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1. 发明专利

DE60135839D1 未知
公开(公告)号：DE60135839D1
公开(公告)日：2008-10-30
申请号：DE60135839
申请日：2001-04-09
申请人： UNIV STRATHCLYDE GLASGOW
发明人： SMITH WILLIAM EWEN , GRAHAM DUNCAN , MCHUGH CALLUM JOHN , KEIR RUTH LYNDSEY , WHITE PETER CYRIL , CAMPBELL MAIRI
IPC分类号： G01N21/65 , C07D213/53 , C07D213/79 , C07D215/38 , C07D249/18 , C07D333/12 , C07D403/04 , C07D487/08 , C07D487/18 , G01N33/543
摘要： The present invention relates to sensitive SE(R)RS based methods for detecting analytes such as explosives and drugs, which may be present in a sample at extremely low levels. The methods may be generally carried out in situ employing novel chemistry which is compatible with flow-cell technology and with time-scales and concentrations required for rapid and informative screening of large numbers of samples. The present invention also relates to novel compounds e.g. synthons and apparatus for use with the methods disclosed.

2. 发明专利

DE69637065T2 未知
公开(公告)号：DE69637065T2
公开(公告)日：2008-01-03
申请号：DE69637065
申请日：1996-07-25
申请人： UNIV STRATHCLYDE GLASGOW
发明人： GRAHAM DUNCAN , LINACRE ADRIAN MATTHEW , MUNRO CALUM HUGH , SMITH WILLIAM EWAN , WATSON NIGEL DEAN , WHITE PETER CYRIL
IPC分类号： C12Q1/68 , G01N33/543 , C07D249/18 , C12N15/09 , C12Q1/6816 , G01N21/65 , G01N33/566 , G01N33/58
摘要： PCT No. PCT/GB96/01830 Sec. 371 Date Apr. 21, 1998 Sec. 102(e) Date Apr. 21, 1998 PCT Filed Jul. 25, 1996 PCT Pub. No. WO97/05280 PCT Pub. Date Feb. 13, 1997The invention relates to the detection of target nucleic acids or nucleic acid units in a sample, by obtaining a SER(R)S spectrum for a SER(R)S-active complex containing, or derived directly from, the target. The complex includes at least a SER(R)S-active label, and optionally a target binding species containing a nucleic acid or nucleic acid unit. In this detection method, the concentration of the target present in the SER(R)S-active complex, or of the nucleic acid or unit contained in the target binding species in the SER(R)S-active complex, is no higher than 10-10 moles per liter. Additionally or alternatively, one or more of the following features may be used with the method: i) the introduction of a polyamine; ii) modification of the target, and/or of the nucleic acid or nucleic acid unit contained in the target binding species, in a manner that promotes or facilitates its chemi-sorption onto a SER(R)S-active surface; iii) inclusion of a chemi-sorptive functional group in the SER(R)S-active label. The invention also provides SER(R)S-active complexes for use in such a method, a kit for use in carrying out the method or preparing the complexes and a method for sequencing a nucleic acid which comprises the use of the detection method to detect at least one target nucleotide or sequence of nucleotides within the acid.

3. 发明专利

DE60220815D1 未知
公开(公告)号：DE60220815D1
公开(公告)日：2007-08-02
申请号：DE60220815
申请日：2002-11-04
申请人： UNIV STRATHCLYDE GLASGOW , UNIV GLASGOW
发明人： SMITH WILLIAM EWEN , GRAHAM DUNCAN , COOPER JONATHAN MARK , KEIR RUTH , IGATA EISHI
IPC分类号： G01N21/65 , G01N33/58 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01J3/44 , G01N33/48 , G01N33/483
摘要： The present invention relates to a microfluidic method of generating in situ a colloid for use in detecting an analyte using for example SER(R)S, as well as a method of detecting an analyte using SER(R)S in a microfluidic system. The invention also relates to microfluidic devices for use in detecting analytes such as by way of SER(R)S signals.

4. 发明专利

DE69911007D1 未知
公开(公告)号：DE69911007D1
公开(公告)日：2003-10-09
申请号：DE69911007
申请日：1999-05-20
申请人： UNIV STRATHCLYDE GLASGOW
发明人： WHITCOMBE MARK , GRAHAM DUNCAN , SMITH EWEN
IPC分类号： G01N21/65 , C12Q1/68 , C12Q1/6825 , G01N33/50 , G01N33/543

5. 发明专利

DE60220815T2 未知
公开(公告)号：DE60220815T2
公开(公告)日：2008-03-06
申请号：DE60220815
申请日：2002-11-04
申请人： UNIV STRATHCLYDE GLASGOW , UNIV GLASGOW
发明人： SMITH WILLIAM EWEN , GRAHAM DUNCAN , COOPER JONATHAN MARK , KEIR RUTH , IGATA EISHI
IPC分类号： G01N21/65 , G01N33/58 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01J3/44 , G01N33/48 , G01N33/483
摘要： The present invention relates to a microfluidic method of generating in situ a colloid for use in detecting an analyte using for example SER(R)S, as well as a method of detecting an analyte using SER(R)S in a microfluidic system. The invention also relates to microfluidic devices for use in detecting analytes such as by way of SER(R)S signals.

6. 发明专利

DE69637065D1 未知
公开(公告)号：DE69637065D1
公开(公告)日：2007-06-14
申请号：DE69637065
申请日：1996-07-25
申请人： UNIV STRATHCLYDE GLASGOW
发明人： GRAHAM DUNCAN , LINACRE ADRIAN MATTHEW , MUNRO CALUM HUGH , SMITH WILLIAM EWAN , WATSON NIGEL DEAN , WHITE PETER CYRIL
IPC分类号： C12Q1/68 , G01N33/543 , C07D249/18 , C12N15/09 , C12Q1/6816 , G01N21/65 , G01N33/566 , G01N33/58
摘要： PCT No. PCT/GB96/01830 Sec. 371 Date Apr. 21, 1998 Sec. 102(e) Date Apr. 21, 1998 PCT Filed Jul. 25, 1996 PCT Pub. No. WO97/05280 PCT Pub. Date Feb. 13, 1997The invention relates to the detection of target nucleic acids or nucleic acid units in a sample, by obtaining a SER(R)S spectrum for a SER(R)S-active complex containing, or derived directly from, the target. The complex includes at least a SER(R)S-active label, and optionally a target binding species containing a nucleic acid or nucleic acid unit. In this detection method, the concentration of the target present in the SER(R)S-active complex, or of the nucleic acid or unit contained in the target binding species in the SER(R)S-active complex, is no higher than 10-10 moles per liter. Additionally or alternatively, one or more of the following features may be used with the method: i) the introduction of a polyamine; ii) modification of the target, and/or of the nucleic acid or nucleic acid unit contained in the target binding species, in a manner that promotes or facilitates its chemi-sorption onto a SER(R)S-active surface; iii) inclusion of a chemi-sorptive functional group in the SER(R)S-active label. The invention also provides SER(R)S-active complexes for use in such a method, a kit for use in carrying out the method or preparing the complexes and a method for sequencing a nucleic acid which comprises the use of the detection method to detect at least one target nucleotide or sequence of nucleotides within the acid.

7. 发明专利

DE69911007T2 未知
公开(公告)号：DE69911007T2
公开(公告)日：2004-07-08
申请号：DE69911007
申请日：1999-05-20
申请人： UNIV STRATHCLYDE GLASGOW
发明人： WHITCOMBE MARK , GRAHAM DUNCAN , SMITH EWEN
IPC分类号： G01N21/65 , C12Q1/68 , C12Q1/6825 , G01N33/50 , G01N33/543

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