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1. 发明申请

WO2007027764A3 NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 审中-公开
标题翻译：新型线性离子阱用于质谱分析
公开(公告)号：WO2007027764A3
公开(公告)日：2007-12-13
申请号：PCT/US2006033843
申请日：2006-08-30
申请人： UNIV ROCKEFELLER , KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： B01D59/44
CPC分类号： H01J49/423
摘要： A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross- section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.
摘要翻译：用于操纵离子阱中的离子的方法包括根据质荷比存储离子，空间压缩和喷射选定的离子。离子阱包括注入口，具有用于限制和空间压缩离子的第一和第二端的臂以及用于从第二端喷射离子的喷射口。该臂包括两对相对的电极，其在离子阱的任何横截面处提供四极电场电势。相对电极之间的距离和电极的横截面积从第一端到第二端增加。电极可以是锥形圆柱形棒或双曲线横截面。选择用于喷射的离子在空间上压缩成第二（较宽）端的区域。离子阱可以包括一个臂，具有正交或轴向喷射，或者两个臂具有用于正交喷射的中心插入物。

2. 发明申请

WO2014134043A2 MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 审中-公开
标题翻译：用于大量光谱的多点离子阱
公开(公告)号：WO2014134043A2
公开(公告)日：2014-09-04
申请号：PCT/US2014018330
申请日：2014-02-25
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , SHERMAN VADIM , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： H01J49/42
CPC分类号： H01J49/06 , H01J49/02 , H01J49/36 , H01J49/4225 , H01J49/424
摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.
摘要翻译：离子阱包括用于容纳离子的容纳区域和位于包围容纳区域的规则多面体结构上的多个电极。电极位于包围结构的每个顶点上，并且多边形表面中的至少一个包括配置成在表面上形成多个四极的附加电极。交替的RF电压被施加到多个电极，使得直接相邻的电极在任何时间点具有相等的幅度和相反的极性。在多面体结构上的这种构造形成了用于排斥来自每个正多边形表面的离子并将其包含在陷阱中的势垒。质量选择过滤器可以从四极杆形成，用于在不同的m / z窗口中进行并行质量分析。将小直流电势施加到四极体之外的平板电极优先消耗单电荷离子以增强信噪比分析。

3. 发明申请

WO02083275A9 METHOD AND SYSTEM FOR MASS SPECTROSCOPY 审中-公开
标题翻译：大量光谱法的方法与系统
公开(公告)号：WO02083275A9
公开(公告)日：2003-03-20
申请号：PCT/US0211275
申请日：2002-04-10
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW , COHEN HERBERT , KALKUM MARKUS , SHERMAN VADIM , CHAIT BRIAN
IPC分类号： H01J49/16 , H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/063 , H01J49/0481 , H01J49/161 , H01J49/164
摘要： A system for determining the ratio of mass to charge of an ion including a pulsed ionizer (12), a high pressure co-linear ion guide/accelerator (14), and a mass analyzer (16). The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.
摘要翻译：一种用于确定包括脉冲离子发生器（12），高压共线性离子导向器/加速器（14）和质量分析器（16）的离子的质量与电荷的比率的系统。脉冲电离器从待分析的物质样品中产生完整的分析物离子。高压共线离子导向器/加速器与离子源接口以接收样品的完整离子。离子导向器/加速器在基本上不存在离子碎裂的同时抑制和线性加速完整离子，以提供基本上连续的完整离子束用于质量分析。质量分析器连接到离子导向器/加速器以接收离子束，并确定完整离子的质荷比。

4. 发明公开

EP1928582A4 NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 有权
标题翻译：新的线性离子阱质谱FOR
公开(公告)号：EP1928582A4
公开(公告)日：2011-01-05
申请号：EP06813946
申请日：2006-08-30
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： H01J49/42 , B01D59/44
CPC分类号： H01J49/423

5. 发明公开

EP1381446A4 METHOD AND SYSTEM FOR MASS SPECTROSCOPY 审中-公开
标题翻译：方法和systme FOR质谱
公开(公告)号：EP1381446A4
公开(公告)日：2007-05-09
申请号：EP02762030
申请日：2002-04-10
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW , COHEN HERBERT , KALKUM MARKUS , SHERMAN VADIM , CHAIT BRIAN
IPC分类号： H01J49/16 , H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/063 , H01J49/0481 , H01J49/161 , H01J49/164
摘要： A system for determining the ratio of mass to charge of an ion including a pulsed ionizer (12), a high pressure co-linear ion guide/accelerator (14), and a mass analyzer (16). The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.

6. 发明专利

CA2444614A1 METHOD AND SYSTEM FOR MASS SPECTROSCOPY 未知
公开(公告)号：CA2444614A1
公开(公告)日：2002-10-24
申请号：CA2444614
申请日：2002-04-10
申请人： UNIV ROCKEFELLER
发明人： COHEN HERBERT , KRUTCHINSKY ANDREW , SHERMAN VADIM , CHAIT BRIAN , KALKUM MARKUS
IPC分类号： H01J49/16 , H01J49/42 , H01J49/00 , B01D59/44
摘要： A system for determining the ratio of mass to charge of an ion including a pulsed ionizer (12), a high pressure co-linear ion guide/accelerator (14), a nd a mass analyzer (16). The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intac t ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.

7. 发明公开

EP2962094A4 MULTI-POLE ION TRAP FOR MASS SPECTROMETRY 有权
标题翻译：多极离子陷阱MASS
公开(公告)号：EP2962094A4
公开(公告)日：2016-10-12
申请号：EP14756573
申请日：2014-02-25
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , SHERMAN VADIM , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： G01N27/62 , G01N27/70 , G01T1/185 , H01J49/02 , H01J49/06 , H01J49/36 , H01J49/42
CPC分类号： H01J49/06 , H01J49/02 , H01J49/36 , H01J49/4225 , H01J49/424
摘要： An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.

8. 发明专利

CA2444614C METHOD AND SYSTEM FOR MASS SPECTROSCOPY 未知
公开(公告)号：CA2444614C
公开(公告)日：2010-12-07
申请号：CA2444614
申请日：2002-04-10
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW , COHEN HERBERT , KALKUM MARKUS , SHERMAN VADIM , CHAIT BRIAN
IPC分类号： H01J49/00 , B01D59/44 , H01J49/16 , H01J49/42
摘要： A system for determining the ratio of mass to charge of an ion including a pulsed ionizer (12), a high pressure co-linear ion guide/accelerator (14), and a mass analyzer (16). The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.

9. 发明专利

CA2620608A1 NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 未知
公开(公告)号：CA2620608A1
公开(公告)日：2007-03-08
申请号：CA2620608
申请日：2006-08-30
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： B01D59/44
摘要： A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross-section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.

10. 发明专利

CA2620608C NOVEL LINEAR ION TRAP FOR MASS SPECTROMETRY 未知
公开(公告)号：CA2620608C
公开(公告)日：2014-08-12
申请号：CA2620608
申请日：2006-08-30
申请人： UNIV ROCKEFELLER
发明人： KRUTCHINSKY ANDREW N , COHEN HERBERT , CHAIT BRIAN T
IPC分类号： H01J49/00 , H01J49/26 , H01J49/42
摘要： A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross-section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.

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