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1. 发明申请

WO2008077138A1 3-BENZOFURANYL-4-INDOLYL MALEIMIDES AS POTENT GSK3 INHIBITORS FOR NEUROGENERATIVE DISORDERS 审中-公开
标题翻译： 3-BENZOFURANYL-4-INDOLYL maleimides as POTENT GSK3 INHIBITORS FOR NEUROGENERATIVE DISORDERS
公开(公告)号：WO2008077138A1
公开(公告)日：2008-06-26
申请号：PCT/US2007/088248
申请日：2007-12-19
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , KOZIKOWSKI, Alan, P. , GAYSINA, Irina
发明人： KOZIKOWSKI, Alan, P. , GAYSINA, Irina
IPC分类号： C07C49/00 , C07D249/00 , C07D285/00
CPC分类号： C07D405/14
摘要： Compounds of formula (I): and pharmaceutically acceptable salts, esters and solvates thereof, where variables are defined in the specification, useful generally as inhibitors of protein kinases and particularly useful for inhibition of GSK-3. Pharmaceutically compositions and medicaments containing a compound of the invention are provided. The invention provides methods of treatment of protein kinase-related disease, disorders or conditions. The invention provides methods of treatment of GSK-3-related diseases, disorders or conditions. More specifically, methods of treatment of bipolar disorder, including mania, schizophrenia, stroke, epilepsy, motor neuron disease, cranial or spinal trauma, neurodegenerative disorders, including multiple sclerosis (MS), Alzheimer's disease, Fragile X syndrome, autism, Huntington's disease, Parkinson's
摘要翻译：式（I）化合物及其药学上可接受的盐，酯和溶剂合物，其中变量在说明书中定义，其通常用作蛋白激酶的抑制剂，特别可用于抑制GSK-3。提供含有本发明化合物的药物组合物和药物。本发明提供了治疗蛋白激酶相关疾病，病症或病症的方法。本发明提供治疗GSK-3相关疾病，病症或病症的方法。更具体地，治疗双相情感障碍的方法，包括躁狂症，精神分裂症，中风，癫痫，运动神经元疾病，颅脑损伤或脊髓损伤，包括多发性硬化症（MS），阿尔茨海默氏病，脆性X综合征，自闭症，亨廷顿舞蹈病在内的神经变性疾病，帕金森氏

2. 发明申请

WO2007008514A3 INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 审中-公开
标题翻译：糖原合成酶激酶抑制剂3
公开(公告)号：WO2007008514A3
公开(公告)日：2007-10-04
申请号：PCT/US2006026137
申请日：2006-07-06
申请人： UNIV GEORGETOWN , KOZIKOWSKI ALAN P , GAYSINA IRINA , PETUKHOV PAVEL , SRIDHAR JAYALAKSHMI , TUECKMANTEL WERNER
发明人： KOZIKOWSKI ALAN P , GAYSINA IRINA , PETUKHOV PAVEL , SRIDHAR JAYALAKSHMI , TUECKMANTEL WERNER
IPC分类号： A01N43/56
CPC分类号： C07D403/14 , C07D403/04
摘要： One aspect of the present invention relates to heterocyclic compounds that inhibit mammalian or human glycogen synthase kinase 3. Another aspect of the invention relates to pharmaceutical compositions comprising such a heterocyclic compound. The present invention also relates to methods of treating a mammal or human suffering from a malady that is based at least in part on abnormal activity of glycogen synthase kinase 3. The present invention also relates to methods of treating a mammal or human suffering from diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, ALS, MS, or schizophrenia.
摘要翻译：本发明的一个方面涉及抑制哺乳动物或人糖原合酶激酶3的杂环化合物。本发明的另一方面涉及包含这种杂环化合物的药物组合物。本发明还涉及治疗患有至少部分基于糖原合酶激酶3的异常活性的疾病的哺乳动物或人的方法。本发明还涉及治疗患有糖尿病的哺乳动物或人的方法，阿尔茨海默氏病，亨廷顿舞蹈病，帕金森病，艾滋病相关性痴呆，ALS，MS或精神分裂症。

3. 发明申请

WO2007008514A2 INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 审中-公开
标题翻译： GLYCOGEN SYNTHASE KINASE的抑制剂3
公开(公告)号：WO2007008514A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/026137
申请日：2006-07-06
申请人： GEORGETOWN UNIVERSITY , KOZIKOWSKI, Alan, P. , GAYSINA, Irina , PETUKHOV, Pavel , SRIDHAR, Jayalakshmi , TUECKMANTEL, Werner
发明人： KOZIKOWSKI, Alan, P. , GAYSINA, Irina , PETUKHOV, Pavel , SRIDHAR, Jayalakshmi , TUECKMANTEL, Werner
IPC分类号： A61K31/426
CPC分类号： C07D403/14 , C07D403/04
摘要： One aspect of the present invention relates to heterocyclic compounds that inhibit mammalian or human glycogen synthase kinase 3. Another aspect of the invention relates to pharmaceutical compositions comprising such a heterocyclic compound. The present invention also relates to methods of treating a mammal or human suffering from a malady that is based at least in part on abnormal activity of glycogen synthase kinase 3. The present invention also relates to methods of treating a mammal or human suffering from diabetes, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, ALS, MS, or schizophrenia.
摘要翻译：本发明的一个方面涉及抑制哺乳动物或人糖原合成酶激酶3的杂环化合物。本发明的另一方面涉及包含这种杂环化合物的药物组合物。本发明还涉及治疗至少部分基于糖原合成酶激酶3的异常活性的患有疾病的哺乳动物或人的方法。本发明还涉及治疗患有糖尿病的哺乳动物或人的方法，阿尔茨海默病，亨廷顿氏病，帕金森病，AIDS相关性痴呆，ALS，MS或精神分裂症。

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