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1. 发明申请

WO2010040047A3 CHITOSAN-COATED WIRES FOR BIOSENSING 审中-公开
标题翻译：用于生物传感器的壳聚糖涂层电线
公开(公告)号：WO2010040047A3
公开(公告)日：2010-07-22
申请号：PCT/US2009059372
申请日：2009-10-02
申请人： UNIV MARYLAND BIOTECH INST , LIU YI , SHI XIAO-WEN , PAYNE GREGORY F , MEYER W LEE
发明人： LIU YI , SHI XIAO-WEN , PAYNE GREGORY F , MEYER W LEE
IPC分类号： G01N33/50
CPC分类号： G01N33/54393
摘要： A method of forming a bioelectronic device including a protein on an electrically conductive substrate, by electrodepositing aminopolysaccharide chitosan on the substrate while applying a cathodic voltage to the substrate, to form an aminopolysaccharide chitosan film thereon, applying an anodic voltage to the substrate in the presence of NaCl to activate the aminopolysaccharide chitosan film so that it is reactive with protein. The method also optionally includes reacting the aminopolysaccharide film, after activation thereof, with the protein, so that the protein assembles on and is coupled to the substrate, thereby forming a bioelectronic device. The protein can include single or multiple protein species, and including biosensing proteins. Additional methods include biosensing of electrochemically active compounds either present in a sample or generated during a biological recognition event and devices useful in such methods. The resulting devices are useful as sensors in hand-held devices, textiles, garments and the like.
摘要翻译：一种在导电基底上形成包括蛋白质的生物电子装置的方法，通过在基底上电沉积氨基多糖脱乙酰壳多糖，同时对基底施加阴极电压，在其上形成氨基多糖脱乙酰壳多糖膜，在存在的情况下向基底施加阳极电压的NaCl活化氨基多糖壳聚糖膜，使其与蛋白质反应。该方法还任选地包括使氨基多糖膜在其活化后与蛋白质反应，以使得蛋白质聚集并耦合至基底，由此形成生物电子装置。蛋白质可以包括单个或多个蛋白质种类，并且包括生物传感蛋白质。另外的方法包括对存在于样品中或在生物学识别事件期间产生的电化学活性化合物的生物传感以及在这些方法中有用的装置。所得到的装置可用作手持装置，纺织品，服装等中的传感器。

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