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1. 发明专利

JP2005224248A Process, apparatus and reagents for isolating cellular components 审中-公开
标题翻译：用于分离细胞成分的方法，装置和试剂
公开(公告)号：JP2005224248A
公开(公告)日：2005-08-25
申请号：JP2005134577
申请日：2005-05-02
申请人： Univ Rockefeller , ザロックフェラーユニヴァーシティ
发明人： FISCHETTI VINCENT A , CHEUNG AMBROSE
IPC分类号： B65D81/32 , B01D11/04 , C07H1/08 , C12M1/00 , C12M1/02 , C12M1/24 , C12M1/33 , C12N1/06 , C12N15/09 , C12N15/10
CPC分类号： C12N1/06 , C12N15/1003 , C12N15/1006
摘要： PROBLEM TO BE SOLVED: To provide a reagent, method and apparatus for effectively isolating cellular components such as ribonucleic acid (RNA) from cells.
SOLUTION: Provided are a reagent, method and apparatus for isolating cellular components such as RNA from cells in a liquid solution. The apparatus comprises (i) a holder containing RNA extractant solvent, a plurality of micron-sized particles and at least one of larger particles; (ii) a cover assembly removably fastened onto the holder and having a cavity therein which is of sufficient volume to contain the liquid medium and the extraction solvent; and (iii) a friable sealing layer adapted to be broken by the larger particle upon reciprocating motion of the container, the sealing layer being adapted to separate the extractant solvent from the liquid medium until the sealing layer is broken by the larger particle.
COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供用于从细胞中有效分离细胞成分如核糖核酸（RNA）的试剂，方法和装置。解决方案：提供了用于从液体溶液中的细胞中分离诸如RNA的细胞成分的试剂，方法和装置。该装置包括（i）包含RNA提取剂溶剂，多个微米级颗粒和至少一种较大颗粒的保持器; （ii）可拆卸地固定在保持器上且在其中具有足够体积以容纳液体介质和提取溶剂的空腔的盖组件; 和（iii）适于在容器往复运动时被较大颗粒破碎的易碎密封层，所述密封层适于将萃取剂溶剂与液体介质分离，直到密封层被较大颗粒破坏。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2006115862A Process, apparatus and reagents for isolating cellular components 有权
标题翻译：用于分离细胞成分的方法，装置和试剂
公开(公告)号：JP2006115862A
公开(公告)日：2006-05-11
申请号：JP2006024935
申请日：2006-02-01
申请人： Univ Rockefeller , ザロックフェラーユニヴァーシティ
发明人： FISCHETTI VINCENT A , CHEUNG AMBROSE
IPC分类号： B65D81/32 , C12M1/33 , B01D11/04 , C07H1/08 , C12M1/00 , C12M1/02 , C12M1/24 , C12N1/06 , C12N15/09 , C12N15/10
CPC分类号： C12N1/06 , C12N15/1003 , C12N15/1006
摘要： PROBLEM TO BE SOLVED: To provide a reagent, a method and a device for the efficient isolation of cellular components such as ribonucleic acid (RNA) from cells.
SOLUTION: The reagent, method and device for isolation of cellular components such as ribonucleic acid (RNA) from cells in a liquid solution. This device comprises (i) a holder having an RNA extraction solvent, micrometer size particles, and at least one large particle, (ii) a cover-assembling portion which is detachably attached to the holder and has a cavity having a volume enough to contain the liquid culture solution and the extraction solvent, and (iii) a fragile closing layer which is adapted to be broken with the large particles on the reciprocating movement of the device and is adapted to separate the extraction solvent from the liquid culture solution, until the closing layer is broken with the large particles.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于从细胞有效分离细胞成分如核糖核酸（RNA）的试剂，方法和装置。解决方案：用于从液体溶液中的细胞中分离细胞组分如核糖核酸（RNA）的试剂，方法和装置。该装置包括（i）具有RNA提取溶剂，微米尺寸颗粒和至少一个大颗粒的保持器，（ii）可拆卸地附接到保持器并具有足够容纳容积的空腔的盖组件部分液体培养溶液和提取溶剂，以及（iii）脆性封闭层，其适于在装置的往复运动中与大颗粒断裂，并且适于将萃取溶剂与液体培养溶液分离，直到封闭层与大颗粒断裂。版权所有（C）2006，JPO＆NCIPI

3. 发明公开

EP0152468A4 PRODUCTION OF STREPTOCOCAL M PROTEIN IMMUNOGENS AND MOLECULAR PROBES. 失效
标题翻译：制造链球菌M蛋白免疫和分子探针。
公开(公告)号：EP0152468A4
公开(公告)日：1987-03-12
申请号：EP84903223
申请日：1984-08-09
申请人： UNIV ROCKEFELLER , UNIV EMORY
发明人： SCOTT JUNE R , FISCHETTI VINCENT A
IPC分类号： A61K39/09 , A61K39/00 , C07H1/00 , C07H21/04 , C07K14/005 , C07K14/195 , C07K14/315 , C07K14/41 , C12N1/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/70 , C12P21/00 , C12Q1/14 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/569 , G01N33/577 , G01N37/00 , A61K39/02 , C07H15/12 , C07H17/00 , C12N1/20
CPC分类号： C07K14/315 , A61K39/00 , C12N15/70 , C12Q1/689 , Y10S530/806

4. 发明公开

EP2956171A4 METHODS TO PROTECT AGAINST AND TREAT MULTIPLE SCLEROSIS 有权
标题翻译： VERFAHREN ZUM SCHUTZ GEGEN MULTIPLE SKLEROSE UND ZUR BEHANDLUNG DAVON
公开(公告)号：EP2956171A4
公开(公告)日：2016-07-20
申请号：EP14751390
申请日：2014-02-14
申请人： UNIV CORNELL , UNIV ROCKEFELLER
发明人： VARTANIAN TIMOTHY , RUMAH KAREEM RASHID , FISCHETTI VINCENT A
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28
CPC分类号： C07K16/1282 , A61K31/7048 , A61K35/741 , A61K35/742 , A61K38/47 , A61K39/00 , A61K2039/505 , C07K2317/76 , C12Q1/689 , C12Q2600/118 , C12Q2600/142 , C12Y302/01017 , G01N33/56911 , G01N2333/33 , G01N2469/20 , G01N2500/04 , G01N2500/10 , G01N2800/285
摘要： The invention provides epsilon toxin (ETX) produced by Clostridium perfringens type B or type D as a causative toxin for human multiple sclerosis (MS). The invention further identifies ETX binding receptor MAL for ETX mediated cell death and other toxin-logical activities in MS. Methods and compositions to prevent humans from multiple sclerosis (MS) and/or treating MS by directly or indirectly interfering with epsilon toxin (ETX), its binding receptor (e.g., MAL), or ETX-receptor interactions so as to inhibit or suppress downstream ETX mediated receptor signaling activities are provided. Also provided are various methods to detect, diagnose, monitor, assess multiple sclerosis (MS) by determining an expression level of ETX gene or its encoding protein in human patient suspected for and/or at risk for multiple sclerosis (MS).
摘要翻译：本发明提供由产气荚膜梭菌B型或D型产生的用于人多发性硬化（MS）的致病性毒素产生的ε毒素（ETX）。本发明进一步鉴定了ETX结合受体MAL，用于ETX介导的细胞死亡和MS中的其他毒素 - 逻辑活性。通过直接或间接干扰ε-毒素（ETX），其结合受体（例如MAL）或ETX-受体相互作用来抑制或抑制多发性硬化（MS）和/或治疗MS以抑制或抑制下游的方法和组合物提供了ETX介导的受体信号传导活性。还提供了通过确定怀疑为和/或处于多发性硬化（MS）风险的人类患者中ETX基因或其编码蛋白的表达水平来检测，诊断，监测，评估多发性硬化（MS）的各种方法。

5. 发明公开

EP2882756A4 INHIBITION OF ANTIMICROBIAL TARGETS WITH REDUCED POTENTIAL FOR RESISTANCE 审中-公开
标题翻译：抑制抗菌具有减少的潜力在性目标
公开(公告)号：EP2882756A4
公开(公告)日：2016-11-23
申请号：EP13828087
申请日：2013-08-08
申请人： AVACYN PHARMACEUTICALS INC , UNIV ROCKEFELLER
发明人： FISCHETTI VINCENT A , GOLDBERG ALLAN R , SCHUCH RAYMOND
IPC分类号： C07D513/04 , A61K31/4166 , A61P31/04 , C07D233/96 , C07D235/28 , C07D239/66 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/533
CPC分类号： C07D513/04 , C07D233/86 , C07D233/96 , C07D235/28 , C07D239/66 , C07D403/04 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D413/06 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C12Q1/18 , C12Q1/533

6. 发明申请

WO2004104213A2 NUCLEIC ACIDS AND POLYPEPTIDES OF C1 BACTERIOPHAGE AND USES THEREOF 审中-公开
标题翻译： C1类细菌的核酸和多肽及其用途
公开(公告)号：WO2004104213A2
公开(公告)日：2004-12-02
申请号：PCT/US2004015052
申请日：2004-05-14
申请人： UNIV ROCKEFELLER , FISCHETTI VINCENT A , NELSON DANIEL , SCHUCH RAYMOND
发明人： FISCHETTI VINCENT A , NELSON DANIEL , SCHUCH RAYMOND
IPC分类号： C07H19/00 , C07K11/00 , C12N9/50 , C12N15/52 , C12N15/75 , C12Q20060101 , C12Q
CPC分类号： C12N9/503
摘要： The full-length nucleic acid sequence of the C1 bacteriophage is disclosed in the present application. The specific regions of the C1 genome encoding the P1yC lysin have also been identified and sequenced. The invention relates to the pharmaceutical and diagnostic utility of these sequences and provides for development of pharmaceutical compositions for treating or preventing streptococcal infections in mammals, for compositions for decontamination of inanimate surfaces and for diagnosis of streptococcal infections.
摘要翻译： C1噬菌体的全长核酸序列在本申请中公开。编码P1yC溶素的C1基因组的特定区域也已被鉴定和测序。本发明涉及这些序列的药物和诊断实用性，并且提供用于治疗或预防哺乳动物中链球菌感染的药物组合物的开发，用于无生命表面的去污组合物和用于诊断链球菌感染的组合物。

7. 发明申请

WO2004008938A3 A NOVEL METHOD TO IDENTIFY TARGETS FOR ANTIBIOTIC DEVELOPMENT 审中-公开
标题翻译：一种鉴别抗生素发展靶点的新方法
公开(公告)号：WO2004008938A3
公开(公告)日：2004-11-25
申请号：PCT/US0238880
申请日：2002-12-05
申请人： UNIV ROCKEFELLER , FISCHETTI VINCENT A , NELSON DANIEL C , LOEFFLER JUTTA
发明人： FISCHETTI VINCENT A , NELSON DANIEL C , LOEFFLER JUTTA
IPC分类号： C12N7/01 , C12Q1/04 , C12Q1/14 , C12Q1/18 , C12Q1/00 , C12Q1/70
CPC分类号： C12Q1/18 , C12Q1/04 , C12Q1/14
摘要： The present invention identifies a new approach for antibiotic development. By identifying molecules in the cell wall of bacteria responsible for binding bacteriophage lytic enzymes, the present invention focuses on the pathways for possible antibiotic development. The pathway for the bacterial molecule is critical for bacterial survival and thus serves as a target for antibiotic identification.
摘要翻译：本发明确定了抗生素发展的新方法。通过鉴定负责结合噬菌体裂解酶的细菌细胞壁中的分子，本发明集中于可能的抗生素发展的途径。细菌分子的途径对细菌存活至关重要，因此可作为抗生素鉴定的目标。

8. 发明申请

WO2004000222A3 THE USE OF BACTERIAL PHAGE ASSOCIATED LYSING PROTEINS FOR TREATING BACTERIAL DENTAL CARIES 审中-公开
标题翻译：使用细菌相关蛋白处理细菌牙科
公开(公告)号：WO2004000222A3
公开(公告)日：2004-07-01
申请号：PCT/US0319654
申请日：2003-06-23
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER , FISCHETTI VINCENT A , LOOMIS LAWRENCE
发明人： FISCHETTI VINCENT A , LOOMIS LAWRENCE
IPC分类号： A23G3/00 , A23G3/36 , A23G3/44 , A61K6/00 , A61K38/46 , A61K9/20 , A61K38/00 , A61K38/43
CPC分类号： A23G3/44 , A23G3/366 , A23G3/368 , A61K38/162 , A61K38/46 , A61K2300/00
摘要： A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：一种用于治疗细菌性龋齿的组合物和方法，所述组合物和方法通过使用有效量的至少一种特异于溶解于引起龋齿的细菌的裂解液。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

9. 发明申请

WO9318163A3 DELIVERY AND EXPRESSION OF A HYBRID SURFACE PROTEIN ON THE SURFACE OF GRAM POSITIVE BACTERIA 审中-公开
标题翻译：混合表面蛋白在GRAM阳性细菌表面的递送和表达
公开(公告)号：WO9318163A3
公开(公告)日：1993-11-11
申请号：PCT/US9302355
申请日：1993-03-12
申请人： UNIV ROCKEFELLER
发明人： FISCHETTI VINCENT A , POZZI GIANNI , SCHNEEWIND OLAF
IPC分类号： G01N33/53 , A61K38/00 , A61K38/46 , A61K39/00 , A61K39/02 , A61K39/09 , A61K39/12 , A61K39/35 , A61K39/385 , C07K14/025 , C07K14/195 , C07K14/28 , C07K14/315 , C07K19/00 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/31 , C12N15/62 , C12N15/74 , C12N15/90 , C12R1/46 , C40B40/02 , G01N33/569 , A61K37/02
CPC分类号： C40B40/02 , A61K39/00 , A61K39/385 , A61K2039/523 , A61K2039/6068 , C07K14/005 , C07K14/28 , C07K14/315 , C07K2319/00 , C07K2319/035 , C07K2319/40 , C12N15/1037 , C12N15/62 , C12N15/746 , C12N2710/20022
摘要： Process is described for the delivery and expression of hybrid surface proteins to the surface of bacteria. The transformed bacteria are useful as vaccines, for the delivery of other active peptides to animal hosts, as diagnostic reagents and for other purposes.

10. 发明申请

WO2005089527A3 LYTIC ENZYMES AND SPORE SURFACE ANTIGEN FOR DETECTION AND TREATMENT OF BACILLUS ANTHRACIS BACTERIA AND SPORES 审中-公开
标题翻译：用于检测和处理巴氏杆菌细菌和体育的LYTIC酶和表面抗原
公开(公告)号：WO2005089527A3
公开(公告)日：2008-11-20
申请号：PCT/US2005009928
申请日：2005-03-23
申请人： UNIV ROCKEFELLER , FISCHETTI VINCENT A , SCHUCH RAYMOND
发明人： FISCHETTI VINCENT A , SCHUCH RAYMOND
IPC分类号： C07H21/04 , A61K38/00 , A61K39/12 , C07K14/32 , C12Q1/04 , G01N33/569
CPC分类号： G01N33/56911 , C07K14/32 , C12Q1/04 , G01N2333/32
摘要： Novel bacteriophages of Bacillus anthracis, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described. Therapeutic and diagnostic compositions, methods and kits related thereto are also provided.
摘要翻译：描述了炭疽芽孢杆菌的新型噬菌体，其基因组的核酸，包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。还提供了与其相关的治疗和诊断组合物，方法和试剂盒。

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