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1. 发明申请

WO2012103059A3 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 审中-公开
标题翻译： BCL-2 / BCL-XL抑制剂及其治疗方法
公开(公告)号：WO2012103059A3
公开(公告)日：2012-10-18
申请号：PCT/US2012022315
申请日：2012-01-24
申请人： UNIV MICHIGAN , WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
CPC分类号： C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
摘要翻译：公开了Bcl-2 / Bcl-xL的抑制剂及其组合物。还公开了使用Bcl-2 / Bcl-xL抑制剂治疗其中Bcl-2 / Bcl-xL的抑制提供益处的疾病和病症的方法，如癌症。

2. 发明专利

AU2012209295B2 Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same 未知
公开(公告)号：AU2012209295B2
公开(公告)日：2016-06-30
申请号：AU2012209295
申请日：2012-01-24
申请人： UNIV MICHIGAN REGENTS
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.

3. 发明公开

EP2668180A4 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 有权
标题翻译： BCL-2- / BCL-XL-HEMMER在DIESE VERWENDENDE THERAPEUTISCHE VERFAHREN
公开(公告)号：EP2668180A4
公开(公告)日：2014-08-13
申请号：EP12739376
申请日：2012-01-24
申请人： UNIV MICHIGAN
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
CPC分类号： C07D239/28 , C07D207/34 , C07D231/12 , C07D233/28 , C07D233/56 , C07D261/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.
摘要翻译：公开了Bcl-2 / Bcl-xL的抑制剂和含有它们的组合物。还公开了使用Bcl-2 / Bcl-xL抑制剂治疗其中抑制Bcl-2 / Bcl-xL提供益处的疾病和病症的方法，如癌症。

4. 发明专利

SG192126A1 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 未知
公开(公告)号：SG192126A1
公开(公告)日：2013-09-30
申请号：SG2013056544
申请日：2012-01-24
申请人： UNIV MICHIGAN
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.

5. 发明专利

NZ613504A Bcl-2/bcl-xl inhibitors and therapeutic methods using the same 未知
公开(公告)号：NZ613504A
公开(公告)日：2015-03-27
申请号：NZ61350412
申请日：2012-01-24
申请人： UNIV MICHIGAN
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
摘要： Disclosed are inhibitors of Bcl-2/Bcl-xL represented by the structural formula (I) shown herein, and compositions containing the same, wherein A is pyrrolyl, B, C, D, and E individually are substituted or unsubstituted phenyl, and X and Y taken together is as defined in the specification. These Bcl-2/Bcl-xL inhibitors are suitable in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers.

6. 发明专利

CA2825306A1 BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 未知
公开(公告)号：CA2825306A1
公开(公告)日：2012-08-02
申请号：CA2825306
申请日：2012-01-24
申请人： UNIV MICHIGAN
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.

7. 发明专利

CA2825306C BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 未知
公开(公告)号：CA2825306C
公开(公告)日：2019-02-26
申请号：CA2825306
申请日：2012-01-24
申请人： UNIV MICHIGAN REGENTS
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
摘要： Disclosed are inhibitors of Bcl-2/Bcl-xL having, for example, a structural formula: (see above formula) wherein A, B, C, D, E, X and Y are as defined herein. Compositions containing the same are also disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.

8. 发明专利

ES2693107T3 Inhibidores de Bcl-2/Bcl-xL para su uso en el tratamiento del cáncer 未知
公开(公告)号：ES2693107T3
公开(公告)日：2018-12-07
申请号：ES12739376
申请日：2012-01-24
申请人： UNIV MICHIGAN REGENTS
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D403/10 , A61K31/496 , A61P35/00 , C07D403/14
摘要： Un compuesto que tiene una fórmula estructural:**Fórmula** en la que A se selecciona entre el grupo que consiste en**Fórmula** en la que R1 y R2, independientemente, se seleccionan entre el grupo que consiste en H, CN, NO2, halo, alquilo, cicloalquilo, alquenilo, cicloalquenilo, alquinilo, arilo, heteroarilo, heterocicloalquilo, OR', SR', NR'R", COR', CO2R', OCOR', CONR'R", CONR'SO2R", NR'COR", NR'CONR''R'", NR'C>=SNR"R'", NR'SO2R", SO2R' y SO2NR'R"; R3 se selecciona entre un grupo que consiste en H, alquilo, cicloalquilo, alquenilo, cicloalquenilo, alquinilo, arilo, heteroarilo, heterocicloalquilo, OR', NR'R", CO2R', COR', CONR'R", CONR'SO2R", alquilen C1-3-CH(OH)CH2OH, SO2R' y SO2NR'R"; R', R" y R'", independientemente, son H, alquilo, cicloalquilo, alquenilo, cicloalquenilo, alquinilo, CF3, arilo, heteroarilo, alquilen C1-3-heterocicloaicilo o heterocicloalquilo; R' y R", o R" y R'", pueden tomarse junto con el átomo al que están unidos para formar un anillo de 3 a 7 miembros; B, C, D y E individualmente son fenilo opcionalmente sustituido, en los que el fenilo contiene de uno a cuatro sustituyentes seleccionados independientemente entre el grupo que consiste en CN, NO2, halo, alquilo, cicloalquilo, alquenilo, cicloalquenilo, alquinilo, arilo, heteroarilo, heterocicloalquilo, OR', SR', NR'R", CO2R', COR', OCOR', CONR'R", CONR'SO2R", NR'COR", NR'SO2R", alquilen C1-3-CH(OH)CH2OH, SO2R' y SO2NR'R", en los que cada R' y R", independientemente, es H, alquilo, cicloalquilo, alquenilo, cicloalquenilo, alquinilo, CF3, arilo, heteroarilo, alquilen C1-3-heterocicloalquilo o heterocicloalquilo; y X e Y se seleccionan entre el grupo que consiste en -C≡C-, -CH2-CH2-, **Fórmula** o una sal farmacéuticamente aceptable del mismo.

9. 发明专利

ZA201305571B BCL-2/BCL-XL INHIBITORS AND THERAPEUTIC METHODS USING THE SAME 未知
公开(公告)号：ZA201305571B
公开(公告)日：2014-10-29
申请号：ZA201305571
申请日：2013-07-23
申请人： UNIV MICHIGAN REGENTS
发明人： WANG SHAOMENG , ZHOU HAIBIN , CHEN JIANFANG , AGUILAR ANGELO , MEAGHER JENNIFER LYNN , SUN DUXIN , YANG CHAO-YIE , LIU LIU , BAI LONGCHUAN , MCEACHERM DONNA , STUCKEY JEANNE , LI XIAOQIN
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101
摘要： Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.

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