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1. 发明申请

WO2009038729A3 COMPOSITIONS AND METHODS UTILIZING FIBRIN BETA CHAIN FRAGMENTS OF THE BBETA CHAIN OF FIBRINOGEN 审中-公开
标题翻译：利用纤维蛋白原β链纤维蛋白原链断链碎片的组合物和方法
公开(公告)号：WO2009038729A3
公开(公告)日：2009-12-30
申请号：PCT/US2008010832
申请日：2008-09-17
申请人： REGENERX BIOPHARMACEUTICALS , UNIV MARYLAND , MEDVED LEONID , ZHANG LI , YAKOVLEV SERGIY , GOLDSTEIN ALLAN L , CROCKFORD DAVID
发明人： MEDVED LEONID , ZHANG LI , YAKOVLEV SERGIY , GOLDSTEIN ALLAN L , CROCKFORD DAVID
IPC分类号： A61K38/16 , C07K14/435
CPC分类号： C07K14/75
摘要： A composition including a peptide sequence of the formula ßX1-X2, the peptide sequence corresponding to an amino acid sequence of a fibrin beta chain fragment of a Bbeta chain of fibrinogen, wherein X1 represents an N-terminal end of the peptide sequence, and X2 represents a C-terminal end of the peptide sequence, wherein the peptide sequence includes additional amino acids between X1 and X2, wherein the peptide sequence may contain a non-naturally occurring amino acid residue, wherein the peptide sequence is other than a wild-type ß15-42 monomer sequence per se, and wherein the peptide sequence is other than (ß15-66)2 dimer having two chains with each chain limited to wild type amino acids ß15-65 and each chain further including a non-naturally occurring Gly at position 66 of each chain. Methods for treatment and pharmaceutical combinations may include a polypeptide agent such as Thymosin beta 4. In such methods and combinations, a dimer of the peptide sequence may include amino acids 15-66 of the fibrin beta chain.
摘要翻译：一种组合物，其包含式X 1 -X 2的肽序列，所述肽序列对应于纤维蛋白原的Bβ链的纤维蛋白β链片段的氨基酸序列，其中X 1代表所述肽序列的N-末端，并且X 2 代表肽序列的C-末端，其中所述肽序列包含X1和X2之间的额外氨基酸，其中所述肽序列可含有非天然存在的氨基酸残基，其中所述肽序列不是野生型其中所述肽序列不是具有两条链的（β15-66）2二聚体，其中每条链限于野生型氨基酸β15-65，并且每条链还包含非天然存在的Gly 每个链的位置66。用于治疗和药物组合的方法可以包括多肽试剂，例如胸腺素β4。在这样的方法和组合中，肽序列的二聚体可以包括纤维蛋白β链的氨基酸15-66。

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