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1. 发明申请

WO2007123979A3 CERVICAL PLATE SYSTEM 审中-公开
标题翻译：陶瓷板系统
公开(公告)号：WO2007123979A3
公开(公告)日：2008-03-06
申请号：PCT/US2007009544
申请日：2007-04-18
申请人： UNIV SOUTH FLORIDA , FREEMAN THOMAS B , JOHNSON WESLEY
发明人： FREEMAN THOMAS B , JOHNSON WESLEY
IPC分类号： A61B17/70
CPC分类号： A61B17/7059 , A61B17/1728 , A61B17/1757 , A61B17/8014 , A61B17/808
摘要： An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked sponges, etc.), to telescope into the vertebral body and to minimize failure due to cages that telescope into adjacent vertebral bodies on a delayed basis after surgery, as well as creation of reverse lordosis due to such telescoping. Another embodiment provides method to reduce the gap between the inter-body cage and the vertebral body end plate intra-operatively using compression from the plate caused by an offset between the screw bores on the plate and the drill holes, as established with an asymmetric drill guide.
摘要翻译：提供了具有界面可视化的抗沉降，抗移位，融合压缩宫颈板系统，钻引导和临时引脚。在一个实施例中，本发明提供了一种脊椎板，用于使填充有骨（或BMP-浸泡的海绵等）的体间笼子的能力最小化，以望远镜到椎体中并且将由于笼罩的望远镜手术后延迟的相邻椎体，以及由于这种伸缩引起的反向脊柱前凸的产生。另一个实施例提供了如下方法：使用由不对称钻头建立的板上螺钉孔与钻孔之间的偏移导致的板内压缩从而减小了体内笼和椎体内端板之间的间隙指南。

2. 发明申请

WO2006029368A3 PROSTHESES FOR SPINE DISCS HAVING FUSION CAPABILITY 审中-公开
标题翻译：具有融合能力的椎间盘突出症
公开(公告)号：WO2006029368A3
公开(公告)日：2007-02-08
申请号：PCT/US2005032286
申请日：2005-09-09
申请人： UNIV SOUTH FLORIDA , JOHNSON WESLEY M , FREEMAN THOMAS B
发明人： JOHNSON WESLEY M , FREEMAN THOMAS B
IPC分类号： A61F2/44
CPC分类号： A61F2/441 , A61F2/442 , A61F2002/30009 , A61F2002/30075 , A61F2002/30242 , A61F2002/30586 , A61F2002/30914 , A61F2002/4495 , A61F2210/0061 , A61F2230/0071 , A61F2250/0028
摘要： The present invention provides both a device and a method. The device is a human made replacement for the soft discs in the spine. A fabric pouch encloses a central hydraulic element made up of small soft beads. Two pouches with beads are implanted into a prepared disc space to function as an intervertebral disc. The method is conversion of the device into a fusion element.
摘要翻译：本发明提供了一种装置和方法。该装置是用于人造脊柱中的软盘的替代品。织物袋包围由小软珠组成的中央液压元件。将具有珠的两个袋植入制备的盘空间中，用作椎间盘。该方法是将装置转换成融合元件。

3. 发明申请

WO2022159837A1 SYSTEMS AND METHODS FOR TREATING A SACROILIAC JOINT 审中-公开
公开(公告)号：WO2022159837A1
公开(公告)日：2022-07-28
申请号：PCT/US2022/013561
申请日：2022-01-24
申请人： UNIVERSITY OF SOUTH FLORIDA , FREEMAN, Thomas B. , HOGHAUG, Thomas G.
发明人： FREEMAN, Thomas B. , HOGHAUG, Thomas G.
IPC分类号： A61B17/88 , A61B17/16 , A61B17/70 , A61B17/86
摘要： A method of treating a sacroiliac joint and/or a region proximate the sacroiliac joint includes distracting and/or stabilizing a recess between a sacral wall of a sacrum and an ilial wall of an ilium, cutting a surface of the ilial wall using a cutting device, and positioning an implant having a first planar wall and a second planar wall opposite the first planar wall into the recess, such that the first planar wall of the implant is in contact with an uncut surface of the sacral wall, and the second planar wall is in contact with the cut surface of the ilial wall. The implant can be formed as a wedge-shape, a double-wedge shape, or a cuboid shape.

4. 发明申请

WO2004087860A3 MATERIALS AND METHODS FOR REGULATING PROCESS FORMATION IN CELL CULTURE 审中-公开
标题翻译：调节细胞培养过程形成的材料和方法
公开(公告)号：WO2004087860A3
公开(公告)日：2005-03-24
申请号：PCT/US2004010162
申请日：2004-03-31
申请人： UNIV SOUTH FLORIDA , UNIV CHILE , CAVIEDES PABLO , CAVIEDES RAUL , FREEMAN THOMAS B , ASENJO JUAN A , ANDREWS BARBARA A , SEPULVEDA DARIO , ARRIAGADA CHRISTIAN , RIVERA JULIO SALAZAR
发明人： CAVIEDES PABLO , CAVIEDES RAUL , FREEMAN THOMAS B , ASENJO JUAN A , ANDREWS BARBARA A , SEPULVEDA DARIO , ARRIAGADA CHRISTIAN , RIVERA JULIO SALAZAR
IPC分类号： A61K35/12 , C12M20060101 , C12M1/00 , C12N5/02 , C12N5/0793 , C12P7/06 , C12N5/06
CPC分类号： C12N5/0619 , A61K35/12 , C12N2533/30 , C12N2533/92 , Y02E50/17
摘要： The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In another aspect, the subject invention concerns methods of transplantation using process-forming cells that have been cultured by the process-inhibiting methods of the invention.
摘要翻译：本发明涉及用于抑制培养物中细胞形成和延伸的方法的材料和方法。本发明还包括其中过程的形成和延伸已经被抑制的过程形成细胞的培养物。在另一方面，本发明涉及使用已经通过本发明的方法抑制方法培养的过程形成细胞的移植方法。

5. 发明申请

WO2005017201A1 METHOD OF TREATING HERPES VIRUS INFECTIONS 审中-公开
标题翻译：治疗病毒性感染的方法
公开(公告)号：WO2005017201A1
公开(公告)日：2005-02-24
申请号：PCT/US2003/024479
申请日：2003-08-05
申请人： UNIVERSITY OF SOUTH FLORIDA , FREEMAN, Thomas, B. , NAUERT, Michael, G.
发明人： FREEMAN, Thomas, B. , NAUERT, Michael, G.
IPC分类号： C12Q1/68
CPC分类号： A61K39/205 , A61K39/12 , A61K2039/5252 , A61K2039/55 , A61K2039/58 , C12N2760/20134
摘要： The present invention is a novel alternative use of the rabies vaccine for the purposes of suppressing herpes outbreaks.
摘要翻译：本发明是用于抑制疱疹爆发的狂犬病疫苗的新型替代用途。

6. 发明申请

WO2009042672A1 VERTEBRAL BODY CAGE 审中-公开
标题翻译： VERTEBRAL身体笼
公开(公告)号：WO2009042672A1
公开(公告)日：2009-04-02
申请号：PCT/US2008/077504
申请日：2008-09-24
申请人： UNIVERSITY OF SOUTH FLORIDA , FREEMAN, Thomas B. , JOHNSON, Wesley
发明人： FREEMAN, Thomas B. , JOHNSON, Wesley
IPC分类号： A61F2/44
CPC分类号： A61F2/44 , A61F2/28 , A61F2/447 , A61F2/4611 , A61F2002/2817 , A61F2002/30331 , A61F2002/30459 , A61F2002/3055 , A61F2002/30551 , A61F2002/30601 , A61F2002/30604 , A61F2002/30785 , A61F2002/30841 , A61F2002/4475 , A61F2002/448 , A61F2002/4629 , A61F2220/0033 , A61F2220/0066 , A61F2310/00359
摘要： A intervertebral body device for supporting adjacent vertebrae includes a vertebral body member having at least one containment portion and one communicating portion. The containment portion and communication portion provide two distinct functional regions within the cage. One region of the cage provides for the use of a biologic material, and the region of the cage provides holes in the side or the front of the cage in order to allow bony ingrowth into that portion of the cage. Where numerous segments are needed, these components can be arranged in any combination.
摘要翻译：用于支撑相邻椎骨的椎间体装置包括具有至少一个容纳部分和一个连通部分的椎体主体部件。容纳部分和连通部分在笼内提供两个不同的功能区域。笼的一个区域提供使用生物材料，并且笼的区域在保持架的侧面或前部提供孔，以允许骨向内生长进入笼的该部分。在需要许多部分的情况下，这些组件可以以任何组合的方式排列。

7. 发明申请

WO2009029929A1 ASYMMETRIC DISC DISTRACTING CAGE 审中-公开
标题翻译：不对称盘分配笼
公开(公告)号：WO2009029929A1
公开(公告)日：2009-03-05
申请号：PCT/US2008/075010
申请日：2008-09-02
申请人： UNIVERSITY OF SOUTH FLORIDA , FREEMAN, Thomas B. , JOHNSON, Wesley
发明人： FREEMAN, Thomas B. , JOHNSON, Wesley
IPC分类号： A61F2/44
CPC分类号： A61F2/447 , A61B2017/0256 , A61F2/30965 , A61F2/4611 , A61F2002/2817 , A61F2002/2835 , A61F2002/30092 , A61F2002/30112 , A61F2002/30433 , A61F2002/30904 , A61F2002/4475 , A61F2002/448 , A61F2210/0014 , A61F2220/0041 , A61F2230/0004 , A61F2310/00023 , A61F2310/00029
摘要： An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate during the distraction process when the interbody cage is impacted.
摘要翻译：具有偏心地位于笼的前端的楔形的椎间盘。该实施例的外形形状的前缘有助于更容易的体间隔离物放置，具有更少的神经损伤的风险，并且在椎间盘被撞击时在分心过程期间端板的破坏风险可能降低。

8. 发明申请

WO2007123979A2 CERVICAL PLATE SYSTEM 审中-公开
标题翻译：陶瓷板系统
公开(公告)号：WO2007123979A2
公开(公告)日：2007-11-01
申请号：PCT/US2007/009544
申请日：2007-04-18
申请人： UNIVERSITY OF SOUTH FLORIDA , FREEMAN, Thomas, B. , JOHNSON, Wesley
发明人： FREEMAN, Thomas, B. , JOHNSON, Wesley
IPC分类号： A61B17/70
CPC分类号： A61B17/7059 , A61B17/1728 , A61B17/1757 , A61B17/8014 , A61B17/808
摘要： An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked sponges, etc.), to telescope into the vertebral body and to minimize failure due to cages that telescope into adjacent vertebral bodies on a delayed basis after surgery, as well as creation of reverse lordosis due to such telescoping. Another embodiment provides method to reduce the gap between the inter-body cage and the vertebral body end plate intra-operatively using compression from the plate caused by an offset between the screw bores on the plate and the drill holes, as established with an asymmetric drill guide.
摘要翻译：提供了具有界面可视化的抗沉降，抗移位，融合压缩宫颈板系统，钻引导和临时引脚。在一个实施例中，本发明提供了一种脊椎板，用于使填充有骨（或BMP-浸泡的海绵等）的体间笼子的能力最小化，以望远镜到椎体中并且将由于笼罩的望远镜手术后延迟的相邻椎体，以及由于这种伸缩引起的反向脊柱前凸的产生。另一个实施例提供了如下方法：使用由不对称钻头建立的板上螺钉孔与钻孔之间的偏移导致的板内压缩从而减小了体内笼和椎体内端板之间的间隙指南。

9. 发明申请

WO2004087860A2 MATERIALS AND METHODS FOR REGULATING PROCESS FORMATION IN CELL CULTURE 审中-公开
标题翻译：调节细胞培养过程形成的材料和方法
公开(公告)号：WO2004087860A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/010162
申请日：2004-03-31
申请人： UNIVERSITY OF SOUTH FLORIDA , UNIVERSITY OF CHILE , CAVIEDES, PABLO , CAVIEDES, Raul , FREEMAN, Thomas, B. , ASENJO, Juan, A. , ANDREWS, Barbara, A. , SEPULVEDA, Dario , ARRIAGADA, Christian , RIVERA, Julio, Salazar
发明人： CAVIEDES, PABLO , CAVIEDES, Raul , FREEMAN, Thomas, B. , ASENJO, Juan, A. , ANDREWS, Barbara, A. , SEPULVEDA, Dario , ARRIAGADA, Christian , RIVERA, Julio, Salazar
IPC分类号： C12M
CPC分类号： C12N5/0619 , A61K35/12 , C12N2533/30 , C12N2533/92 , Y02E50/17
摘要： The subject invention pertains to materials and methods for inhibiting process formation and extension by cells in culture. The subject invention further includes cultures of process-forming cells wherein formation and extension of processes have been inhibited. In another aspect, the subject invention concerns methods of transplantation using process-forming cells that have been cultured by the process-inhibiting methods of the invention.
摘要翻译：本发明涉及用于抑制培养物中细胞形成和延伸的方法的材料和方法。本发明还包括其中过程的形成和延伸已经被抑制的过程形成细胞的培养物。在另一方面，本发明涉及使用已经通过本发明的方法抑制方法培养的过程形成细胞的移植方法。

10. 发明申请

WO2004045394A2 PUTAMEN GRID 审中-公开
公开(公告)号：WO2004045394A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/037519
申请日：2003-11-20
申请人： UNIVERSITY OF SOUTH FLORIDA , FREEMAN, Thomas, B. , O'CONNOR, James
发明人： FREEMAN, Thomas, B. , O'CONNOR, James
IPC分类号： A61B
CPC分类号： A61B90/11 , A61B2017/00969 , A61B2017/3411
摘要： The present invention makes a grid array, for use in the transplantation of materials into the brain, in the shape of a predetermined structure, such as the putamen, based on anatomic analysis the structure. Alternatively, a smaller grid array is used which only includes the putamen target and not the caudate target, and also has two windows within the grid array. Because of the smaller size of this grid array as well as the two cutouts in the middle, it is possible for the first time to observe the brain as the needle enters the brain through the grid array. The previous solid and larger grid array made the passage of the needle into the brain a blind maneuver. Therefore if there was a cortical bleeding at the time of needle insertion, it would not be known until after the transplant was done.
摘要翻译：基于解剖学分析，本发明构成了用于将材料移植到脑中的网格阵列，其形状为预定结构（例如壳核）。或者，使用较小的网格阵列，其仅包括壳核目标而不是尾状物靶，并且在网格阵列内还具有两个窗口。由于这个网格阵列的尺寸较小以及中间的两个切口，所以当针头通过网格阵列进入大脑时，首次可以观察大脑。以前的固体和更大的网格阵列使得针头进入大脑的盲目机动。因此，如果在针插入时出现皮层出血，直到移植完成后才会知道。

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