专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2012100010A1 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE 审中-公开
标题翻译： APOLIPOPROTEIN AIV作为抗生素
公开(公告)号：WO2012100010A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/021802
申请日：2012-01-19
申请人： UNIVERSITY OF CINCINNATI , TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
发明人： TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
IPC分类号： A61K38/17 , C07K14/775 , A61P3/10
CPC分类号： C07K14/775 , A61K38/00 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/22 , A61K38/26 , A61K38/28 , A61K39/00 , C07K9/005 , C07K9/008 , C07K14/47 , C07K14/605 , C07K14/6555
摘要： Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include administering an effective amount of apolipoprotein A- IV to the subject. The pharmaceutical composition includes apolipoprotein A- IV formulated for administration to a subject for the treatment of type two diabetes mellitus. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof.
摘要翻译：公开了在有需要的受试者中治疗2型糖尿病的方法和用于治疗2型糖尿病的药物组合物。所述方法包括向受试者施用有效量的载脂蛋白A-IV。药物组合物包括配制用于给予受试者用于治疗2型糖尿病的载脂蛋白A-IV。还公开了将有需要的受试者的葡萄糖耐量基本上恢复到正常水平的方法和用于降低有需要的受试者的血糖水平的方法。

2. 发明申请

WO2005015201A1 USE OF NON-ABSORBABLE FAT IN DETERMINING DIETARY FAT ABSORPTION 审中-公开
标题翻译：使用不可吸收的脂肪来测定食物中的脂肪吸收
公开(公告)号：WO2005015201A1
公开(公告)日：2005-02-17
申请号：PCT/US2004/025350
申请日：2004-08-05
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , UNIVERSITY OF CINCINNATI , JANDACEK, Ronald, James , TSO, Patrick , HEUBI, James, E.
发明人： JANDACEK, Ronald, James , TSO, Patrick , HEUBI, James, E.
IPC分类号： G01N31/00
CPC分类号： G01N33/03 , A23L33/26 , Y10T436/13 , Y10T436/143333
摘要： The use of sucrose polyester containing behenate fatty acid chains as a non-absorbable fat marker to determine total dietary fat absorption by the digestive tract of a subject. A test food for use in measuring fat absorption contains a non-absorbable fat and a dietary fat. The method is useful for diagnostic testing for diagnosing malabsorption of dietary fat by the digestive tract of the subject, and impairment of dietary fat digestion in the subject.
摘要翻译：使用含有山嵛酸脂肪酸链的蔗糖聚酯作为不可吸收的脂肪标记，以确定受试者消化道的总膳食脂肪吸收。用于测量脂肪吸收的测试食品含有不可吸收的脂肪和膳食脂肪。该方法对于诊断受试者消化道对膳食脂肪吸收不良和受试者膳食脂肪消化的损伤的诊断测试是有用的。

3. 发明申请

WO2014018763A2 METHOD OF TREATING TYPE I DIABETES USING APOLIPOPROTEIN AIV 审中-公开
标题翻译：使用APOLIPOPROTEIN AIV治疗I型糖尿病的方法
公开(公告)号：WO2014018763A2
公开(公告)日：2014-01-30
申请号：PCT/US2013/052078
申请日：2013-07-25
申请人： UNIVERSITY OF CINCINNATI
发明人： TSO, Patrick , LI, Xiaoming
IPC分类号： A61K38/17 , A61K38/28 , A61P3/10
CPC分类号： A61K38/1709 , A61K38/16 , A61K38/28 , C07K14/775
摘要： Methods for treating type one diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type one diabetes mellitus are disclosed, including combination therapies with insulin. The methods include administering an effective amount of apolipoprotein A-IV to the subject having type I diabetes. The pharmaceutical composition includes apolipoprotein A-IV formulated for administration to a subject for the treatment of type one diabetes mellitus.
摘要翻译：公开了在有需要的受试者中治疗1型糖尿病的方法和用于治疗1型糖尿病的药物组合物，包括与胰岛素的联合疗法。所述方法包括向有I型糖尿病的受试者施用有效量的载脂蛋白A-IV。药物组合物包括配制用于给予受试者治疗1型糖尿病的载脂蛋白A-IV。

4. 发明公开

EP1068239A2 ANTIOXIDANT PEPTIDES DERIVED FROM APOLIPOPROTEIN A-IV 审中-公开
标题翻译： OFF载脂蛋白A-IV ENTSTAMMENDE抗氧化肽
公开(公告)号：EP1068239A2
公开(公告)日：2001-01-17
申请号：EP99914142.7
申请日：1999-03-25
申请人： UNIVERSITY OF CINCINNATI
发明人： HUI, David, Y. , TSO, Patrick
IPC分类号： C07K14/775
CPC分类号： C07K14/775 , A61K38/00
摘要： The present invention provides a method and means for inhibiting lipid oxidation. In accordance with the present invention, a number of novel lipid oxidation suppressant peptides, derived from apolipoprotein A-IV, have been made. These peptides possess lipid oxidation inhibiting properties which when administered orally or intravenously, can be used to decrease atherosclerosis. Since the peptides comprise specific portions of the native apo A-IV protein, there should be no immunogenicity problems associated with their administration to humans.

5. 发明公开

EP2877197A2 METHOD OF TREATING TYPE I DIABETES USING APOLIPOPROTEIN AIV 审中-公开
标题翻译： VERFAHREN ZUR BEHANDLUNG VON TYP-1-DIABETES MITTELS DES APOLIPOPROTEINS AIV
公开(公告)号：EP2877197A2
公开(公告)日：2015-06-03
申请号：EP13745314.8
申请日：2013-07-25
申请人： University Of Cincinnati
发明人： TSO, Patrick , LI, Xiaoming
IPC分类号： A61K38/17 , A61K38/28 , A61P3/10
CPC分类号： A61K38/1709 , A61K38/16 , A61K38/28 , C07K14/775
摘要： Methods for treating type one diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type one diabetes mellitus are disclosed, including combination therapies with insulin. The methods include administering an effective amount of apolipoprotein A-IV to the subject having type I diabetes. The pharmaceutical composition includes apolipoprotein A-IV formulated for administration to a subject for the treatment of type one diabetes mellitus.
摘要翻译：公开了在有需要的受试者中治疗1型糖尿病的方法和用于治疗1型糖尿病的药物组合物，包括与胰岛素的联合疗法。所述方法包括向有I型糖尿病的受试者施用有效量的载脂蛋白A-IV。药物组合物包括配制用于给予受试者治疗1型糖尿病的载脂蛋白A-IV。

6. 发明申请

WO2014018079A8 METHOD OF TREATING HYPERGLYCEMIC DISORDERS USING APOLIPOPROTEIN AIV 审中-公开
标题翻译：使用载脂蛋白AIV治疗高血糖障碍的方法
公开(公告)号：WO2014018079A8
公开(公告)日：2014-01-30
申请号：PCT/US2012/066334
申请日：2012-11-21
申请人： UNIVERSITY OF CINCINNATI
发明人： TSO, Patrick , WANG, Fei , DAVIDSON, Sean , WOODS, Stephen
IPC分类号： A61K38/17 , C07K14/775
摘要： Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject having hyperglycemic disorders, including insulin resistant disorders, such as prediabetes, metabolic syndrome, polycystic ovary disease, type A syndrome, gestational diabetes, and endocrine conditions associated with hyperglycemia, including Cushing's Disease, glucagon excess (glucagon secreting tumors) and acromegaly.
摘要翻译：公开了用于治疗有需要的受试者的高血糖障碍的方法和用于治疗高血糖障碍的药物组合物。该方法包括向受试者施用有效量的载脂蛋白A-IV。还公开了用于将有此需要的受试者中的葡萄糖耐受性基本上恢复至正常水平的方法以及用于降低具有高血糖障碍的受试者中的血糖水平的方法，所述受试者包括胰岛素抵抗性障碍，例如前驱糖尿病，代谢综合征，多囊卵巢疾病，与高血糖相关的综合征，妊娠糖尿病和内分泌疾病，包括库欣病，胰高血糖素过剩（胰高血糖素分泌肿瘤）和肢端肥大症。

7. 发明申请

WO2013109342A8 METHOD OF TREATING DIABETES USING NON-GLYCOSYLATED APOLIPOPROTEIN A-IV 审中-公开
公开(公告)号：WO2013109342A8
公开(公告)日：2013-07-25
申请号：PCT/US2012/066314
申请日：2012-11-21
申请人： UNIVERSITY OF CINCINNATI
发明人： TSO, Patrick , WANG, Fei , DAVIDSON, Sean
IPC分类号： A61K38/17 , C07K14/775 , A61P3/10
摘要： Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed, wherein the methods and compositions of the invention are based on the use of non-glycosylated apolipoprotein A-IV produced by a protein expression system, such as a bacterial expression system. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof based on administering non- glycosylated apolipoprotein A-IV produced by a protein expression system.

8. 发明授权

EP2804618B1 METHOD OF TREATING DIABETES USING NON-GLYCOSYLATED APOLIPOPROTEIN A-IV 有权
标题翻译：使用非糖基化载脂蛋白A-IV治疗糖尿病的方法
公开(公告)号：EP2804618B1
公开(公告)日：2018-03-07
申请号：EP12795976.5
申请日：2012-11-21
申请人： University Of Cincinnati
发明人： TSO, Patrick , WANG, Fei , DAVIDSON, Sean
IPC分类号： A61K38/17 , C07K14/775 , A61P3/10
CPC分类号： C07K14/775 , A61K38/16 , A61K38/1709
摘要： Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed, wherein the methods and compositions of the invention are based on the use of non-glycosylated apolipoprotein A-IV produced by a protein expression system, such as a bacterial expression system. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof based on administering non-glycosylated apolipoprotein A-IV produced by a protein expression system.

9. 发明公开

EP2665485A1 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE 失效
标题翻译： APOLIPOPROTEIN AIV ALS抗生素PEPTID
公开(公告)号：EP2665485A1
公开(公告)日：2013-11-27
申请号：EP12705517.6
申请日：2012-01-19
申请人： University Of Cincinnati
发明人： TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
IPC分类号： A61K38/17 , C07K14/775 , A61P3/10
CPC分类号： C07K14/775 , A61K38/00 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/22 , A61K38/26 , A61K38/28 , A61K39/00 , C07K9/005 , C07K9/008 , C07K14/47 , C07K14/605 , C07K14/6555
摘要： Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include administering an effective amount of apolipoprotein A- IV to the subject. The pharmaceutical composition includes apolipoprotein A- IV formulated for administration to a subject for the treatment of type two diabetes mellitus. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof.
摘要翻译：公开了在有需要的受试者中治疗2型糖尿病的方法和用于治疗2型糖尿病的药物组合物。所述方法包括向受试者施用有效量的载脂蛋白A-IV。药物组合物包括配制用于给予受试者治疗2型糖尿病的载脂蛋白A-IV。还公开了将有需要的受试者的葡萄糖耐量基本上恢复到正常水平的方法和用于降低有需要的受试者的血糖水平的方法。

10. 发明授权

EP2665485B1 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE 失效
标题翻译：载脂蛋白AIV作为抗糖尿病肽
公开(公告)号：EP2665485B1
公开(公告)日：2017-01-11
申请号：EP12705517.6
申请日：2012-01-19
申请人： University Of Cincinnati
发明人： TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
IPC分类号： C07K14/775 , A61K38/17 , A61K39/00 , A61P3/10
CPC分类号： C07K14/775 , A61K38/00 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/22 , A61K38/26 , A61K38/28 , A61K39/00 , C07K9/005 , C07K9/008 , C07K14/47 , C07K14/605 , C07K14/6555

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式