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1. 发明申请

WO2005002510A3 DEPLOYABLE MULTIFUNCTIONAL HEMOSTATIC AGENT 审中-公开
标题翻译：可配置的多功能血液净化剂
公开(公告)号：WO2005002510A3
公开(公告)日：2005-06-09
申请号：PCT/US2004018575
申请日：2004-06-14
申请人： UNIV LOMA LINDA MED , ZHU YONG HUA , YANG CHANG ZHENG , KIRSCH WOLFF M , SHEN QUN-DONG , HU YONG , DICKSON CINDY
发明人： ZHU YONG HUA , YANG CHANG ZHENG , KIRSCH WOLFF M , SHEN QUN-DONG , HU YONG , DICKSON CINDY
IPC分类号： A61F13/00 , A61K20060101 , A61K9/70 , A61K47/36 , A61L15/22 , A61L26/00
CPC分类号： A61K9/70 , A61B17/0057 , A61B17/06166 , A61B2017/00884 , A61B2017/00898 , A61K47/36 , A61L15/225 , A61L26/0052 , A61L26/0066 , A61L2300/232 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/622 , A61L2400/04 , C08L5/08
摘要： This invention relates to deployable hemostatic materials comprising chitosan fibers upon which hemostatic microporous polysaccharide microspheres and a medicament or biologically active substance are deposited. The hemostatic materials are suitable for use in controlling active bleeding from artery and vein lacerations, sealing femoral artery punctures, and controlling oozing from tissue.
摘要翻译：本发明涉及包含壳聚糖纤维的可展开的止血材料，其上沉积止血微孔多糖微球体和药物或生物活性物质。止血材料适用于控制来自动脉和静脉撕裂的活动性出血，密封股动脉穿刺以及控制组织渗出。

2. 发明申请

WO2005002510A2 DEPLOYABLE MULTIFUNCTIONAL HEMOSTATIC AGENT 审中-公开
标题翻译：可配合的多功能止血药
公开(公告)号：WO2005002510A2
公开(公告)日：2005-01-13
申请号：PCT/US2004/018575
申请日：2004-06-14
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER , ZHU, Yong, Hua , YANG, Chang, Zheng , KIRSCH, Wolff, M. , SHEN, Qun-Dong , HU, Yong , DICKSON, Cindy
发明人： ZHU, Yong, Hua , YANG, Chang, Zheng , KIRSCH, Wolff, M. , SHEN, Qun-Dong , HU, Yong , DICKSON, Cindy
IPC分类号： A61K
CPC分类号： A61K9/70 , A61B17/0057 , A61B17/06166 , A61B2017/00884 , A61B2017/00898 , A61K47/36 , A61L15/225 , A61L26/0052 , A61L26/0066 , A61L2300/232 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/416 , A61L2300/418 , A61L2300/45 , A61L2300/622 , A61L2400/04 , C08L5/08
摘要： This invention relates to deployable hemostatic materials comprising chitosan fibers upon which hemostatic microporous polysaccharide microspheres and a medicament or biologically active substance are deposited. The hemostatic materials are suitable for use in controlling active bleeding from artery and vein lacerations, sealing femoral artery punctures, and controlling oozing from tissue.
摘要翻译：本发明涉及包含壳聚糖纤维的可部署止血材料，其上沉积有止血微孔多糖微球和药物或生物活性物质。止血材料适用于控制动脉和静脉撕裂的活动性出血，密封股动脉穿刺，以及控制组织渗出。

3. 发明申请

WO2003028546A3 METHOD AND DEVICE FOR CREATING MICROVASCULAR ANASTOMOSES 审中-公开
公开(公告)号：WO2003028546A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031787
申请日：2002-10-02
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER , KIRSCH, Wolff, M. , DICKSON, Cindy , ZHU, Yong, Hua
发明人： KIRSCH, Wolff, M. , DICKSON, Cindy , ZHU, Yong, Hua
IPC分类号： A61B17/08
摘要： A coupler or a coupling vessel for creating an anastomosis between a first vessel and a second vessel, the coupler (10) comprising a proximal portion (12) comprising a tubular portion (16) having a proximal end (18), a distal end (20), an outer surface (22), an inner surface (24), and an axial lumen (26) defined by the inner surface (24) and extending between the proximal end (18) and the distal end (20), and a distal portion (14) comprising a flange (30) surrounding the distal end of the tubular portion (16). A method for creating an anastomosis between a first vessel and a second vessel, the method comprising selecting the first vessel and the second vessel, providing a coupler or a coupling vessel according to the present invention, and joining the first vessel to the coupler and joining the second vessel to the coupler.

4. 发明申请

WO03028546A2 METHOD AND DEVICE FOR CREATING MICROVASCULAR ANASTOMOSES 审中-公开
标题翻译：用于创建微血管平滑肌的方法和装置
公开(公告)号：WO03028546A2
公开(公告)日：2003-04-10
申请号：PCT/US0231787
申请日：2002-10-02
申请人： UNIV LOMA LINDA MED , KIRSCH WOLFF M , DICKSON CINDY , ZHU YONG HUA
发明人： KIRSCH WOLFF M , DICKSON CINDY , ZHU YONG HUA
IPC分类号： A61B17/11 , A61B17/115 , A61F2/06 , A61B
CPC分类号： A61B17/11 , A61B17/1152 , A61B2017/1107 , A61B2017/1135 , A61F2/064
摘要： A coupler or a coupling vessel for creating an anastomosis between a first vessel and a second vessel, the coupler (10) comprising a proximal portion (12) comprising a tubular portion (16) having a proximal end (18), a distal end (20), an outer surface (22), an inner surface (24), and an axial lumen (26) defined by the inner surface (24) and extending between the proximal end (18) and the distal end (20), and a distal portion (14) comprising a flange (30) surrounding the distal end of the tubular portion (16). A method for creating an anastomosis between a first vessel and a second vessel, the method comprising selecting the first vessel and the second vessel, providing a coupler or a coupling vessel according to the present invention, and joining the first vessel to the coupler and joining the second vessel to the coupler.
摘要翻译：一种用于在第一容器和第二容器之间产生吻合的联接器或联接容器，所述联接器（10）包括近端部分（12），所述近端部分包括具有近端（18）的管状部分（16），远端 20），由所述内表面（24）限定并在所述近端（18）和所述远端（20）之间延伸的外表面（22），内表面（24）和轴向内腔（26），以及远端部分（14）包括围绕所述管状部分（16）的远端的凸缘（30）。一种用于在第一容器和第二容器之间产生吻合的方法，所述方法包括选择第一容器和第二容器，提供根据本发明的耦合器或耦合容器，并将第一容器连接到耦合器并连接第二个容器到耦合器。

5. 发明申请

WO2003008003A1 ADHESIVE INCLUDING MEDICAMENT 审中-公开
标题翻译：粘合剂包括药物
公开(公告)号：WO2003008003A1
公开(公告)日：2003-01-30
申请号：PCT/US2002/023222
申请日：2002-07-19
申请人： LOMA LINDA UNIVERSITY MEDICAL CENTER , ZHU, Yong-Hua , KIRSCH, Wolff, M. , DICKSON, Cindy , GU, Min, Di , YANG, Chang, Zheng , SHEN, Qun-Dong
发明人： ZHU, Yong-Hua , KIRSCH, Wolff, M. , DICKSON, Cindy , GU, Min, Di , YANG, Chang, Zheng , SHEN, Qun-Dong
IPC分类号： A61L24/06
CPC分类号： A61L24/0015 , A61B17/085 , A61B2017/081 , A61F13/00063 , A61F13/0253 , A61L2/00 , A61L15/58 , A61L24/06 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/602 , C08L35/04
摘要： The present invention provides medicament-containing cyanoacrylate adhesive formulations for sealing wounds. The adhesive comprises a cyanoacrylate, a substance, and a defect forming agent, wherein the defect forming agent is capable of being removed from a cured cyanoacrylate matrix by solvation in an aqueous solution whereby a plurality of defects in the matrix are formed permitting release of the substance from the matrix at a controlled rate.
摘要翻译：本发明提供用于密封伤口的药物含氰基丙烯酸酯粘合剂制剂。粘合剂包括氰基丙烯酸酯，物质和缺陷形成剂，其中缺陷形成剂能够通过在水溶液中溶剂化从固化的氰基丙烯酸酯基体中除去，从而形成基质中的多个缺陷，从而释放物质以受控的速率从基质中得到。

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