缓冲液，与生理液体等渗，并且是无菌的，并且将有效量的含水凝胶制剂局部施用给动物的组织或器官。

2. 发明申请

WO2020198634A1 COMPOSITIONS AND METHODS FOR TREATING AGE-RELATED MACULAR DEGENERATION 审中-公开
公开(公告)号：WO2020198634A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/025354
申请日：2020-03-27
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , YATES, Paul, Andrew , REICHEL, Elias , LEONE, Ashton
发明人： YATES, Paul, Andrew , REICHEL, Elias , LEONE, Ashton
IPC分类号： A61K38/06 , A61K38/07 , A61K45/06
摘要： Provided are chemically modified tetracycline (CMT) derivatives for the treatment of non-exudative macular degeneration. The CMT derivatives lack antimicrobial activity, include a phenol ring, and a chemical structure sufficient to chelate Zn2+. Methods of inhibiting and/or minimizing inflammation in a subject, including administering to the subject a dose of a CMT derivative, are also provided. Methods of treating non-exudative age-related macular degeneration (AMD) are provided.

3. 发明申请

WO2021207217A1 COMPOSITIONS AND METHODS FOR TREATING VIRUSES 审中-公开
公开(公告)号：WO2021207217A1
公开(公告)日：2021-10-14
申请号：PCT/US2021/025986
申请日：2021-04-06
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , REICHEL, Elias
发明人： YATES, Paul Andrew , LEONE, Ashton
IPC分类号： A61K31/65 , A61P31/12
摘要： Disclosed are compositions and methods that can be used for the prevention, mitigation, and/or prophylactic treatment of a viral infection, such but not limited to a coronavirus infection, such as but not limited to a COVID-19 infection. In some embodiments, a chemically modified tetracycline (CMT) derivative for the prevention, mitigation and/or prophylactic treatment of a viral infection is provided. In some embodiments, the CMT derivative lacks anti-microbial activity; comprises a phenol ring; and/or comprises a chemical structure sufficient to chelate and/or bind a divalent cation. In some embodiments, the divalent cation comprises Zn2+. In some embodiments, the viral infection is a coronavirus infection. In some embodiments, the viral infection is a COVID-19 infection.

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