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1. 发明申请

WO2006108474A3 USE OF A GALECTIN-1-TRAGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的GALECTIN-1-TRAGETED基于RNAi的方法的应用
公开(公告)号：WO2006108474A3
公开(公告)日：2006-12-21
申请号：PCT/EP2006002170
申请日：2006-03-09
申请人： UNIV BRUXELLES , UNIV LOUVAIN , CAMBY ISABELLE , HENRIET PATRICK , LEFRANC FLORENCE , COURTOY PIERRE , KISS ROBERT
发明人： CAMBY ISABELLE , HENRIET PATRICK , LEFRANC FLORENCE , COURTOY PIERRE , KISS ROBERT
IPC分类号： A61K48/00 , C12N15/113
CPC分类号： C12N15/1138 , C12N15/113 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.
摘要翻译：本发明涉及适用于降低含有SEQ ID NO：1-33的任何序列，优选SEQ ID NO：2,3或4的序列的半乳凝素-1的表达的RNAi分子，并且涉及或用于制备用于治疗和/或延迟癌症进展的药物，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤。本发明还涉及用于治疗和延迟癌症，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤的进展的组合物和方法，用于减少肿瘤细胞，优选胶质瘤细胞，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，和/或用于增强癌症疗法治疗癌症的功效，优选神经胶质瘤，胰腺癌，头颈癌，黑素瘤，非小细胞肺癌和非霍奇金淋巴瘤，选自化疗，放射治疗，免疫治疗和/或基因治疗。

2. 发明专利

AT523591T 未知
公开(公告)号：AT523591T
公开(公告)日：2011-09-15
申请号：AT06707489
申请日：2006-03-09
申请人： UNIV BRUXELLES , UNIV LOUVAIN
发明人： CAMBY ISABELLE , HENRIET PATRICK , LEFRANC FLORENCE , COURTOY PIERRE , KISS ROBERT
IPC分类号： A61K48/00 , C12N15/113
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

3. 发明专利

AU2006233522A1 Use of a galectin-1-trageted RNAi-based approach for the treatment of cancer 未知
公开(公告)号：AU2006233522A1
公开(公告)日：2006-10-19
申请号：AU2006233522
申请日：2006-03-09
申请人： UNIV LOUVAIN , UNIV BRUXELLES
发明人： HENRIET PATRICK , COURTOY PIERRE , CAMBY ISABELLE , LEFRANC FLORENCE , KISS ROBERT
IPC分类号： A61K48/00 , C12N15/113
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

4. 发明专利

CA2604288C USE OF A GALECTIN-1-TARGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 未知
公开(公告)号：CA2604288C
公开(公告)日：2021-07-06
申请号：CA2604288
申请日：2006-03-09
申请人： UNIV BRUXELLES , UNIV LOUVAIN
发明人： CAMBY ISABELLE , HENRIET PATRICK , LEFRANC FLORENCE , COURTOY PIERRE , KISS ROBERT
IPC分类号： C12N15/11 , A61K48/00 , C12N15/113
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33, and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereof as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

5. 发明专利

CA2604288A1 USE OF A GALECTIN-1-TARGETED RNAI-BASED APPROACH FOR THE TREATMENT OF CANCER 未知
公开(公告)号：CA2604288A1
公开(公告)日：2006-10-19
申请号：CA2604288
申请日：2006-03-09
申请人： UNIV LOUVAIN , UNIV BRUXELLES
发明人： LEFRANC FLORENCE , COURTOY PIERRE , KISS ROBERT , CAMBY ISABELLE , HENRIET PATRICK
IPC分类号： A61K48/00 , C12N15/113
摘要： The present invention relates to an RNAi molecule suitable for reducing the expression of galectin-1 containing any of the sequences of SEQ ID NOs: 1-33 , and preferably the sequences of SEQ ID NO: 2, 3, or 4, and to the use thereo f as a medicament, or for the manufacture of a medicament for treating and/or for delaying the progression of cancer, preferably glioma, pancreatic cancer , head and neck cancer, melanoma, non-small-cell lung cancer and non-Hodgkin's lymphoma. The present invention also relates to compositions and methods for treating and for delaying the progression of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lung cance r and non-Hodgkin's lymphoma, for reducing the migration of tumor cells, preferably cells of glioma, pancreatic cancer, head and neck cancer, melanom a, non-small-cell lung cancer and non-Hodgkin's lymphoma, and/or for enhancing the efficacy of cancer therapies for the treatment of cancer, preferably glioma, pancreatic cancer, head and neck cancer, melanoma, non-small-cell lu ng cancer and non-Hodgkin's lymphoma, selected from the group comprising chemotherapy, radiation therapy, immunotherapy, and/or gene therapy.

6. 发明申请

WO2011137925A1 NEW PRO-DRUGS OF AMARYLLIDACEAE ISOCARBOSTYRIL PRODUCTS AND THEIR USE AGAINST BRAIN TUMORS 审中-公开
标题翻译：新陈代谢异烟肼产品及其对脑肿瘤的使用
公开(公告)号：WO2011137925A1
公开(公告)日：2011-11-10
申请号：PCT/EP2010055972
申请日：2010-05-03
申请人： UNIV BRUXELLES , MATHIEU VERONIQUE , VAN GOIETSENOVEN GWENDOLINE , DUBOIS JACQUES , LEFRANC-KISS FLORENCE , INGRASSIA LAURENT , KISS ROBERT
发明人： MATHIEU VERONIQUE , VAN GOIETSENOVEN GWENDOLINE , DUBOIS JACQUES , LEFRANC-KISS FLORENCE , INGRASSIA LAURENT , KISS ROBERT
IPC分类号： C07D491/056 , A61K31/4355 , A61P35/00
CPC分类号： C07D491/056
摘要： The present invention relates to the biology and mechanism of action of the naturally occurring compound Narciclasine, especially as an anti-cancer agent for brain tumors. The invention provides new insights on the target molecule of Amaryllidaceae isocarbostyril derivatives as for example Narciclasine and provides new prodrugs of these Amaryllidceae isocabostyril constituents for treating cancer, specifically cancers or tumors located in the brain.
摘要翻译：本发明涉及天然存在的化合物Narciclasine的生物学和作用机理，特别是作为脑肿瘤的抗癌剂。本发明提供了关于芳樟科异卡泊霉素衍生物如Narciclasine的靶分子的新见解，并且提供了用于治疗癌症，特别是位于脑中的癌症或肿瘤的这些芳樟脑异卡培司替尔成分的新前药。

7. 发明申请

WO2005058934A3 GLYCOSYLATED STEROID DERIVATIVES WITH ANTI-MIGRATORY ACTIVITY 审中-公开
标题翻译：具有抗活性的甘氨酸甾族化合物衍生物
公开(公告)号：WO2005058934A3
公开(公告)日：2005-10-06
申请号：PCT/EP2004014408
申请日：2004-12-17
申请人： UNIBIOSCREEN SA , BRAEKMAN JEAN-CLAUDE , INGRASSIA LAURENT , NSHIMYUMUKIZA PROSPER , VAN QUAQUEBEKE ERIC , DEWELLE JANIQUE , VAN DEN HOVE LAURENT , KISS ROBERT , DARRO FRANCIS , UNIV BRUXELLES
发明人： BRAEKMAN JEAN-CLAUDE , INGRASSIA LAURENT , NSHIMYUMUKIZA PROSPER , VAN QUAQUEBEKE ERIC , DEWELLE JANIQUE , VAN DEN HOVE LAURENT , KISS ROBERT , DARRO FRANCIS
IPC分类号： A61K31/57 , A61K31/575 , C07J7/00 , C07J9/00 , A61P35/00
CPC分类号： C07J7/00 , C07J7/0095 , C07J9/00
摘要： The present invention relates to novel glycosylated steroid compounds having anti-migratory activity. The present invention also relates to a method for the preparation of said glycosylated steroid compounds. The invention further relates to a pharmaceutical composition comprising an effective amount of said glycosylated steroid compounds. Furthermore, the present invention concerns the use of said glycosylated steroid compounds as a medicament and in the preparation of a medicament for the treatment of diseases associated with cell migration, and even in particular in the treatment of cancer. The present invention also relates to the use of a glycosylated steroid compound or a pharmaceutical composition comprising said glycosylated steroid compound according to the invention in the treatment of diseases associated with cell migration, and even in particular in the treatment of cancer.
摘要翻译：本发明涉及具有抗迁移活性的新的糖基化类固醇化合物。本发明还涉及制备所述糖基化类固醇化合物的方法。本发明还涉及包含有效量的所述糖基化类固醇化合物的药物组合物。此外，本发明涉及所述糖基化类固醇化合物作为药物和制备用于治疗与细胞迁移相关的疾病，甚至特别是治疗癌症的药物的用途。本发明还涉及糖基化类固醇化合物或包含本发明的所述糖基化类固醇化合物的药物组合物在治疗与细胞迁移有关的疾病中，甚至特别是用于治疗癌症中的应用。

8. 发明专利

DE602004011574T2 未知
公开(公告)号：DE602004011574T2
公开(公告)日：2009-01-29
申请号：DE602004011574
申请日：2004-12-17
申请人： UNIBIOSCREEN SA , UNIV BRUXELLES
发明人： BRAEKMAN JEAN-CLAUDE , INGRASSIA LAURENT , NSHIMYUMUKIZA PROSPER , VAN QUAQUEBEKE ERIC , DE WELLE JANIQUE , VAN DEN HOVE LAURENT , KISS ROBERT , DARRO FRANCIS
IPC分类号： C07J7/00 , A61K31/57 , A61K31/575 , A61P35/00 , C07J9/00

9. 发明专利

DE60310742D1 未知
公开(公告)号：DE60310742D1
公开(公告)日：2007-02-08
申请号：DE60310742
申请日：2003-10-09
申请人： UNIBIOSCREEN SA , UNIV BRUXELLES
发明人： DARRO FRANCIS , BRAEKMAN JEAN-CLAUDE , GUISSOU PIERRE , NACOULMA GERMAINE , EL YAZIDI MOHAMED , DEWELLE JANIQUE , VAN GINKEL ROB , VAN DAMME MARC , KISS ROBERT
IPC分类号： A61K36/27 , A61P35/00 , A61P39/00

10. 发明专利

HK1082727A1 2" oxo-voruscharin and derivatives thereof 未知
公开(公告)号：HK1082727A1
公开(公告)日：2006-06-16
申请号：HK06100634
申请日：2006-01-13
申请人： UNIBIOSCREEN SA , UNIV BRUXELLES
发明人： QUAQUEBEKE ERIC VAN , BRAEKMAN JEAN-CLAUDE , SIMON GENTIANE , GUISSOU PIERRE , NACOULMA ODILE GERMAINE , DEWELLE JANIQUE , DARRO FRANCIS , KISS ROBERT
IPC分类号： C07D20060101 , A61K20060101 , A61K31/429 , A61P20060101 , A61P35/00 , C07D513/20 , C07F20060101 , C07F7/18
摘要： 2'' oxo-voruscharin compound and derivatives thereof are disclosed as well as pharmaceutical compositions which include 2'' oxo-voruscharin compound or derivatives thereof. The disclosed 2'' oxo-voruscharin compound and its derivatives are useful for cancer treatment. Methods of treating cancer using the disclosed compounds are also disclosed.

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