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1. 发明专利

JP2009108092A Method for modulating binding activity of novel icam-3 binding receptor on sinusoidal endothelial cell in liver and lymph node 审中-公开
标题翻译：用于调节新鲜ICAM-3结合受体在肝脏和淋巴结中的神经内皮细胞上的结合活性的方法
公开(公告)号：JP2009108092A
公开(公告)日：2009-05-21
申请号：JP2008315098
申请日：2008-12-10
申请人： Stichting Katholieke Univ Radboud Univ Nijmegen Medical Center , スチヒティングカソリーケユニバーシテット, ラッドボウドユニバーシティネイメヘンメディカルセンター
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HER , KOOYK YVETTE VAN , TORENSMA RUURD
IPC分类号： C07K16/28 , C12N15/09 , A61K38/00 , A61K38/11 , A61K39/00 , A61K39/02 , A61K39/21 , A61K39/395 , A61K45/00 , A61P31/18 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/705 , C12N5/00 , C12N5/071 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： A61K39/21 , A61K38/00 , A61K39/12 , A61K2039/505 , A61K2039/6087 , C07K14/7056 , C07K16/2851 , C12N5/069 , C12N2740/16134
摘要： PROBLEM TO BE SOLVED: To provide a compound which binds to a C-type lectin on the surface of a sinusoidal endothelial cell in a liver and a lymph node for modulating the immune response in animal. SOLUTION: A use of a compound which binds to a C-type lectin on the surface of a sinusoidal endothelial layer, in the preparation of a composition for modulating, in particular reducing, the immune response in animal, in particular a human or another mammal is a use in an embodiment wherein the above sinusoidal endothelial layer is constituted by a liver sinusoidal endothelial cell (LSEC), or a use in another embodiment wherein the above sinusoidal endothelial layer is constituted by a lymph node sinusoidal zone. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供结合肝脏和淋巴结中的正弦内皮细胞表面上的C型凝集素的化合物，以调节动物的免疫应答。解决方案：在制备用于调节，特别是降低动物，特别是人类中的免疫应答的组合物中，使用与正弦内皮层表面上的C型凝集素结合的化合物或另一种哺乳动物是在上述正弦内皮层由肝窦状内皮细胞（LSEC）构成的实施方案中的用途，或在上述窦状内皮层由淋巴结正弦区构成的另一个实施方案中的用途。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2010285450A Composition and method for modulating interaction between dendritic cell and t-cell 有权
标题翻译：用于调节细胞和T细胞之间相互作用的组合物和方法
公开(公告)号：JP2010285450A
公开(公告)日：2010-12-24
申请号：JP2010176824
申请日：2010-08-05
申请人： Katholieke Univ Nijmegen , カトリーケ・ウニベルジテート・ニイメゲン
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HERMAN , VAN KOOYK YVETTE , TORENSMA RUURD
IPC分类号： A61K45/00 , G01N33/53 , A61K31/70 , A61K31/7004 , A61K31/715 , A61K38/00 , A61K39/00 , A61K39/395 , A61P3/10 , A61P19/02 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K16/18 , C07K16/28 , C12N5/06 , C12N5/0784 , C12N5/08 , C12N15/09 , G01N33/574 , G01N33/577
CPC分类号： C07K16/28 , A61K2039/505 , A61K2039/5154 , C07K16/2851 , C07K2317/73
摘要： PROBLEM TO BE SOLVED: To provide a composition and a method for modulating an interaction between a dendritic cell and T-cell. SOLUTION: A compound that binds to a C-type lectin on the surface of a dendritic cell is used for preparing a composition for modulating, in particular reducing, an immune response in an animal, in particular a human or another mammal. The composition in particular modulates the interaction between a dendritic cell and a T-cell, more specifically between a C-type lectin on the surface of a dendritic cell and an ICAM (intercellular adhesion molecule) receptor on the surface of a T-cell. The composition can be used for preventing/inhibiting an immune response to a specific antigen, for immunotherapy, for immunosuppression, for treating auto-immune diseases, for treating allergy and/or for inhibiting HIV infection. The compound that binds to a C-type lectin is preferably chosen from mannose, fucose, a plant lectin, an antibiotic, a sugar, a protein or an antibody against C-type lectin. Such the antibody and a method for isolating dendritic cells using the same are also provided. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供调节树突状细胞和T细胞之间的相互作用的组合物和方法。解决方案：结合树枝状细胞表面上的C型凝集素的化合物用于制备用于调节，特别是降低动物，特别是人或其他哺乳动物的免疫应答的组合物。该组合物特别调节树突细胞和T细胞之间的相互作用，更具体地说是树突细胞表面上的C型凝集素与T细胞表面上的ICAM（细胞间粘附分子）受体之间的相互作用。该组合物可用于预防/抑制对特异性抗原的免疫应答，免疫治疗，免疫抑制，治疗自身免疫疾病，治疗过敏和/或抑制HIV感染。与C-型凝集素结合的化合物优选选自甘露糖，岩藻糖，植物凝集素，抗生素，糖，蛋白质或抗C型凝集素的抗体。还提供了这种抗体和使用其分离树突状细胞的方法。版权所有（C）2011，JPO＆INPIT

3. 发明专利

PT1516881E COMPOSIÇÃO E MÉTODO PARA MODULAR A INTERACÇÃO CÉLULA DENDRÍTICA-CÉLULA T 未知
公开(公告)号：PT1516881E
公开(公告)日：2010-08-25
申请号：PT04078220
申请日：2000-04-19
申请人： UNIV NIJMEGEN
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HERMAN , KOOYK YVETTE VAN , TORENSMA RUURD
IPC分类号： C07K16/28 , A61K31/7004 , G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C12N5/06 , C12N5/08 , G01N33/574 , G01N33/577

4. 发明专利

DK1086137T3 未知
公开(公告)号：DK1086137T3
公开(公告)日：2008-10-27
申请号：DK00921181
申请日：2000-04-19
申请人： UNIV NIJMEGEN
发明人： FIGDOR CARL GUSTAV , TORENSMA RUURD , GEIJTENBEEK TEUNIS BERNARD HERMAN , VAN KOOYK YVETTE
IPC分类号： C07K16/28 , G01N33/53 , A61K31/7004 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C12N5/06 , C12N5/08 , G01N33/574 , G01N33/577
摘要： Use of a compound (I) that binds to a C-type lectin (II) on the surface of a dendritic cell (DC) for producing a composition for modulating (especially reducing) the immune response in an animal (particularly human or other mammal), provided that (II) is not the DEC-205 receptor. Independent claims are also included for the following: (1) an antibody (Ab), preferably monoclonal, directed against a C-type lectin (IIa) having a fully defined sequence of about 400 amino acids (given in the specification) or its natural variants, equivalents, parts, fragments or epitopes; (2) a pharmaceutical composition containing Ab and at least one carrier, excipient, adjuvant or auxiliary; (3) a combination of (I) attached to an antigen (Ag) or its fragment; (4) a method for producing, isolating and/or purifying DC from a biological sample or culture medium; and (5) DC prepared by method in (4). ACTIVITY : Immunosuppressant; immunostimulant; anti-allergic; antiviral; antitumor; antibacterial; antiprotozoal. MECHANISM OF ACTION : (I) mediates adhesion between DC and other cells by inhibiting interaction between (II) and (i) an ICAM (intracellular adhesion molecule) on T cells or (ii) gp 120 on HIV (human immune deficiency virus)-infected cells. A new (II), DC-SIGN, is not only involved in DC-T cell clumping but is also a major HIV receptor. Cells of the leukemia line K562 were transfected to express ICAM-3 and tested for binding to DC. Clumping between the cells was inhibited by antibodies directed against DC-SIGN, and DC-mediated T cell proliferation was then only about 1/3 of that in an antibody-free medium. The effect was greatly increased when anti-LFA3 antibodies were additionally present (practically no proliferation).

5. 发明专利

AU776317B2 Composition and method for modulating dendritic cell-t cell interaction 未知
公开(公告)号：AU776317B2
公开(公告)日：2004-09-02
申请号：AU4152600
申请日：2000-04-19
申请人： UNIV NIJMEGEN
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HERMAN , VAN KOOYK YVETTE , TORENSMA RUURD
IPC分类号： G01N33/53 , A61K31/7004 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K16/28 , C12N5/06 , C12N5/08 , G01N33/574 , G01N33/577
摘要： Use of a compound (I) that binds to a C-type lectin (II) on the surface of a dendritic cell (DC) for producing a composition for modulating (especially reducing) the immune response in an animal (particularly human or other mammal), provided that (II) is not the DEC-205 receptor. Independent claims are also included for the following: (1) an antibody (Ab), preferably monoclonal, directed against a C-type lectin (IIa) having a fully defined sequence of about 400 amino acids (given in the specification) or its natural variants, equivalents, parts, fragments or epitopes; (2) a pharmaceutical composition containing Ab and at least one carrier, excipient, adjuvant or auxiliary; (3) a combination of (I) attached to an antigen (Ag) or its fragment; (4) a method for producing, isolating and/or purifying DC from a biological sample or culture medium; and (5) DC prepared by method in (4). ACTIVITY : Immunosuppressant; immunostimulant; anti-allergic; antiviral; antitumor; antibacterial; antiprotozoal. MECHANISM OF ACTION : (I) mediates adhesion between DC and other cells by inhibiting interaction between (II) and (i) an ICAM (intracellular adhesion molecule) on T cells or (ii) gp 120 on HIV (human immune deficiency virus)-infected cells. A new (II), DC-SIGN, is not only involved in DC-T cell clumping but is also a major HIV receptor. Cells of the leukemia line K562 were transfected to express ICAM-3 and tested for binding to DC. Clumping between the cells was inhibited by antibodies directed against DC-SIGN, and DC-mediated T cell proliferation was then only about 1/3 of that in an antibody-free medium. The effect was greatly increased when anti-LFA3 antibodies were additionally present (practically no proliferation).

6. 发明专利

CA2330231C COMPOSITION AND METHOD FOR MODULATING DENDRITIC CELL-T CELL INTERACTION 未知
公开(公告)号：CA2330231C
公开(公告)日：2013-07-16
申请号：CA2330231
申请日：2000-04-19
申请人： UNIV NIJMEGEN
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HERMAN , VAN KOOYK YVETTE , TORENSMA RUURD
IPC分类号： C07K16/28 , G01N33/53 , A61K31/7004 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C12N5/06 , C12N5/0784 , C12N5/08 , G01N33/574 , G01N33/577
摘要： The present invention relates to the use of a compound that binds to a C-type lectin on the surface of a dendritic cell, in the preparation of a composition for modulating, in particular reducing, the immune response in an animal, in particular a human or another mammal. The composition in particular modulates the interactions between a dendritic cell and a T-cell, more specifically between a C-type lectin on the surface of a dendritic cell and an ICAM receptor on the surface of a T-cell. The compositions can be used for preventing/inhibiting immune responses to specific antigens, for inducing tolerance, for immunotherapy, for immunosuppression, for the treatment of auto-immune diseases, the treatment of allergy, and/or for inhibiting HIV infection. The compound that binds to a C-type lectin is preferably chosen from mannose, fucose, plant lectins, antibiotics, sugars, proteins or antibodies against C-type lectins. The invention also relates to such antibodies, and to a method for isolating dendritic cells using such antibodies.

7. 发明专利

AT398140T 未知
公开(公告)号：AT398140T
公开(公告)日：2008-07-15
申请号：AT00921181
申请日：2000-04-19
申请人： UNIV NIJMEGEN
发明人： FIGDOR CARL , GEIJTENBEEK TEUNIS , VAN KOOYK YVETTE , TORENSMA RUURD
IPC分类号： C07K16/28 , G01N33/53 , A61K31/7004 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C12N5/06 , C12N5/08 , G01N33/574 , G01N33/577
摘要： Use of a compound (I) that binds to a C-type lectin (II) on the surface of a dendritic cell (DC) for producing a composition for modulating (especially reducing) the immune response in an animal (particularly human or other mammal), provided that (II) is not the DEC-205 receptor. Independent claims are also included for the following: (1) an antibody (Ab), preferably monoclonal, directed against a C-type lectin (IIa) having a fully defined sequence of about 400 amino acids (given in the specification) or its natural variants, equivalents, parts, fragments or epitopes; (2) a pharmaceutical composition containing Ab and at least one carrier, excipient, adjuvant or auxiliary; (3) a combination of (I) attached to an antigen (Ag) or its fragment; (4) a method for producing, isolating and/or purifying DC from a biological sample or culture medium; and (5) DC prepared by method in (4). ACTIVITY : Immunosuppressant; immunostimulant; anti-allergic; antiviral; antitumor; antibacterial; antiprotozoal. MECHANISM OF ACTION : (I) mediates adhesion between DC and other cells by inhibiting interaction between (II) and (i) an ICAM (intracellular adhesion molecule) on T cells or (ii) gp 120 on HIV (human immune deficiency virus)-infected cells. A new (II), DC-SIGN, is not only involved in DC-T cell clumping but is also a major HIV receptor. Cells of the leukemia line K562 were transfected to express ICAM-3 and tested for binding to DC. Clumping between the cells was inhibited by antibodies directed against DC-SIGN, and DC-mediated T cell proliferation was then only about 1/3 of that in an antibody-free medium. The effect was greatly increased when anti-LFA3 antibodies were additionally present (practically no proliferation).

9. 发明专利

PT1086137E COMPOSIÇÃO E MÉTODO PARA MODULAR A INTERACÇÃO CÉLULA DENDRÍTICA-CÉLULA-T 未知
公开(公告)号：PT1086137E
公开(公告)日：2008-09-09
申请号：PT00921181
申请日：2000-04-19
申请人： UNIV NIJMEGEN
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HERMAN , KOOYK YVETTE VAN , TORENSMA RUURD
IPC分类号： C07K16/28 , A61K31/7004 , G01N33/53 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C12N5/06 , C12N5/08 , G01N33/574 , G01N33/577

10. 发明专利

AU4152600A Composition and method for modulating dendritic cell-t cell interaction 未知
公开(公告)号：AU4152600A
公开(公告)日：2000-11-02
申请号：AU4152600
申请日：2000-04-19
申请人： KATHOLIEKE UNIV NIJMEGEN
发明人： FIGDOR CARL GUSTAV , GEIJTENBEEK TEUNIS BERNARD HERMAN , VAN KOOYK YVETTE , TORENSMA RUURD
IPC分类号： G01N33/53 , A61K31/7004 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P19/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07K16/28 , C12N5/06 , C12N5/08 , G01N33/574 , G01N33/577
摘要： Use of a compound (I) that binds to a C-type lectin (II) on the surface of a dendritic cell (DC) for producing a composition for modulating (especially reducing) the immune response in an animal (particularly human or other mammal), provided that (II) is not the DEC-205 receptor. Independent claims are also included for the following: (1) an antibody (Ab), preferably monoclonal, directed against a C-type lectin (IIa) having a fully defined sequence of about 400 amino acids (given in the specification) or its natural variants, equivalents, parts, fragments or epitopes; (2) a pharmaceutical composition containing Ab and at least one carrier, excipient, adjuvant or auxiliary; (3) a combination of (I) attached to an antigen (Ag) or its fragment; (4) a method for producing, isolating and/or purifying DC from a biological sample or culture medium; and (5) DC prepared by method in (4). ACTIVITY : Immunosuppressant; immunostimulant; anti-allergic; antiviral; antitumor; antibacterial; antiprotozoal. MECHANISM OF ACTION : (I) mediates adhesion between DC and other cells by inhibiting interaction between (II) and (i) an ICAM (intracellular adhesion molecule) on T cells or (ii) gp 120 on HIV (human immune deficiency virus)-infected cells. A new (II), DC-SIGN, is not only involved in DC-T cell clumping but is also a major HIV receptor. Cells of the leukemia line K562 were transfected to express ICAM-3 and tested for binding to DC. Clumping between the cells was inhibited by antibodies directed against DC-SIGN, and DC-mediated T cell proliferation was then only about 1/3 of that in an antibody-free medium. The effect was greatly increased when anti-LFA3 antibodies were additionally present (practically no proliferation).

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