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    • 1. 发明申请
    • THERMO-RESPONSIVE BLOCK CO-POLYMERS, AND USE THEREOF
    • 热响应嵌段共聚物及其用途
    • WO2007075502A9
    • 2007-08-16
    • PCT/US2006048103
    • 2006-12-15
    • UNIV PENNSYLVANIAQIN SHUHUIYANG SHUDISCHER DENNISGENG YAN
    • QIN SHUHUIYANG SHUDISCHER DENNISGENG YAN
    • A61K9/50
    • A61K9/1273A61K47/34C08F293/005C08F2438/03
    • Provided are thermo-responsive polymersomes, which display cold-controlled encapsulation near the physiological temperatures, and have a PDI less than 1.2. Morphology of the thermo- responsive polymersomes is a function of the weight fraction of the hydrophilic block in the block copolymer and the number average molecular weight (Mn) of the block copolymer. When the lower critical solution temperature (LCST) is at, or slightly above physiological temperature, the thermo-responsive block displays hydrophobic properties, such that the block copolymer self-assembles in aqueous solution to form a polymersome with the thermo- responsive block occupying the core of the polymersome and the hydrophilic block occupying the corona of the polymersome. Below the LCST, the thermo-responsive block displays hydrophilic properties, such that the polymersome dissociates, providing fast release of an active agent encapsulated therein.
    • 提供的是热响应性聚合物囊泡,其显示接近生理温度的冷控制囊封,并且具有小于1.2的PDI。 热敏聚合物囊泡的形态是嵌段共聚物中亲水嵌段的重量分数和嵌段共聚物的数均分子量(Mn)的函数。 当较低临界溶解温度(LCST)处于或略高于生理温度时,热响应性嵌段显示疏水性,使得嵌段共聚物在水溶液中自组装形成聚合物体,热响应性嵌段占据 聚合物囊泡的核心和占据聚合物囊泡的冠部的亲水嵌段。 在LCST以下,热响应性嵌段显示出亲水性,使得聚合物囊泡解离,从而提供封装在其中的活性剂的快速释放。
    • 2. 发明申请
    • THERMO-RESPONSIVE BLOCK CO-POLYMERS, AND USE THEREOF
    • 热反应块共聚物及其用途
    • WO2007075502A3
    • 2008-11-20
    • PCT/US2006048103
    • 2006-12-15
    • UNIV PENNSYLVANIAQIN SHUHUIYANG SHUDISCHER DENNISGENG YAN
    • QIN SHUHUIYANG SHUDISCHER DENNISGENG YAN
    • C04B35/56
    • A61K9/1273A61K47/34C08F293/005C08F2438/03
    • Provided are thermo-responsive polymersomes, which display cold-controlled encapsulation near the physiological temperatures, and have a PDI less than 1.2. Morphology of the thermo- responsive polymersomes is a function of the weight fraction of the hydrophilic block in the block copolymer and the number average molecular weight (Mn) of the block copolymer. When the lower critical solution temperature (LCST) is at, or slightly above physiological temperature, the thermo-responsive block displays hydrophobic properties, such that the block copolymer self-assembles in aqueous solution to form a polymersome with the thermo- responsive block occupying the core of the polymersome and the hydrophilic block occupying the corona of the polymersome. Below the LCST, the thermo-responsive block displays hydrophilic properties, such that the polymersome dissociates, providing fast release of an active agent encapsulated therein.
    • 提供的是热响应聚合物囊泡,其在生理温度附近显示冷控制的包封,并且PDI小于1.2。 热响应性聚合物的形态是嵌段共聚物中亲水嵌段的重量分数和嵌段共聚物的数均分子量(Mn)的函数。 当低临界溶解温度(LCST)处于或略高于生理温度时,热响应性嵌段显示疏水性质,使得嵌段共聚物在水溶液中自组装形成聚合物体,其中热响应性嵌段占据 聚合物的核心和占聚合物的电晕的亲水性嵌段。 在LCST之下,热响应块显示出亲水性质,使得聚合物组分解,提供封装在其中的活性剂的快速释放。
    • 8. 发明申请
    • DISPLAY PIXELS, DISPLAYS, AND METHODS OF OPERATING DISPLAY PIXELS
    • 显示像素,显示器和操作显示像素的方法
    • WO2011020020A8
    • 2012-03-29
    • PCT/US2010045472
    • 2010-08-13
    • UNIV CINCINNATIHEIKENFELD JASONKREIT ERICYANG SHU
    • HEIKENFELD JASONKREIT ERICYANG SHU
    • G02F1/153
    • B01L3/502792B01L3/502715G02B26/004
    • Electrofluidic and electrowetting display pixels, electrofluidic and electro wetting displays, and methods of operating electrofluidic and electrowetting display pixels. The pixel includes a hydrophobic channel formed between first and second substrates and containing a polar fluid and a non-polar fluid, of which at least one is visible through at least one substrate. An electrode with a dielectric is electrically connected to a voltage source. A Laplace barrier defines a fluid pathway for fluid movement in the channel. The polar fluid moves a first position when the voltage source is biased at a first voltage of less than or equal to a threshold voltage to provide a first display state. The polar fluid moves to a second position when the voltage source is biased with a second voltage, greater than the first voltage, to provide a second display state.
    • 电流和电润湿显示像素,电流和电润湿显示器,以及操作电流和电润湿显示像素的方法。 该像素包括在第一和第二基底之间形成并含有极性流体和非极性流体的疏水通道,其中至少一个通过至少一个基底可见。 具有电介质的电极电连接到电压源。 拉普拉斯屏障限定了通道中流体运动的流体通道。 当电压源被偏置在小于或等于阈值电压的第一电压时,极性液体移动第一位置以提供第一显示状态。 当电压源以大于第一电压的第二电压偏置时,极性流体移动到第二位置,以提供第二显示状态。
    • 9. 发明申请
    • DISPLAY PIXELS, DISPLAYS, AND METHODS OF OPERATING DISPLAY PIXELS
    • 显示像素,显示器和操作显示像素的方法
    • WO2011020020A3
    • 2014-03-20
    • PCT/US2010045472
    • 2010-08-13
    • UNIV CINCINNATIHEIKENFELD JASONKREIT ERICYANG SHU
    • HEIKENFELD JASONKREIT ERICYANG SHU
    • G02B26/08
    • B01L3/502792B01L3/502715G02B26/004
    • Electrofluidic and electrowetting display pixels, electrofluidic and electro wetting displays, and methods of operating electrofluidic and electrowetting display pixels. The pixel includes a hydrophobic channel formed between first and second substrates and containing a polar fluid and a non-polar fluid, of which at least one is visible through at least one substrate. An electrode with a dielectric is electrically connected to a voltage source. A Laplace barrier defines a fluid pathway for fluid movement in the channel. The polar fluid moves a first position when the voltage source is biased at a first voltage of less than or equal to a threshold voltage to provide a first display state. The polar fluid moves to a second position when the voltage source is biased with a second voltage, greater than the first voltage, to provide a second display state.
    • 电流和电润湿显示像素,电流和电润湿显示器,以及操作电流和电润湿显示像素的方法。 该像素包括在第一和第二基底之间形成并含有极性流体和非极性流体的疏水通道,其中至少一个通过至少一个基底可见。 具有电介质的电极电连接到电压源。 拉普拉斯屏障限定了通道中流体运动的流体通路。 当电压源被偏置在小于或等于阈值电压的第一电压时,极性流体移动第一位置以提供第一显示状态。 当电压源以大于第一电压的第二电压偏置时,极性流体移动到第二位置,以提供第二显示状态。