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1. 发明申请

WO2011123683A2 PROTEASE ACTIVATED CYTOKINES 审中-公开
标题翻译： PROTEASE激活细胞因子
公开(公告)号：WO2011123683A2
公开(公告)日：2011-10-06
申请号：PCT/US2011/030787
申请日：2011-03-31
申请人： UNIVERSITY OF ROCHESTER , FRELINGER, John G. , PUSKAS, John , KIM, Baek , SULLIVAN, Mark
发明人： FRELINGER, John G. , PUSKAS, John , KIM, Baek , SULLIVAN, Mark
IPC分类号： C12N15/62 , C12N15/26 , C07K19/00 , C07K14/55 , A61K38/17 , A61P35/00
CPC分类号： C07K19/00 , A61K38/00 , C07K14/55 , C07K2319/21 , C07K2319/50 , C07K2319/70
摘要： Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.
摘要翻译：本文提供编码嵌合多肽的嵌合核酸序列。本文还提供嵌合多肽。本文进一步提供了治疗患有癌症或具有发展癌症风险的受试者的方法。所述方法包括选择具有或具有发展癌症风险的受试者，并向受试者施用有效量的本文提供的嵌合多肽。

2. 发明申请

WO2015023927A3 COMPOSITION AND METHOD FOR DETECTION OF NANOMATERIALS 审中-公开
公开(公告)号：WO2015023927A3
公开(公告)日：2015-02-19
申请号：PCT/US2014/051227
申请日：2014-08-15
申请人： UNIVERSITY OF ROCHESTER , DeLOUISE, Lisa , RAVICHANDRAN, Supriya , SULLIVAN, Mark
发明人： DeLOUISE, Lisa , RAVICHANDRAN, Supriya , SULLIVAN, Mark
IPC分类号： H01B1/02
摘要： The present invention provides compositions and methods for detecting the presence, location, or abundance of a nanomaterial. In certain embodiments, the composition of the invention is identified using a screening method utilizing phage display of a library of test compounds.

3. 发明申请

WO2007011907A2 ALPHA-SYNUCLEIN ANTIBODIES AND METHODS RELATED THERETO 审中-公开
标题翻译： ALPHA-SYNUCLEIN抗体及其相关方法
公开(公告)号：WO2007011907A2
公开(公告)日：2007-01-25
申请号：PCT/US2006/027772
申请日：2006-07-19
申请人： UNIVERSITY OF ROCHESTER , FEDEROFF, Howard, J. , MAGUIRE-ZEISS, Kathleen , SULLIVAN, Mark
发明人： FEDEROFF, Howard, J. , MAGUIRE-ZEISS, Kathleen , SULLIVAN, Mark
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/622
摘要： Disclosed are antibodies specific for alpha-synuclein conformers and methods related thereto. For example, disclosed are methods of diagnosing a neurodegenerative such as Parkinson's disease, monitoring a neurodegenerative disease progression, and monitoring a neurodegenerative disease treatment using the disclosed antibodies. Assays, kits, and solid supports related to alpha-synuclein and antibodies specific for alpha- synuclein are also disclosed.
摘要翻译：公开了针对α-突触核蛋白构象的特异性抗体及其相关方法。例如，公开了诊断神经变性如帕金森病，监测神经变性疾病进展和使用公开的抗体监测神经变性疾病治疗的方法。还公开了与α-突触核蛋白相关的测定，试剂盒和固体支持物和针对α-突触核蛋白特异性的抗体。

4. 发明公开

EP1915177A2 ALPHA-SYNUCLEIN ANTIBODIES AND METHODS RELATED THERETO 审中-公开
标题翻译： α-突触核蛋白抗体和相关程序
公开(公告)号：EP1915177A2
公开(公告)日：2008-04-30
申请号：EP06787652.4
申请日：2006-07-19
申请人： University of Rochester
发明人： FEDEROFF, Howard, J. , MAGUIRE-ZEISS, Kathleen , SULLIVAN, Mark
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/622
摘要： Disclosed are antibodies specific for alpha-synuclein conformers and methods related thereto. For example, disclosed are methods of diagnosing a neurodegenerative such as Parkinson's disease, monitoring a neurodegenerative disease progression, and monitoring a neurodegenerative disease treatment using the disclosed antibodies. Assays, kits, and solid supports related to alpha-synuclein and antibodies specific for alpha- synuclein are also disclosed.

5. 发明公开

EP2553101A2 PROTEASE ACTIVATED CYTOKINES 审中-公开
标题翻译：蛋白酶激活的细胞因子
公开(公告)号：EP2553101A2
公开(公告)日：2013-02-06
申请号：EP11763460.0
申请日：2011-03-31
申请人： University of Rochester
发明人： FRELINGER, John G. , PUSKAS, John , KIM, Baek , SULLIVAN, Mark
IPC分类号： C12N15/62 , C12N15/26 , C07K19/00 , C07K14/55 , A61K38/17 , A61P35/00
CPC分类号： C07K19/00 , A61K38/00 , C07K14/55 , C07K2319/21 , C07K2319/50 , C07K2319/70
摘要： Provided herein are chimeric nucleic acid sequences encoding chimeric polypeptides. Also provided herein are chimeric polypeptides. Further provided herein are methods of treating a subject with or at risk of developing a cancer. The methods comprise selecting a subject with or at risk of developing a cancer, and administering to the subject an effective amount of the chimeric polypeptides provided herein.

6. 发明申请

WO2011154740A1 A METHOD FOR IMPROVING THE SCALABILITY AND RESPONSIVENESS OF AN ONLINE SERVICE 审中-公开
标题翻译：一种提高在线服务的可扩展性和响应性的方法
公开(公告)号：WO2011154740A1
公开(公告)日：2011-12-15
申请号：PCT/GB2011/051079
申请日：2011-06-09
申请人： OMNIFONE LTD , KNIGHT, Mark , SANT, Philip , LAMB, Michael , SULLIVAN, Mark
发明人： KNIGHT, Mark , SANT, Philip , LAMB, Michael , SULLIVAN, Mark
IPC分类号： G06F21/02 , G06F21/00 , G06F9/50
CPC分类号： G06F9/5061
摘要： An online service may be made scalable without compromising maintenance requirements and while maintaining modularity. Multiple levels of hierarchically organised clusters allow the processing required by the service to be devolved to the appropriate level in the clustered hierarchy. This is accomplished by assigning each user of the service to a "home" cluster ("ACI" - Application Cluster Instance) and maintaining a Global User Directory ("GUD") which may be used to locate the home cluster of a given user. Thus, rather than having to synchronise multiple servers or clusters, the user's requests are instead served by their "home" cluster wherever possible and appropriate.
摘要翻译：可以使在线服务可扩展，而不会影响维护需求并保持模块化。多层次的层次组织的集群允许将服务所需的处理转移到集群层次结构中的适当级别。这是通过将服务的每个用户分配给“家庭”集群（“ACI” - 应用集群实例））并维护可用于定位给定用户的归属集群的全局用户目录（“GUD”）来实现的。因此，不必同步多个服务器或集群，用户的请求就是由他们的“家”集群在可能和适当的地方提供服务。

7. 发明申请

WO2005099171A1 ADVANCED SWITCHING FABRIC DISCOVERY PROTOCOL 审中-公开
标题翻译：高级开关织物发现协议
公开(公告)号：WO2005099171A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/010711
申请日：2005-03-30
申请人： INTEL CORPORATION , GENOVKER, Victoria, V. , MCQUEEN, Ward , ROOHOLAMINI, Mo , SULLIVAN, Mark
发明人： GENOVKER, Victoria, V. , MCQUEEN, Ward , ROOHOLAMINI, Mo , SULLIVAN, Mark
IPC分类号： H04L12/24
CPC分类号： H04L41/00
摘要： Method and apparatus to perform fabric discovery for a communications fabric are described.
摘要翻译：描述了对通信结构进行结构发现的方法和装置。

8. 发明申请

WO2010029362A2 EMBEDDED BACKGROUND LIFECYCLE MANAGER 审中-公开
标题翻译：嵌入式背景生物科技经理
公开(公告)号：WO2010029362A2
公开(公告)日：2010-03-18
申请号：PCT/GB2009/051168
申请日：2009-09-10
申请人： OMNIFONE LTD , EVANS, Christopher, John , SANT, Philip , NAJT, Pablo , SULLIVAN, Mark , POCOCK, Stephen , RAWDEN, Lucien
发明人： EVANS, Christopher, John , SANT, Philip , NAJT, Pablo , SULLIVAN, Mark , POCOCK, Stephen , RAWDEN, Lucien
IPC分类号： G06F9/445 , G06F9/48
CPC分类号： G06F21/10 , G06F2221/074 , G06F2221/2137
摘要： A mobile computing device includes a service-oriented environment that allows an application running on the device to run as a service application. The service-oriented environment:  (a) starts automatically on device start-up or boot without presenting a user interface; (b) automatically invokes or starts the application running as a service; and (c) continues to run in background. The service-oriented environment supports third-party applications as well as core  applications on a mobile device and permits the remote management and updating of those third-party applications, hence managing their lifecycle.
摘要翻译：移动计算设备包括允许在设备上运行的应用程序作为服务应用程序运行的面向服务的环境。面向服务的环境：（a）在设备启动或启动时自动启动而不显示用户界面; （b）自动调用或启动作为服务运行的应用程序; 和（c）继续在后台运行。面向服务的环境支持移动设备上的第三方应用程序和核心应用程序，并允许远程管理和更新这些第三方应用程序，从而管理其生命周期。

9. 发明申请

WO2010135171A1 INVERTER TOPOLOGY FOR IMPROVED EFFICIENCY AND REDUCED HARMONIC DISTORTION AND ASSOCIATED METHODS 审中-公开
标题翻译：改进效率和减少谐波失真的逆变器拓扑及相关方法
公开(公告)号：WO2010135171A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/034839
申请日：2010-05-14
申请人： CAPTECH DEVELOPMENT CORPORATION , SULLIVAN, Mark
发明人： SULLIVAN, Mark
IPC分类号： H02M7/60
CPC分类号： H02M1/12 , H02M7/5387
摘要： An inverter circuit for generating an AC signal from a DC input comprises a primary inverter for generating a first portion of a signal, the primary inverter using switches that when actuated efficiently produce the first portion of the signal, the first portion of the signal being an approximation of a sine wave, the approximation of the sine wave having an error component; a secondary inverter for generating a second portion of the signal, the secondary inverter using switches to produce a waveform that attenuates the error component of the first portion of the signal; and combining means such as a transformer which combine the first and second portions of the generated signal to produce a substantially improved approximation of a sine wave. An inverter circuit may further comprise: a filter connected to the transformer for smoothing a residual carrier frequency from the secondary portion of the signal.
摘要翻译：用于从DC输入产生AC信号的逆变器电路包括用于产生信号的第一部分的主逆变器，所述主逆变器使用当致动时有效地产生信号的第一部分的开关，所述信号的第一部分是正弦波的近似，具有误差分量的正弦波的近似; 用于产生信号的第二部分的次级逆变器，次级逆变器使用开关来产生衰减信号的第一部分的误差分量的波形; 以及组合装置，例如组合产生的信号的第一和第二部分的变压器，以产生基本上改进的正弦波近似。逆变器电路还可以包括：连接到变压器的滤波器，用于从信号的次级部分平滑残余载波频率。

10. 发明申请

WO2010116181A1 ENABLING DIGITAL MEDIA CONTENT TO BE DOWNLOADED TO AND USED ON MULTIPLE TYPES OF COMPUTING DEVICE 审中-公开
标题翻译：使用数字媒体内容下载并使用多种类型的计算设备
公开(公告)号：WO2010116181A1
公开(公告)日：2010-10-14
申请号：PCT/GB2010/050596
申请日：2010-04-07
申请人： OMNIFONE LTD , KNIGHT, Mark , VIDAL, Jaume , BEDWELL, Ed , EDWARDS, Duncan , SULLIVAN, Mark , LAMB, Michael
发明人： KNIGHT, Mark , VIDAL, Jaume , BEDWELL, Ed , EDWARDS, Duncan , SULLIVAN, Mark , LAMB, Michael
IPC分类号： G06F17/30 , H04L29/08
CPC分类号： G06F17/30017 , H04L67/1095 , H04L67/303 , H04L67/306
摘要： The invention is a method for enabling digital content to be downloaded to and used on multiple types of computing device by (i) linking user accounts on each device to a "master" user account defined and stored on a remote server; and (ii) managing the user's access to a defined service using his devices via the said master user account; and (iii) allowing the download of digital content to each said device on which the user is permitted to access the said service using a file format which is appropriate for use on each said device type. A user may manage and access the same user account from multiple types of computing devices. Furthermore, the number of device platforms accessible in a similar manner by the user is extensible and the user's information is kept automatically synchronized across all devices.
摘要翻译：本发明是一种通过（i）将每个设备上的用户帐户与定义并存储在远程服务器上的“主”用户帐户相关联的方式，使数字内容能够下载到多种类型的计算设备上并被使用的方法; 和（ii）经由所述主用户帐户管理用户使用其设备访问定义的服务; 以及（iii）允许使用适合于在每种所述设备类型上使用的文件格式将数字内容下载到允许用户访问所述服务的每个所述设备。用户可以从多种类型的计算设备来管理和访问相同的用户帐户。此外，由用户以类似的方式可访问的设备平台的数量是可扩展的，并且用户的信息在所有设备之间保持自动同步。

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