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1. 发明申请

WO2009022125A8 IDENTIFICATION OF NUCLEIC ACID SEQUENCES 审中-公开
标题翻译：核酸序列的鉴定
公开(公告)号：WO2009022125A8
公开(公告)日：2009-07-16
申请号：PCT/GB2008002727
申请日：2008-08-13
申请人： UNIV STRATHCLYDE , GRAHAM DUNCAN , FAULDS KAREN , SMITH EWAN , RICKETTS ALASTAIR
发明人： GRAHAM DUNCAN , FAULDS KAREN , SMITH EWAN , RICKETTS ALASTAIR
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6823 , C12Q2565/632 , C12Q2563/107 , C12Q2521/319
摘要： The invention provides a method for use in the detection of a target nucleic acid comprising the steps of: (i) contacting a single-stranded probe nucleic acid with a sample of interest under conditions effective to generate a probe/target nucleic acid duplex by specific hybridisation of said probe nucleic acid to a target nucleic acid, if said target nucleic acid is present; (ii) contacting any probe/target nucleic acid duplex with an exonuclease to effect digestion of the duplex and release of a label molecule from the duplex; and (iii) detecting the label by Raman spectroscopy.
摘要翻译：本发明提供了一种用于检测靶核酸的方法，包括以下步骤：（i）在有效通过特异性产生探针/靶核酸双链体的条件下，将单链探针核酸与感兴趣的样品接触如果存在所述靶核酸，则所述探针核酸与靶核酸的杂交; （ii）使任何探针/靶核酸双链体与外切核酸酶接触以实现双链体的消化和从双链体释放标记分子; 和（iii）通过拉曼光谱法检测标记。

2. 发明申请

WO2008050109A8 FUNCTIONALISED POLYMERS FOR BINDING METAL SURFACES 审中-公开
标题翻译：用于结合金属表面的功能化聚合物
公开(公告)号：WO2008050109A8
公开(公告)日：2008-07-03
申请号：PCT/GB2007004038
申请日：2007-10-23
申请人： UNIV STRATHCLYDE , CORMACK PETER , GRAHAM DUNCAN , HERNANDEZ-SANTANA AARON , RAMASWAMY ARUN PRASATH , SMITH WILLIAM EWEN
发明人： CORMACK PETER , GRAHAM DUNCAN , HERNANDEZ-SANTANA AARON , RAMASWAMY ARUN PRASATH , SMITH WILLIAM EWEN
IPC分类号： C08F8/30 , B22F1/02 , C08F212/08 , C08F222/08 , C23F11/173 , G01N21/65
CPC分类号： B22F1/0018 , B22F1/0062 , B22F1/0096 , B22F2998/00 , B82Y30/00 , C08F8/32 , C08F2800/20 , G01N21/65 , G01N21/658 , Y10T428/2998 , Y10T428/31678 , C08F212/08 , B22F1/0022 , C08F222/06
摘要： The invention relates generally to polyvalent macromolecules comprising: (a) a polymer backbone and (b) pendent groups attached to said polymer backbone, wherein some or all of said pendent groups comprise: (i) optionally a linker, (ii) a surface-seeking group, which is capable of binding strongly to a metal surface, (iii) optionally a chromophore, which is detectable by at least one spectroscopic method. Such molecules can modify metal surfaces and have a variety of uses including (without limitation) appending chromophores to metal surfaces without the need to establish complex chemistry; for the stabilisation and labelling of metal nanoparticles; and for preparing and aggregating nanoparticles in a controlled fashion.
摘要翻译：本发明一般涉及多价大分子，其包含：（a）聚合物主链和（b）连接到所述聚合物主链上的侧基，其中一些或所有所述侧基包含：（i）任选的连接基团，（ii）寻找基团，其能够强烈地与金属表面结合，（iii）任选的可通过至少一种光谱方法检测的发色团。这种分子可以修饰金属表面并具有多种用途，包括（但不限于）将发色团附加到金属表面而不需要建立复杂的化学反应; 用于金属纳米粒子的稳定和标记; 并以受控方式制备和聚集纳米颗粒。

3. 发明申请

WO2010139942A2 NANOPARTICLE FOR BIOMOLECULE DELIVERY 审中-公开
标题翻译：用于生物分子递送的纳米颗粒
公开(公告)号：WO2010139942A2
公开(公告)日：2010-12-09
申请号：PCT/GB2010001070
申请日：2010-06-01
申请人： UNIV STRATHCLYDE , GRAHAM DUNCAN , WHEATE NIAL JOSEPH , BROWN SARAH , CRAIG GEMMA
发明人： GRAHAM DUNCAN , WHEATE NIAL JOSEPH , BROWN SARAH , CRAIG GEMMA
IPC分类号： A61K47/48 , A61K41/00 , A61P35/00
CPC分类号： A61K41/00 , A61K47/6923
摘要： A nanoparticle comprises a metal nanoparticle, e.g. gold, functionalised with at least one linker, the at least one linker comprising at least one first moiety capable of interacting with the metal nanoparticle, and at least one second moiety capable of interacting with at least one platinum group metal-based biologically active compound, e.g. a drug, wherein the molar ratio or capacity of platinum group metal-based biologically active compounds per nanoparticle is greater than (150). The present invention also relates to a method of preparing a nanoparticle according to the present invention. The present invention also relates to a biologically active nanoparticle comprising a nanoparticle according to the present invention, and at least one platinum group metal-based biologically active compound. The biologically active nanoparticle is more efficiently targeted to specific parts of the body, e.g. cancer cells, while reducing the side effects of the biomolecules being delivered.
摘要翻译：纳米颗粒包括金属纳米颗粒，例如金，其与至少一个接头官能化，所述至少一个连接体包含至少一个能够与金属纳米颗粒相互作用的第一部分，以及至少一个能够与至少一种基于金属的金属基生物活性化合物相互作用的第二部分，例如一种药物，其中每个纳米颗粒的铂族金属基生物活性化合物的摩尔比或容量大于（150）。本发明还涉及根据本发明的制备纳米颗粒的方法。本发明还涉及包含根据本发明的纳米颗粒的生物活性纳米颗粒和至少一种基于金属的金属基生物活性化合物。生物活性纳米颗粒更有效地靶向身体的特定部位，例如，同时减少正在递送的生物分子的副作用。

4. 发明申请

WO2004007767A2 SERRS REACTIVE PARTICLES 审中-公开
标题翻译： SERRS反应性颗粒
公开(公告)号：WO2004007767A2
公开(公告)日：2004-01-22
申请号：PCT/GB0303009
申请日：2003-07-11
申请人： UNIV STRATHCLYDE , SMITH WILLIAM EWEN , GRAHAM DUNCAN , CORMACK PETER , MCCABE AILIE
发明人： SMITH WILLIAM EWEN , GRAHAM DUNCAN , CORMACK PETER , MCCABE AILIE
IPC分类号： G01N21/65 , B01J13/14 , C07B61/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/566 , G01N33/58 , G01N33/531
CPC分类号： G01N33/587 , B01J13/14 , B82Y15/00 , C07B2200/11 , C12Q1/6816 , C40B20/04 , G01N21/658 , C12Q2563/149 , C12Q2563/137
摘要： The present invention relates to the provision of SERRS active polymer beads and a method of their production for use in detecting target molecules, as well as methods of detecting target molecules.
摘要翻译：本发明涉及提供SERRS活性聚合物珠粒及其制备用于检测靶分子的方法以及检测靶分子的方法。

5. 发明授权

EP0871774B1 DETECTION OF NUCLEIC ACIDS AND NUCLEIC ACID UNITS 失效
标题翻译：测定NUCLEIC和核酸单位
公开(公告)号：EP0871774B1
公开(公告)日：2007-05-02
申请号：EP96925873
申请日：1996-07-25
申请人： UNIV STRATHCLYDE
发明人： GRAHAM DUNCAN , LINACRE ADRIAN MATTHEW THORNTO , MUNRO CALUM HUGH , SMITH WILLIAM EWAN , WATSON NIGEL DEAN , WHITE PETER CYRIL
IPC分类号： C12Q1/68 , G01N33/543 , C07D249/18 , C12N15/09 , G01N21/65 , G01N33/566 , G01N33/58
CPC分类号： C12Q1/6816 , G01N21/658 , Y10T436/24 , C12Q2565/632
摘要： The invention relates to the detection of target nucleic acids or nucleic acid units in a sample, by obtaining a SER(R)S spectrum for a SER(R)S-active complex containing, or derived directly from, the target. The complex includes at least a SER(R)S-active label, and optionally a target binding species containing a nucleic acid or nucleic acid unit. In this detection method, the concentration of the target present in the SER(R)S-active complex, or of the nucleic acid or unit contained in the target binding species in the SER(R)S-active complex, is no higher than 10-10 moles per litre. Additionally or alternatively, one or more of the following features may be used with the method: i) the introduction of a polyamine; ii) modification of the target, and/or of the nucleic acid or nucleic acid unit contained in the target binding species, in a manner that promotes or facilitates its chemi-sorption onto a SER(R)S-active surface; iii) inclusion of a chemi-sorptive functional group in the SER(R)S-active label. The invention also provides SER(R)S-active complexes for use in such a method, a kit for use in carrying out the method or preparing the complexes and a method for sequencing a nucleic acid which comprises the use of the detection method to detect at least one target nucleotide or sequence of nucleotides within the acid.

6. 发明专利

CA354027A DELIVERY VEHICLE 未知
公开(公告)号：CA354027A
公开(公告)日：1935-11-12
申请号：CA354027D
申请人： GRAHAM DUNCAN , GILLILAND JAMES , SHIELDS JAMES
发明人： GRAHAM DUNCAN , GILLILAND JAMES , SHIELDS JAMES

7. 发明专利

DE60135839D1 未知
公开(公告)号：DE60135839D1
公开(公告)日：2008-10-30
申请号：DE60135839
申请日：2001-04-09
申请人： UNIV STRATHCLYDE GLASGOW
发明人： SMITH WILLIAM EWEN , GRAHAM DUNCAN , MCHUGH CALLUM JOHN , KEIR RUTH LYNDSEY , WHITE PETER CYRIL , CAMPBELL MAIRI
IPC分类号： G01N21/65 , C07D213/53 , C07D213/79 , C07D215/38 , C07D249/18 , C07D333/12 , C07D403/04 , C07D487/08 , C07D487/18 , G01N33/543
摘要： The present invention relates to sensitive SE(R)RS based methods for detecting analytes such as explosives and drugs, which may be present in a sample at extremely low levels. The methods may be generally carried out in situ employing novel chemistry which is compatible with flow-cell technology and with time-scales and concentrations required for rapid and informative screening of large numbers of samples. The present invention also relates to novel compounds e.g. synthons and apparatus for use with the methods disclosed.

8. 发明专利

AU2003281070B2 Serrs reactive particles 未知
公开(公告)号：AU2003281070B2
公开(公告)日：2008-01-24
申请号：AU2003281070
申请日：2003-07-11
申请人： UNIV STRATHCLYDE
发明人： CORMACK PETER , GRAHAM DUNCAN , MCCABE AILIE , SMITH WILLIAM EWEN
IPC分类号： G01N21/65 , B01J13/14 , C07B61/00 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , C12Q1/6816 , G01N33/53 , G01N33/543 , G01N33/553 , G01N33/566 , G01N33/58

9. 发明专利

AT365324T 未知
公开(公告)号：AT365324T
公开(公告)日：2007-07-15
申请号：AT02772626
申请日：2002-11-04
申请人： UNIV STRATHCLYDE , UNIV GLASGOW
发明人： SMITH WILLIAM , GRAHAM DUNCAN , COOPER JONATHAN MARK , KEIR RUTH , IGATA EISHI
IPC分类号： G01N21/65 , G01N33/58 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01J3/44 , G01N33/48 , G01N33/483
摘要： The present invention relates to a microfluidic method of generating in situ a colloid for use in detecting an analyte using for example SER(R)S, as well as a method of detecting an analyte using SER(R)S in a microfluidic system. The invention also relates to microfluidic devices for use in detecting analytes such as by way of SER(R)S signals.

10. 发明专利

AT495434T 未知
公开(公告)号：AT495434T
公开(公告)日：2011-01-15
申请号：AT04768226
申请日：2004-08-26
申请人： UNIV STRATHCLYDE
发明人： GRAHAM DUNCAN , SMITH WILLIAM E , FRUK LJILJANA
IPC分类号： G01N21/65 , C12Q1/68 , G01J3/44 , G01N33/58
摘要： The invention provides modified molecular beacons detectable by surface enhanced Raman spectroscopy (SERS) and related materials, processes, and methods of use. Examples methods provide for the determination of the presence or absence of a target nucleotide sequence in a sample nucleic acid by (a) providing a detection agent, which agent comprises: (i) a probe comprising a target complement sequence (TCS) being complementary to the target sequence and flanking the TCS, first and second oligonucleotide arms, said first and second oligonucleotide arms forming a stem duplex, and said first arm incorporating a first label moiety being detectable by SERS (e.g. a fluoroscein dye) and said second arm terminating in a second label moiety being detectable by SERS, which second arm further includes a surface seeking group (SSG-e.g. an azo-benzotriazole) capable of promoting association of the second label onto an enhancing surface ii) associated with said probe via said SSG, an enhancing surface, such that said first and second label moieties are in close proximity to each other and to the enhancing surface (b) exposing the sample to the detection agent, (c) detecting hybridisation of the TCS to any target sequence present in the sample by a change in the SERS spectra of said agent.

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