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1. 发明公开

EP0874591A4 VASCULAR WOUND CLOSURE DEVICE 失效
标题翻译：装置 - 合闸血管伤口
公开(公告)号：EP0874591A4
公开(公告)日：2007-01-03
申请号：EP96945202
申请日：1996-12-05
申请人： UNIV LOMA LINDA MED
发明人： ZHU YONG HUA , KIRSCH WOLFF M
IPC分类号： A61B17/34 , A61B17/00 , A61B17/02 , A61B17/06 , A61B17/128
CPC分类号： A61B17/0206 , A61B17/0057 , A61B17/128 , B29K2067/003
摘要： A device (100) which facilitates the closure of puncture wounds in the vasculature of a patient is used in conjunction with a guidewire, and helps locate and isolate the site of the puncture wound in the patient. The retractor (100) moves the surrounding tissue laterally when positioned in the patient, and acts as a guide for the physician in locating the exact site of the wound. A double-sleeved balloon can be used in conjunction with the retractor (100) to move the tissues laterally and form a tunnel from the surface of the patient's body to the puncture site. The retractor (100) is preferably used in combination with a surgical clip applicator which delivers clips to the site of the wound, but can also be used with other methods of wound closure such as suturing and stapling.

2. 发明申请

WO2005081866A3 HEMOSTATIC AGENT FOR TOPICAL AND INTERNAL USE 审中-公开
标题翻译：用于局部和内部使用的HEMOSTATIC AGENT
公开(公告)号：WO2005081866A3
公开(公告)日：2006-11-09
申请号：PCT/US2005005239
申请日：2005-02-18
申请人： UNIV LOMA LINDA MED , ZHU YONG HUA , YANG CHANG ZHENG , KIRSCH WOLFF M
发明人： ZHU YONG HUA , YANG CHANG ZHENG , KIRSCH WOLFF M
IPC分类号： A61K31/722 , A01N43/04 , A61F13/00 , A61L15/28 , A61L24/08 , A61L26/00
CPC分类号： A61L15/28 , A61B17/0057 , A61B17/06166 , A61B2017/00526 , A61B2017/00623 , A61B2017/00884 , A61B2017/00898 , A61L26/0023 , A61L2400/04 , C08L5/08
摘要： This invention relates to deployable hemostatic materials comprising chitosan fibers. The hemostatic materials are suitable for use in sealing or controlling active bleeding from artery and vein lacerations and punctures, and for controlling oozing from tissue.
摘要翻译：本发明涉及包含壳聚糖纤维的可展开的止血材料。止血材料适合用于密封或控制动脉和静脉撕裂和穿刺的活动性渗血，并用于控制从组织渗出。

3. 发明申请

WO2005016152B1 VASCULAR WOUND CLOSURE DEVICE 审中-公开
标题翻译：血管闭合装置
公开(公告)号：WO2005016152B1
公开(公告)日：2005-09-15
申请号：PCT/US2004026609
申请日：2004-08-16
申请人： UNIV LOMA LINDA MED
发明人： ZHU YONG HUA , KIRSCH WOLFF M
IPC分类号： A61B17/00 , A61B17/02 , A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/02 , A61B2017/00637 , A61B2017/00654
摘要： An apparatus (430) for closing a vascular wound includes an apparatus that can be threaded over a guidewire(458) into place at or adjacent the wound. The apparatus includes a chamber(520) that encloses a hemostatic material (270) therein. When the apparatus is positioned adjacent the wound as desired, the hemostatic material is deployed from the chamber. Blood contacts the hemostatic material, and blood clotting preferably is facilitated by a hemostatic agent within the material. Thus, the vascular puncture wound is sealed by blood clot formation.
摘要翻译：用于封闭血管伤口的装置（430）包括可以将导丝（458）穿过伤口处或邻近伤口处的位置的装置。该装置包括在其中包围止血材料（270）的腔室（520）。当根据需要将装置定位在伤口附近时，止血材料从腔室展开。血液接触止血材料，血液凝固优选由材料内的止血剂促进。因此，血管穿刺伤口被血块形成密封。

4. 发明申请

WO0205719A8 METHOD AND DEVICE FOR URETHRAL-VESICLE ANASTOMOSIS 审中-公开
标题翻译： URETHRAL-VESICLE ANASTOMOSIS的方法和装置
公开(公告)号：WO0205719A8
公开(公告)日：2002-09-19
申请号：PCT/US0122406
申请日：2001-07-17
申请人： UNIV LOMA LINDA MED
发明人： KIRSCH WOLFF M , ZHU YONG HUA , TORREY ROBERT J JR
IPC分类号： A61B17/11 , A61B17/115 , A61B
CPC分类号： A61B17/11 , A61B17/1152 , A61B2017/1103
摘要： l'invention concerne un dispositif et une méthode améliorés permettant d'effectuer la jonction de l'urètre et de la vessie après une chirurgie. Un trocart est introduit dans l'urètre. Puis il est fixé amovible à ladite urètre afin de permettre la progression de son extrémité proximale vers la vessie. Une gaine est introduite dans la vessie et y est fixée afin d'accompagner la progression de la vessie vers l'urètre. Le système amélioré permet au personnel médical de clamper l'urètre et la vessie sans avoir recours à l'introduction de sutures laborieuses et consommatrices de temps. L'invention concerne également une méthode de jonction de l'urètre et de la vessie à l'aide du dispositif précité.

5. 发明申请

WO0162159A3 PATCH AND GLUE DELIVERY SYSTEM FOR CLOSING TISSUE OPENINGS DURING SURGERY 审中-公开
标题翻译：用于在外科手术期间关闭组织开口的护理和手术输送系统
公开(公告)号：WO0162159A3
公开(公告)日：2002-04-18
申请号：PCT/US0106149
申请日：2001-02-26
申请人： UNIV LOMA LINDA MED
发明人： ZHU YONG HUA , KIRSCH WOLFF M
IPC分类号： A61B17/00 , A61M37/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00637 , A61B2017/00659
摘要： A patch applicator has an elongate body with an inner lumen and an outer lumen arranged concentrically. First and second connectors are provided and correspond to the inner and outer lumens, respectively. A patch is also provided. In operation, a source of vacuum is connected to the first connector and draws a vacuum through the inner lumen. The inner lumen is then applied to a patch to releasably hold the patch. The patch is advanced within the patient until it is placed on top of and over a wound in tissue. The source of vacuum is then transferred to the second connector and pulls a vacuum through the outer lumen to clear bodily fluid from a field around the wound. After the field is cleared, the source of vacuum is removed and replaced by a source of flowable adhesive. Adhesive is injected through the outer lumen onto the patch and tissue surrounding the patch. The patch applicator holds the patch in place, allowing the adhesive to set. A release rod is advanced through the first connector and through the inner lumen into contact with the patch. The applicator is then removed from the patch, followed by the release rod. Thus, an adhesive patch is attached to close an opening in tissue.
摘要翻译：贴片施加器具有细长体，其具有内腔和同心排列的外腔。提供第一和第二连接器并分别对应于内腔和外腔。还提供了一个补丁。在操作中，真空源连接到第一连接器并且通过内腔抽真空。然后将内腔施加到贴片以可释放地保持贴片。贴片在患者体内前进，直至放置在组织中的伤口顶部和上面。然后将真空源转移到第二连接器，并通过外腔抽真空以从伤口周围的场清除体液。在场清除之后，真空源被去除并由可流动的粘合剂源代替。胶粘剂通过外腔注射到补片周围的贴片和组织上。贴片器将贴片保持在适当位置，使粘合剂固定。释放杆通过第一连接器前进并穿过内腔与贴片接触。然后从贴片上取下涂敷器，然后将其放在释放杆上。因此，粘附贴片以封闭组织中的开口。

6. 发明申请

WO9962405A9 TISSUE OPENING LOCATOR AND EVERTER AND METHOD 审中-公开
标题翻译：组织打开定位器和优化器和方法
公开(公告)号：WO9962405A9
公开(公告)日：2000-04-27
申请号：PCT/US9912507
申请日：1999-06-04
申请人： UNIV LOMA LINDA MED
发明人： ZHU YONG HUA , KIRSCH WOLFF M
IPC分类号： A61B17/00 , A61B17/02 , A61B17/068 , A61B17/128 , A61B17/30 , A61B17/34
CPC分类号： A61B17/0206 , A61B17/0057 , A61B17/02 , A61B17/0682 , A61B17/128 , A61B17/3439 , A61B2017/306 , B29K2067/003
摘要： An apparatus for facilitating the locating, everting, and closing of an opening in a blood vessel. The apparatus can include a closure instrument having an elongated member defining a longitudinal axis and proximal and distal ends. The elongated member has a vacuum lumen extending at least a portion of the length thereof for conveying a vacuum and terminating in a vacuum port adjacent the distal end of the elongated member. The distal end of the elongated member is dimensioned to be positioned proximal a vessel opening in a blood vessel whereby vessel edge portions defining the vessel opening are at least partially drawn toward the vacuum port in response to a vacuum conveyed through the vacuum lumen. At least one surgical clip is mounted adjacent the distal end of the elongated member and is adapted to be formed to an at least partially formed condition thereof. The one clip is positioned with respect to the vacuum port so as to engage the vessel edge portions drawn toward the vacuum port when the clip is moved to the formed condition, thus at least partially closing the vessel opening. A method for locating, everting, and closing an opening in a blood vessel is also disclosed.
摘要翻译：一种用于促进血管中的开口的定位，旋转和关闭的装置。该装置可以包括具有限定纵向轴线和近端和远端的细长构件的封闭器械。细长构件具有延伸其长度的至少一部分的真空腔，用于输送真空并终止在与细长构件的远端相邻的真空口中。细长构件的远端的尺寸被设计成位于血管中的容器开口的近侧，由此响应于通过真空腔输送的真空，限定容器开口的容器边缘部分至少部分地被抽吸到真空端口。至少一个手术夹子被安装在细长构件的远端附近，并适于形成至少部分形成的状态。一个夹子相对于真空端口定位，以便当夹子移动到形成状态时接合朝向真空端口拉出的容器边缘部分，从而至少部分地关闭容器开口。还公开了一种用于在血管中定位，旋转和关闭开口的方法。

7. 发明申请

WO03028546A2 METHOD AND DEVICE FOR CREATING MICROVASCULAR ANASTOMOSES 审中-公开
标题翻译：用于创建微血管平滑肌的方法和装置
公开(公告)号：WO03028546A2
公开(公告)日：2003-04-10
申请号：PCT/US0231787
申请日：2002-10-02
申请人： UNIV LOMA LINDA MED , KIRSCH WOLFF M , DICKSON CINDY , ZHU YONG HUA
发明人： KIRSCH WOLFF M , DICKSON CINDY , ZHU YONG HUA
IPC分类号： A61B17/11 , A61B17/115 , A61F2/06 , A61B
CPC分类号： A61B17/11 , A61B17/1152 , A61B2017/1107 , A61B2017/1135 , A61F2/064
摘要： A coupler or a coupling vessel for creating an anastomosis between a first vessel and a second vessel, the coupler (10) comprising a proximal portion (12) comprising a tubular portion (16) having a proximal end (18), a distal end (20), an outer surface (22), an inner surface (24), and an axial lumen (26) defined by the inner surface (24) and extending between the proximal end (18) and the distal end (20), and a distal portion (14) comprising a flange (30) surrounding the distal end of the tubular portion (16). A method for creating an anastomosis between a first vessel and a second vessel, the method comprising selecting the first vessel and the second vessel, providing a coupler or a coupling vessel according to the present invention, and joining the first vessel to the coupler and joining the second vessel to the coupler.
摘要翻译：一种用于在第一容器和第二容器之间产生吻合的联接器或联接容器，所述联接器（10）包括近端部分（12），所述近端部分包括具有近端（18）的管状部分（16），远端 20），由所述内表面（24）限定并在所述近端（18）和所述远端（20）之间延伸的外表面（22），内表面（24）和轴向内腔（26），以及远端部分（14）包括围绕所述管状部分（16）的远端的凸缘（30）。一种用于在第一容器和第二容器之间产生吻合的方法，所述方法包括选择第一容器和第二容器，提供根据本发明的耦合器或耦合容器，并将第一容器连接到耦合器并连接第二个容器到耦合器。

8. 发明申请

WO0209591A2 METHOD AND APPARATUS FOR CLOSING VASCULAR PUNCTURE USING HEMOSTATIC MATERIAL 审中-公开
标题翻译：使用麻醉药物封闭血管瘤的方法和装置
公开(公告)号：WO0209591A2
公开(公告)日：2002-02-07
申请号：PCT/US0124462
申请日：2001-08-02
申请人： UNIV LOMA LINDA MED
发明人： ZHU YONG HUA , KIRSCH WOLFF M
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659
摘要： A method and apparatus for closing a vascular wound includes a guidewire (58) and/or other surgical implement (32) extending from the wound (w). A sponge-like hemostatic material (80) is advanced over the surgical implement and into contact with an area of the blood vessel (94) surrounding the wound. The surgical implement (32) is removed. Blood (b) soaks the hemostatic material (80), and blood clotting is facilitated by the hemostatic agent within the material. A sealing layer of adhesive (106) can be applied to the sponge-like material (80), confining the blood flow to the sponge. Thus, the vascular puncture wound (w) is sealed by natural blood clot formation.
摘要翻译：用于闭合血管伤口的方法和装置包括从伤口（w）延伸的导丝（58）和/或其它手术器械（32）。海绵状止血材料（80）在外科器具上前进并与围绕伤口的血管（94）的区域接触。移除手术器具（32）。血液（b）浸泡止血材料（80），血液凝固由材料内的止血剂促进。粘合剂（106）的密封层可以施加到海绵状材料（80）上，将血流限制在海绵上。因此，血管穿刺伤口（w）被天然血块形成密封。

9. 发明公开

EP1643934A4 DEPLOYABLE HEMOSTATIC AGENT 审中-公开
标题翻译： ABLEGBARES止血剂
公开(公告)号：EP1643934A4
公开(公告)日：2008-05-28
申请号：EP04816749
申请日：2004-06-14
申请人： UNIV LOMA LINDA MED
发明人： ZHU YONG HUA , KIRSCH WOLFF M , YANG CHANG ZHENG , DRAKE JAMES
IPC分类号： A61F13/00 , A61B17/08 , A61F20060101 , A61L15/22 , A61L26/00
CPC分类号： A61L15/225 , A61B17/0057 , A61B17/06166 , A61B2017/00654 , A61B2017/00884 , A61B2017/00898 , A61L26/0052 , A61L2400/04 , C08L5/08
摘要： This invention relates to deployable hemostatic materials comprising chitosan fibers upon which hemostatic microporous polysaccharide microspheres are deposited. The hemostatic materials are suitable for use in controlling active bleeding from artery and vein lacerations, sealing femoral artery punctures, and controlling oozing from tissue.

10. 发明公开

EP1638491A4 DEPLOYABLE MULTIFUNCTIONAL HEMOSTATIC AGENT 审中-公开
标题翻译：多媒体多媒体播放器HÄMOSTASEMITTEL
公开(公告)号：EP1638491A4
公开(公告)日：2008-05-28
申请号：EP04776473
申请日：2004-06-14
申请人： UNIV LOMA LINDA MED
发明人： ZHU YONG HUA , YANG CHANG ZHENG , KIRSCH WOLFF M , SHEN QUN-DONG , HU YONG , DICKSON CINDY
IPC分类号： A61F13/00 , A61K20060101 , A61K9/70 , A61K47/36 , A61L15/22 , A61L26/00
CPC分类号： A61K9/70 , A61B17/0057 , A61B17/06166 , A61B2017/00884 , A61B2017/00898 , A61K47/36 , A61L15/225 , A61L26/0052 , A61L26/0066 , A61L2300/232 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/622 , A61L2400/04 , C08L5/08

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