专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007129113A3 PHENOTYPE PREDICTION 审中-公开
标题翻译： PHENOTYPE预测
公开(公告)号：WO2007129113A3
公开(公告)日：2008-05-02
申请号：PCT/GB2007050229
申请日：2007-05-02
申请人： UNIV SOUTHAMPTON , AUCKLAND UNISERVICES LTD , GODFREY KEITH MALCOLM , HANSON MARK ADRIAN , BURDGE GRAHAM CHARLES , LILLYCROP KAREN ANN , COOPER CYRUS , GLUCKMAN PETER DAVID , VICKERS MARK HEDLEY
发明人： GODFREY KEITH MALCOLM , HANSON MARK ADRIAN , BURDGE GRAHAM CHARLES , LILLYCROP KAREN ANN , COOPER CYRUS , GLUCKMAN PETER DAVID , VICKERS MARK HEDLEY
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/154 , C12Q2600/158
摘要： Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual.
摘要翻译：检测基因或基因组合的表观遗传改变，特别是甲基化，优选在围产期组织样品例如脐带中，用于预测多种表型特征如肥胖倾向，改变的身体组成，认知受损，低骨矿物质含量，神经行为问题和改变的心血管结构和功能发生在个体。

2. 发明申请

WO2010086663A3 PREDICTIVE USE OF CPG METHYLATION 审中-公开
标题翻译：预防性使用CPG甲基化
公开(公告)号：WO2010086663A3
公开(公告)日：2010-11-11
申请号：PCT/GB2010050141
申请日：2010-01-29
申请人： UNIV SOUTHAMPTON , AUCKLAND UNISERVICES LTD , AGRES LTD , GODFREY KEITH MALCOLM , HANSON MARK ADRIAN , BURDGE GRAHAM CHARLES , LILLYCROP KAREN ANN , SLATER-JEFFERIES JOANNE LESLEY , COOPER CYRUS , GLUCKMAN PETER DAVID , SHEPPARD ALLAN MICHAEL
发明人： GODFREY KEITH MALCOLM , HANSON MARK ADRIAN , BURDGE GRAHAM CHARLES , LILLYCROP KAREN ANN , SLATER-JEFFERIES JOANNE LESLEY , COOPER CYRUS , GLUCKMAN PETER DAVID , SHEPPARD ALLAN MICHAEL
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2523/125 , C12Q2600/154
摘要： Determination of the methylation status of individual selected Cp/G dinucleotides/ CpG groups 5' to the coding region of selected genes, preferably in a perinatal tissue sample such as umbilical cord, can be used to predict future development of diverse phenotypic characteristics, such as indices of body composition indicative of, for example, obesity or low bone mineral content, indices of impaired cardiovascular structure or function, ability to learn and cognitive function, neurobehavourial problems and allergic disorders such as atopic eczema.
摘要翻译：单独选择的Cp / G二核苷酸/ CpG基团的5'甲基化状态的测定可以用于预测未来发展的多种表型特征，例如选择的基因的编码区，优选在围产期组织样品例如脐带指示例如肥胖或低骨矿物质含量的心理结构指数，心血管结构或功能受损的指标，学习能力和认知功能，神经营养问题和过敏性疾病如特应性湿疹。

3. 发明专利

CA2650443A1 PHENOTYPE PREDICTION 未知
公开(公告)号：CA2650443A1
公开(公告)日：2007-11-15
申请号：CA2650443
申请日：2007-05-02
申请人： UNIV SOUTHAMPTON , AUCKLAND UNISERVICES LTD
发明人： GODFREY KEITH MALCOLM , BURDGE GRAHAM CHARLES , HANSON MARK ADRIAN , LILLYCROP KAREN ANN , VICKERS MARK HEDLEY , GLUCKMAN PETER DAVID , COOPER CYRUS
IPC分类号： C12Q1/68
摘要： Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting cognitive development in an individual.

4. 发明申请

WO2015030677A3 A METHOD OF PREDICTING ONE OR MORE NEURO-DEVELOPMENTAL PHENOTYPES OF A SUBJECT 审中-公开
标题翻译：预测一个或多个神经发育基因的方法
公开(公告)号：WO2015030677A3
公开(公告)日：2016-08-25
申请号：PCT/SG2014000404
申请日：2014-08-27
申请人： UNIV SOUTHAMPTON , AGENCY SCIENCE TECH & RES
发明人： LILLYCROP KAREN ANN , GODFREY KEITH MALCOLM , HOLBROOK JOANNA DAWN
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12Q1/6883 , C12Q2600/154
摘要： The present application relates to a method of predicting at least one neuro-developmental phenotype of a subject, comprising detecting a degree of an epigenetic alteration of at least one gene or a regulatory element of the at least one gene in a sample of the subject, wherein the at least one gene is selected from the group consisting of DBH, KLK7, HES1, NR4A2, COMT, FAM83F, FANK1, MPP3, CMBL, C21 orf49, C11 orf61, TMEM65, IL1RN, SLC35F5, OR6N2, NFE2L2, TTC26, EYA2, TCF4, GAS2L3, ZMPSTE24, CIB4, LONRF1, KLRC4, RTN3, FGFBP3, RNF103, INHBA-AS1, CIA01, CLEC12A, SIM2, ACADSB, C9orf5, ABCA5, FER1L5, DERA, FGF11, ETS1, GAB1, CNN1, and OR1S1, and wherein the degree of the epigenetic alteration of the at least one gene or the regulatory element of the at least one gene indicates the - neuro-developmental phenotype of the subject. There is also provided a kit for performing a method of predicting at least one neuro-developmental phenotype of a subject, and a method of screening a prenatal composition for improving at least one neuro-developmental phenotype of a subject.
摘要翻译：本申请涉及预测受试者的至少一种神经发育表型的方法，其包括检测受试者样品中至少一种基因的至少一种基因或调节元件的表观遗传改变程度，其中所述至少一个基因选自由DBH，KLK7，HES1，NR4A2，COMT，FAM83F，FANK1，MPP3，CMBL，C21或f49，C11或f61，TMEM65，IL1RN，SLC35F5，OR6N2，NFE2L2，TTC26，EYA2组成的组，TCF4，GAS2L3，ZMPSTE24，CIB4，LONRF1，KLRC4，RTN3，FGFBP3，RNF103，INHBA-AS1，CIA01，CLEC12A，SIM2，ACADSB，C9orf5，ABCA5，FER1L5，DERA，FGF11，ETS1，GAB1，CNN1和OR1S1，并且其中所述至少一种基因或所述至少一种基因的调节元件的表观遗传改变程度指示所述受试者的神经发育表型。还提供了用于进行预测受试者的至少一种神经发育表型的方法的试剂盒，以及筛选用于改善受试者的至少一种神经发育表型的产前组合物的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式