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1. 发明申请

WO2004000222A3 THE USE OF BACTERIAL PHAGE ASSOCIATED LYSING PROTEINS FOR TREATING BACTERIAL DENTAL CARIES 审中-公开
标题翻译：使用细菌相关蛋白处理细菌牙科
公开(公告)号：WO2004000222A3
公开(公告)日：2004-07-01
申请号：PCT/US0319654
申请日：2003-06-23
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER , FISCHETTI VINCENT A , LOOMIS LAWRENCE
发明人： FISCHETTI VINCENT A , LOOMIS LAWRENCE
IPC分类号： A23G3/00 , A23G3/36 , A23G3/44 , A61K6/00 , A61K38/46 , A61K9/20 , A61K38/00 , A61K38/43
CPC分类号： A23G3/44 , A23G3/366 , A23G3/368 , A61K38/162 , A61K38/46 , A61K2300/00
摘要： A composition and method for treating bacterial dental caries by the use of an effective amount of at least one lytic specific for the bacteria causing dental caries. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：一种用于治疗细菌性龋齿的组合物和方法，所述组合物和方法通过使用有效量的至少一种特异于溶解于引起龋齿的细菌的裂解液。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

2. 发明申请

WO2004064732A3 THE USE OF BACTERIAL PHAGE-ASSOCIATED LYSING PROTEINS FOR PREVENTING AND TREATING BACTERIAL INFECTIONS IN HUMANS, ANIMALS AND FOWL 审中-公开
标题翻译：使用细菌相关蛋白来预防和治疗人体，动物和动物中的细菌感染
公开(公告)号：WO2004064732A3
公开(公告)日：2006-04-20
申请号：PCT/US2004001077
申请日：2004-01-16
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER , LOOMIS LAWRENCE , FISCHETTI VINCENT A
发明人： LOOMIS LAWRENCE , FISCHETTI VINCENT A
IPC分类号： A61K38/43 , A61K20060101 , A61K38/46 , A61K38/47 , A61P31/04
CPC分类号： A61K38/47
摘要： A composition and method for treating bacterial infections by the use of an effective amount of at least one lytic specific for the bacteria causing specific. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
摘要翻译：通过使用有效量的至少一种特异性细菌的裂解液来治疗细菌感染的组合物和方法。裂解酶由可能对所述细菌特异的噬菌体进行遗传编码。该酶可以是至少一种裂解蛋白或天然或修饰形式的肽。

3. 发明申请

WO2004027020A3 IDENTIFICATION OF A PHAGE ASSOCIATED LYTIC ENZYME TO RAPIDLY AND SPECIFICALLY DETECT AND KILL BACILLUS ANTHRACIS 审中-公开
标题翻译：鉴定一株噬菌体相关的淋巴酶，以快速，特异地检测和杀灭芽孢杆菌
公开(公告)号：WO2004027020A3
公开(公告)日：2004-12-02
申请号：PCT/US0315719
申请日：2003-05-19
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER , FISCHETTI VINCENT A , SCHUCH RAYMOND , NELSON DANIEL , LOOMIS LAWRENCE , TRUDIL DAVID
发明人： FISCHETTI VINCENT A , SCHUCH RAYMOND , NELSON DANIEL , LOOMIS LAWRENCE , TRUDIL DAVID
IPC分类号： A61K31/00 , A61K31/197 , A61K38/46 , A61K38/48 , A61K45/06 , C07K14/01 , C07K14/32 , C12N9/14 , C12N9/48 , C12N9/80 , C12Q1/04 , G01N33/66 , C12N9/78 , C07H21/04 , C07K17/00 , C12P21/06 , C12Q1/18 , C12Q1/34 , C12Q1/70
CPC分类号： C12N9/80 , A61K31/00 , A61K31/197 , A61K38/00 , A61K45/06 , C07K14/005 , C07K14/32 , C12N9/14 , C12N9/48 , C12N2795/10022 , C12Q1/04 , G01N33/66 , G01N2333/32 , A61K2300/00
摘要： A method and composition for treating a Bacillus anthracis infection is disclosed which comprises the steps of: administering to the site of an infection or colonization an effective amount of at least one lytic enzyme genetically coded for by a bacteriophage specific for Bacillus anthracis, wherein said at least one said lytic enzyme is specific for and has the ability to digest a cell wall of said Bacillus anthracis. The lytic enzyme may be chimeric or shuffled, and a holin protein may also be used. The sequence for the lytic enzyme gamma bacteriophage is disclosed.
摘要翻译：公开了用于治疗炭疽芽孢杆菌感染的方法和组合物，其包括以下步骤：向感染或殖民地部位施用有效量的至少一种由炭疽芽孢杆菌特异性噬菌体遗传编码的裂解酶，其中所述至少一种所述裂解酶对炭疽芽孢杆菌的细胞壁具有特异性并具有消化细胞壁的能力。裂解酶可以是嵌合或混洗的，并且也可以使用穴蛋白。披露了裂解酶γ噬菌体的序列。

4. 发明申请

WO2004027020A9 IDENTIFICATION OF A PHAGE ASSOCIATED LYTIC ENZYME TO RAPIDLY AND SPECIFICALLY DETECT AND KILL BACILLUS ANTHRACIS 审中-公开
标题翻译：鉴定相关联的LYTIC ENZYME快速和特异性检测和杀死BACILLUS ANTHRACIS
公开(公告)号：WO2004027020A9
公开(公告)日：2004-05-21
申请号：PCT/US0315719
申请日：2003-05-19
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER , FISCHETTI VINCENT A , SCHUCH RAYMOND , NELSON DANIEL , LOOMIS LAWRENCE , TRUDIL DAVID
发明人： FISCHETTI VINCENT A , SCHUCH RAYMOND , NELSON DANIEL , LOOMIS LAWRENCE , TRUDIL DAVID
IPC分类号： A61K31/00 , A61K31/197 , A61K38/46 , A61K38/48 , A61K45/06 , C07K14/01 , C07K14/32 , C12N9/14 , C12N9/48 , C12N9/80 , C12Q1/04 , G01N33/66 , C12N
CPC分类号： C12N9/80 , A61K31/00 , A61K31/197 , A61K38/00 , A61K45/06 , C07K14/005 , C07K14/32 , C12N9/14 , C12N9/48 , C12N2795/10022 , C12Q1/04 , G01N33/66 , G01N2333/32 , A61K2300/00
摘要： A method and composition for treating a Bacillus anthracis infection is disclosed which comprises the steps of: administering to the site of an infection or colonization an effective amount of at least one lytic enzyme genetically coded for by a bacteriophage specific for Bacillus anthracis, wherein said at least one said lytic enzyme is specific for and has the ability to digest a cell wall of said Bacillus anthracis. The lytic enzyme may be chimeric or shuffled, and a holin protein may also be used. The sequence for the lytic enzyme gamma bacteriophage is disclosed.
摘要翻译：公开了一种治疗炭疽芽孢杆菌感染的方法和组合物，其包括以下步骤：向感染或定植部位施用有效量的至少一种由对炭疽芽孢杆菌特异性噬菌体进行遗传编码的裂解酶，其中所述至少一种所述溶解酶对所述炭疽芽孢杆菌的细胞壁是特异性的并且具有消化所述炭疽芽孢杆菌的细胞壁的能力。溶解酶可以是嵌合的或洗牌的，也可以使用霍宁蛋白。公开了溶解酶γ噬菌体的序列。

5. 发明申请

WO02102405B1 THE USE OF BACTERIAL PHAGE ASSOCIATED LYTIC ENZYMES TO PREVENT FOOD POISONING 审中-公开
标题翻译：使用细菌相关的LYTIC ENZYMES预防食物毒素
公开(公告)号：WO02102405B1
公开(公告)日：2004-04-15
申请号：PCT/US0142886
申请日：2001-11-01
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER , FISCHETTI VINCENT , LOOMIS LAWRENCE , TRUDIL DAVID
发明人： FISCHETTI VINCENT , LOOMIS LAWRENCE , TRUDIL DAVID
IPC分类号： A23B4/22 , A23B5/16 , A23B7/155 , A23K1/165 , A23K1/17 , A23K3/00 , A23L3/3463 , A23L3/3571 , A61K38/43 , C12N9/36 , C12S3/00
CPC分类号： A23B7/155 , A23B4/22 , A23B5/16 , A23K20/189 , A23K30/00 , A23L3/3463 , A23L3/3571
摘要： The present invention discloses a method and composition for the treatment of bacterial contamination of food by the use of a phage associated lysing enzyme, preferably blended with an appropriate carrier. The method for treating food stuffs comprises treating the food stuffs with an anti-infection agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for the bacteria.. Additionally, chimeric lytic enzymes shuffled lytic enzymes, and holin proteins, either alone or in combination, may be used to treat or prevent bacterial contamination of foodstuffs. The lytic enzyme can be used for the treatment or prevention of various strains of Staphylococcus, Streptococcus, Listeria, Salmonella, E. coli, Campylobacter, Pseudomonas, Brucella, other bacteria, and an,Y combination thereof. Feed for livestock, poultry and beef in slaughterhouses, canned and bottled goods, salad bars, and eggs are just some of the food items that can be treated with at least one lytic enzyme to reduce the risk of food contamination by bacteria.
摘要翻译：本发明公开了一种通过使用噬菌体相关的裂解酶处理食物细菌污染的方法和组合物，优选与合适的载体共混。用于处理食物的方法包括用抗感染剂处理食物，所述抗感染剂包含有效量的由细菌特异性感染的细菌产生的至少一种裂解酶。另外，嵌合裂解酶洗涤裂解酶，和单独或组合的蛋白质可用于治疗或预防食品的细菌污染。溶解酶可用于治疗或预防葡萄球菌，链球菌，利斯特氏菌，沙门氏菌，大肠杆菌，弯曲杆菌，假单胞菌，布鲁杆菌，其他细菌及其Y组合的各种菌株。在屠宰场，罐装和瓶装食品，沙拉吧和鸡蛋中饲养牲畜，家禽和牛肉只是一些可以用至少一种溶解酶处理的食物，以减少细菌食物污染的风险。

6. 发明申请

WO0151073A9 THE PARENTERAL USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE THERAPEUTIC TREATMENT OF BACTERIAL INFECTIONS 审中-公开
标题翻译：细菌感染细菌治疗细菌感染的临床使用
公开(公告)号：WO0151073A9
公开(公告)日：2002-08-08
申请号：PCT/US0100913
申请日：2001-01-12
申请人： NEW HORIZONS DIAGNOSTICS CORP , FISCHETTI VINCENT , LOOMIS LAWRENCE
发明人： FISCHETTI VINCENT , LOOMIS LAWRENCE
IPC分类号： A61K47/04 , A61K31/43 , A61K31/545 , A61K38/46 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/42 , A61P31/00
CPC分类号： A61K38/46 , A61K38/162 , A61K2300/00
摘要： The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of a therapeutic agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein the lytic enzyme is selected from the group consisting of lytic enzymes, and modified lytic enzymes such as shuffled lytic enzymes, chimeric lytic enzymes, and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The therapeutic agent may additionally include a holin enzyme, which may be a shuffled holin enzyme or a chimeric holin enzyme. The injection can be done intramuscularly, subcutaneously, or intravenously.
摘要翻译：本发明公开了一种通过肠胃外引入治疗剂治疗细菌感染的方法和组合物，所述方法和组合物包含有效量的至少一种溶解酶，所述裂解酶是由细菌感染的细菌产生的，所述细菌特异于所述细菌，其中所述溶解酶被选择来自由裂解酶组成的组和改良的溶解酶如洗牌裂解酶，嵌合裂解酶及其组合，其中所述裂解酶在合适的载体中，用于将溶解酶递送到患者体内。治疗剂可以另外包括可以是洗牌的胃蛋白酶或嵌合整合酶的胃蛋白酶。注射可以肌内，皮下或静脉内注射。

7. 发明申请

WO0151073A2 THE PARENTERAL USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE THERAPEUTIC TREATMENT OF BACTERIAL INFECTIONS 审中-公开
标题翻译：细菌感染细菌治疗细菌感染的临床使用
公开(公告)号：WO0151073A2
公开(公告)日：2001-07-19
申请号：PCT/US0100913
申请日：2001-01-12
申请人： NEW HORIZONS DIAGNOSTICS CORP , FISCHETTI VINCENT , LOOMIS LAWRENCE
发明人： FISCHETTI VINCENT , LOOMIS LAWRENCE
IPC分类号： A61K47/04 , A61K31/43 , A61K31/545 , A61K38/46 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/20 , A61K47/26 , A61K47/36 , A61K47/42 , A61P31/00 , A61K38/00
CPC分类号： A61K38/46 , A61K38/162 , A61K2300/00
摘要： The present invention discloses a method and composition for the treatment of bacterial infections by the parenteral introduction of a therapeutic agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein the lytic enzyme is selected from the group consisting of lytic enzymes, and modified lytic enzymes such as shuffled lytic enzymes, chimeric lytic enzymes, and combinations thereof, wherein said lytic enzyme is in an appropriate carrier for delivering the lytic enzyme into a patient. The therapeutic agent may additionally include a holin enzyme, which may be a shuffled holin enzyme or a chimeric holin enzyme. The injection can be done intramuscularly, subcutaneously, or intravenously.
摘要翻译：本发明公开了一种通过肠胃外引入治疗剂治疗细菌感染的方法和组合物，所述方法和组合物包含有效量的至少一种溶解酶，所述裂解酶是由细菌感染的细菌产生的，所述细菌特异于所述细菌，其中所述溶解酶被选择来自由裂解酶组成的组和改良的溶解酶如洗牌裂解酶，嵌合裂解酶及其组合，其中所述裂解酶在合适的载体中，用于将溶解酶递送到患者体内。治疗剂可以另外包括可以是洗牌的胃蛋白酶或嵌合整合酶的胃蛋白酶。注射可以肌内，皮下或静脉内注射。

8. 发明申请

WO0119385A3 THE USE OF BACTERIAL PHAGE ASSOCIATED LYSING ENZYMES FOR THE PROPHYLACTIC AND THERAPEUTIC TREATMENT OF VARIOUS ILLNESSES 审中-公开
标题翻译：细菌病相关的解痉酶在预防和治疗各种疾病中的应用
公开(公告)号：WO0119385A3
公开(公告)日：2001-11-22
申请号：PCT/US0025093
申请日：2000-09-14
申请人： NEW HORIZONS DIAGNOSTICS CORP , FISCHETTI VINCENT , LOOMIS LAWRENCE
发明人： FISCHETTI VINCENT , LOOMIS LAWRENCE
IPC分类号： A61K38/43 , A61K9/30 , A61K38/00 , A61K38/46 , A61P31/04 , C12N9/50 , A61K38/48 , A61P15/02 , A61P17/02 , A61P27/02 , A61P31/02
CPC分类号： A61K9/00 , A61K38/00 , A61L15/00 , C12N9/503 , Y10S424/15 , Y10S514/924 , Y10S514/937 , Y10S514/944 , Y10S514/948
摘要： A method for the prophylactic and therapeutic treatment of bacterial infections is disclosed which comprises the treatment of an individual with an effective amount of a modified version of a lytic enzyme produced by a bacteria infected with a bacteriophage specific for said bacteria wherein said modified version of said at least one lytic enzyme is selected from the group consisting of shuffled lytic enzymes, chimeric lytic enzymes, wherein the lytic enzyme is in an environment having a pH which allows for activity of said lytic enzyme; and a carrier for delivering said lytic enzyme. Additionally, a holin enzyme for puncturing the membrane may be included in the composition. This method, and composition can be used for the treatment of upper respiratory infections, skin infections, wounds, and burns, vaginal infections, eye infections, intestinal disorders and dental problems.
摘要翻译：公开了预防和治疗细菌感染的方法，其包括用有效量的由细菌噬菌体感染的细菌产生的裂解酶的修饰形式的治疗，所述细菌特异于所述细菌，其中所述修饰形式的所述至少一种裂解酶选自由改组裂解酶，嵌合裂解酶组成的组，其中裂解酶处于具有允许所述裂解酶活性的pH的环境中; 和输送所述裂解酶的载体。另外，用于穿刺膜的穴蛋白酶可以包含在组合物中。该方法和组合物可用于治疗上呼吸道感染，皮肤感染，伤口和烧伤，阴道感染，眼部感染，肠道疾病和牙齿问题。

9. 发明公开

EP1333854A4 THE USE OF BACTERIAL PHAGE ASSOCIATED LYTIC ENZYMES TO PREVENT FOOD POISONING 审中-公开
标题翻译： BACTERIELLEN相关噬菌体来裂解酶防止食品中毒USE
公开(公告)号：EP1333854A4
公开(公告)日：2005-10-05
申请号：EP01274135
申请日：2001-11-01
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER
发明人： FISCHETTI VINCENT , LOOMIS LAWRENCE , TRUDIL DAVID
IPC分类号： A23B4/22 , A23B5/16 , A23B7/155 , A23K1/165 , A23K1/17 , A23K3/00 , A23L3/3463 , A23L3/3571 , A61K38/43 , C12N9/36 , C12S3/00
CPC分类号： A23B7/155 , A23B4/22 , A23B5/16 , A23K20/189 , A23K30/00 , A23L3/3463 , A23L3/3571
摘要： The present invention discloses a method and composition for the treatment of bacterial contamination of food by the use of a phage associated lysing enzyme, preferably blended with an appropriate carrier. The method for treating food stuffs comprises treating the food stuffs with an anti-infection agent comprising an effective amount of at least one lytic enzyme produced by a bacteria infected with a bacteriophage specific for the bacteria.. Additionally, chimeric lytic enzymes shuffled lytic enzymes, and holin proteins, either alone or in combination, may be used to treat or prevent bacterial contamination of foodstuffs. The lytic enzyme can be used for the treatment or prevention of various strains of Staphylococcus, Streptococcus, Listeria, Salmonella, E. coli, Campylobacter, Pseudomonas, Brucella, other bacteria, and an,Y combination thereof. Feed for livestock, poultry and beef in slaughterhouses, canned and bottled goods, salad bars, and eggs are just some of the food items that can be treated with at least one lytic enzyme to reduce the risk of food contamination by bacteria.
摘要翻译：本发明盘通过使用相关联的裂解酶，优选与适当的载体混合的噬菌体的松用于食品的细菌污染的处理的方法和组合物。用于治疗食品，该方法包括在抗感染剂治疗的食品有效量的由感染了噬菌体特异于细菌的细菌产生的至少一种溶解酶的包括。的溶解酶是优选在pH为哪个溶解酶。所述的活性允许一个环境。的溶解酶可用于治疗或预防金黄色葡萄球菌，链球菌属，利斯特氏菌属，沙门氏菌，大肠杆菌，弯曲杆菌属，假单胞菌属，布鲁氏杆菌的各种菌株，其它细菌和它们的任意组合。家畜饲料，家禽屠宰场的牛肉，罐装和瓶装品，沙拉吧，和鸡蛋只是一些食品中也可以与至少一种裂解酶进行处理，以减少食品污染的细菌的风险。

10. 发明公开

EP1501925A4 IDENTIFICATION OF A PHAGE ASSOCIATED LYTIC ENZYME TO RAPIDLY AND SPECIFICALLY DETECT AND KILL BACILLUS ANTHRACIS 审中-公开
标题翻译：识别相关联的PHAG溶解酶快速和具体的证据和杀灭炭疽杆菌
公开(公告)号：EP1501925A4
公开(公告)日：2006-10-25
申请号：EP03768500
申请日：2003-05-19
申请人： NEW HORIZONS DIAGNOSTICS CORP , UNIV ROCKEFELLER
发明人： FISCHETTI VINCENT A , SCHUCH RAYMOND , NELSON DANIEL , LOOMIS LAWRENCE , TRUDIL DAVID
IPC分类号： A61K31/00 , A61K31/197 , A61K38/46 , A61K38/48 , A61K45/06 , C07K14/01 , C07K14/32 , C12N9/14 , C12N9/48 , C12N9/80 , C12Q1/04 , G01N33/66 , C12N9/78 , C07H21/04 , C07K17/00 , C12Q1/18 , C12Q1/34 , C12Q1/70
CPC分类号： C12N9/80 , A61K31/00 , A61K31/197 , A61K38/00 , A61K45/06 , C07K14/005 , C07K14/32 , C12N9/14 , C12N9/48 , C12N2795/10022 , C12Q1/04 , G01N33/66 , G01N2333/32 , A61K2300/00
摘要： A method and composition for treating a Bacillus anthracis infection is disclosed which comprises the steps of: administering to the site of an infection or colonization an effective amount of at least one lytic enzyme genetically coded for by a bacteriophage specific for Bacillus anthracis, wherein said at least one said lytic enzyme is specific for and has the ability to digest a cell wall of said Bacillus anthracis. The lytic enzyme may be chimeric or shuffled, and a holin protein may also be used. The sequence for the lytic enzyme gamma bacteriophage is disclosed.

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