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1. 发明公开

EP1461606A4 MICROFLUIDIC DEVICE AND SURFACE DECORATION PROCESS FOR SOLID PHASE AFFINITY BINDING ASSAYS 审中-公开
标题翻译： S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S
公开(公告)号：EP1461606A4
公开(公告)日：2005-06-29
申请号：EP02795760
申请日：2002-12-05
申请人： UNIV WASHINGTON
发明人： YAGER PAUL , GARCIA ELENA
IPC分类号： B01L3/00 , C12M1/34 , G01N21/03 , G01N21/05 , G01N21/27 , G01N21/59 , G01N21/64 , G01N27/447 , G01N33/487 , G01N33/53 , G01N33/543 , G01N37/00 , G01N27/26
CPC分类号： B01L3/502707 , B01J2219/00353 , B01J2219/00511 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00644 , B01J2219/00704 , B01L3/502753 , B01L2200/0647 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2400/0415 , G01N21/03 , G01N21/05 , G01N21/6428 , G01N21/6456 , G01N33/54366 , G01N2021/0346 , G01N2021/058 , Y10T436/25375 , Y10T436/2575
摘要： This invention comprises a microfluidic device having a fluid inlet (105) connected to a pump (230) and sample reservoir (220) for the detection of one or more analytes in a fluid using solid-phase affinity binding assay.
摘要翻译：本发明提供一种微流体装置，用于使用固相亲和力结合测定法检测流体中的一种或多种分析物。该设备提供了一个实用，易于使用，便携，便宜，稳定的分析系统，用于并行和定量检测多种分析物。此外，本发明提供了用于形成固定在固相上的捕获分子的浓度梯度的方法和装置。

2. 发明公开

EP1146855A4 THERAPEUTIC DELIVERY USING COMPOUNDS SELF-ASSEMBLED INTO HIGH AXIAL RATIO MICROSTRUCTURES 审中-公开
标题翻译：治疗性给药使用高轴甚至能够共享组装CONNECTIONS微构造
公开(公告)号：EP1146855A4
公开(公告)日：2004-06-16
申请号：EP99966656
申请日：1999-12-21
申请人： UNIV WASHINGTON
发明人： YAGER PAUL , GELB MICHAEL H , LUKYANOV ANATOLY N , GOLDSTEIN ALEX S , DISIS MARY L
IPC分类号： A61K9/127 , A61K47/48 , A61K48/00
CPC分类号： A61K48/00 , A61K9/1274 , A61K47/6919

3. 发明公开

EP1242813A4 FLUIDIC INTERCONNECT, INTERCONNECT MANIFOLD AND MICROFLUIDIC DEVICES FOR INTERNAL DELIVERY OF GASES AND APPLICATION OF VACUUM 审中-公开
标题翻译： HYDROMECHANISCHE VERBINDUNG，VERBINDUNG VON VERTEILERN UND MIKROFLUIDISCHENGERÄTENZUR INTERNEN BEREITSTELLUNG VON GASEN UND VAKUUMANWENDUNGEN
公开(公告)号：EP1242813A4
公开(公告)日：2002-10-30
申请号：EP00953737
申请日：2000-07-28
申请人： UNIV WASHINGTON
发明人： HOLL MARK R , MACOUNOVA KATERINA , YAGER PAUL , KAMHOLZ ANDREW E , CABRERA CATHERINE R
IPC分类号： B01L3/00 , F16L39/00 , G01N27/447 , G01N27/26 , F15C5/00 , F16L35/00
CPC分类号： B01L3/502723 , B01J2219/00783 , B01J2219/00813 , B01J2219/00833 , B01J2219/00891 , B01J2219/00898 , B01J2219/00907 , B01L3/502707 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2200/0689 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2400/0421 , B01L2400/049 , F16L39/00 , G01N27/44791
摘要： Interconnect configurations and an interconnect manifold for microfluidic devices (6) is provided. Devices for introducing one or more gases or removing gases from microfluidic cavity elements (8) is also provided. The invention is also directed to methods for making interconnects and to methods for delivery or removal of gasses from microfluidic devices (6).
摘要翻译：提供了用于微流体装置（6）的互连配置和互连歧管。还提供了用于引入一种或多种气体或从微流体空腔元件（8）除去气体的装置。本发明还涉及用于制造互连的方法以及用于从微流体装置（6）输送或去除气体的方法。

4. 发明申请

WO2006088876A3 METHOD OF FORMING A BIOLOGICAL SENSOR 审中-公开
标题翻译：形成生物传感器的方法
公开(公告)号：WO2006088876A3
公开(公告)日：2006-11-02
申请号：PCT/US2006005183
申请日：2006-02-13
申请人： HEWLETT PACKARD DEVELOPMENT CO , UNIV WASHINGTON , DUDENHOEFER CHRISTIE , DUNNFIELD JOHN STEPHEN , YAGER PAUL , HENRY LAUREN , OLBRICH CRAIG A
发明人： DUDENHOEFER CHRISTIE , DUNNFIELD JOHN STEPHEN , YAGER PAUL , HENRY LAUREN , OLBRICH CRAIG A
IPC分类号： B01J19/00 , B01L3/00 , C12Q1/68 , G01N33/543
CPC分类号： G01N33/54373 , B01J19/0046 , B01J2219/00358 , B01J2219/00378 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01L3/502707 , B01L2200/12 , B01L2200/16 , B01L2300/0636 , B01L2300/0864 , B82Y15/00 , B82Y30/00 , C40B40/06 , C40B40/10 , C40B60/14
摘要： A method of forming a biological sensor (14) on a predetermined area of a substrate (12). The method includes dispensing a plurality of layers (16, 18, 20, 22, 24) on the predetermined area of the substrate (12). Each of the plurality of layers (16, 18, 20, 22, 24) is formed of a substantially different fluid having a substantially different function. The dispensing of the layers (16, 18, 20, 22, 24) is accomplished by a drop generating member.
摘要翻译：一种在衬底（12）的预定区域上形成生物传感器（14）的方法。该方法包括在衬底（12）的预定区域上分配多个层（16,18,20,22,24）。多个层（16,18,20,22,24）中的每一个由具有基本上不同的功能的基本上不同的流体形成。层（16,18,20,22,24）的分配通过液滴生成元件完成。

5. 发明公开

EP1179181A4 MICROSCALE DIFFUSION IMMUNOASSAY 审中-公开
标题翻译： DIFFUSIONSIMMUNOASSAY IM MIKROMASSSTAB
公开(公告)号：EP1179181A4
公开(公告)日：2004-12-29
申请号：EP00932644
申请日：2000-05-19
申请人： UNIV WASHINGTON
发明人： WEIGL BERNHARD H , YAGER PAUL , KAMHOLZ ANDREW , HATCH ANSON
IPC分类号： G01N30/00 , G01N33/532 , G01N33/558 , B01D11/00 , B01D11/04 , G01N15/06 , G01N21/00 , G01N21/29 , G01N21/41 , G01N21/47 , G01N33/00 , G01N33/48 , G01N33/543 , G01N33/557
CPC分类号： G01N33/558 , G01N30/0005
摘要： Methods and apparatuses are provided for determining presence and concentration of analytes by exploiting molecular binding reactions and differential diffusion rates. Analyte particles and binding particles are allowed to diffuse toward each other, and slowing of the diffusion front is detected when they meet. From the position of the diffusion front, presence and concentration of analyte particles can be determined. One embodiment provides a competitive immunoassay in a microfluidic format. This diffusion immunoassay (DIA) relies on measuring the concentration of labeled antigen along one dimension of a microchannel after allowing it to diffuse for a short time into a region containing specific antibodies. A simple microfluidic device, the T-Sensor, was used to implement a DIA to measure the concentration of phenytoin, a small drug molecule. Concentrations of analyte over the range of 50 to 1600 nM can be measured in less than a minute. The assay is homogenous, rapid, requires only microliter volumes of reagents and sample, and is applicable to a wide range of analytes, including therapeutic drugs, molecular biological markers, and environmental contaminants. Methods for separating particles of similar size in a diffusion separator are also provided.
摘要翻译：提供了通过利用分子结合反应和差异扩散速率来确定分析物的存在和浓度的方法和设备。允许分析物颗粒和结合颗粒朝向彼此扩散，并且当它们相遇时检测到扩散前沿的减慢。从扩散前沿的位置可以确定分析物颗粒的存在和浓度。一个实施方案提供微流体形式的竞争性免疫测定。该扩散免疫测定法（DIA）依赖于在允许其短时间扩散到含有特异性抗体的区域中后，沿着微通道的一维测量标记抗原的浓度。使用简单的微流体装置T传感器来实施DIA以测量苯妥英（一种小分子药物）的浓度。在不到一分钟的时间内可以测量50至1600 nM范围内的分析物浓度。该检测方法均匀，快速，只需要微升体积的试剂和样品，适用于各种分析物，包括治疗药物，分子生物标志物和环境污染物。还提供了用于在扩散分离器中分离相似尺寸的颗粒的方法。

6. 发明公开

EP0910474A4 ABSORPTION-ENHANCED DIFFERENTIAL EXTRACTION DEVICE 失效
标题翻译： ABSORBTIONSVERBESSERTE微分萃取装置
公开(公告)号：EP0910474A4
公开(公告)日：1999-08-18
申请号：EP97932185
申请日：1997-06-13
申请人： UNIV WASHINGTON
发明人： YAGER PAUL , BRODY JAMES P
IPC分类号： G01N15/00 , A61M1/36 , B01D57/00 , B01J19/00 , B03B5/00 , C07K1/02 , G01N1/02 , G01N30/00 , G01N30/02 , G01N30/58 , G01N30/60 , B03B5/28
CPC分类号： G01N30/0005 , A61M1/3679 , B01J19/0093 , B01J2219/00828 , B01J2219/00952 , B01J2219/00995 , B03B5/00 , G01N30/02 , G01N30/6095 , G01N2030/582 , Y10S366/01 , B01D15/3804
摘要： This invention provides an extraction device and method for extracting desired particles from a sample stream (2) containing the desired particles. The device comprises a sample stream inlet (1); an extraction stream inlet (5); an extraction channel (7) in fluid communication with the sample stream inlet (1) and the extraction stream inlet (5) for receiving a sample stream (2) from the sample stream inlet (1) in adjacent laminar flow with an extraction stream (4) from the extraction stream inlet (5); a sequestering material within the extraction channel (7) for capturing desired particles (18) in the extraction stream (9); a by-product stream outlet (15) in fluid communication with the extraction channel (7) for receiving a by-product stream (12) comprising at least a portion of the sample stream (2) from which desired particles (18) have been extracted; and a product outlet (14) in fluid communication with the extraction channel (7) for receiving a product comprising the sequestering material and at least a portion of the desired particles (18).

7. 发明申请

WO2011087813A3 CAPILLARITY-BASED DEVICES FOR PERFORMING CHEMICAL PROCESSES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于进行化学过程的基于薄膜的装置以及相关的系统和方法
公开(公告)号：WO2011087813A3
公开(公告)日：2011-11-17
申请号：PCT/US2010061675
申请日：2010-12-21
申请人： UNIV WASHINGTON , YAGER PAUL , LUTZ BARRY R , FU ELAIN S , KAUFFMAN PETER C
发明人： YAGER PAUL , LUTZ BARRY R , FU ELAIN S , KAUFFMAN PETER C
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01L3/5023 , B01L3/502707 , B01L3/502746 , B01L2200/0605 , B01L2200/0621 , B01L2300/069 , B01L2300/0816 , B01L2400/0406 , B01L2400/0677 , B01L2400/088
摘要： The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a base configured to receive one or more fluids, a porous wick carried by the base portion, and a flow-metering element along the porous wick to modify a rate or volume of fluid flow along the porous wick. The porous wick can comprise a first pathway, a second pathway, and an intersection at which the first pathway and the second pathway converge. Input ends of the first and second pathways can be wettably distinct. Upon wetting of the input ends, fluid is configured to travel by capillary action along each pathway. The device may also include volume-metering features configured to automatically and independently control or modify a volume of fluid flow along one or more pathways of the porous wick.
摘要翻译：本技术涉及用于执行化学过程和相关系统和方法的基于毛细管现象的装置。在一个实施例中，例如，装置可以包括被配置成接收一种或多种流体的基部，由基部承载的多孔芯和沿着多孔芯的流量计量元件，以沿着多孔芯改变流体流的速率或体积多孔芯。多孔芯可以包括第一路径，第二路径以及第一路径和第二路径会聚的交点。第一和第二路径的输入端可以湿润地不同。在润湿输入端时，流体被配置为通过沿每个通路的毛细作用行进。该装置还可以包括体积计量特征，该体积计量特征被配置成自动地且独立地控制或修改沿着多孔芯的一个或多个路径的流体流的体积。

8. 发明申请

WO2004040717A2 WAVELENGTH TUNABLE SURFACE PLASMON RESONANCE SENSOR 审中-公开
标题翻译：波长能表面等离子体共振传感器
公开(公告)号：WO2004040717A2
公开(公告)日：2004-05-13
申请号：PCT/US0334265
申请日：2003-10-28
申请人： UNIV WASHINGTON , YAGER PAUL , FU ELAIN S
发明人： YAGER PAUL , FU ELAIN S
IPC分类号： G01N21/55 , H01S
CPC分类号： G01N21/553 , G01N21/648
摘要： This invention provides methods, devices and device components for sensing, imaging and characterizing changes in the composition of a probe region. More particularly, the present invention provides methods and devices for detecting changes in the refractive index of a probe region positioned adjacent to a sensing surface, preferably a sensing surface comprising a thin conducting film supporting surface plasmon formation. In addition, the present invention provides methods and device for generating surface plasmons in a probe region and characterizing the composition of the probe region by generating one or more surface plasmon resonances curves and/or surface plasmon resonance images of the probe region.
摘要翻译：本发明提供用于感测，成像和表征探针区域的组成的变化的方法，装置和装置部件。更具体地，本发明提供了用于检测位于邻近检测表面的探针区域的折射率变化的方法和装置，优选地包括支撑表面等离子体激元形成的薄导电膜的感测表面。此外，本发明提供了用于在探针区域中产生表面等离子体激元的方法和装置，并且通过产生探针区域的一个或多个表面等离子体共振曲线和/或表面等离子体共振图像来表征探针区域的组成。

9. 发明申请

WO03048736A3 MICROFLUIDIC DEVICE AND SURFACE DECORATION PROCESS FOR SOLID PHASE AFFINITY BINDING ASSAYS 审中-公开
标题翻译：用于固体相位结合测定的微流体装置和表面装饰方法
公开(公告)号：WO03048736A3
公开(公告)日：2003-09-12
申请号：PCT/US0238953
申请日：2002-12-05
申请人： UNIV WASHINGTON
发明人： YAGER PAUL , GARCIA ELENA
IPC分类号： B01L3/00 , C12M1/34 , G01N21/03 , G01N21/05 , G01N21/27 , G01N21/59 , G01N21/64 , G01N27/447 , G01N33/487 , G01N33/53 , G01N33/543 , G01N37/00 , G01N27/26
CPC分类号： B01L3/502707 , B01J2219/00353 , B01J2219/00511 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00644 , B01J2219/00704 , B01L3/502753 , B01L2200/0647 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2400/0415 , G01N21/03 , G01N21/05 , G01N21/6428 , G01N21/6456 , G01N33/54366 , G01N2021/0346 , G01N2021/058 , Y10T436/25375 , Y10T436/2575
摘要： This invention comprises a microfluidic device having a fluid inlet (105) connected to a pump (230) and sample reservoir (220) for the detection of one or more analytes in a fluid using solid-phase affinity binding assay.
摘要翻译：本发明包括具有连接到泵（230）的流体入口（105）和用于使用固相亲和力结合测定法检测流体中的一种或多种分析物的样品储存器（220）的微流体装置。

10. 发明申请

WO0072020A9 MICROSCALE DIFFUSION IMMUNOASSAY 审中-公开
公开(公告)号：WO0072020A9
公开(公告)日：2002-08-29
申请号：PCT/US0013864
申请日：2000-05-19
申请人： UNIV WASHINGTON
发明人： WEIGL BERNHARD H , YAGER PAUL , KAMHOLZ ANDREW , HATCH ANSON
IPC分类号： G01N30/00 , G01N33/532 , G01N33/558 , B01D11/00 , B01D11/04 , G01N15/06 , G01N21/00 , G01N21/29 , G01N21/41 , G01N21/47 , G01N33/00 , G01N33/48 , G01N33/543 , G01N33/557
CPC分类号： G01N33/558 , G01N30/0005
摘要： Methods and apparatuses are provided for determining presence and concentration of analytes by exploiting molecular binding reactions and differential diffusion rates. Analyte particles and binding particles are allowed to diffuse toward each other, and slowing of the diffusion front is detected when they meet. From the position of the diffusion front, presence and concentration of analyte particles can be determined. One embodiment provides a competitive immunoassay in a microfluidic format. This diffusion immunoassay (DIA) relies on measuring the concentration of labeled antigen along one dimension of a microchannel after allowing it to diffuse for a short time into a region containing specific antibodies. A simple microfluidic device, the T-Sensor, was used to implement a DIA to measure the concentration of phenytoin, a small drug molecule. Concentrations of analyte over the range of 50 to 1600 nM can be measured in less than a minute. The assay is homogenous, rapid, requires only microliter volumes of reagents and sample, and is applicable to a wide range of analytes, including therapeutic drugs, molecular biological markers, and environmental contaminants. Methods for separating particles of similar size in a diffusion separator are also provided.
摘要翻译：提供了通过开发分子结合反应和差异扩散速率来确定分析物的存在和浓度的方法和装置。允许分析物颗粒和结合颗粒彼此扩散，并且当它们相遇时检测到扩散前沿的减慢。从扩散前沿的位置可以确定分析物颗粒的存在和浓度。一个实施方案提供了以微流体形式的竞争性免疫测定。这种扩散免疫测定（DIA）依赖于在允许其在短时间内扩散到含有特异性抗体的区域之后测量沿着微通道的一个维度的标记抗原的浓度。使用简单的微流体装置T-Sensor来实施DIA来测量苯妥英（一种小药物分子）的浓度。可以在不到一分钟的时间内测量分析物在50至1600nM范围内的浓度。该测定法是均匀的，快速的，仅需要微量体积的试剂和样品，并且适用于广泛的分析物，包括治疗药物，分子生物标志物和环境污染物。还提供了在扩散分离器中分离类似尺寸的颗粒的方法。

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