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1. 发明申请

WO1994000118A1 PRODUCTION AND USE OF IMINES OF PORPHYRINS 审中-公开
标题翻译：生产和使用吡啶的方法
公开(公告)号：WO1994000118A1
公开(公告)日：1994-01-06
申请号：PCT/US1993005727
申请日：1993-06-16
申请人： THE UNIVERSITY OF TOLEDO , MEDICAL COLLEGE OF OHIO
发明人： THE UNIVERSITY OF TOLEDO , MEDICAL COLLEGE OF OHIO , SKALKOS, Dimitris , SELMAN, Steven, H. , HAMPTON, James, A.
IPC分类号： A61K31/40
CPC分类号： C07D487/22 , A61K31/40 , A61K31/555
摘要： Purified imines of porphyrins, chlorins, bacteriochlorins, chlorophylls, bacteriochlorophylls, purpurins, reduced purpurins, verdins, Diels Alder adducts, benzochlorins and metal complexes of the foregoing imines are disclosed. The formulas of the benzochlorinimines and of the benzochlorinimine metal complexes are set forth (1) and (2). In specific examples, M in the metal complexes is a copper cation that is complexed with two of the nitrogens of the benzochlorinimine R' and R"" are methyl, and R1 through R8 are ethyl.
摘要翻译：公开了卟啉，二氢卟酚，细菌二氢卟酚，叶绿素，细菌叶绿素，紫草素，还原紫草素，葡蛋白，狄尔斯lder木加合物，苯并二氢卟酚和前述亚胺的金属络合物的亚胺。（1）和（2）列出了苯并氯嘧啶和苯并氯亚胺金属络合物的配方。在具体实例中，金属络合物中的M是与两个苯并氯嘧啶R'的氮络合的铜阳离子，R“”是甲基，R 1至R 8是乙基。

2. 发明申请

WO1991012802A1 PRODUCTION AND USE OF PORPHYRIN DERIVATIVES AND OF COMPOSITIONS CONTAINING SUCH DERIVATIVES 审中-公开
标题翻译：吡啶衍生物的生产和使用以及含有这些衍生物的组合物
公开(公告)号：WO1991012802A1
公开(公告)日：1991-09-05
申请号：PCT/US1990001156
申请日：1990-03-01
申请人： UNIVERSITY OF TOLEDO , MEDICAL COLLEGE OF OHIO
发明人： UNIVERSITY OF TOLEDO , MEDICAL COLLEGE OF OHIO , MORGAN, Alan, R. , SELMAN, Steven, H.
IPC分类号： A61K31/40
CPC分类号： C07D487/22
摘要： A family of benzochlorins, a family of verdins, a family of porphyrin derivatives and metal complexes thereof are disclosed. The benzochlorins have the formula of Fig. 3 of the attached drawings; their metal complexes have the formula of Fig. 1. The verdins have the formula of Fig. 4 of the attached drawings; their metal complexes have the formula of Fig. 2. The porphyrin derivatives have the formula of Fig. 9 of the attached drawings; their metal complexes have the formula of Fig. 10. Solutions of the benzochlorins, verdins, porphyrin derivatives and metal complexes which are physiologically acceptable for intravenous administration are also disclosed, as are emulsions or suspensions of the solutions, and compositions which additionally include cyclodextrin, and wherein the molecules of the benzochlorin, verdin, porphyrin derivative or metal complex are encapsulated within the molecules of the cyclodextrin. The solvent for the solutions can be a product of the reaction of ethylene oxide with castor oil. A method for detecting and treating tumors in human and animal patients is also disclosed. The method comprises administering one of the benzochlorins, verdins, porphyrin derivatives or metal complexes to the patient. For detection, the tumor area is then illuminated with ultraviolet light; for treatment, the tumor area is illuminated with visible light of a wavelength at which the benzochlorin, verdin, porphyrin derivative or complex administered shows an absorption peak.

3. 发明申请

WO1996031605A1 CANCER DIAGNOSIS AND THERAPY BASED ON MUTATIONS IN TGF-BETA RECEPTORS 审中-公开
标题翻译：基于TGF-β受体中的突变的癌症诊断和治疗
公开(公告)号：WO1996031605A1
公开(公告)日：1996-10-10
申请号：PCT/US1996004727
申请日：1996-04-05
申请人： CASE WESTERN UNIVERSITY , MEDICAL COLLEGE OF OHIO , MARKOWITZ, Sanford, D. , BRATTAIN, Michael, G. , WILLSON, James, K., V.
发明人： CASE WESTERN UNIVERSITY , MEDICAL COLLEGE OF OHIO
IPC分类号： C12N15/12
CPC分类号： G01N33/57492 , A61K38/00 , A61K48/00 , C07K14/71 , Y02A90/26 , Y10S436/811
摘要： This invention is based on the discovery that the type II TGF beta receptor (RII) is a cancer suppressor gene which is genetically inactivated (mutated) in approximately 25 % of colon cancers, including nearly all colon cancers of the class identified as mutator/microsatellite instability/RER. Methods are provided for detecting inactivation of RII for use in cancer diagnosis or prognosis.
摘要翻译：本发明基于以下发现：II型TGFβ受体（RII）是在约25％的结肠癌中被遗传灭活（突变）的癌抑制基因，其包括几乎所有被称为变异体/微卫星的结肠癌不稳定/ RER。提供了用于检测用于癌症诊断或预后的RII的失活的方法。

4. 发明申请

WO1995009146A1 PARENTERAL NUTRIENTS BASED ON WATER SOLUBLE GLYCEROL BISACETOACETATES 审中-公开
标题翻译：基于水溶性甘油二磺酸酯的营养营养
公开(公告)号：WO1995009146A1
公开(公告)日：1995-04-06
申请号：PCT/US1994010966
申请日：1994-09-29
申请人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO
发明人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO , BIRKHAHN, Ronald, H. , CLEMENS, Robert, J. , HUBBS, John, C.
IPC分类号： C07C69/72
CPC分类号： A61K31/22 , A23L33/10 , A23V2002/00 , C07C69/72 , A23V2200/132 , A23V2250/30
摘要： Novel parenteral nutrient compositions are disclosed. These compositions are sterile aqueous solutions containing an effective amount of at least one glycerol bisacetoacetate of formula (I) wherein one R group is hydrogen, and two R groups are -(COCH2COCH3). These compositions are useful as a substitute for glucose in intravenous feeding.
摘要翻译：公开了新型肠外营养组合物。这些组合物是含有有效量的式（I）的至少一种甘油双乙酰乙酸酯的无菌水溶液，其中一个R基团是氢，两个R基团是 - （COCH 2 COCH 3）。这些组合物可用作静脉内给药中葡萄糖的替代物。

5. 发明申请

WO1995008949A1 USE OF PHOTODYNAMIC THERAPY TO TREAT PROSTATIC TISSUE 审中-公开
标题翻译：使用光化疗治疗前列腺组织
公开(公告)号：WO1995008949A1
公开(公告)日：1995-04-06
申请号：PCT/US1994007755
申请日：1994-07-08
申请人： MEDICAL COLLEGE OF OHIO
发明人： MEDICAL COLLEGE OF OHIO , SELMAN, Steven, H.
IPC分类号： A61B06/08
CPC分类号： A61K41/0057 , A61B2018/2261 , A61M25/10 , A61M2025/1075 , A61N5/0601 , A61N5/062 , A61N2005/061
摘要： The present invention provides a method for diagnosing or treating prostatic tissue in a human or animal patient which comprises sensitizing the prostatic tissue with an effective amount of a photosensitive composition which accumulates in the prostatic tissue and exposing the sensitized tissue to a source of light energy for a predetermined time and intensity sufficient to cause cellular and/or tissue function of the sensitized prostatic tissue to diminish or cease.
摘要翻译：本发明提供一种用于诊断或治疗人或动物患者中的前列腺组织的方法，其包括用有效量的积累在前列腺组织中的感光组合物对前列腺组织进行敏化，并将敏化组织暴露于光能来源足以引起致敏的前列腺组织的细胞和/或组织功能减少或停止的预定时间和强度。

6. 发明申请

WO1996023521A1 IL-12 INHIBITION OF B1 CELL ACTIVITY 审中-公开
标题翻译： IL-12抑制B1细胞活性
公开(公告)号：WO1996023521A1
公开(公告)日：1996-08-08
申请号：PCT/US1996001452
申请日：1996-02-01
申请人： MEDICAL COLLEGE OF OHIO , GENETICS INSTITUTE, INC.
发明人： MEDICAL COLLEGE OF OHIO , GENETICS INSTITUTE, INC. , METZGER, Dennis, W. , VAN CLEAVE, Victor, H.
IPC分类号： A61K38/20
CPC分类号： G01N33/5052 , A61K38/208 , G01N33/5008 , G01N33/5011 , G01N33/5088
摘要： The invention relates to a method of suppressing B1 cell activity in a host (e.g., mammalian, including human) comprising administering to the host an effective amount of IL-12 that significantly suppresses or inhibits B1 cell activity. In addition, the invention relates to a method of treating a B1 cell disorder in a host, comprising administering to the host an effective therapeutic amount of IL-12. The invention further encompasses a method of screening for substances (e.g., proteins, peptides, small molecules) which enhance or suppress the inhibition of B1 cell activity by IL-12. The invention also relates to a substance identified by the methods of screening for a substance which enhances or suppresses IL-12 inhibition of B1 cell activity.
摘要翻译：本发明涉及一种抑制宿主（例如哺乳动物，包括人）中的B1细胞活性的方法，包括向宿主施用显着抑制或抑制B1细胞活性的有效量的IL-12。此外，本发明涉及一种治疗宿主中B1细胞病症的方法，其包括向宿主施用有效治疗量的IL-12。本发明还包括筛选增强或抑制IL-12对B1细胞活性的抑制的物质（例如蛋白质，肽，小分子）的方法。本发明还涉及通过筛选增强或抑制B1细胞活性的IL-12抑制的物质的方法鉴定的物质。

7. 发明申请

WO1995013392A1 STABLE CELL LINES CAPABLE OF EXPRESSING THE ADENO-ASSOCIATED VIRUS REPLICATION GENE 审中-公开
标题翻译：表达ADENO相关病毒基因的稳定细胞系
公开(公告)号：WO1995013392A1
公开(公告)日：1995-05-18
申请号：PCT/US1994012582
申请日：1994-11-03
申请人： MEDICAL COLLEGE OF OHIO , TARGETED GENETICS CORPORATION , TREMPE, James, P. , YANG, Qicheng
发明人： MEDICAL COLLEGE OF OHIO , TARGETED GENETICS CORPORATION
IPC分类号： C12P21/02
CPC分类号： C12N15/86 , C12N2750/14143
摘要： Stable packaging cell lines derived from human 293 cells which are transfected with an AAV vector having the AAV rep gene operably linked to a heterologous transcription promoter, such as the metallothionein promoter, or an AAV Rep78 insensitive homologous promoter and which are capable of producing AAV Rep proteins and being useful for packaging recombinant AAV vectors containing target polynucleotides.
摘要翻译：来自人293细胞的稳定的包装细胞系，其用具有与异源转录启动子（例如金属硫蛋白启动子）或AAV Rep78不敏感同源启动子可操作地连接的具有AAV rep基因的AAV载体转染并且能够产生AAV Rep 蛋白质，并且可用于包装含有靶多核苷酸的重组AAV载体。

8. 发明申请

WO1995009145A1 NUTRITIVE GLYCEROL ESTERS OF 'beta'-ACYLOXY BUTYRATES 审中-公开
标题翻译： β-乙酰丁酸的营养甘油酯
公开(公告)号：WO1995009145A1
公开(公告)日：1995-04-06
申请号：PCT/US1994010965
申请日：1994-09-29
申请人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO
发明人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO , BIRKHAHN, Ronald, H. , CLEMENS, Robert, J. , McCOMBS, Charles, A. , HUBBS, John, C.
IPC分类号： C07C69/675
CPC分类号： C07C69/675
摘要： Novel compositions that are useful as nutrients are disclosed. These compounds are preferably water soluble parenteral nutrients and are glycerol esters of beta -acyloxybutyrates of formula (I) wherein each R is the same or different and is hydrogen, or (COCH2CHOR'CH3), provided that at least one R is not hydrogen and wherein R' is a linear acid ester of even carbon number from 2 to 20 carbons. These compositions are useful as a substitute for glucose in feeding.
摘要翻译：公开了可用作营养物质的新型组合物。这些化合物优选是水溶性肠胃外营养物，并且是式（I）的β-酰氧基丁酸酯的甘油酯，其中每个R相同或不同且为氢，或（COCH 2 CHOR'CH 3），条件是至少一个R不是氢，其中R'是碳原子数为2〜20的直链酸酯。这些组合物可用作饲料中葡萄糖的替代物。

9. 发明申请

WO1995019735A1 PHOTOCHEMICAL ABLATION OF GASTRO-INTESTINAL TISSUE 审中-公开
标题翻译：胃肠组织的光化学吸收
公开(公告)号：WO1995019735A1
公开(公告)日：1995-07-27
申请号：PCT/US1995000359
申请日：1995-01-11
申请人： MEDICAL COLLEGE OF OHIO
发明人： MEDICAL COLLEGE OF OHIO , SELMAN, Steven, H. , KROPP, Kenneth, A. , HASELHUHN, Gregory, D.
IPC分类号： A61B17/00
CPC分类号： A61N5/062 , A61B17/00 , A61B18/20 , A61B18/22 , A61N5/0601 , A61N2005/0609 , A61N2005/061
摘要： A method for treating a human or animal patient amenable to organ augmentation with gastro-intestinal tissue (30) which is, or will be, surgically transplanted into the patient's organ. The gastro-intestinal tissue (30) is sensitized with an effective amount of a photosensitive composition. The sensitized tissue is exposed to a source of electromagnetic radiation energy (28) for a predetermined time, wavelength and intensity sufficient to cause cellular and/or mucosal tissue function of the sensitized tissue to diminish or cease.
摘要翻译：一种用于或将手术移植到患者器官中的胃肠组织（30）治疗适于增加器官的人或动物患者的方法。胃肠组织（30）用有效量的光敏组合物敏化。致敏组织暴露于电磁辐射能量（28）的预定时间，足以使致敏组织的细胞和/或粘膜组织功能减弱或停止的波长和强度。

10. 发明申请

WO1995009144A1 NUTRITIVE WATER SOLUBLE GLYCEROL ESTERS OF HYDROXY BUTYRIC ACID 审中-公开
标题翻译：营养水溶性甘油酯的羟基丁酸
公开(公告)号：WO1995009144A1
公开(公告)日：1995-04-06
申请号：PCT/US1994010940
申请日：1994-09-29
申请人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO
发明人： EASTMAN CHEMICAL COMPANY , MEDICAL COLLEGE OF OHIO , BIRKHAHN, Ronald, H. , CLEMENS, Robert, J. , McCOMBS, Charles, A. , HUBBS, John, C.
IPC分类号： C07C69/675
CPC分类号： C07C69/675 , A61K31/22
摘要： Novel compositions that are useful as parenteral nutrients are disclosed. These compounds are water soluble glycerol esters of 3-hydroxybutyric acid of formula (I) wherein each R is the same or different and is hydrogen, -(COCH2CHOHCH3) (A), or -(COCH2COCH3) (B), provided that at least one R is group (A). These compositions are useful as a substitute for glucose in intravenous feeding.
摘要翻译：公开了可用作肠胃外营养物质的新型组合物。这些化合物是式（I）的3-羟基丁酸的水溶性甘油酯，其中每个R相同或不同，为氢， - （COCH 2 CHOHCH 3）（A）或 - （COCH 2 COCH 3）（B），条件是至少一个R是组（A）。这些组合物可用作静脉内给药中葡萄糖的替代物。

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