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    • 6. 发明申请
    • 10-SUBSTITUTED CYTISINE DERIVATIVES AND METHODS OF USE THEREOF
    • 10替代的CYTISINE衍生物及其使用方法
    • WO2007115092A3
    • 2008-07-31
    • PCT/US2007065498
    • 2007-03-29
    • UNIV GEORGETOWNKOZIKOWSKI ALAN PTUECKMANTEL WERNERCHELLAPPAN SHEELAKELLAR KENNETH JXIAO YINGXIAN
    • KOZIKOWSKI ALAN PTUECKMANTEL WERNERCHELLAPPAN SHEELAKELLAR KENNETH JXIAO YINGXIAN
    • A61K31/4375A61K31/439
    • C07D471/18
    • The present invention relates to substituted cytisine compounds that are useful in treating diseases impacted by a nicotinic ACh receptor. One aspect of the invention relates to 10-substituted cytisine compounds. In certain instances, the cytisine is substituted in the 10-position by an alkyl, aryl or aralkyl group. The present invention also relates to a pharmaceutical composition comprises the substituted cytisine compound or the 10- substituted cytisine compound. The invention also relates to a method of modulation a nicotinic ACh receptor in a mammal, comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a substituted cytisine. In certain instances, the substituted cytisine is a 10-substituted cytisine. Another aspect of the present invention relates a method of treating a disease impacted by a nicotinic ACh receptor, comprising the step of administering to a mammal in need thereof a therapeutically effective amount of a substituted cytisine. In certain instances, the substituted cytisine is a 10-substituted cytisine.
    • 本发明涉及可用于治疗受烟碱性ACh受体影响的疾病的取代的仙培酮化合物。 本发明的一个方面涉及10-取代的仙客来化合物。 在某些情况下,通过烷基,芳基或芳烷基在十位置替代赤藓酸。 本发明还涉及一种药物组合物,其包含取代的赤藓苷化合物或10-取代的仙茅素化合物。 本发明还涉及一种调节哺乳动物中烟碱性ACh受体的方法,其包括向有需要的哺乳动物施用治疗有效量的取代的氰尿酸的步骤。 在某些情况下,取代的洋甘菊是一种10-取代的胞苷。 本发明的另一方面涉及一种治疗由烟碱性ACh受体影响的疾病的方法,其包括向有需要的哺乳动物施用治疗有效量的取代的氰尿酸的步骤。 在某些情况下,取代的洋甘菊是一种10-取代的胞苷。