专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008036175A3 METHODS FOR PREDICTING PSYCHOTROPIC DRUGS WHICH ELICIT WEIGHT GAIN 审中-公开
标题翻译：用于预测精子重量增加的心理药物的方法
公开(公告)号：WO2008036175A3
公开(公告)日：2008-10-30
申请号：PCT/US2007019617
申请日：2007-09-10
申请人： UNIV JOHNS HOPKINS , SNYDER SOLOMON H , HUANG ALEX , TEUSCHER CORY , KIM SANGWON
发明人： SNYDER SOLOMON H , HUANG ALEX , TEUSCHER CORY , KIM SANGWON
IPC分类号： A01N61/00 , A61K49/00
CPC分类号： G01N33/566 , C12Q1/485 , G01N2333/726 , G01N2333/91235 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase (AMPK), an action abolished in mice with deletion of histamine Hl receptors. These findings afford a means of developing better therapeutic agents and provide insight into the hypothalamic regulation of food intake.
摘要翻译：非典型抗精神病药物（AAPD）显着增强了精神分裂症的治疗，但其使用受到一些AAPD引起的主要体重增加的阻碍。我们发现，诱导性AAPD有效并选择性地激活下丘脑AMP激酶（AMPK），这是在具有组胺H 1受体缺失的小鼠中消除的作用。这些发现提供了开发更好的治疗药物的方法，并提供对食物摄取的下丘脑调节的了解。

2. 发明申请

WO2008057839A3 CATHETER WITH ADJUSTABLE COLUMN STABILITY AND METHODS FOR ITS USE 审中-公开
标题翻译：具有可调节柱稳定性的导管及其使用方法
公开(公告)号：WO2008057839A3
公开(公告)日：2008-08-07
申请号：PCT/US2007082889
申请日：2007-10-29
申请人： PERCUTANEOUS SYSTEMS INC , HUANG ALEX , DESAI RUPESH
发明人： HUANG ALEX , DESAI RUPESH
IPC分类号： A61M25/08
CPC分类号： A61M25/0043 , A61M2025/0063
摘要： CATHETER WITH ADJUSTABLE COLUMN STABILITY AND METHODS FOR ITS USE ABSTRACT OF THE DISCLOSURE The catheter includes an inner column and an outer elastic member. The inner column is bendable wherein the column strength and flexibility of the inner column are adjusted by axially tensioning the outer elastic member. The inner column comprises a helical spring, slotted or slit tube, or individual links that, when axially compressed by advancement forces or by tensioning an elastic outer sheath, assume a straight or other pre-determined geometry. The column strength and flexibility of the catheter may be adjusted during introduction of the catheter into a body lumen as necessitated by the conditions encountered, as well as made highly flexible when left in position.
摘要翻译：具有可调节柱稳定性的导管及其使用摘要的方法导管包括内柱和外弹性构件。内柱是可弯曲的，其中内柱的柱强度和柔性通过轴向张紧外弹性构件来调节。内柱包括螺旋弹簧，开槽或狭缝管，或单独的连接件，当通过推进力轴向压缩或通过张紧弹性外护套时，其呈现直线或其它预定几何形状。导管的柱强度和弹性可以在将导管引入体腔时被调整，如所遇到的条件所必需的，并且当放置在适当位置时使其具有高度的柔性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式