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1. 发明公开

EP1682568A4 MULTIFUNCTIONAL BIOMATERIALS AS SCAFFOLDS FOR ELECTRONIC, OPTICAL, MAGNETIC, SEMICONDUCTING, AND BIOTECHNOLOGICAL APPLICATIONS 审中-公开
标题翻译：多功能生物材料作为支架于电子，光学，磁和生物技术应用HALBLEITDENDE
公开(公告)号：EP1682568A4
公开(公告)日：2009-10-28
申请号：EP04795143
申请日：2004-10-15
申请人： UNIV TEXAS , MASSACHUSETTS INST TECHNOLOGY
发明人： BELCHER ANGELA M , PEELE B , NAM K T
IPC分类号： C12N7/00 , A61K9/70 , C07K20060101 , C12N15/86 , C12Q1/70 , H01L51/00
CPC分类号： H01L51/0093 , B82Y5/00 , B82Y10/00 , C12N7/00 , C12N15/1037 , C12N2795/14011 , C12N2795/14051 , H01L51/0508 , Y10S977/773 , Y10S977/775 , Y10S977/802 , Y10S977/81

2. 发明公开

EP1432527A4 BIOLOGICAL CONTROL OF NANOPARTICLES 审中-公开
标题翻译：纳米粒子的生物防治
公开(公告)号：EP1432527A4
公开(公告)日：2007-01-31
申请号：EP02780408
申请日：2002-09-27
申请人： UNIV TEXAS , RICE UNIVERSITY
发明人： BELCHER ANGELA M , SMALLEY RICHARD E , RYAN ESTHER , LEE SEUNG-WUK , FLYNN CHRISTINE
IPC分类号： A61K47/04 , A61K47/48 , A61P9/00 , A61P35/00 , C07B61/00 , C07K1/04 , C07K7/06 , C07K7/08 , C12N15/10 , C40B40/02 , C40B50/06 , G01N33/543 , H01L21/368 , H01L51/00 , H01L51/30 , B05D3/10 , B05D7/02 , B32B5/16 , C07H17/00 , C07H19/00 , C12Q1/00 , C12Q1/68 , G01J5/02 , G01N1/36 , G01N21/63
CPC分类号： C40B40/02 , B01J2219/005 , B82Y10/00 , C07B2200/11 , C07K1/047 , C07K7/06 , C07K7/08 , C12N15/1037 , G01N33/54386 , H01L51/0093 , H01L51/0595

3. 发明申请

WO2004033488B1 PEPTIDE MEDIATED SYNTHESIS OF METALLIC AND MAGNETIC MATERIALS 审中-公开
标题翻译：肽介导的金属和磁性材料的合成
公开(公告)号：WO2004033488B1
公开(公告)日：2005-01-20
申请号：PCT/US0329555
申请日：2003-09-22
申请人： UNIV TEXAS , BELCHER ANGELA M , REISS BRIAN , MAO CHUANBIN , SOLIS DANIEL
发明人： BELCHER ANGELA M , REISS BRIAN , MAO CHUANBIN , SOLIS DANIEL
IPC分类号： A61K49/18 , B01J19/00 , B01J19/08 , C07K1/00 , C07K1/04 , C07K17/14
CPC分类号： C07K17/14 , A61K49/1872 , B82Y5/00 , B82Y10/00 , B82Y30/00
摘要： The present invention includes methods of producing magnectic na nocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific b inding to a magnectic material.
摘要翻译：本发明包括通过使用已经被修饰为具有能够特异性地延伸到一种强度材料的氨基酸低聚物的生物分子来产生无定形纳米晶体的方法。

4. 发明公开

EP1488010A4 NANOSCALING ORDERING OF HYBRID MATERIALS USING GENETICALLY ENGINEERED MESOSCALE VIRUS 审中-公开
标题翻译：杂交分子纳米级布置使用的基因所制造的病毒中尺度
公开(公告)号：EP1488010A4
公开(公告)日：2007-04-25
申请号：EP02795498
申请日：2002-10-02
申请人： UNIV TEXAS
发明人： BELCHER ANGELA M , LEE SEUNG-WUK
IPC分类号： B82B3/00 , H01L51/00 , C12N7/00 , C12N15/00 , C30B7/00 , C30B29/54 , C30B29/58 , G01N33/58 , H01L21/02 , H01L29/04 , H01L29/06 , H01L51/30 , H01L51/40
CPC分类号： H01L29/045 , B82Y5/00 , B82Y10/00 , B82Y15/00 , B82Y30/00 , C30B7/00 , C30B7/005 , C30B29/58 , G01N33/588 , H01L21/02 , H01L51/0012 , H01L51/0093 , Y10T428/31504
摘要： The present invention includes methods for producing nanocrystals of semiconductor material that have specific crystallographic features such as phase and alignment by using a self-assembling biological molecule that has been modified to possess an amino acid oligomer that is capable of specific binding to semi-conductor material. One form of the present invention is a method to construct ordered nanoparticles within the liquid crystal of the self-assembling biological molecule.

5. 发明公开

EP1730337A4 INORGANIC NANOWIRES 审中-公开
标题翻译：无机纳米线
公开(公告)号：EP1730337A4
公开(公告)日：2010-03-17
申请号：EP05726223
申请日：2005-01-05
申请人： UNIV TEXAS , MASSACHUSETTS INST TECHNOLOGY
发明人： BELCHER ANGELA M , MAO CHUANBIN , SOLIS DANIEL J
IPC分类号： D02G3/00 , C04B35/64 , H01L29/06 , H01L29/22 , H01L29/745 , H05B6/00
CPC分类号： H01B1/10 , B82Y10/00 , B82Y30/00 , C01B19/007 , C01G9/08 , C01P2004/04 , C01P2004/16 , C04B35/62272 , C04B2235/3284 , C04B2235/446 , H01B1/06 , H01F1/01 , H01F1/068 , H01L29/0665 , H01L29/0669 , H01L29/0673 , H01L29/22 , Y10T428/249924 , Y10T428/2913 , Y10T428/2927 , Y10T428/298

6. 发明公开

EP1685376A4 VIRAL FIBERS 审中-公开
标题翻译： VIRUSFASERN
公开(公告)号：EP1685376A4
公开(公告)日：2010-03-03
申请号：EP04795141
申请日：2004-10-15
申请人： UNIV TEXAS , MASSACHUSETTS INST TECHNOLOGY
发明人： BELCHER ANGELA M
IPC分类号： C12N7/00 , A61K9/70 , A61K35/76 , A61K39/12 , C12N7/02 , C12Q1/70 , D01D5/00 , D01F1/10 , G01N20060101
CPC分类号： C12Q1/70 , A61K35/76 , A61K47/58 , A61K47/62 , B82Y5/00 , C12N7/00 , C12N2795/14111 , C12N2795/14122 , D01D5/0007 , D01D5/0053 , D01F1/10 , D01F9/00 , Y10T428/2927 , Y10T442/2525
摘要： Long rod shaped M13 viruses were used to fabricate one dimensional (1D) micro- and nanosized diameter fibers by mimic the spinning process of the silk spider. Liquid crystalline virus suspensions were extruded through the micrometer diameter capillary tubes in cross-linking solution (glutaraldehyde). Resulting fibers were tens of micrometers in diameter depending on the inner diameter of the capillary tip. AFM image verified that molecular long axis of the virus fibers were parallel to the fiber long axis. Although aqueous M13 virus suspension could not be spun by electrospinning, M13 viruses suspended in 1,1,1,3,3,3-hexafluoro-2-propanol were spun into fibers. After blending with highly water soluble polymer, polyvinyl 2-pyrolidone (PVP), M13 viruses was spun into continuous uniform virus blended PVP (virus-PVP) fibers. Resulting virus-PVP electrospun fibers showed intact infecting ability to bacterial hosts after suspending in the buffer solution.

7. 发明申请

WO2005067683A8 INORGANIC NANOWIRES 审中-公开
标题翻译：无机纳米级
公开(公告)号：WO2005067683A8
公开(公告)日：2006-12-14
申请号：PCT/US2005000075
申请日：2005-01-05
申请人： UNIV TEXAS , MASSACHUSETTS INST TECHNOLOGY , BELCHER ANGELA M , MAO CHUANBIN , SOLIS DANIEL J
发明人： BELCHER ANGELA M , MAO CHUANBIN , SOLIS DANIEL J
IPC分类号： D02G3/00 , C04B35/64 , H01L29/06 , H01L29/22 , H01L29/745 , H05B6/00
CPC分类号： H01B1/10 , B82Y10/00 , B82Y30/00 , C01B19/007 , C01G9/08 , C01P2004/04 , C01P2004/16 , C04B35/62272 , C04B2235/3284 , C04B2235/446 , H01B1/06 , H01F1/01 , H01F1/068 , H01L29/0665 , H01L29/0669 , H01L29/0673 , H01L29/22 , Y10T428/249924 , Y10T428/2913 , Y10T428/2927 , Y10T428/298
摘要： An inorganic nanowire having an organic scaffold substantially removed from the inorganic nanowire, the inorganic nanowire consisting essentially of fused inorganic nanoparticles substantially free of the organic scaffold, and methods of making same. For example, a virus-based scaffold for the synthesis of single crystal ZnS, CdS and free-standing L10 CoPt and FePt nanowires can be used, with the means of modifying substrate specificity through standard biological methods. Peptides can be selected through an evolutionary screening process that exhibit control of composition, size, and phase during nanoparticle nucleation have been expressed on the highly ordered filamentous capsid of the M13 bacteriophage. The incorporation of specific, nucleating peptides into the generic scaffold of the M13 coat structure can provide a viable template for the directed synthesis of a variety of materials including semiconducting and magnetic materials. Removal of the viral template via annealing can promote oriented aggregation-based crystal growth, forming individual crystalline nanowires. The unique ability to interchange substrate specific peptides into the linear selfassembled filamentous construct of the M 13 virus introduces a material tunability not seen in previous synthetic routes. Therefore, this system provides a genetic tool kit for growing and organizing nanowires from various materials including semiconducting and magnetic materials.
摘要翻译：具有基本上从无机纳米线除去的有机支架的无机纳米线，基本上不含有机支架的熔融无机纳米线组成的无机纳米线及其制备方法。例如，可以使用用于合成单晶ZnS，CdS和独立的L10 CoPt和FePt纳米线的基于病毒的支架，具有通过标准生物学方法修饰底物特异性的方法。可以通过进化筛选方法选择肽，其在M13噬菌体的高度有序的丝状衣壳上表达纳米颗粒成核期间组合物，大小和相位的控制。将特定的成核肽并入M13涂层结构的通用支架中可以提供用于定向合成各种材料（包括半导体和磁性材料）的可行模板。通过退火去除病毒模板可促进取向聚集的晶体生长，形成单独的晶体纳米线。将底物特异性肽转化为M13病毒的线性自组装丝状构建体的独特能力引入了在以前的合成途径中未见的材料可调性。因此，该系统提供了一种遗传工具包，用于从包括半导体和磁性材料的各种材料生长和组织纳米线。

8. 发明申请

WO2004033488A3 PEPTIDE MEDIATED SYNTHESIS OF METALLIC AND MAGNETIC MATERIALS 审中-公开
标题翻译：多肽金属和磁性材料的合成
公开(公告)号：WO2004033488A3
公开(公告)日：2004-10-07
申请号：PCT/US0329555
申请日：2003-09-22
申请人： UNIV TEXAS , BELCHER ANGELA M , REISS BRIAN , MAO CHUANBIN , SOLIS DANIEL
发明人： BELCHER ANGELA M , REISS BRIAN , MAO CHUANBIN , SOLIS DANIEL
IPC分类号： A61K49/18 , B01J19/00 , B01J19/08 , C07K1/00 , C07K1/04 , C07K17/14
CPC分类号： C07K17/14 , A61K49/1872 , B82Y5/00 , B82Y10/00 , B82Y30/00
摘要： The present invention includes methods of producing magnectic na nocrystals by using a biological molecule that has been modified to possess an amino acid oligomer that is capable of specific b inding to a magnectic material.
摘要翻译：本发明包括通过使用经修饰而具有能够特异性结合到磁性材料上的氨基酸低聚物的生物分子来生产磁性非晶体的方法。

9. 发明申请

WO2005038430A3 VIRAL FIBERS 审中-公开
标题翻译：虚拟光纤
公开(公告)号：WO2005038430A3
公开(公告)日：2006-08-31
申请号：PCT/US2004033941
申请日：2004-10-15
申请人： UNIV TEXAS , MASSACHUSETTS INST TECHNOLOGY , BELCHER ANGELA M , LEE SEUNG-WUK
发明人： BELCHER ANGELA M , LEE SEUNG-WUK
IPC分类号： C12N7/00 , A61K9/70 , A61K35/76 , A61K39/12 , C12N7/02 , C12Q1/70 , D01D5/00 , D01F1/10 , G01N20060101
CPC分类号： C12Q1/70 , A61K35/76 , A61K47/58 , A61K47/62 , B82Y5/00 , C12N7/00 , C12N2795/14111 , C12N2795/14122 , D01D5/0007 , D01D5/0053 , D01F1/10 , D01F9/00 , Y10T428/2927 , Y10T442/2525
摘要： Long rod shaped M13 viruses were used to fabricate one dimensional (1D) micro- and nanosized diameter fibers by mimic the spinning process of the silk spider. Liquid crystalline virus suspensions were extruded through the micrometer diameter capillary tubes in cross-linking solution (glutaraldehyde). Resulting fibers were tens of micrometers in diameter depending on the inner diameter of the capillary tip. AFM image verified that molecular long axis of the virus fibers were parallel to the fiber long axis. Although aqueous M13 virus suspension could not be spun by electrospinning, M13 viruses suspended in 1,1,1,3,3,3-hexafluoro-2-propanoI were spun into fibers. After blending with highly water soluble polymer, polyvinyl 2-pyrolidone (PVP), M13 viruses was spun into continuous uniform virus blended PVP (virus-PVP) fibers. Resulting virus-PVP electrospun fibers showed intact infecting ability to bacterial hosts after suspending in the buffer solution.
摘要翻译：长棒状M13病毒用于通过模拟丝蜘蛛的纺丝过程制造一维（1D）微米和纳米尺寸的纤维。将液晶病毒悬浮液通过交联溶液（戊二醛）中的微米直径毛细管挤出。所得纤维的直径为几十微米，取决于毛细管尖端的内径。 AFM图像验证了病毒纤维的分子长轴平行于纤维长轴。虽然M13病毒悬浮液不能通过静电纺丝，悬浮在1,1,1,3,3,3-六氟-2-丙酰胺中的M13病毒被纺成纤维。在与高度水溶性聚合物共混后，将聚乙烯吡咯烷酮（PVP），M13病毒纺丝成连续均匀的病毒混合PVP（病毒 - PVP）纤维。得到的病毒PVP静电纺纤维悬浮于缓冲溶液中后显示细菌宿主的完整感染能力。

10. 发明申请

WO2004035612A3 COMPOSITION, METHOD AND USE OF BI-FUNCTIONAL BIOMATERIALS 审中-公开
标题翻译：双功能生物材料的组成，方法和用途
公开(公告)号：WO2004035612A3
公开(公告)日：2004-10-07
申请号：PCT/US0327489
申请日：2003-09-04
申请人： UNIV TEXAS , BELCHER ANGELA M , SCHMIDT CHRISTINE E , MILLER KILEY P H , SANGHVI ARCHIT
发明人： BELCHER ANGELA M , SCHMIDT CHRISTINE E , MILLER KILEY P H , SANGHVI ARCHIT
IPC分类号： C07K14/47 , C08G63/91 , C12N11/06 , C12N15/10
CPC分类号： C08G63/912 , C07K14/47 , C12N11/06 , Y10S530/808 , Y10S530/815
摘要： The present invention includes a bifunctional specificity structure that includes a peptide linker having a first and a second binding domain, wherein the first binding domain is selective for a first biomaterial and the second binding domain is selective for a second biomaterial. The present invention also includes a method of making and identifying the bifunctional structure of the present invention and methods of using the same.
摘要翻译：本发明包括双功能特异性结构，其包括具有第一和第二结合结构域的肽接头，其中第一结合结构域对第一生物材料是选择性的而第二结合结构域对第二生物材料是选择性的。本发明还包括制造和鉴定本发明的双功能结构的方法及其使用方法。

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