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1. 发明申请

WO2003065999A2 PROLIFERATED CELL LINES AND USES THEREOF 审中-公开
标题翻译：增殖细胞系及其用途
公开(公告)号：WO2003065999A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003753
申请日：2003-02-07
申请人： UNIVERSITY OF SOUTH FLORIDA , UNIVERSITY OF CHILE , CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
发明人： CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
IPC分类号： A61K
CPC分类号： A61K35/26 , C12N5/0018 , C12N2500/84 , C12N2502/078 , C12N2502/30 , C12N2503/02
摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, nonfertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.
摘要翻译：本发明涉及可用于增加培养物中任何人或动物细胞的增殖潜力的肿瘤细胞系，从而提供永生化或连续的细胞系和培养物。本发明还涉及增殖因子和含有能够增加培养物中任何人或其他动物细胞的增殖潜力的因素的组合物。本发明还涉及通过使细胞与增殖因子接触来增殖培养细胞的方法。增殖的细胞可以在可塑性范围内，并且可以包括例如胚细胞，受精卵，非受精配子，胚胎干细胞，成体干细胞，前体或祖细胞和高度专门的细胞。任选地，可诱导细胞停止增殖。本发明的增殖细胞可用于细胞治疗，细胞/基因治疗，分子的生物制备，以及用于研究，毒性测试和药物开发的体外模型。

2. 发明申请

WO2003065999A3 PROLIFERATED CELL LINES AND USES THEREOF 审中-公开
公开(公告)号：WO2003065999A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003753
申请日：2003-02-07
申请人： UNIVERSITY OF SOUTH FLORIDA , UNIVERSITY OF CHILE , CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
发明人： CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
IPC分类号： A01N1/00 , A01N1/02 , A61K38/00 , A61K39/00 , A01N37/18 , C07K1/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , G01N33/53
摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferating cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, nonfertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferated cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

3. 发明公开

EP1575524A2 PROLIFERATED CELL LINES AND USES THEREOF 审中-公开
标题翻译：增殖细胞系和它们的用途
公开(公告)号：EP1575524A2
公开(公告)日：2005-09-21
申请号：EP03713393.1
申请日：2003-02-07
申请人： UNIVERSITY OF SOUTH FLORIDA , University of Chile
发明人： CAVIEDES, Pablo , CAVIEDES, Raul , FREEMAN, Thomas, B. , SANBERG, Paul, R. , CAMERON, Don, F.
IPC分类号： A61K7/00
CPC分类号： A61K35/26 , C12N5/0018 , C12N2500/84 , C12N2502/078 , C12N2502/30 , C12N2503/02
摘要： The subject invention pertains to tumor cell lines useful for increasing the proliferation potential of any human or animal cell in culture, thereby providing immortalized or continuous cell lines and cultures. The invention also concerns proliferation factors, and compositions containing the factors, which are capable of increasing the proliferation potential of any human or other animal cell in culture. The subject invention further pertains to a method for proliferation cells in culture by contacting cells with the proliferation factors. The proliferated cells can range in plasticity and can include, for example, blast cells, fertilized ova, non-fertilized gametes, embryonic stem cells, adult stem cells, precursor or progenitor cells, and highly specialized cells. Optionally, the cells can be induced to cease proliferation. The proliferation cells of the subject invention are useful for cell therapy, cell/gene therapy, biological production of molecules, and as in vitro models for research, toxicity testing, and drug development.

4. 发明授权

EP0814819B1 SERTOLI CELLS AS TRANSPLANTATION FACILITATOR FOR CELL TRANSPLANTATION 失效
标题翻译：支持细胞移植SUPPORTER FOR细胞移植
公开(公告)号：EP0814819B1
公开(公告)日：2004-07-14
申请号：EP96908759.2
申请日：1996-03-12
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： SANBERG, Paul, R. , CAMERON, Don, F. , BORLONGAN, Cesario, V. , HELLER, Richard
IPC分类号： A61K35/30 , A61K35/48 , A61P25/00
CPC分类号： C12N5/0683 , A61K35/12 , A61K35/30 , A61K35/48 , A61K2035/122 , C12N5/0618 , C12N2502/246
摘要： A method of producing a sustained localized immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the tissue.

5. 发明申请

WO1996033264A1 PURIFIED AND ISOLATED SERTOLI CELL AGGREGATE 审中-公开
标题翻译：纯化和分离的SERTOLI细胞聚集
公开(公告)号：WO1996033264A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005066
申请日：1996-04-12
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , HELLER, Richard , CAMERON, Don, F. , SANBERG, Paul, R. , JAROSZESKI, Mark, J.
IPC分类号： C12N05/00
CPC分类号： C12N5/0683 , A61K35/12 , A61K35/39 , A61K35/48 , A61K38/00 , A61K2035/122 , C12N5/16
摘要： A purified and isolated Sertoli cell aggregate characterized by being a) capable of survival in situ after transplantation; b) able to provide immunoprotection for co-transplanted cells; and c) able to provide a mechanism for prolonged viability and functionality of the transplanted cells.
摘要翻译：一种纯化和分离的Sertoli细胞聚集体，其特征在于a）能够在移植后原位生存; b）能够为共移植细胞提供免疫保护; 和c）能够提供延长移植细胞活力和功能的机制。

6. 发明公开

EP1006801A1 SERTOLI CELLS AS NEURORECOVERY INDUCING CELLS FOR NEURODEGENERATIVE DISORDERS 失效
标题翻译： SERTOLI-ZELLEN ALS INDIKATOREN DER NEUROREGENERATION IN NEURODEGENERATIVEN ERKRANKUNGEN
公开(公告)号：EP1006801A1
公开(公告)日：2000-06-14
申请号：EP96908758.4
申请日：1996-03-12
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： SANBERG, Paul, R. , CAMERON, Don, F. , BORLONGAN, Cesario, V.
IPC分类号： A01N63/00 , C12N5/00
CPC分类号： A61K35/48
摘要： A method of generating in situ trophic factor production by transplanting Sertoli cells into a tissue in need of trophic factors of a mammal, the cells creating trophic factors in situ.
摘要翻译：通过将Sertoli细胞移植到需要哺乳动物营养因子的组织中的原位营养因子产生的方法，所述细胞在原位产生营养因子。

7. 发明公开

EP0814819A1 SERTOLI CELLS AS TRANSPLANTATION FACILITATOR FOR CELL TRANSPLANTATION 失效
标题翻译：支持细胞移植SUPPORTER FOR细胞移植
公开(公告)号：EP0814819A1
公开(公告)日：1998-01-07
申请号：EP96908759.0
申请日：1996-03-12
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： SANBERG, Paul, R. , CAMERON, Don, F. , BORLONGAN, Cesario, V. , HELLER, Richard
IPC分类号： A61K35 , C12N5
CPC分类号： C12N5/0683 , A61K35/12 , A61K35/30 , A61K35/48 , A61K2035/122 , C12N5/0618 , C12N2502/246
摘要： A method of producing a sustained localized immunosuppressive effect in localized tissues is achieved by transplanting Sertoli cells proximate to the tissue.

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