专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007087637A3 COMPOSITIONS AND METHODS USING MATRIX METALLOPROTEINASE (MMP) INHIBITORS FOR TREATING COGNITIVE IMPAIRMENT CHARACTERIZED BY PERSISTENT OR SUSTAINED MMP EXPRESSION AND/OR ACTIVITY 审中-公开
标题翻译：使用基质金属蛋白酶（MMP）抑制剂治疗以持续或持续MMP表达和/或活性为特征的认知减退的组合物和方法
公开(公告)号：WO2007087637A3
公开(公告)日：2007-11-29
申请号：PCT/US2007061167
申请日：2007-01-26
申请人： UNIV WASHINGTON , HARDING JOSEPH , WRIGHT JOHN , MEIGHAN PETER , MEIGHAN STALA
发明人： HARDING JOSEPH , WRIGHT JOHN , MEIGHAN PETER , MEIGHAN STALA
IPC分类号： C12Q1/37 , C12N9/50
CPC分类号： A61K38/55 , A61K38/07 , A61K45/06 , A61K2300/00
摘要： Particular aspects provide methods for treating cognitive impairment, comprising administration of a therapeutically effective amount of at least one matrix metalloproteinase (MMP) inhibitor sufficient to provide for at least one of precluding, alleviating, reversing, or inhibiting cognitive impairment characterized by sustained elevated expression and/or activity of at least one MMP. Persistent elevations in the expression of MMPs in the hippocampus of aged individuals have a detrimental effect on hippocampal synaptic plasticity, and are an underlying cause of cognitive deficits associated with ageing, and particular aspects therefore provide novel compositions and methods comprising use of MMP (e.g., MMP3 and/or MMP9, etc.) inhibitors to treat age-related cognitive impairment (e.g., cognitive decline). Additional embodiments comprise inhibition of MMP-3 and at least one other MMP (e.g., MMP-9, etc). Exemplary MMP inhibitors comprise a zinc-binding hydroxamate moiety (or a non-hydroxamate zinc-binding moiety), and a peptide or peptidomimetic backbone capable of binding at least one MMP.
摘要翻译：特定方面提供了用于治疗认知障碍的方法，其包括施用治疗有效量的至少一种基质金属蛋白酶（MMP）抑制剂，所述基质金属蛋白酶抑制剂足以提供以持续升高的表达为特征的排除，缓解，逆转或抑制认知障碍中的至少一种， /或至少一种MMP的活性。老年个体海马中MMP表达的持续升高对海马突触可塑性具有有害作用，并且是与衰老相关的认知缺陷的潜在原因，因此特定方面提供了新颖的组合物和方法，包括使用MMP（例如， MMP3和/或MMP9等）抑制剂以治疗年龄相关的认知障碍（例如，认知减退）。另外的实施方案包括抑制MMP-3和至少一种其他MMP（例如MMP-9等）。示例性MMP抑制剂包含锌结合异羟肟酸酯部分（或非异羟肟酸锌结合部分）和能够结合至少一种MMP的肽或拟肽骨架。

2. 发明专利

GB190202315A Improved Automatic Ventilator 未知
公开(公告)号：GB190202315A
公开(公告)日：1903-05-01
申请号：GB190202315D
申请日：1902-05-01
申请人： HARDING JOSEPH
发明人： HARDING JOSEPH
摘要： 2315. Harding, J. May 1. Ventilators. - To operate automatically the balanced valve 4 of the ventilator according to the temperature of the room, the change of position of the centre of gravity of a column of expansible fluid within a tube 7 balanced upon pivots 10 is utilized. On a rise of temperature, the tube rocks on its pivots, and, by a suitable connection, opens the valve. The tube shown is formed with double bends and may contain ether, creosote, or mercury as the expansible medium.

3. 发明专利

ES2622385T3 Miméticos de factor de crecimiento de hepatocitos como agentes terapéuticos 未知
公开(公告)号：ES2622385T3
公开(公告)日：2017-07-06
申请号：ES12768043
申请日：2012-04-02
申请人： UNIV WASHINGTON STATE
发明人： HARDING JOSEPH , WRIGHT JOHN , BENOIST CAROLINE , KAWAS LEEN , WAYMAN GARY
IPC分类号： A61K38/18 , A61K38/00 , A61K38/06 , A61K38/07 , A61K38/17 , A61K45/06 , A61P3/10 , A61P25/28 , A61P35/00 , C07K5/02 , C07K5/083
摘要： Mimético de factor de crecimiento de hepatocitos (HGF) que tiene la fórmula general:**Fórmula** en la que R1 es uno de un grupo N-acilo, y un aminoácido, seleccionándose dicho aminoácido del grupo que consiste en tirosina, fenilalanina, ácido aspártico, arginina, isoleucina, serina, histidina, glicina, cisteína, metionina, triptófano, lisina, norvalina, ornitina y s-bencilcisteína; R2 es un aminoácido seleccionado del grupo seleccionado del grupo que consiste en tirosina, fenilalanina, ácido aspártico, arginina, isoleucina, serina, histidina, glicina, cisteína, metionina, triptófano, lisina y valina; R3 es isoleucina; y n oscila entre 3-6; y en la que los enlaces covalentes 1, 2 y 3 se seleccionan del grupo que consiste en enlaces peptídicos o enlaces peptídicos reducidos.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式