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1. 发明申请

WO2011044328A3 METHODS TO PREPARE PATCHY MICROPARTICLES 审中-公开
标题翻译：制备贴剂微粒的方法
公开(公告)号：WO2011044328A3
公开(公告)日：2011-09-29
申请号：PCT/US2010051771
申请日：2010-10-07
申请人： UNIV PITTSBURGH , LITTLE STEVEN R , KAMALASANAN KALADHAR
发明人： LITTLE STEVEN R , KAMALASANAN KALADHAR
IPC分类号： B01J13/02 , B01J13/14
CPC分类号： B01J13/18 , Y10T428/2982 , Y10T428/2991
摘要： A method for making microparticles having an exterior surface that includes preparing a self-assembled arrangement of microparticles; contacting the self- assembled microparticles with a patch-forming agent resulting in a microparticle/patch-forming agent assembly having proximal regions between adjacent microparticles and/or proximal regions between a microparticle and another substrate, wherein the patch-forming agent is present in the proximal region; and condensing the patch- forming agent such that a pattern of a plurality of discrete patches of patch-forming agent are formed on the exterior surfaces of the microparticles at the proximal regions. A synthetic microsphere having an exterior spherical surface, wherein the exterior spherical surface comprises a first material and a plurality of discrete, uniformly-dimensioned, patches of a second bioactive material arranged in an orderly array over more than one hemisphere of the microsphere.
摘要翻译：一种制造具有外表面的微粒的方法，所述方法包括制备微粒的自组装排列; 使自组装微粒与补丁形成剂接触，产生微粒/补丁形成剂组件，其具有邻近微粒之间的近侧区域和/或微粒与另一基底之间的近侧区域，其中所述补丁形成剂存在于近端区域; 以及使所述斑块形成剂冷凝，使得在所述近端区域处的所述微粒的外表面上形成斑块形成剂的多个离散贴片的图案。具有外部球形表面的合成微球体，其中所述外部球形表面包含第一材料和多个离散的，均匀尺寸的第二生物活性材料的贴片，所述第二生物活性材料贴片以有序排列的方式排列在所述微球体的多于一个半球上。

2. 发明公开

EP2964194A4 THERMORESPONSIVE HYDROGEL CONTAINING POLYMER MICROPARTICLES FOR NONINVASIVE OCULAR DRUG DELIVERY 有权
标题翻译： HEAT SENSIBLES水凝胶随着高分子无创眼部药物释放
公开(公告)号：EP2964194A4
公开(公告)日：2016-08-24
申请号：EP14761105
申请日：2014-03-04
申请人： UNIV PITTSBURGH
发明人： FEDORCHAK MORGAN V , LITTLE STEVEN R , SCHUMAN JOEL S , CUGINI ANTHONY
IPC分类号： A61K9/50 , A61K9/06 , A61K9/10 , A61K31/498 , A61K47/34 , A61P27/02 , A61P27/06
CPC分类号： A61K9/5021 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K9/10 , A61K9/5031 , A61K31/498 , A61K47/34

3. 发明公开

EP2475396A4 ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERY 审中-公开
标题翻译：操纵微粒透露有关大分子
公开(公告)号：EP2475396A4
公开(公告)日：2013-10-16
申请号：EP10816175
申请日：2010-09-10
申请人： UNIV PITTSBURGH
发明人： LITTLE STEVEN R , ROTHSTEIN SAM
IPC分类号： A61K47/36 , A61K9/20 , A61K9/22 , A61K47/30 , A61K47/48
CPC分类号： A61K47/34 , A61K9/1647 , A61K9/1694 , A61K9/48
摘要： A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition; assessing degradation effect on release of the active agent from the composition including plotting polymer molecular weight (Mwr) at onset of active agent release vs. active agent molecular weight (MwA); predicting performance of multiple potential formulations for the composition based on the degradation assessment and average polymer matrix initial molecular weight (Mwo) to define a library of building blocks; determining the optimal ratio of the building blocks to satisfy a specified release profile; and making a modified release composition based on the optimal ratio determination.

4. 发明申请

WO2011031996A3 ENGINEERED MICROPARTICLES FOR MACROMOLECULE DELIVERY 审中-公开
标题翻译：用于大分子量递送的工程微粒
公开(公告)号：WO2011031996A3
公开(公告)日：2011-10-06
申请号：PCT/US2010048465
申请日：2010-09-10
申请人： UNIV PITTSBURGH , LITTLE STEVEN R , ROTHSTEIN SAM
发明人： LITTLE STEVEN R , ROTHSTEIN SAM
IPC分类号： A61K47/36 , A61K9/20 , A61K9/22 , A61K47/30 , A61K47/48
CPC分类号： A61K47/34 , A61K9/1647 , A61K9/1694 , A61K9/48
摘要： A method for making a modified release composition, comprising: selecting a desired active agent and polymer matrix for formulating into a modified release composition; assessing degradation effect on release of the active agent from the composition including plotting polymer molecular weight (Mwr) at onset of active agent release vs. active agent molecular weight (MwA); predicting performance of multiple potential formulations for the composition based on the degradation assessment and average polymer matrix initial molecular weight (Mwo) to define a library of building blocks; determining the optimal ratio of the building blocks to satisfy a specified release profile; and making a modified release composition based on the optimal ratio determination.
摘要翻译：一种制备改性释放组合物的方法，包括：选择用于配制成改良释放组合物的所需活性剂和聚合物基质; 评估活性剂从组合物中释放的降解作用，包括在活性剂释放开始时相对活性剂分子量（MwA）绘制聚合物分子量（Mwr）; 基于降解评估和平均聚合物基质初始分子量（Mwo）预测组合物的多种潜在制剂的性能以确定构件块的文库; 确定构件块的最佳比例以满足指定的释放曲线; 并且基于最佳比率确定制造改良释放组合物。

5. 发明专利

CA3082148A1 COMPOSITIONS AND METHODS FOR ADMINISTERING A YAP1/WWRT1 INHIBITING COMPOSITION AND A GLS1 INHIBITING COMPOSITION 未知
公开(公告)号：CA3082148A1
公开(公告)日：2019-05-31
申请号：CA3082148
申请日：2018-11-20
申请人： UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION
发明人： ACHARYA ABHINAV PRAKASH , CHAN STEPHEN YU-WAH , LITTLE STEVEN R
IPC分类号： A61K31/501 , A61K9/14 , A61K31/409 , A61K31/473 , A61K47/34 , A61P9/12 , A61P11/00 , C07H21/04
摘要： Disclosed are compositions comprising a YAP1/WWRT1 inhibiting agent and a glutaminase inhibiting agent and methods of their use. Disclosed herein are therapeutic particles comprising a biocompatible polymer, a YAP1/WWRT1 inhibiting agent, and a glutaminase inhibiting agent. In one aspect, disclosed herein are methods of treating a pulmonary disease in a subject in need of such treatment comprising administering the therapeutic particle to the subject.

6. 发明专利

CA2939952C THERMORESPONSIVE HYDROGEL CONTAINING POLYMER MICROPARTICLES FOR NONINVASIVE OCULAR DRUG DELIVERY 未知
公开(公告)号：CA2939952C
公开(公告)日：2022-03-22
申请号：CA2939952
申请日：2014-03-04
申请人： UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION
发明人： FEDORCHAK MORGAN V , LITTLE STEVEN R , SCHUMAN JOEL S , CUGINI ANTHONY
IPC分类号： A61K9/10 , A61K9/16 , A61K31/498 , A61K47/34 , A61P27/02
摘要： A method for sustained delivery of an agent to an ocular organ in a subject, comprising topically delivering to the ocular surface a liquid thermoresponsive hydrogel comprising agent-loaded polymer microparticles, wherein the agent is sustainably released for a period of at least five days.

7. 发明专利

ES2930433T3 Hidrogel termosensible que contiene micropartículas de polímero para la administración ocular no invasiva de fármaco 未知
公开(公告)号：ES2930433T3
公开(公告)日：2022-12-12
申请号：ES14761105
申请日：2014-03-04
申请人： UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION
发明人： FEDORCHAK MORGAN V , LITTLE STEVEN R , SCHUMAN JOEL S , CUGINI ANTHONY
IPC分类号： A61K9/50 , A61K9/06 , A61K9/10 , A61K31/498 , A61K47/34 , A61P27/02 , A61P27/06

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