专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0164752A3 ANTIBODY INHIBITING THE BINDING BETWEEN GP120 AND DC-SIGN AND SCREENING METHODS 审中-公开
标题翻译：抗体抑制GP120与DC-SIGN和筛选方法之间的结合
公开(公告)号：WO0164752A3
公开(公告)日：2002-04-18
申请号：PCT/US0106322
申请日：2001-02-28
申请人： UNIV NEW YORK , UNIV NIJMEGEN , LITTMAN DAN R , KWON DOUGLAS , KOOYK YVETTE VAN , GEIJTENBEEK TEUNIS
发明人： LITTMAN DAN R , KWON DOUGLAS , VAN KOOYK YVETTE , GEIJTENBEEK TEUNIS
IPC分类号： A61K38/17 , A61K39/00 , A61P31/18 , C07K14/705 , C07K16/10 , A01K67/027 , A61K39/21 , A61K39/39 , A61K39/395 , C12N5/10 , C12N5/20 , G01N33/53
CPC分类号： C07K16/1063 , A01K2217/05 , A61K38/178 , A61K39/00 , A61K2039/505 , A61K2039/525 , C07K14/70525 , C07K2317/77 , G01N33/5032 , G01N33/505 , G01N2333/162
摘要： The present invention demonstrates that a receptor, named DC-SIGN, is specifically expressed on dendritic cells, and facilitates infection of T lymphocytes with HIV. Assays for identifying compounds that modulate the interaction of DC-SIGN and HIV and/or T cells and macrophage are provided. Compounds so identified are also part of the present invention.
摘要翻译：本发明表明，一种称为DC-SIGN的受体在树突状细胞上特异性表达，并且有助于HIV感染T淋巴细胞。提供了用于鉴定调节DC-SIGN和HIV和/或T细胞和巨噬细胞的相互作用的化合物的测定。如此鉴定的化合物也是本发明的一部分。

2. 发明专利

AU3992101A Methods of using a facilitator of retroviral entry into cells 未知
公开(公告)号：AU3992101A
公开(公告)日：2001-09-12
申请号：AU3992101
申请日：2001-02-28
申请人： UNIV NEW YORK , UNIV NIJMEGEN
发明人： LITTMAN DAN R , KWON DOUGLAS , KOOYK YVETTE VAN , GEIJTENBEEK TEUNIS
IPC分类号： A61K38/17 , A61K39/00 , A61P31/18 , C07K14/705 , C07K16/10 , A01K67/027 , A61K39/21 , A61K39/39 , A61K39/395 , C12N5/10 , C12N5/20 , G01N33/53

3. 发明专利

CA2402054A1 ANTIBODY INHIBITING THE BINDING BETWEEN GP120 AND DC-SIGN AND SCREENING METHODS 未知
公开(公告)号：CA2402054A1
公开(公告)日：2001-09-07
申请号：CA2402054
申请日：2001-02-28
申请人： UNIV NEW YORK , UNIV NIJMEGEN
发明人： VAN KOOYK YVETTE , GEIJTENBEEK TEUNIS , LITTMAN DAN R , KWON DOUGLAS
IPC分类号： A61K38/17 , A61K39/00 , A61P31/18 , C07K14/705 , C07K16/10 , A01K67/027 , A61K39/21 , A61K39/39 , A61K39/395 , C12N5/10 , C12N5/20 , G01N33/53

4. 发明专利

AU2001239921B2 Methods of using a facilitator of retroviral entry into cells 未知
公开(公告)号：AU2001239921B2
公开(公告)日：2006-11-23
申请号：AU2001239921
申请日：2001-02-28
申请人： KATHOLIEKE UNIV NIJMEGEN , UNIV NEW YORK
发明人： GEIJTENBEEK TEUNIS , LITTMAN DAN R , KOOYK YVETTE VAN , KWON DOUGLAS
IPC分类号： C07K16/10 , A61K38/17 , A61K39/00 , A61P31/18 , C07K14/705

5. 发明专利

AT398140T 未知
公开(公告)号：AT398140T
公开(公告)日：2008-07-15
申请号：AT00921181
申请日：2000-04-19
申请人： UNIV NIJMEGEN
发明人： FIGDOR CARL , GEIJTENBEEK TEUNIS , VAN KOOYK YVETTE , TORENSMA RUURD
IPC分类号： C07K16/28 , G01N33/53 , A61K31/7004 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C12N5/06 , C12N5/08 , G01N33/574 , G01N33/577
摘要： Use of a compound (I) that binds to a C-type lectin (II) on the surface of a dendritic cell (DC) for producing a composition for modulating (especially reducing) the immune response in an animal (particularly human or other mammal), provided that (II) is not the DEC-205 receptor. Independent claims are also included for the following: (1) an antibody (Ab), preferably monoclonal, directed against a C-type lectin (IIa) having a fully defined sequence of about 400 amino acids (given in the specification) or its natural variants, equivalents, parts, fragments or epitopes; (2) a pharmaceutical composition containing Ab and at least one carrier, excipient, adjuvant or auxiliary; (3) a combination of (I) attached to an antigen (Ag) or its fragment; (4) a method for producing, isolating and/or purifying DC from a biological sample or culture medium; and (5) DC prepared by method in (4). ACTIVITY : Immunosuppressant; immunostimulant; anti-allergic; antiviral; antitumor; antibacterial; antiprotozoal. MECHANISM OF ACTION : (I) mediates adhesion between DC and other cells by inhibiting interaction between (II) and (i) an ICAM (intracellular adhesion molecule) on T cells or (ii) gp 120 on HIV (human immune deficiency virus)-infected cells. A new (II), DC-SIGN, is not only involved in DC-T cell clumping but is also a major HIV receptor. Cells of the leukemia line K562 were transfected to express ICAM-3 and tested for binding to DC. Clumping between the cells was inhibited by antibodies directed against DC-SIGN, and DC-mediated T cell proliferation was then only about 1/3 of that in an antibody-free medium. The effect was greatly increased when anti-LFA3 antibodies were additionally present (practically no proliferation).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式