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1. 发明申请

WO2014018079A8 METHOD OF TREATING HYPERGLYCEMIC DISORDERS USING APOLIPOPROTEIN AIV 审中-公开
标题翻译：使用载脂蛋白AIV治疗高血糖障碍的方法
公开(公告)号：WO2014018079A8
公开(公告)日：2014-01-30
申请号：PCT/US2012/066334
申请日：2012-11-21
申请人： UNIVERSITY OF CINCINNATI
发明人： TSO, Patrick , WANG, Fei , DAVIDSON, Sean , WOODS, Stephen
IPC分类号： A61K38/17 , C07K14/775
摘要： Methods for treating hyperglycemia disorders in a subject in need thereof and pharmaceutical compositions for the treatment of hyperglycemia disorders are disclosed. The methods include administering an effective amount of apolipoprotein A-IV to the subject. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject having hyperglycemic disorders, including insulin resistant disorders, such as prediabetes, metabolic syndrome, polycystic ovary disease, type A syndrome, gestational diabetes, and endocrine conditions associated with hyperglycemia, including Cushing's Disease, glucagon excess (glucagon secreting tumors) and acromegaly.
摘要翻译：公开了用于治疗有需要的受试者的高血糖障碍的方法和用于治疗高血糖障碍的药物组合物。该方法包括向受试者施用有效量的载脂蛋白A-IV。还公开了用于将有此需要的受试者中的葡萄糖耐受性基本上恢复至正常水平的方法以及用于降低具有高血糖障碍的受试者中的血糖水平的方法，所述受试者包括胰岛素抵抗性障碍，例如前驱糖尿病，代谢综合征，多囊卵巢疾病，与高血糖相关的综合征，妊娠糖尿病和内分泌疾病，包括库欣病，胰高血糖素过剩（胰高血糖素分泌肿瘤）和肢端肥大症。

2. 发明授权

EP2665485B1 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE 失效
标题翻译：载脂蛋白AIV作为抗糖尿病肽
公开(公告)号：EP2665485B1
公开(公告)日：2017-01-11
申请号：EP12705517.6
申请日：2012-01-19
申请人： University Of Cincinnati
发明人： TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
IPC分类号： C07K14/775 , A61K38/17 , A61K39/00 , A61P3/10
CPC分类号： C07K14/775 , A61K38/00 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/22 , A61K38/26 , A61K38/28 , A61K39/00 , C07K9/005 , C07K9/008 , C07K14/47 , C07K14/605 , C07K14/6555

3. 发明申请

WO2012100010A1 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE 审中-公开
标题翻译： APOLIPOPROTEIN AIV作为抗生素
公开(公告)号：WO2012100010A1
公开(公告)日：2012-07-26
申请号：PCT/US2012/021802
申请日：2012-01-19
申请人： UNIVERSITY OF CINCINNATI , TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
发明人： TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
IPC分类号： A61K38/17 , C07K14/775 , A61P3/10
CPC分类号： C07K14/775 , A61K38/00 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/22 , A61K38/26 , A61K38/28 , A61K39/00 , C07K9/005 , C07K9/008 , C07K14/47 , C07K14/605 , C07K14/6555
摘要： Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include administering an effective amount of apolipoprotein A- IV to the subject. The pharmaceutical composition includes apolipoprotein A- IV formulated for administration to a subject for the treatment of type two diabetes mellitus. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof.
摘要翻译：公开了在有需要的受试者中治疗2型糖尿病的方法和用于治疗2型糖尿病的药物组合物。所述方法包括向受试者施用有效量的载脂蛋白A-IV。药物组合物包括配制用于给予受试者用于治疗2型糖尿病的载脂蛋白A-IV。还公开了将有需要的受试者的葡萄糖耐量基本上恢复到正常水平的方法和用于降低有需要的受试者的血糖水平的方法。

4. 发明公开

EP2665485A1 APOLIPOPROTEIN AIV AS AN ANTIDIABETIC PEPTIDE 失效
标题翻译： APOLIPOPROTEIN AIV ALS抗生素PEPTID
公开(公告)号：EP2665485A1
公开(公告)日：2013-11-27
申请号：EP12705517.6
申请日：2012-01-19
申请人： University Of Cincinnati
发明人： TSO, Patrick , DAVIDSON, Sean , WOODS, Stephen , WANG, Fei
IPC分类号： A61K38/17 , C07K14/775 , A61P3/10
CPC分类号： C07K14/775 , A61K38/00 , A61K38/17 , A61K38/1709 , A61K38/177 , A61K38/22 , A61K38/26 , A61K38/28 , A61K39/00 , C07K9/005 , C07K9/008 , C07K14/47 , C07K14/605 , C07K14/6555
摘要： Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are disclosed. The methods include administering an effective amount of apolipoprotein A- IV to the subject. The pharmaceutical composition includes apolipoprotein A- IV formulated for administration to a subject for the treatment of type two diabetes mellitus. Also disclosed are methods for substantially restoring glucose tolerance in a subject in need thereof to a normal level and methods for lowering blood glucose levels in a subject in need thereof.
摘要翻译：公开了在有需要的受试者中治疗2型糖尿病的方法和用于治疗2型糖尿病的药物组合物。所述方法包括向受试者施用有效量的载脂蛋白A-IV。药物组合物包括配制用于给予受试者治疗2型糖尿病的载脂蛋白A-IV。还公开了将有需要的受试者的葡萄糖耐量基本上恢复到正常水平的方法和用于降低有需要的受试者的血糖水平的方法。

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