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1. 发明申请

WO2007027764A3 NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 审中-公开
标题翻译：新型线性离子阱用于质谱分析
公开(公告)号：WO2007027764A3
公开(公告)日：2007-12-13
申请号：PCT/US2006033843
申请日：2006-08-30
申请人： UNIV ROCKEFELLER , KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： B01D59/44
CPC分类号： H01J49/423
摘要： A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross- section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.
摘要翻译：用于操纵离子阱中的离子的方法包括根据质荷比存储离子，空间压缩和喷射选定的离子。离子阱包括注入口，具有用于限制和空间压缩离子的第一和第二端的臂以及用于从第二端喷射离子的喷射口。该臂包括两对相对的电极，其在离子阱的任何横截面处提供四极电场电势。相对电极之间的距离和电极的横截面积从第一端到第二端增加。电极可以是锥形圆柱形棒或双曲线横截面。选择用于喷射的离子在空间上压缩成第二（较宽）端的区域。离子阱可以包括一个臂，具有正交或轴向喷射，或者两个臂具有用于正交喷射的中心插入物。

2. 发明申请

WO9938185A3 SPECTROMETER PROVIDED WITH PULSED ION SOURCE AND TRANSMISSION DEVICE TO DAMP ION MOTION AND METHOD OF USE 审中-公开
标题翻译：提供脉冲离子源和传输装置的光谱仪进行吸附离子运动和使用方法
公开(公告)号：WO9938185A3
公开(公告)日：1999-10-21
申请号：PCT/CA9900034
申请日：1999-01-25
申请人： UNIV MANITOBA , KRUTCHINSKY ANDREW N , LOBODA ALEXANDRE V , SPICER VICTOR L , ENS ERICH W , STANDING KENNETH G
发明人： KRUTCHINSKY ANDREW N , LOBODA ALEXANDRE V , SPICER VICTOR L , ENS ERICH W , STANDING KENNETH G
IPC分类号： H01J49/42 , H01J1/00 , H01J49/10 , H01J49/40 , H01J49/04
CPC分类号： H01J49/063 , H01J49/10 , H01J49/40
摘要： A method and apparatus are provided for providing an ion transmission device or interface between an ion source and a spectrometer. The ion transmission device can include a multipole rod set and includes a damping gas, to damp spatial and energy spreads of ions generated by a pulsed ion source. The multipole rod set has the effect of guiding the ions along an ion path, so that they can be directed into the inlet of a mass spectrometer. The invention has particular application to MALDI (matrix-assisted laser desorption/ionization) ion sources, which produce a small supersonic jet of matrix molecules and ions, which is substantially non-directional, and can have ions travelling in all available directions from the source and having a wide range of energy spreads. The ion transmission device can have a number of effects, including: substantially spreading out the generated ions along an ion axis to generate a quasi-continuous beam; reducing the energy spread of ions emitted from the source; and at least partially suppressing unwanted fragmentation of analyte ions. Consequently, a number of pulses of ions can be delivered to the time-of-flight or other spectrometer, for each cycle of the ion generation.
摘要翻译：提供了一种用于在离子源和光谱仪之间提供离子传递装置或界面的方法和装置。离子传递装置可以包括多极杆组，并且包括阻尼气体，以阻止由脉冲离子源产生的离子的空间和能量扩散。多极杆组具有沿着离子路径引导离子的作用，使得它们可以被引导到质谱仪的入口中。本发明特别适用于MALDI（基质辅助激光解吸/离子化）离子源，其产生基本无定向的基质分子和离子的小超音速射流，并且可以使离子在源的所有可用方向上行进并具有广泛的能量传播。离子传递装置可以具有许多效果，包括：基本上沿离子轴扩展产生的离子以产生准连续的束; 减少从源头发射的离子的能量传播; 并且至少部分地抑制分析物离子的不希望的碎裂。因此，对于离子产生的每个循环，可以将多个离子脉冲输送到飞行时间或其他光谱仪。

3. 发明申请

WO2014134043A2 MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于大量光谱的多点离子阱
公开(公告)号：WO2014134043A2
公开(公告)日：2014-09-04
申请号：PCT/US2014018330
申请日：2014-02-25
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , SHERMAN VADIM , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： H01J49/42
CPC分类号： H01J49/06 , H01J49/02 , H01J49/36 , H01J49/4225 , H01J49/424
摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.
摘要翻译：离子阱包括用于容纳离子的容纳区域和位于包围容纳区域的规则多面体结构上的多个电极。电极位于包围结构的每个顶点上，并且多边形表面中的至少一个包括配置成在表面上形成多个四极的附加电极。交替的RF电压被施加到多个电极，使得直接相邻的电极在任何时间点具有相等的幅度和相反的极性。在多面体结构上的这种构造形成了用于排斥来自每个正多边形表面的离子并将其包含在陷阱中的势垒。质量选择过滤器可以从四极杆形成，用于在不同的m / z窗口中进行并行质量分析。将小直流电势施加到四极体之外的平板电极优先消耗单电荷离子以增强信噪比分析。

4. 发明公开

EP1928582A4 NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 有权
标题翻译：新的线性离子阱质谱FOR
公开(公告)号：EP1928582A4
公开(公告)日：2011-01-05
申请号：EP06813946
申请日：2006-08-30
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： H01J49/42 , B01D59/44
CPC分类号： H01J49/423

5. 发明公开

EP2962094A4 MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 有权
标题翻译：多极离子陷阱MASS
公开(公告)号：EP2962094A4
公开(公告)日：2016-10-12
申请号：EP14756573
申请日：2014-02-25
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , SHERMAN VADIM , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： G01N27/62 , G01N27/70 , G01T1/185 , H01J49/02 , H01J49/06 , H01J49/36 , H01J49/42
CPC分类号： H01J49/06 , H01J49/02 , H01J49/36 , H01J49/4225 , H01J49/424
摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.

6. 发明专利

CA2620608A1 NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 未知
公开(公告)号：CA2620608A1
公开(公告)日：2007-03-08
申请号：CA2620608
申请日：2006-08-30
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： B01D59/44
摘要： A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross-section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.

7. 发明专利

CA2620608C NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 未知
公开(公告)号：CA2620608C
公开(公告)日：2014-08-12
申请号：CA2620608
申请日：2006-08-30
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： H01J49/00 , H01J49/26 , H01J49/42
摘要： A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross-section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.

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