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1. 发明申请

WO2006029347A3 INTEGRIN CD18 IS A NOVEL STROMAL STEM CELL MARKER AND FUNCTIONS TO PROMOTE OSTEOGENESIS 审中-公开
标题翻译： INTEGRIN CD18是一种新的结构干细胞标记和功能来促进骨质疏松
公开(公告)号：WO2006029347A3
公开(公告)日：2006-12-07
申请号：PCT/US2005032220
申请日：2005-09-06
申请人： UNIV MARYLAND , ZHANG LI , MIURA YASUO , SHI SONGTAO
发明人： ZHANG LI , MIURA YASUO , SHI SONGTAO
IPC分类号： G01N33/567 , A01N1/02 , C12N5/077 , C12N5/0775
CPC分类号： C12N5/0663 , A61K35/28 , A61K48/00 , A61K2035/124 , G01N33/56966 , Y10T436/25375
摘要： The present invention is directed to a new bone marrow stromal stem cell (BMSSC) marker, CD18, for use in selecting a population of cells enriched in BMSSCs, from bone marrow cells, adipose cells, or peripheral blood. The invention is further directed to methods for selecting a population of cells enriched in BMSSCs based on the selective expression of CD18 on their surface, using techniques known in the art such as fluorescent assisted cell sorting, an immunomagnetic method, flow microfluorimetry, immunofluorescence, immunoperoxidase staining, radioimmunoassay and immunoaffinity chromatography. The invention is further directed to the BMSSCs isolated based on CD18 expression, and their use to treat various diseases. In one aspect, the BMSSCs are transformed with a vector having a normal gene for CD18, and the transformed BMSSCs are administered to treat bone degenerative diseases and diseases of bone involving abnormal expression of CD18 expression of CD18.
摘要翻译：本发明涉及用于从骨髓细胞，脂肪细胞或外周血中选择富含BMSSC的细胞群的新型骨髓基质干细胞（BMSSC）标记物CD18。本发明还涉及使用本领域已知的技术例如荧光辅助细胞分选，免疫磁性法，流量显微荧光法，免疫荧光，免疫过氧化物酶，基于CD18在其表面上的选择性表达来选择富集BMSSC的细胞群的方法染色，放射免疫测定和免疫亲和层析。本发明进一步针对基于CD18表达分离的BMSSC及其用于治疗各种疾病的用途。一方面，用具有CD18正常基因的载体转化BMSSC，并施用转化的BMSSC以治疗涉及CD18 CD18表达异常表达的骨退行性疾病和骨疾病。

2. 发明申请

WO2009038729A3 COMPOSITIONS AND METHODS UTILIZING FIBRIN BETA CHAIN FRAGMENTS OF THE BBETA CHAIN OF FIBRINOGEN 审中-公开
标题翻译：利用纤维蛋白原β链纤维蛋白原链断链碎片的组合物和方法
公开(公告)号：WO2009038729A3
公开(公告)日：2009-12-30
申请号：PCT/US2008010832
申请日：2008-09-17
申请人： REGENERX BIOPHARMACEUTICALS , UNIV MARYLAND , MEDVED LEONID , ZHANG LI , YAKOVLEV SERGIY , GOLDSTEIN ALLAN L , CROCKFORD DAVID
发明人： MEDVED LEONID , ZHANG LI , YAKOVLEV SERGIY , GOLDSTEIN ALLAN L , CROCKFORD DAVID
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： C07K14/75
摘要： A composition including a peptide sequence of the formula ßX1-X2, the peptide sequence corresponding to an amino acid sequence of a fibrin beta chain fragment of a Bbeta chain of fibrinogen, wherein X1 represents an N-terminal end of the peptide sequence, and X2 represents a C-terminal end of the peptide sequence, wherein the peptide sequence includes additional amino acids between X1 and X2, wherein the peptide sequence may contain a non-naturally occurring amino acid residue, wherein the peptide sequence is other than a wild-type ß15-42 monomer sequence per se, and wherein the peptide sequence is other than (ß15-66)2 dimer having two chains with each chain limited to wild type amino acids ß15-65 and each chain further including a non-naturally occurring Gly at position 66 of each chain. Methods for treatment and pharmaceutical combinations may include a polypeptide agent such as Thymosin beta 4. In such methods and combinations, a dimer of the peptide sequence may include amino acids 15-66 of the fibrin beta chain.
摘要翻译：一种组合物，其包含式X 1 -X 2的肽序列，所述肽序列对应于纤维蛋白原的Bβ链的纤维蛋白β链片段的氨基酸序列，其中X 1代表所述肽序列的N-末端，并且X 2 代表肽序列的C-末端，其中所述肽序列包含X1和X2之间的额外氨基酸，其中所述肽序列可含有非天然存在的氨基酸残基，其中所述肽序列不是野生型其中所述肽序列不是具有两条链的（β15-66）2二聚体，其中每条链限于野生型氨基酸β15-65，并且每条链还包含非天然存在的Gly 每个链的位置66。用于治疗和药物组合的方法可以包括多肽试剂，例如胸腺素β4。在这样的方法和组合中，肽序列的二聚体可以包括纤维蛋白β链的氨基酸15-66。

3. 发明公开

EP1833247A4 APPARATUS FOR PROJECTING VIDEO IMAGE AND METHOD THEREOF 审中-公开
标题翻译：装置用于投影图像的视频及其方法
公开(公告)号：EP1833247A4
公开(公告)日：2010-04-07
申请号：EP05771306
申请日：2005-07-26
申请人： YUAN NING , ZHANG LI
发明人： YUAN NING , ZHANG LI
IPC分类号： H04N5/74
CPC分类号： H04N9/31 , H04N9/3129

4. 发明公开

EP2263668A4 USE OF TEA POLYPHENOLS IN PREPARING MEDICAMENTS FOR PREVENTION OR TREATMENT OF TUMORS 有权
标题翻译：茶多酚的药品生产用于肿瘤的预防和治疗
公开(公告)号：EP2263668A4
公开(公告)日：2012-05-09
申请号：EP09716802
申请日：2009-03-05
申请人： ZHANG LI , LIU YUNHUA
发明人： ZHANG LI , LIU YUNHUA
IPC分类号： A61K31/353 , A61K9/08 , A61K9/16 , A61K9/20 , A61P35/00
CPC分类号： A61K31/353
摘要： Use of tea polyphenols in preparing medicaments for prevention or treatment of tumors is provided. The tea polyphenols are tea extracts comprising EGCG, EGC, and ECG, or Tegreen 97 ® , a green tea capsule of PHARMANEX, INC.

5. 发明专利

RU2721015C2 СОСТАВ ГЛАЗУРНОГО ОКРАСОЧНОГО МАТЕРИАЛА С БЖ-ЭФФЕКТОМ И СПОСОБ ОКРАСКИ 未知
公开(公告)号：RU2721015C2
公开(公告)日：2020-05-15
申请号：RU2018124618
申请日：2016-01-12
申请人： ZHANG LI
发明人： ZHANG LI
IPC分类号： C09D5/06
摘要： Настоящееизобретениеотноситсяк глазурномуокрасочномусоставус БЖ-эффектом. Составомвключаетсоставокрасочногоматериала, цветнуюглазурь, белуютонирующуюглазурьи бесцветнуютонирующуюглазурьв разныхпроцентныхсоотношениях. Изобретениеобеспечиваетдостижениечистыхи насыщенныхцветовприиспользованиикомпозициис БЖ-эффектом. 2 з.п. ф-лы, 11 ил.

6. 发明专利

AU5519300A Apparatus of collecting and discharging polluted air 未知
公开(公告)号：AU5519300A
公开(公告)日：2001-01-31
申请号：AU5519300
申请日：2000-06-28
申请人： ZHANG LI , ZHANG SHIMENG
发明人： ZHANG LI , ZHANG SHIMENG
IPC分类号： F24F7/06 , F24F7/04
摘要： The present invention provides an apparatus of collecting and discharging polluted air, including discharging pipes, gas collecting suction inlets, gas discharging chimney, in which some gas collecting suction inlets are formed in the discharging pipes, the outlet end portion is linked with the bottom end of the discharging chimney. The gas guide is also connected between the outlet end of the discharging pipe and the discharging chimney. The discharging pipes are installed in the streets polluted serious, and suck in the exhaust gas discharged by motor-vehicle from the suction inlets, and guides the exhaust gas to the open area or the top of the mountain, discharges the exhaust gas of high temperature into the high sky through the discharging pipe and the chimney. So the polluted air is purified naturally by means of the temperature difference and the pressure difference between the air of the earth surface and the air of the high sky.

7. 发明专利

AU2005279578A1 A keyboard used in the information terminal and arrangement thereof 未知
公开(公告)号：AU2005279578A1
公开(公告)日：2006-03-09
申请号：AU2005279578
申请日：2005-08-30
申请人： HAN JINGLI MR , HE WEI MR , JIANG NAN MR , ZHANG LI , ZHANG WEILI MR
发明人： ZHANG LI
IPC分类号： G06F3/023
摘要： A keyboard used with information terminals/devices and key arrangement on the keyboard. The keyboard comprises a high click frequency key group chain consisting of at least four of the five vowel keys and the 'N' key. Within the key group chain, each member key is next to at least one another member key along a row or along a column. The five vowel keys are A, E, I, O, U. The keyboard can be operated by a single hand, and can have an alphabet input region with 4 to 6 columns of keys, depending on the particular usage requirement, but still maintain a same central module. The keyboard is convenient for inputting Chinese phonetic letters and alphabets of Western languages.

8. 发明专利

AU7636900A Novel cells and molecules involved in immune regulation 未知
公开(公告)号：AU7636900A
公开(公告)日：2001-04-23
申请号：AU7636900
申请日：2000-10-06
申请人： YANG LIMING , ZHANG LI , ZHANG ZHU XU
发明人： ZHANG LI , ZHANG ZHU XU , YANG LIMING
IPC分类号： A61K35/12 , A61K35/17 , A61K38/00 , A61K38/13 , A61K38/17 , A61K38/19 , A61K38/20 , A61K39/00 , A61K48/00 , A61P37/02 , C07K16/28 , C12N5/0783

9. 发明专利

RU2745624C1 СПОСОБ ОКРАСКИ, ИСПОЛЬЗУЮЩИЙ СОСТАВ ГЛАЗУРНОГО ОКРАСОЧНОГО МАТЕРИАЛА С БЖ-ЭФФЕКТОМ 未知
公开(公告)号：RU2745624C1
公开(公告)日：2021-03-29
申请号：RU2020115339
申请日：2020-05-02
申请人： ZHANG LI
发明人： ZHANG LI
IPC分类号： B44D2/00
摘要： Предложенспособокраски, причемспособокраскивключаетэтапыподготовкихолстаподокраску, созданияосновыи нанесениярисунка. Наэтапенанесениярисункатребуемоеколичествосоставаглазурногоокрасочногоматериалас БЖ-эффектомготовятисходяизразмерахолстаподокраскуи последостаточногоперемешиваниядобавляютв неготермостойкиеминералыи водув заданныхмассовыхотношениях, чтобыполучитьсоответственнокраснуюглазурь, желтуюглазурь, синююглазурь, зеленуюглазурь, пурпурнуюглазурь, оранжевуюглазурьи циановуюглазурь, послечегоихсмешивают, чтобысоздатьхудожественныйрисунокс БЖ-эффектом, образующийв целомнерегулярныйузор. 11 ил.

10. 发明专利

CA2316089A1 NOVEL CELLS AND MOLECULES INVOLVED IN IMMUNE REGULATION 未知
公开(公告)号：CA2316089A1
公开(公告)日：2001-04-08
申请号：CA2316089
申请日：2000-08-24
申请人： ZHANG ZHU XU , ZHANG LI , YOUNG KEVIN
发明人： ZHANG ZHU XU , ZHANG LI , YOUNG KEVIN
IPC分类号： A61K35/12 , A61K35/17 , A61K38/00 , A61K38/13 , A61K38/17 , A61K38/19 , A61K38/20 , A61K39/00 , A61K48/00 , A61P37/02 , C07K16/28 , C12N5/0783 , C12N15/12 , A61K35/14 , A61K35/28 , C07K14/725 , C07K19/00 , C12N5/00 , C12N5/10
摘要： Novel cells and molecules involved in immune regulation are disclosed. The novel cells are regulatory T cells having the phenotype CD3+.alpha..beta.-TcR+CD4-CD8-CD44-CD28-NK1.1-. The regulatory cells express high levels of Ly-6A and osteopontin while non-regulatory cells do not. Inhibiting Ly-6A or osteopontin inhibits the suppressive properties of t he cells.

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