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1. 发明公开

EP1046032A4 LIQUID ANALYSIS CARTRIDGE 审中-公开
标题翻译：墨盒油液分析
公开(公告)号：EP1046032A4
公开(公告)日：2002-05-29
申请号：EP99920149
申请日：1999-04-29
申请人： UNIV WASHINGTON
发明人： HOLL MARK R , EDWARDS FLOYD , MORFF ROBERT J , KLEIN GERALD L
IPC分类号： B01L3/00 , B01L99/00 , G01N15/14 , G01N33/483 , G01N21/01
CPC分类号： B01L3/502707 , B01F5/0646 , B01F5/0647 , B01F5/0648 , B01F13/0059 , B01L3/502715 , B01L3/502738 , B01L3/502746 , B01L3/502776 , B01L3/565 , B01L2200/025 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , B01L2400/0655 , G01N15/14 , Y10T156/1064 , Y10T436/11 , Y10T436/117497 , Y10T436/118339 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/2575
摘要： The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel (20) having a plurality of particle capture regions. The storage channel (20) is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge (160) having a convoluted storage channel (20) therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels (24A-24B) can be included in a single cartridge (160). The analysis channels (24A-24B) can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel (80) can be positioned between the reagent inlet and the analysis region (30) to allow mixing and reaction of the reagent. The cartridge (160) can include additional valves (V1-V5) and pumps (P11-P15) for flow management. The analysis cartridge (160) can be a self-contained disposable cartridge having an integral waste storage container (100). This invention further provides a sheath flow assembly (70). The sheath flow assembly (70) includes a sample channel (26) and first and second sheath fluid channels positioned on either side of and converging with the sample channel. The assembly (70) also includes upper and lower sheath fluid chambers prositioned above and below and converging with the sample channel (26). The flow cartridges (160) of this invention can be formed by molding, machining or etching. In a preferred embodiment they are laminated.

2. 发明公开

EP1242813A4 FLUIDIC INTERCONNECT, INTERCONNECT MANIFOLD AND MICROFLUIDIC DEVICES FOR INTERNAL DELIVERY OF GASES AND APPLICATION OF VACUUM 审中-公开
标题翻译： HYDROMECHANISCHE VERBINDUNG，VERBINDUNG VON VERTEILERN UND MIKROFLUIDISCHENGERÄTENZUR INTERNEN BEREITSTELLUNG VON GASEN UND VAKUUMANWENDUNGEN
公开(公告)号：EP1242813A4
公开(公告)日：2002-10-30
申请号：EP00953737
申请日：2000-07-28
申请人： UNIV WASHINGTON
发明人： HOLL MARK R , MACOUNOVA KATERINA , YAGER PAUL , KAMHOLZ ANDREW E , CABRERA CATHERINE R
IPC分类号： B01L3/00 , F16L39/00 , G01N27/447 , G01N27/26 , F15C5/00 , F16L35/00
CPC分类号： B01L3/502723 , B01J2219/00783 , B01J2219/00813 , B01J2219/00833 , B01J2219/00891 , B01J2219/00898 , B01J2219/00907 , B01L3/502707 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2200/0689 , B01L2300/0681 , B01L2300/0816 , B01L2300/0874 , B01L2300/0887 , B01L2400/0421 , B01L2400/049 , F16L39/00 , G01N27/44791
摘要： Interconnect configurations and an interconnect manifold for microfluidic devices (6) is provided. Devices for introducing one or more gases or removing gases from microfluidic cavity elements (8) is also provided. The invention is also directed to methods for making interconnects and to methods for delivery or removal of gasses from microfluidic devices (6).
摘要翻译：提供了用于微流体装置（6）的互连配置和互连歧管。还提供了用于引入一种或多种气体或从微流体空腔元件（8）除去气体的装置。本发明还涉及用于制造互连的方法以及用于从微流体装置（6）输送或去除气体的方法。

3. 发明公开

EP1002227A4 SIMULTANEOUS ANALYTE DETERMINATION AND REFERENCE BALANCING IN REFERENCE T-SENSOR DEVICES 失效
标题翻译：同时测定的分析物与基准补偿的设备的参照T传感器
公开(公告)号：EP1002227A4
公开(公告)日：2000-10-04
申请号：EP97948431
申请日：1997-11-21
申请人： UNIV WASHINGTON
发明人： WEIGL BERNHARD H , HOLL MARK R , ZEBERT DIANE , KENNY MARGARET , WU CAICAI
IPC分类号： G01N31/20 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , G01N15/10 , G01N15/14 , G01N21/64 , G01N30/00 , G01N30/38 , G01N30/60 , G01N30/74 , G01N35/00 , G01N35/08 , G01N37/00 , G01N15/06 , G01N21/05
CPC分类号： B01F13/0093 , B01F5/0403 , B01F13/0059 , B01J19/0093 , B01L3/502776 , B01L2200/0636 , B01L2200/148 , B01L2300/0816 , B01L2400/0406 , B01L2400/0415 , B01L2400/0457 , B01L2400/0487 , G01N15/10 , G01N15/14 , G01N15/1404 , G01N15/1484 , G01N30/0005 , G01N30/38 , G01N30/6095 , G01N30/74 , G01N35/085 , G01N2035/00237 , Y10T436/117497 , Y10T436/118339 , Y10T436/25375 , Y10T436/2575
摘要： A reference T-sensor system is provided for detecting the presence and/or measuring the concentration of analyte particles in a sample stream comprising a laminar flow channel (100), three or more inlet means (40, 50, 55) in fluid connection with the laminar flow channel (100) for respectively conducting into the laminar flow channel an indicator stream (70) which may comprise an indicator substance which indicates the presence of the analyte particles by a detectable change in property when contacted with analyte particles, the sample stream (80), and a reference stream (75), which can be either a control stream or an internal standard stream or both.

4. 发明公开

EP1190241A4 MICROFLUIDIC DEVICES FOR TRANSVERSE ELECTROPHORESIS AND ISOELECTRIC FOCUSING 审中-公开
标题翻译：对于Krenzelektroforese和等电聚焦微流体装置
公开(公告)号：EP1190241A4
公开(公告)日：2004-03-31
申请号：EP00964883
申请日：2000-05-26
申请人： UNIV WASHINGTON
发明人： YAGER PAUL , HOLL MARK R , BELL DARREL J , BRODY JAMES , CABRERA CATHERINE R , KAMHOLZ ANDREW E , MACOUNOVA KATERINA , QIN DONG
IPC分类号： G01N33/483 , C12M1/42 , G01N27/447 , G01N27/26 , B01D57/02
CPC分类号： G01N27/44795 , G01N27/44769
摘要： Devices and methods are provided for separation of particles of a first selected electrophoretic mobility or isoelectric point from a fluid comprising particles of at least one other selected electrophoretic mobility or isoelectric point. The devices comprise a microchannel comprising an inlet for introducing the fluid into the microchannel; electrodes to either side of the microchannel for applying a selected voltage to produce an electrical field across the microchannel orthogonal to the length of the microchannel; and outlets in said microchannel placed to receive outlet portions of the fluid containing enhanced concentrations of each type of particle. The devices may be used for particle detection, quantification, separation, mixing, dilution and concentration. Electrophoretic tags may be used to provide particles with altered electrophoretic mobilities and/or isoelectric points. Interior particles of cells or organisms may be released, separated and detected by these devices and methods. The devices and methods may be used to separate particles such as proteins and microorganisms from biological fluids such as blood, or to separate and detect airborne contaminants such as bacterial warfare agents from air. The devices and methods may be included in devices including other separation and detection methods.

5. 发明公开

EP0890094A4 MICROFABRICATED DIFFUSION-BASED CHEMICAL SENSOR 失效
标题翻译： MIKROHERGESTELLTER CHEMISCHER传感器AUF扩散底座
公开(公告)号：EP0890094A4
公开(公告)日：1999-10-06
申请号：EP97936008
申请日：1997-03-31
申请人： UNIV WASHINGTON
发明人： WEIGL BERNHARD H , YAGER PAUL , BRODY JAMES P , HOLL MARK R , KENNY MARGARET , SCHUTTE DAVID , HIXSON GREGORY , ZEBERT M DIANE , KAMHOLZ ANDREW , WU CAICAI , ALTENDORF ERIC
IPC分类号： G01N37/00 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , G01N15/06 , G01N15/14 , G01N30/00 , G01N30/38 , G01N30/60 , G01N30/74 , G01N31/20 , G01N35/08 , G01N21/64
CPC分类号： B01F5/0403 , B01F13/0059 , B01F13/0093 , B01J19/0093 , B01J2219/00828 , B01J2219/00831 , B01J2219/00952 , B01L3/502776 , B01L2200/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/087 , B01L2400/0487 , G01N15/14 , G01N30/0005 , G01N30/38 , G01N30/6095 , G01N30/74 , G01N35/085 , Y10S366/01 , Y10T436/25375 , Y10T436/2575
摘要： A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising a laminar flow channel (100), two inlet means (30, 20) in fluid connection with said laminar flow channel (100) for respectively conducting into the laminar flow channel (100) an indicator stream (70) which may comprise an indicator substance which indicates the presence of said analyte particles by a detectable change in property when contacted with said analyte particles, and the sample stream (80), wherein the laminar flow channel (100) has a depth sufficiently small to allow laminar flow of the streams and a length sufficient to allow particles of the analyte to diffuse into said indicator stream (70) to the substantial exclusion of said larger particles in the sample stream (80) to form a detection area; and outlet means (60) for conducting the streams out of the laminar flow channel (100) to form a single mixed stream.
摘要翻译：提供通道 - 细胞系统用于检测样品流中存在和/或测量分析物颗粒的存在，所述样品流包括层流通道（100），与所述层流通道（100）流体连接的两个入口装置（30,20） 100），用于分别将指示剂流（70）导入层流通道（100）中，所述指示剂流可包含指示剂物质，所述指示剂物质在与所述分析物颗粒接触时通过可检测的性质变化来指示所述分析物颗粒的存在，并且样品流（80），其中所述层流通道（100）具有足够小的深度以允许所述流的层流，并且所述层流通道的长度足以允许所述分析物的颗粒扩散到所述指示剂流（70）中以基本排除所述较大样品流（80）中的颗粒形成检测区域; 和用于将物流引导出层流通道（100）以形成单一混合物流的出口装置（60）。

6. 发明申请

WO0074850A9 MICROFLUIDIC DEVICES FOR TRANSVERSE ELECTROPHORESIS AND ISOELECTRIC FOCUSING 审中-公开
标题翻译：用于横向电泳和等电聚焦的微流体器件
公开(公告)号：WO0074850A9
公开(公告)日：2001-08-09
申请号：PCT/US0014697
申请日：2000-05-26
申请人： UNIV WASHINGTON
发明人： YAGER PAUL , HOLL MARK R , BELL DARREL J , BRODY JAMES , CABRERA CATHERINE R , KAMHOLZ ANDREW E , MACOUNOVA KATERINA , QIN DONG
IPC分类号： G01N33/483 , C12M1/42 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44795 , G01N27/44769
摘要： Devices and methods are provided for separation of particles of a first selected electrophoretic mobility or isoelectric point from a fluid comprising particles of at least one other selected electrophoretic mobility or isoelectric point. The devices comprise a microchannel comprising an inlet for introducing the fluid into the microchannel; electrodes to either side of the microchannel for applying a selected voltage to produce an electrical field across the microchannel orthogonal to the length of the microchannel; and outlets in said microchannel placed to receive outlet portions of the fluid containing enhanced concentrations of each type of particle. The devices may be used for particle detection, quantification, separation, mixing, dilution and concentration. Electrophoretic tags may be used to provide particles with altered electrophoretic mobilities and/or isoelectric points. Interior particles of cells or organisms may be released, separated, and detected by these devices and methods.
摘要翻译：提供设备和方法用于从包含至少一个其他选择的电泳迁移率或等电点的粒子的流体中分离第一选择的电泳迁移率或等电点的粒子。该装置包括微通道，该微通道包括用于将流体引入微通道中的入口; 将电极施加到微通道的任一侧以用于施加选定的电压以在与微通道的长度正交的微通道上产生电场; 并且所述微通道中的出口被设置成接收含有增强浓度的每种类型颗粒的流体的出口部分。这些装置可用于粒子检测，定量，分离，混合，稀释和浓缩。电泳标签可以用于提供具有改变的电泳迁移率和/或等电点的颗粒。这些装置和方法可以释放，分离和检测细胞或生物体的内部颗粒。

7. 发明申请

WO0074850A3 MICROFLUIDIC DEVICES FOR TRANSVERSE ELECTROPHORESIS AND ISOELECTRIC FOCUSING 审中-公开
标题翻译：用于横向电泳和电致电聚焦的微流体装置
公开(公告)号：WO0074850A3
公开(公告)日：2001-06-28
申请号：PCT/US0014697
申请日：2000-05-26
申请人： UNIV WASHINGTON
发明人： YAGER PAUL , HOLL MARK R , BELL DARREL J , BRODY JAMES , CABRERA CATHERINE R , KAMHOLZ ANDREW E , MACOUNOVA KATERINA , QIN DONG
IPC分类号： G01N33/483 , C12M1/42 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44795 , G01N27/44769
摘要： Devices and methods are provided for separation of particles of a first selected electrophoretic mobility or isoelectric point from a fluid comprising particles of at least one other selected electrophoretic mobility or isoelectric point. The devices comprise a microchannel comprising an inlet for introducing the fluid into the microchannel; electrodes to either side of the microchannel for applying a selected voltage to produce an electrical field across the microchannel orthogonal to the length of the microchannel; and outlets in said microchannel placed to receive outlet portions of the fluid containing enhanced concentrations of each type of particle. The devices may be used for particle detection, quantification, separation, mixing, dilution and concentration. Electrophoretic tags may be used to provide particles with altered electrophoretic mobilities and/or isoelectric points. Interior particles of cells or organisms may be released, separated, and detected by these devices and methods.
摘要翻译：提供了设备和方法，用于从包含至少一个其它选择的电泳迁移率或等电点的颗粒的流体分离第一选择的电泳迁移率或等电点的颗粒。所述装置包括微通道，其包括用于将流体引入微通道的入口; 电极到微通道的任一侧，用于施加所选择的电压，以跨过与微通道长度正交的微通道产生电场; 并且所述微通道中的出口被设置成接收含有增强浓度的每种类型的颗粒的流体的出口部分。该装置可用于颗粒检测，定量分离，分离，混合，稀释和浓缩。电泳标签可用于提供具有改变的电泳迁移率和/或等电点的颗粒。细胞或生物体的内部颗粒可以通过这些装置和方法被释放，分离和检测。

8. 发明专利

AU3877797A Microfabricated diffusion-based chemical sensor 未知
公开(公告)号：AU3877797A
公开(公告)日：1997-11-07
申请号：AU3877797
申请日：1997-03-31
申请人： UNIV WASHINGTON
发明人： WEIGL BERNHARD H , YAGER PAUL , BRODY JAMES P , HOLL MARK R , KENNY MARGARET , SCHUTTE DAVID , HIXSON GREGORY , ZEBERT M DIANE , KAMHOLZ ANDREW , WU CAICAI , ALTENDORF ERIC
IPC分类号： G01N37/00 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , G01N15/06 , G01N15/14 , G01N30/00 , G01N30/38 , G01N30/60 , G01N30/74 , G01N31/20 , G01N35/08 , G01N21/64
摘要： A channel-cell system is provided for detecting the presence and/or measuring the presence of analyte particles in a sample stream comprising: a) a laminar flow channel; b) two inlet means in fluid connection with said laminar flow channel for respectively conducting into said laminar flow channel (1) an indicator stream which may comprise an indicator substance which indicates the presence of said analyte particles by a detectable change in property when contacted with said analyte particles, and (2) said sample stream; c) wherein said laminar flow channel has a depth sufficiently small to allow laminar flow of said streams and a length sufficient to allow particles of said analyte to diffuse into said indicator stream to the substantial exclusion of said larger particles in said sample stream to form a detection area; and d) outlet means for conducting said streams out of said laminar flow channel to form a single mixed stream.

9. 发明专利

DE69729808D1 未知
公开(公告)号：DE69729808D1
公开(公告)日：2004-08-12
申请号：DE69729808
申请日：1997-11-21
申请人： UNIV WASHINGTON SEATTLE
发明人： WEIGL BERNHARD H , HOLL MARK R , ZEBERT DIANE , KENNY MARGARET , WU CAICAI
IPC分类号： G01N31/20 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , G01N15/10 , G01N15/14 , G01N21/64 , G01N30/00 , G01N30/38 , G01N30/60 , G01N30/74 , G01N35/00 , G01N35/08 , G01N37/00 , G01N21/05 , G01N15/06
摘要： A reference T-sensor system is provided for detecting the presence and/or measuring the concentration of analyte particles in a sample stream. The system includes: a) a laminar flow channel; b) three or more inlets in fluid connection with the laminar flow channel for respectively conducting into the laminar flow channel (1) an indicator stream which may include an indicator substance which indicates the presence of analyte particles by a detectable change in property when contacted with the analyte particles, (2) the sample stream, and (3) a reference stream, which can be a control stream and/or an internal standard stream; c) wherein the laminar flow channel has a depth and/or width sufficiently small to allow laminar flow of the streams and a length sufficient to allow particles of the analyte to diffuse into the indicator stream to form a detection area; and (d) an outlet for conducting the streams out of the laminar flow channel preferably to form a single mixed stream.

10. 发明专利

AU3771599A Liquid analysis cartridge 未知
公开(公告)号：AU3771599A
公开(公告)日：1999-12-06
申请号：AU3771599
申请日：1999-04-29
申请人： UNIV WASHINGTON
发明人： HOLL MARK R , EDWARDS FLOYD , MORFF ROBERT J , KLEIN GERALD L
IPC分类号： B01L3/00 , B01L99/00 , G01N15/14 , G01N33/483 , G01N21/01
摘要： The present invention provides an apparatus and method for storing a particle-containing liquid. The storage apparatus comprises a microfluidic convoluted flow channel having a plurality of particle capture regions. The storage channel is preferably an isotropic spatially periodic channel. Sedimented particles can be resuspended following storage. This invention further provides a microfluidic analysis cartridge having a convoluted storage channel therein. The sample analysis can use optical, electrical, pressure sensitive, or flow sensitive detection. A plurality of analysis channels can be included in a single cartridge. The analysis channels can be joined to reagent inlets for diluents, indicators or lysing agents. A mixing channel can be positioned between the reagent inlet and the analysis region to allow mixing and reaction of the reagent. The cartridge can include additional valves and pumps for flow management. The analysis cartridge can be a self-contained disposable cartridge having an integral waste storage container. This invention further provides a sheath flow assembly. The sheath flow assembly includes a sample channel and first and second sheath fluid channels positioned on either side of and converging with the sample channel. The assembly also includes upper and lower sheath fluid chambers positioned above and below and converging with the sample channel. The flow cartridges of this invention can be formed by molding, machining or etching. In a preferred embodiment they are laminated. This invention further provides a method of fabricating a laminated microfluidic flow device. In the method, flow elements are formed in rigid sheets and abutting surfaces of the sheets are bonded together.

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