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    • 4. 发明申请
    • PHARMACEUTICAL PREPARATION BASED ON MYRTUCOMMULONE A FOR THE SELECTIVE TUMOUR AND CANCER THERAPY
    • 药物制备基于甲myrtucommulone用于选择性肿瘤和癌症治疗
    • WO2007128537A3
    • 2008-06-12
    • PCT/EP2007003989
    • 2007-05-07
    • UNIV EBERHARD KARLSWERZ OLIVERTRETIAKOVA IRINA
    • WERZ OLIVERTRETIAKOVA IRINA
    • A61K31/122A61K36/61A61P35/00
    • A61K36/61A61K31/122
    • The invention relates to the use of myrtucommulone A as a lipophilic extract from myrtle or in a synthetically produced form or the use of a pharmaceutical composition that comprises the thus obtained myrtucommulone A for producing a medicament that influences cell growth, especially for the selective inhibition of an atypical cell proliferation, for example in the case of cancer. The lipophilic extract is preferably obtained from myrtle leaves, especially in a purified form. The purification is achieved by the fact that the lipophilic extract of myrtucommulone A is processed and concentrated in several steps. After at least a part of the processing steps, the lipophilic extract is absorbed by a solvent, optionally filtered and again extracted. Myrtucommulone A is subsequently obtained essentially as a pure substance in a chromatographic separation process.
    • 本发明涉及使用myrtucommulone A的,作为番石榴的亲脂性提取物或合成产生的形式,或包含myrtucommulone由此获得的A,以制备药物用于影响细胞的生长,特别是用于非典型细胞增殖的选择性抑制的药物组合物, ž。 作为癌症。 所述亲脂性提取物优选从桃金娘叶叶片的,尤其是在纯化的形式。 纯化是这样实现的myrtucommulone A的亲脂提取物在多个步骤中进行后处理,并浓缩,在每种情况下用溶剂溶解所述处理步骤的至少一个部分,任选地过滤和再提取,然后通过色谱分离接收myrtucommulone基本上作为纯物质 是。