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1. 发明申请

WO2012155066A3 SPIRO-OXINDOLE MDM2 ANTAGONISTS 审中-公开
公开(公告)号：WO2012155066A3
公开(公告)日：2013-03-28
申请号：PCT/US2012037570
申请日：2012-05-11
申请人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS , UNIV MICHIGAN , SANOFI SA
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
CPC分类号： C07D487/10
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.
摘要翻译：本文提供了药物化学领域中的化合物，组合物和方法。本文提供的化合物和组合物涉及作为p53和MDM2之间相互作用的拮抗剂的螺羟吲哚，以及它们作为治疗癌症和其它疾病的治疗剂的用途。

2. 发明专利

AU2012253339A1 Spiro-oxindole MDM2 antagonists 未知
公开(公告)号：AU2012253339A1
公开(公告)日：2014-01-09
申请号：AU2012253339
申请日：2012-05-11
申请人： UNIV MICHIGAN , SANOFI SA , WANG SHAOMENG , SUN WEI , GARCIA-ECHEVERRIA CARLOS , AGUILAR ANGELO
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

3. 发明专利

SG194873A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS 未知
公开(公告)号：SG194873A1
公开(公告)日：2013-12-30
申请号：SG2013083118
申请日：2012-05-11
申请人： SANOFI SA , WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS , UNIV MICHIGAN
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

4. 发明申请

WO2012103059A3 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 审中-公开
标题翻译： BCL-2 / BCL-XL抑制剂及其治疗方法
公开(公告)号：WO2012103059A3
公开(公告)日：2012-10-18
申请号：PCT/US2012022315
申请日：2012-01-24
申请人： UNIV MICHIGAN , WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
CPC分类号： C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
摘要翻译：公开了Bcl-2 / Bcl-xL的抑制剂及其组合物。还公开了使用Bcl-2 / Bcl-xL抑制剂治疗其中Bcl-2 / Bcl-xL的抑制提供益处的疾病和病症的方法，如癌症。

5. 发明公开

EP2707372A4 SPIRO-OXINDOLE MDM2 ANTAGONISTS 有权
公开(公告)号：EP2707372A4
公开(公告)日：2014-10-22
申请号：EP12782304
申请日：2012-05-11
申请人： UNIV MICHIGAN , SANOFI SA
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
CPC分类号： C07D487/10

6. 发明专利

NZ617580A Spiro-oxindole mdm2 antagonists 未知
公开(公告)号：NZ617580A
公开(公告)日：2015-07-31
申请号：NZ61758012
申请日：2012-05-11
申请人： SANOFI SA , UNIV MICHIGAN
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
摘要： Disclosed herein are spiro-oxindole-based compounds of formula (I), compositions, and methods in the field of medicinal chemistry, wherein the variables shown in formula (I) are as defined in the specification. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of hyperproliferative disease, particularly cancer selected from the group consisting of melanoma, lung cancer, sarcoma, colon cancer, prostate cancer, choriocarcinoma, breast cancer, retinoblastoma, stomach carcinoma, acute myeloid leukemia, lymph multiple myeloma, and leukemia.

7. 发明专利

ES2624808T3 Antagonistas de MDM2 espirooxindólicos 未知
公开(公告)号：ES2624808T3
公开(公告)日：2017-07-17
申请号：ES12782304
申请日：2012-05-11
申请人： UNIV MICHIGAN REGENTS , SANOFI SA
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
摘要： Un compuesto que tiene la Fórmula II:**Fórmula** en el que: R1a, R1b, R1c y R1d se seleccionan independientemente del grupo que consiste en hidrógeno, halógeno, hidroxi, amino, nitro, ciano, alcoxi, ariloxi, alquilo opcionalmente sustituido, haloalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, cicloalquenilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, carboxamido y sulfonamido; R2 se selecciona del grupo que consiste en arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R3a y R3b tomados juntos forman un anillo de ciclopropilo, ciclobutilo, ciclopentilo, ciclohexilo o cicloheptilo opcionalmente sustituido; R4 se selecciona del grupo que consiste en hidrógeno y alquilo C1-C6 opcionalmente sustituido; R5 se selecciona del grupo que consiste en:**Fórmula** y R14 es hidrógeno o alquilo C1-C4; y R15 es hidrógeno, p es 0, 1, 2 o 3; X se selecciona del grupo que consiste en O, S y NR'; Y se selecciona del grupo que consiste en O, S y NR"; R' se selecciona del grupo que consiste en hidrógeno, alquilo opcionalmente sustituido, aralquilo y cicloalquilo opcionalmente sustituido; R" se selecciona del grupo que consiste en hidrógeno, alquilo opcionalmente sustituido, aralquilo y cicloalquilo opcionalmente sustituido; y --- representa un enlace sencillo o uno doble, o una sal farmacéuticamente del mismo; con la condición de que el compuesto no sea**Fórmula**

8. 发明专利

CA2835422C SPIRO-OXINDOLE MDM2 ANTAGONISTS 未知
公开(公告)号：CA2835422C
公开(公告)日：2016-10-11
申请号：CA2835422
申请日：2012-05-11
申请人： UNIV MICHIGAN REGENTS , SANOFI SA
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

9. 发明专利

AU2012253339B2 Spiro-oxindole MDM2 antagonists 未知
公开(公告)号：AU2012253339B2
公开(公告)日：2016-03-31
申请号：AU2012253339
申请日：2012-05-11
申请人： SANOFI SA , UNIV MICHIGAN REGENTS
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

10. 发明专利

CA2835422A1 SPIRO-OXINDOLE MDM2 ANTAGONISTS 未知
公开(公告)号：CA2835422A1
公开(公告)日：2012-11-15
申请号：CA2835422
申请日：2012-05-11
申请人： UNIV MICHIGAN , SANOFI SA
发明人： WANG SHAOMENG , SUN WEI , AGUILAR ANGELO , GARCIA-ECHEVERRIA CARLOS
IPC分类号： C07D487/10 , A61K31/407 , A61P35/00 , C07D413/12
摘要： Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

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