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1. 发明申请

WO2008085562A3 COMBINATORIEAL THERAPY OF CANCER AND INFECTIOUS DISEASES WITH ANTI-B7-H1 ANTIBODIES 审中-公开
标题翻译：癌症和感染性疾病与抗B7-H1抗体的联合治疗
公开(公告)号：WO2008085562A3
公开(公告)日：2008-11-13
申请号：PCT/US2007079058
申请日：2007-09-20
申请人： UNIV JOHNS HOPKINS , PARDOLL DREW , CHEN LIEPING , DRAKE CHARLES , COX ANDREA
发明人： PARDOLL DREW , CHEN LIEPING , DRAKE CHARLES , COX ANDREA
IPC分类号： A61K39/00
CPC分类号： C07K16/2827 , A61K39/0011 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , C07K16/2818 , C07K2317/76 , A61K2300/00
摘要： Described are uses of an agent that reduces B7-H1 interaction with PD-I, and particularly monoclonal antibodies that bind to B7-H1 and interfere with B7-H1 interaction with PD-I in combination with a vaccine to provide synergistic effects. The application provides methods of treatment and vaccination based on the combination of these compounds on T cell responses.
摘要翻译：描述了减少与PD-1的B7-H1相互作用的试剂的用途，特别是结合B7-H1并干扰与PD-1与疫苗组合以提供协同效应的B7-H1相互作用的单克隆抗体。该应用提供了基于这些化合物对T细胞应答的组合的治疗和疫苗接种的方法。

2. 发明申请

WO2011020024A3 METHODS OF MODULATING IMMUNE FUNCTION 审中-公开
标题翻译：调节免疫功能的方法
公开(公告)号：WO2011020024A3
公开(公告)日：2011-06-23
申请号：PCT/US2010045479
申请日：2010-08-13
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING
发明人： CHEN LIEPING
IPC分类号： C07K14/705 , A61P37/02 , C07K14/28
CPC分类号： C07K16/2827 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K14/70521 , C07K14/70532 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2319/30
摘要： Presented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the therapeutic agents modulate one or more signal transduction pathways induced by the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. In another aspect, the therapeutic agents modulate the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. The therapeutic agents can be used in the prevention, treatment and/or management of diseases in which it might be useful to modulate one or more immune functions (e.g.,cancer, infectious disease, autoimmune disease, and transplantation rejection). In another aspect, presented herein are methods for identifying receptor-ligand interactions.
摘要翻译：本文提供了调节一种或多种免疫功能的治疗剂和这种治疗剂在预防，治疗和管理疾病中的用途。一方面，治疗剂调节由B7-H7与B7-H7CR的结合或B7-H2与ICOS，CD28或CTLA-4的结合诱导的一种或多种信号转导途径。另一方面，治疗剂调节B7-H7与B7-H7CR的结合或B7-H2与ICOS，CD28或CTLA-4的结合。治疗剂可用于预防，治疗和/或控制可能有助于调节一种或多种免疫功能（例如癌症，感染性疾病，自身免疫性疾病和移植排斥）的疾病。另一方面，本文提供了鉴定受体 - 配体相互作用的方法。

3. 发明申请

WO2008083169A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNOLOGIC DISORDERS 审中-公开
标题翻译：用于治疗免疫障碍的组合物和方法
公开(公告)号：WO2008083169A3
公开(公告)日：2008-08-28
申请号：PCT/US2007088841
申请日：2007-12-26
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING , TAMADA KOJI
发明人： CHEN LIEPING , TAMADA KOJI
IPC分类号： C07K14/00
CPC分类号： C07K16/00 , C07K16/2875 , C07K2317/73 , C07K2319/30
摘要： Compositions and methods for preventing, reducing or inhibiting immunologic disorders are provided. Suitable compositions include one or more LIGHT-HVEM antagonists. LIGHT-HVEM antagonists include compounds that inhibit, reduce, or block the biological activity or expression of LIGHT and/or HVEM. LIGHT-HVEM antagonists can reduce or inhibit the binding of LIGHT to HVEM, but do not significantly modulate the binding of LTß to LTBR. Suitable compositions include antibodies and antibody fragments, decoy polypeptides, small molecule inhibitors and inhibitory nucleic acids. Methods for using LIGHT-HVEM antagonists to reduce or inhibit T cell activation and survival are also provided. Therapeutic uses for LIGHT-HVEM antagonists to prevent or treat immunologic diseases and disorders including graft rejection, graft-versus-host disease, inflammatory immune responses, and autoimmune disorders are provided.
摘要翻译：提供了用于预防，减少或抑制免疫疾病的组合物和方法。合适的组合物包括一种或多种LIGHT-HVEM拮抗剂。 LIGHT-HVEM拮抗剂包括抑制，降低或阻断LIGHT和/或HVEM的生物活性或表达的化合物。 LIGHT-HVEM拮抗剂可以降低或抑制LIGHT与HVEM的结合，但不会显着调节LTß与LTBR的结合。合适的组合物包括抗体和抗体片段，诱饵多肽，小分子抑制剂和抑制性核酸。还提供了使用LIGHT-HVEM拮抗剂降低或抑制T细胞活化和存活的方法。提供了用于预防或治疗免疫疾病和疾病的LIGHT-HVEM拮抗剂的治疗用途，包括移植排斥反应，移植物抗宿主病，炎性免疫应答和自身免疫性疾病。

4. 发明申请

WO2009029342A3 B7-DC VARIANTS 审中-公开
标题翻译： B7-DC变体
公开(公告)号：WO2009029342A3
公开(公告)日：2009-08-20
申请号：PCT/US2008069819
申请日：2008-07-11
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING
发明人： CHEN LIEPING
IPC分类号： C07K14/705 , A61K38/17 , A61P37/04 , C12N15/12 , C12N15/62
CPC分类号： C07K14/70532 , A61K38/00
摘要： Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector functions of T cells and/or promoting T cell survival) are provided. Suitable compositions include variant B7-DC polypeptides, fragments and fusion proteins thereof. Variant B7-DC polypeptides have reduced binding affinity for the inhibitory PD-I ligand and substantially retain the ability to costiniulate T cells. Methods for using variant B7-DC polypeptides to stimulate immune responses in subjects in need thereof are provided.
摘要翻译：提供了共刺激T细胞的组合物和方法（即增加T细胞的抗原特异性增殖，增强T细胞的细胞因子产生，刺激T细胞的分化和/或促进T细胞存活）。合适的组合物包括变体B7-DC多肽，其片段和其融合蛋白。变体B7-DC多肽对抑制性PD-1配体具有降低的结合亲和力并且基本上保留了成花型T细胞的能力。提供了在有需要的受试者中使用变体B7-DC多肽刺激免疫应答的方法。

5. 发明申请

WO2008083228A3 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION AND AUTO-IMMUNE DISEASES 审中-公开
标题翻译：用于治疗炎症和自动免疫疾病的组合物和方法
公开(公告)号：WO2008083228A3
公开(公告)日：2008-11-06
申请号：PCT/US2007088960
申请日：2007-12-27
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING
发明人： CHEN LIEPING
IPC分类号： A61K38/17 , A61K38/55 , A61P37/00
CPC分类号： A61K38/1709 , A61M1/3413 , A61M1/3679 , C07K14/70532 , C07K2319/30 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/52
摘要： Compositions containing soluble B7-H4 (sH4) antagonists in an amount effective to reduce, inhibit, or mitigate an inflammatory response in an individual and methods for the treatment or prophylaxis of inflammatory disorders and autoimmune diseases or disorders are provided. Soluble H4 has been discovered to interfere with B7-H4 activity including B7-H4's activity as an inhibitor of T cell immunity. Thus, interference of sH4 biological activity is an effective method to restore B7-H4 activity and thereby provide an effective method for treating inflammatory diseases or disorders including autoimmune diseases or disorders.
摘要翻译：提供了以有效减少，抑制或减轻个体中的炎症反应的量含有可溶性B7-H4（sH4）拮抗剂的组合物以及用于治疗或预防炎性病症和自身免疫性疾病或病症的方法。已发现可溶性H4干扰B7-H4活性，包括B7-H4作为T细胞免疫抑制剂的活性。因此，sH4生物活性的干扰是恢复B7-H4活性的有效方法，并因此提供了治疗炎性疾病或病症（包括自身免疫性疾病或病症）的有效方法。

6. 发明申请

WO2007065014A3 METHODS AND COMPOSITIONS TO INCREASE IMMUNE FUNCTION 审中-公开
标题翻译：增加免疫功能的方法和组合
公开(公告)号：WO2007065014A3
公开(公告)日：2008-04-24
申请号：PCT/US2006046279
申请日：2006-12-04
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING
发明人： CHEN LIEPING
IPC分类号： A61K39/395
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/74
摘要： The invention generally features compositions and methods that are useful for increasing immune function. Such methods can be employed to enhance innate immunity for the prevention or treatment of pathogen infections (e.g., bacterial, viral, or fungal infections), lymphopenia, or cancer by stimulating a CDl 37 polypeptide expressed on an immune cell, such as a memory T cell. The invention further comprises a mouse lacking detectable levels of CD 137, cells derived from the mouse, and methods of producing additional knockouts animals.
摘要翻译：本发明通常具有可用于增加免疫功能的组合物和方法。这种方法可用于通过刺激在免疫细胞上表达的CD117多肽（例如记忆T）来增强预防或治疗病原体感染（例如细菌，病毒或真菌感染），淋巴细胞减少或癌症的先天免疫细胞。本发明还包括缺少可检测水平的CD137，来自小鼠的细胞的小鼠，以及产生额外敲除动物的方法。

7. 发明申请

WO2009046313A3 NOVEL COMPOSITIONS AND METHODS FOR STIMULATING ERYTHROPOIESIS IN A MAMMAL 审中-公开
标题翻译：促进哺乳动物红细胞生成的新颖组合物和方法
公开(公告)号：WO2009046313A3
公开(公告)日：2009-05-22
申请号：PCT/US2008078769
申请日：2008-10-03
申请人： UNIV MARYLAND , UNIV JOHNS HOPKINS , TAMADA KOJI , CHEN LIEPING
发明人： TAMADA KOJI , CHEN LIEPING
IPC分类号： C07K16/18 , C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/74
摘要： The present invention relates to compositions comprising an agent which activates herpes virus entry mediator (HVEM). The present invention also relates to compositions comprising an agonist of HVEM. The present invention also relates to methods of stimulating erythropoiesis in a mammal, comprising administering to a mammal a composition comprising an agent which activates HVEM, or is an agonist of HVEM. The present invention also relates to methods for treating an anemic disorder, comprising administering to a mammal suffering therefrom an agent which activates HVEM.
摘要翻译：本发明涉及包含活化疱疹病毒进入介体（HVEM）的试剂的组合物。本发明还涉及包含HVEM激动剂的组合物。本发明还涉及在哺乳动物中刺激红细胞生成的方法，其包括向哺乳动物施用包含活化HVEM的试剂或HVEM激动剂的组合物。本发明还涉及治疗贫血病症的方法，包括向患有该病症的哺乳动物施用激活HVEM的药剂。

8. 发明申请

WO2008083239A3 COMPOSITIONS AND METHODS FOR STIMULATING AN IMMUNE RESPONSE 审中-公开
标题翻译：刺激免疫应答的组合物和方法
公开(公告)号：WO2008083239A3
公开(公告)日：2008-08-28
申请号：PCT/US2007088979
申请日：2007-12-27
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING
发明人： CHEN LIEPING
IPC分类号： A61K38/17 , A61P31/00 , A61P35/00 , A61P37/00
CPC分类号： A61K38/1709 , A61M1/3413 , A61M1/3679 , C07K14/70532 , C07K2319/30 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/52
摘要： Compositions and methods for the stimulating, enhancing or promoting an immune response in a host are provided. One embodiment provides methods and compositions for stimulating, enhancing, or promoting an immune response in a host by administering an effective amount of a B7-H4 antagonist, preferably sH4 or variant thereof. Compositions of sH4 can be used to enhance an immune response to treat infection, cancer, or as part of a vaccine.
摘要翻译：提供了用于在宿主中刺激，增强或促进免疫应答的组合物和方法。一个实施方案提供了用于通过施用有效量的B7-H4拮抗剂，优选sH4或其变体来刺激，增强或促进宿主中的免疫应答的方法和组合物。 sH4的组合物可用于增强免疫应答以治疗感染，癌症或作为疫苗的一部分。

9. 发明申请

WO2007041694A3 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION 审中-公开
标题翻译：用于治疗炎症的组合物和方法
公开(公告)号：WO2007041694A3
公开(公告)日：2007-07-26
申请号：PCT/US2006039072
申请日：2006-10-04
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING , TAMADA KOJI
发明人： CHEN LIEPING , TAMADA KOJI
IPC分类号： A61K39/395 , A01K67/027 , A61P29/00
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K16/2878 , C07K2317/76
摘要： The present invention relates to compositions to treat inflammation (LIGHT pathway) related disorders, and specifically liver inflammation or hepatitis. The invention also relates to methods of treating LIGHT pathway related disorders by modulating an interaction between LIGHT and LTßR. The invention further relates to kits for treating LIGHT pathway related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating LIGHT pathway related disorders in a subject.
摘要翻译：本发明涉及治疗炎症（LIGHT途径）相关疾病，特别是肝脏炎症或肝炎的组合物。本发明还涉及通过调节LIGHT和LTβR之间的相互作用来治疗LIGHT途径相关疾病的方法。本发明还涉及用于治疗受试者中LIGHT通路相关疾病的试剂盒。本发明还涉及鉴定用于治疗受试者中LIGHT通路相关疾病的新疗法的方法。

10. 发明公开

EP2061504A4 COMBINATORIEAL THERAPY OF CANCER AND INFECTIOUS DISEASES WITH ANTI-B7-H1 ANTIBODIES 审中-公开
标题翻译：联合治疗癌症和感染性疾病的抗B7-H1抗体
公开(公告)号：EP2061504A4
公开(公告)日：2010-01-27
申请号：EP07872306
申请日：2007-09-20
申请人： UNIV JOHNS HOPKINS
发明人： PARDOLL DREW , CHEN LIEPING , DRAKE CHARLES , COX ANDREA
IPC分类号： A61K39/00 , A61K39/39 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/0011 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , C07K16/2818 , C07K2317/76 , A61K2300/00

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