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1. 发明公开

KR20200140255A 숙시닉 세미알데하이드 데하이드로게나제 결핍(SSADHD)을 치료하기 위한 조성물 및 방법 审中-公开
公开(公告)号：KR20200140255A
公开(公告)日：2020-12-15
申请号：KR20207026886
申请日：2019-02-12
申请人： UNIV WASHINGTON STATE
发明人： VOGEL KARA RAIN , GIBSON KENNETH MICHAEL , AINSLIE GARRETT ROBERT
IPC分类号： A61K48/00 , A61K31/196 , A61K31/197 , A61K31/436 , A61K31/444 , A61K38/44 , A61P21/00 , A61P25/08 , C12N9/02
摘要： 숙시닉세미알데하이드데하이드로게나제결핍(SSADHD)을치료하기위한조성물및 방법이본원에제공된다. 조성물은표적화벡터에작동가능하게연결된기능성숙시닉세미알데하이드데하이드로게나제(SSADH) 효소를인코딩하는유전자, 예를들어, ALDH5A1을포함할수 있다. 기능성 SSADH 효소는순환감마-하이드록시부티르산(GHB) 및γ-아미노부티르산(GABA)의수준을낮추는것으로예상된다. 일부구현예에서, 치료적유효량의표적화벡터에작동가능하게연결된기능성 SSADH 효소를인코딩하는유전자를포함하는조성물; 하나이상의 mTOR 억제제; 및 GABA-T 억제제를대상체에투여하는것을포함하는조합요법이예상된다. 적합한 mTOR 억제제는라파마이신을포함하는한편, 적합한 GABA-T 억제제는비가바트린을포함한다.

2. 发明授权

US3036947A Method of laminating wood timbers 失效
标题翻译：木材层压方法
公开(公告)号：US3036947A
公开(公告)日：1962-05-29
申请号：US84301359
申请日：1959-09-28
申请人： UNIV WASHINGTON STATE
发明人： MARRA GEORGE G
IPC分类号： B27G11/00 , B27M3/00
CPC分类号： B27G11/00 , B27M3/0053

3. 发明专利

BRPI9911229B1 processo para produção de um produto de papel de arundo donax e produto de papel de arundo donax 未知
公开(公告)号：BRPI9911229B1
公开(公告)日：2016-04-12
申请号：BR9911229
申请日：1999-06-16
申请人： ALEX ALT BIOMASS INC , UNIV WASHINGTON STATE , UNIV WASHINGTON STATE RES FDN
发明人： ALTHEIMER ERNETT , WOLCOTT MICHAEL P
IPC分类号： B27N3/02 , D21C11/12 , B27J1/00 , B27L11/02 , B27L11/08 , D21B1/00 , D21B1/14 , D21C1/06 , D21C5/00
摘要： "polpa, produtos de papel e papelão de partículas donax arundo". painéis compostos e polpa, e produtos de papel da polpa, são produzidos de donax arundo. na fabricação dos painéis compostos, donax arundo é cominuído (20) a um tamanho adequado, combinado com um aglutinante (40, 50) e consolidado (80) em painéis que satisfazem os padrões para a construção e/ou fornecimento de painéis de grau. os partículas donax arundo podem ser combinados com os partículas de madeira, para produzir uma fonte mista, que pode ser usada na preparação de painéis compostos. donax arundo cominuído é tratado em processos de polpação convencionais para produzir uma polpa de alta resistência à tração, que pode ser usada na produção de papel. a polpa tem uma cor mais clara do que a polpa de madeira e usa, desse modo, menos substâncias químicas alvejantes para atingir uma alvura desejada. a polpa pode ser combinada com a polpa de madeira para produzir vários produtos.

4. 发明申请

WO2015191976A8 DIGITAL WAVEFORM MANIPULATIONS TO PRODUCE MSn COLLISION INDUCED DISSOCIATION 审中-公开
标题翻译：数字波形操作来生产MSn碰撞诱导的分离
公开(公告)号：WO2015191976A8
公开(公告)日：2016-12-08
申请号：PCT/US2015035517
申请日：2015-06-12
申请人： UNIV WASHINGTON STATE
发明人： REILLY PETER THOMAS AQUINAS , BRABECK GREGORY FORREST
IPC分类号： B01D59/48 , B01D59/44 , B01D59/46
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/429
摘要： A novel method and mass spectrometer apparatus is introduced to enable collision induced dissociation inside linear ion traps/guides or 3D ion traps based on digital waveform manipulation. In particular, using the device's digitally produced trapping waveforms to trap, isolate and energize the ions of interest creates a simplified and versatile ion trap/guide that is capable tandem mass spectrometry and high sensitivity. Coupling the digitally operated ion trap/guides to a TOF creates a Q-TOF instrument that outperforms any commercial system in terms of sensitivity and capabilities.
摘要翻译：引入了一种新颖的方法和质谱仪装置，使得基于数字波形操作的线性离子阱/引导件或3D离子阱内的碰撞诱导解离。特别地，使用设备的数字捕获波形来捕获，隔离和激发感兴趣的离子，创建了一个简化和通用的离子阱/导向器，其具有串联质谱和高灵敏度。将数字操作的离子阱/引导件耦合到TOF可以创建一个在灵敏度和能力方面优于任何商业系统的Q-TOF仪器。

5. 发明申请

WO2016011029A3 NANOS KNOCK-OUT THAT ABLATES GERMLINE CELLS 审中-公开
标题翻译： NANOS KNOCK-OUT消除了GERMLINE细胞
公开(公告)号：WO2016011029A3
公开(公告)日：2016-03-10
申请号：PCT/US2015040379
申请日：2015-07-14
申请人： UNIV WASHINGTON STATE , UNIV MARYLAND , UNIV EDINBURGH
发明人： OATLEY JOHN MICHAEL , WHITELAW CHRISTOPHER BRUCE ALEXANDER , LILLICO SIMON GEOFFREY , TELUGU BHANU PRAKASH
IPC分类号： C12N15/00 , A01K67/027
CPC分类号： A01K67/0276 , A01K2217/075 , A01K2227/101 , A01K2227/108 , A01K2267/025 , C12N9/22 , C12N15/907 , C12Y301/00
摘要： The present invention provides livestock animals and methods to create recipient animals for spermatogonial stem cell transplantation through modulation of the NANOS gene. In one embodiment genome editing issued to create animals with insertions or deletions (indels) that inactivate or otherwise modulate NANOS gene activity so that resulting males lack functional germ cells yet retain functional somatic cells, and females are fertile. These males can then be transplanted with donor spermatogonial stem cells and used for breeding.
摘要翻译：本发明提供了家畜动物和通过调节NANOS基因来产生用于精原干细胞移植的受体动物的方法。在一个实施方案中，发布基因组编辑以产生具有失活或以其他方式调节NANOS基因活性的插入或缺失（插入）的动物，从而使得到的雄性缺乏功能性生殖细胞，但保留功能性体细胞，并且雌性是可育的。然后可以将这些雄性动物移植供体精原干细胞并用于育种。

6. 发明申请

WO2012064914A3 PEPTIDOMIMETIC INHIBITORS OF PSMA 审中-公开
标题翻译： PSMA的肽抑制剂
公开(公告)号：WO2012064914A3
公开(公告)日：2012-07-05
申请号：PCT/US2011060088
申请日：2011-11-10
申请人： UNIV WASHINGTON STATE RES FDN , UNIV CALIFORNIA , BERKMAN CLIFFORD E , VANBROCKLIN HENRY F
发明人： BERKMAN CLIFFORD E , VANBROCKLIN HENRY F
IPC分类号： C07F9/09 , A61K31/66 , A61P35/00 , C07F9/11
CPC分类号： C07F9/2458 , A61K31/664 , A61K51/0489 , C07F9/24 , C07F9/2408 , C07F13/005 , G01N33/57434 , G01N33/57492 , G01N2333/705
摘要： Compounds of the formulae, (I), wherein each variable is as defined herein are provided which are useful in (i) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable carrier, excipient, and/or diluent; (3) methods for inhibiting or treating prostrate cancer; and (4) methods for blocking or destabilizing neovasculature of a tumor.
摘要翻译：提供式（I）化合物，其中每个变量如本文所定义，其可用于（i）用于检测和/或鉴定呈现PSMA的细胞的诊断方法; （2）包含本发明化合物与药学上可接受的载体，赋形剂和/或稀释剂的组合物; （3）抑制或治疗前列腺癌的方法; 和（4）阻断或破坏肿瘤新生血管的方法。

7. 发明申请

WO2012074935A2 ALERTNESS MONITORING SYSTEMS AND ASSOCIATED METHODS 审中-公开
标题翻译：警报监测系统和相关方法
公开(公告)号：WO2012074935A2
公开(公告)日：2012-06-07
申请号：PCT/US2011062257
申请日：2011-11-28
申请人： UNIV WASHINGTON STATE RES FDN , VAN DONGEN HANS , FORSMAN PIA
发明人： VAN DONGEN HANS , FORSMAN PIA
IPC分类号： B60W30/08 , B60K28/10 , B60W30/00 , B62D6/00
CPC分类号： G06F7/00 , B60W30/12 , B60W30/146 , B60W40/09 , B60W50/14 , B60W2540/18 , B60W2540/22 , B60W2550/402
摘要： Embodiments of driver alertness monitoring systems, devices, and associated methods based on steering variability and/or lane variability are described herein. In one embodiment, a method for detecting alertness of a driver operating a vehicle includes recording a steering position of the vehicle with a steering sensor and transmitting the recorded steering position to a processor. With the processor, the method also includes deriving a steering variability based on the recorded steering position of the vehicle over time, calculating a lane variability based on the derived steering variability and a transfer function of the vehicle, and estimating an alertness of the driver based on both the derived steering variability and the calculated lane variability.
摘要翻译：本文描述了基于操纵变化性和/或车道可变性的驾驶员警觉性监测系统，装置和相关方法的实施例。在一个实施例中，一种用于检测驾驶车辆的驾驶员的警觉性的方法包括利用转向传感器记录车辆的转向位置并且将所记录的转向位置传送到处理器。利用处理器，该方法还包括基于记录的车辆的转向位置随时间推导出转向可变性，基于导出的转向可变性和车辆的传递函数计算车道可变性，以及基于驾驶员的在导出的转向变化性和计算的车道变化性上。

8. 发明申请

WO2009111587A3 COMPOSITIONS AND METHODS FOR DIFFERENTIAL REGULATION OF FATTY ACID UNSATURATION IN MEMBRANE LIPIDS AND SEED OIL 审中-公开
标题翻译：差异化调节膜脂和籽油中脂肪酸不饱和的组合物和方法
公开(公告)号：WO2009111587A3
公开(公告)日：2009-11-12
申请号：PCT/US2009036066
申请日：2009-03-04
申请人： UNIV WASHINGTON STATE , BROWSE JOHN , LU CHAOFU , XIN ZHONGUO
发明人： BROWSE JOHN , LU CHAOFU , XIN ZHONGUO
IPC分类号： C12N15/63 , A01H1/00 , C12N15/52 , C12P7/64
CPC分类号： C12N15/8247 , A01H5/10 , A23D9/013 , C10L1/026 , C10L2200/0476 , C10L2270/026 , C11B1/00 , C12N9/1288 , C12Y207/08002
摘要： Aspects of the invention provide methods for differential regulation of fatty acid unsaturation in seed oil and membrane lipids of plants based on modulation of a previously unknown biosynthetic pathway involving a novel phosphatidylcholine: diacylglycerol cholinephosphotransferase (PDCT) that regulates phosphatidylcholine biosynthesis in developing oil seed plants. Specific aspects relate to inventive PDCT polypeptides including, for example, variants, deletions, muteins, fusion proteins, and orthologs thereof (collectively PDCT proteins), to nucleic acids encoding same, to plants comprising such PDCT sequences or proteins or devoid or depleted of such PDCT proteins or sequences, and to methods for generating plants having altered or no PDCT expression and/or activity, including but not limited to methods comprising mutagenesis, recombinant DNA, transgenics, etc.
摘要翻译：本发明的方面提供基于先前未知的生物合成途径的调节基于调节开发油种子植物中的磷脂酰胆碱生物合成的新型磷脂酰胆碱：二酰基甘油胆碱磷酸转移酶（PDCT）来调节种子油和植物膜脂质中脂肪酸不饱和度的方法。具体方面涉及本发明的PDCT多肽，包括例如变体，缺失，突变蛋白，融合蛋白及其直系同源物（统称为PDCT蛋白），编码其的核酸，包含此类PDCT序列或蛋白质的植物，或缺乏或缺失 PDCT蛋白或序列，以及产生具有改变的或不具有PDCT表达和/或活性的植物的方法，包括但不限于包括诱变，重组DNA，转基因等的方法

9. 发明申请

WO2007124511A3 RESORBABLE CERAMICS WITH CONTROLLED STRENGTH LOSS RATES 审中-公开
标题翻译：具有控制强度损失率的可再生陶瓷
公开(公告)号：WO2007124511A3
公开(公告)日：2008-12-18
申请号：PCT/US2007067444
申请日：2007-04-25
申请人： UNIV WASHINGTON STATE , BOSE SUSMITA , BANDYOPADHYAY AMIT
发明人： BOSE SUSMITA , BANDYOPADHYAY AMIT
IPC分类号： A61F2/28
CPC分类号： A61L27/58 , A61L27/10 , A61L27/12 , A61L27/306 , A61L27/32 , A61L27/425 , A61L27/54 , A61L27/56 , A61L2400/12 , A61L2420/06 , A61L2430/02 , A61L2430/12 , C04B35/447 , C04B35/6261 , C04B2235/3201 , C04B2235/3206 , C04B2235/3208 , C04B2235/3212 , C04B2235/3213 , C04B2235/3232 , C04B2235/3272 , C04B2235/3281 , C04B2235/3284 , C04B2235/3291 , C04B2235/34 , C04B2235/3418 , C04B2235/442 , C04B2235/445 , C04B2235/5445 , C04B2235/608 , C04B2235/77 , C04B2235/786 , C04B2235/80 , C04B2235/96
摘要： Particular aspects provide bioresorbable and biocompatible compositions for bioengineering, restoring or regenerating tissue or bone, comprising a three-dimensional porous or non-porous scaffold material comprising a calcium phosphate-based ceramic having at least one dopant therein selected from metal ion or ion dopants and metal oxide dopants, wherein the composition is sufficiently biocompatible to provide for a cell or tissue scaffold, and resorbable at a controlled resorption rate for controlled strength loss, depending on dopant composition, under body, body fluid or simulated body fluid conditions. Preferably, the at least one dopant is selected from the group consisting of Zn2+, Mg2+, Si2+, Na+, K+, Sr2+, Cu2+, Fe3+/Fe2+, Ag+, Ti4+, CO3
摘要翻译：具体方面提供用于生物工程，恢复或再生组织或骨骼的生物可再吸收和生物相容性组合物，其包含三维多孔或非多孔支架材料，其包含选自金属离子或离子掺杂剂中的至少一种掺杂剂的磷酸钙基陶瓷，金属氧化物掺杂剂，其中所述组合物具有足够的生物相容性以提供细胞或组织支架，并且根据体内，体液或模拟体液条件下的掺杂剂组成，以受控的吸收速率可再吸收受控的强度损失。优选地，所述至少一种掺杂剂选自Zn2 +，Mg2 +，Si2 +，Na +，K +，Sr2 +，Cu2 +，Fe3 + / Fe2 +，Ag +，Ti4 +，CO3

10. 发明申请

WO2007131071A3 MIG-7 AS A SPECIFIC ANTICANCER TARGET 审中-公开
标题翻译： MIG-7作为特定的反对目标
公开(公告)号：WO2007131071A3
公开(公告)日：2008-11-20
申请号：PCT/US2007068078
申请日：2007-05-02
申请人： UNIV WASHINGTON STATE , LINDSEY SUZANNE J
发明人： LINDSEY SUZANNE J
IPC分类号： C07H21/02 , C12Q1/68
CPC分类号： C07K16/32 , G01N33/57484 , G01N33/57492
摘要： Aspects of the present invention provide novel Mig-7 encoding nucleic acids and Mig-7 polypeptides, recombinant DNA expression systems and host cells containing same, as well as methods of inhibiting expression of the subject nucleic acid molecules, inhibiting production of the encoded proteins or polypeptides, inhibiting metastasis of a carcinoma cell in a subject (including in humans), inhibiting migration/invasion of and mimicking of normal cells by carcinoma cells in a subject, detecting the presence of a cancer cell (e.g., a migrating/invading cancer cell or carcinoma cell mimic, and tumor neovascularization) in a sample of a subject's tissue or body fluids, and inhibiting the migration/invasion of or endothelial cell mimicking by a placental cell into the blood stream or vessels of a female mammal. Particular aspects relate to novel anti-Mig-7 antibodies, diagnostic and/or prognostic methods, and therapeutic methods comprising use of the inventive nucleic acids, polypeptides and antibodies or derivatives thereof.
摘要翻译：本发明的方面提供了新的Mig-7编码核酸和Mig-7多肽，重组DNA表达系统和含有它们的宿主细胞，以及抑制受试者核酸分子表达的方法，抑制编码蛋白质的产生或多肽，抑制受试者（包括人类）中癌细胞的转移，抑制受试者中癌细胞的正常细胞的迁移/侵入和模拟，检测癌细胞（例如迁移/侵袭性癌细胞或癌细胞模拟物和肿瘤新生血管形成），并抑制由胎盘细胞模拟的哺乳动物/内皮细胞进入雌性哺乳动物的血液或血管。具体方面涉及新的抗Mig-7抗体，诊断和/或预后方法以及包括使用本发明的核酸，多肽和抗体或其衍生物的治疗方法。

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