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1. 发明申请

WO2009035554A3 SUPERIOR STRUCTURE STABILITY AND SELECTIVITY OF HAIRPIN NUCLEIC ACID PROBES WITH AN L-DNA STEM 审中-公开
标题翻译：具有L-DNA干细胞的HAIRPIN核酸探针的超结构稳定性和选择性
公开(公告)号：WO2009035554A3
公开(公告)日：2009-05-14
申请号：PCT/US2008010466
申请日：2008-09-08
申请人： UNIV FLORIDA , TAN WEIHONG , KIM YOUNGMI , YANG CHAOYONG JAMES
发明人： TAN WEIHONG , KIM YOUNGMI , YANG CHAOYONG JAMES
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68 , G01N33/58
CPC分类号： C12Q1/6832 , C12Q2525/301 , C12Q2525/101
摘要： Hairpin-shaped nucleic acid probes capable of forming stable hybrids with target nucleic acid sequences are provided. In particular, an oligonucleotide probe for hybridization analysis is provided, wherein the probe comprises a non-natural enantiomeric DNA (L-DNA) that forms the stem and natural DNA (D-DNA) that forms the loop in the hairpin. The invention thereby provides stable probes that experience fewer stem invasions and demonstrate sensitive and selective hybridization to target nucleic acid sequences. The subject probes are useful for a variety of biological and biotechnological applications.
摘要翻译：提供能够与靶核酸序列形成稳定杂交体的发夹状核酸探针。特别地，提供了用于杂交分析的寡核苷酸探针，其中探针包含形成茎的非天然对映体DNA（L-DNA）和在发夹中形成环的天然DNA（D-DNA）。因此，本发明提供了稳定的探针，其经历较少的茎侵入并且显示与靶核酸序列的灵敏和选择性杂交。主题探针可用于各种生物和生物技术应用。

2. 发明申请

WO2008134069A3 ANCHORED LIGAND AGENTS 审中-公开
标题翻译：安装的配对代理
公开(公告)号：WO2008134069A3
公开(公告)日：2009-02-12
申请号：PCT/US2008005528
申请日：2008-04-28
申请人： UNIV FLORIDA , TAN WEIHONG , CAO ZEHUI , KIM YOUNGMI
发明人： TAN WEIHONG , CAO ZEHUI , KIM YOUNGMI
IPC分类号： C12Q1/68
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/50
摘要： The invention provides novel therapeutic agents comprising ligand molecules such as aptamers linked to a molecular anchor (MA). In the absence of a MA, ligands rapidly diffuse into bulk solution after dissociation from a target molecule. With a MA tightly bound to the target molecule, anchored ligand molecules of the invention remain in close proximity to the active site on the target molecule, even after dissociating from the target, permitting rapid re- binding of ligand to its target. Reversibility of binding to the active site can be effectively and rapidly achieved using antidotes based on the complementary DNA sequences. A preferred embodiment in accordance with the invention is a highly efficient anticoagulant agent that demonstrates binding efficiency to thrombin that is increased many fold relative to a corresponding unanchored aptamer-based ligand.
摘要翻译：本发明提供了包含配体分子的新型治疗剂，例如与分子锚（MA）连接的适体。在不存在MA的情况下，配体在从靶分子解离后迅速扩散到本体溶液中。使用与目标分子紧密结合的MA，本发明的锚定配体分子即使在与靶分离之后也保持紧邻目标分子上的活性位点，从而允许配体与靶标快速重结合。使用基于互补DNA序列的解毒剂可以有效快速地实现与活性位点结合的可逆性。根据本发明的优选实施方案是高效抗凝剂，其显示出相对于相应的未锚定的适体基配体增加多倍的凝血酶的结合效率。

3. 发明申请

WO2012016180A3 LIQUEFACTION BIOMASS PROCESSING WITH HEAT RECOVERY 审中-公开
标题翻译：采用热回收的液化生物质处理
公开(公告)号：WO2012016180A3
公开(公告)日：2012-06-07
申请号：PCT/US2011045958
申请日：2011-07-29
申请人： PURDUE RESEARCH FOUNDATION , LADISCH MICHAEL R , MOSIER NATHAN , KIM YOUNGMI , ROOYEN JUSTIN VAN
发明人： LADISCH MICHAEL R , MOSIER NATHAN , KIM YOUNGMI , ROOYEN JUSTIN VAN
IPC分类号： C12P7/06 , C12P7/10
CPC分类号： C08B1/00 , C12N1/22 , C12P7/10 , C12P19/02 , C12P19/14 , Y02E50/16 , Y02E50/17 , Y02P20/124 , Y02P20/59
摘要： Described are processes that include the non-enzymatic, hydrolytic liquefaction of lignocellulosic biomass to form digest slurries and heat recovery from such digest slurries. Due to enhanced flow properties of the digest slurries such heat recovery can be efficiently conducted in spiral, plate and frame or other heat exchanger designs, with the recovered heat going to unit operations of the process such as heating incoming pretreatment media for the liquefaction. Processes can also involve additional hydrolytic digestion of some or all of the initial slurry components with enzyme and/or additional heat recovery from the initial slurry by direct contact heat exchange in which a portion of the digest slurry liquids is flashed to vapor and that vapor is condensed onto incoming lignocellulosic biomass to the process. Processes as described can be integrated into ethanol manufacture by fermentation of sugars from the digested compositions.
摘要翻译：描述了包括木质纤维素生物质的非酶促水解液化以形成消化浆料并从这些消化浆料中热回收的方法。由于消化浆料的流动性能的提高，这种热回收可以在螺旋，板和框架或其它热交换器设计中有效地进行，回收的热量将进行到工艺的单元操作，例如加热输入的用于液化的预处理介质。方法还可以通过直接接触热交换使酶的一些或所有初始浆料组分进一步水解消化，和/或从初始浆料进一步热回收，其中将一部分消化浆料液体闪蒸至蒸气，蒸气为浓缩到进入的木质纤维素生物质上。所描述的方法可以通过从消化的组合物中发酵糖而被整合到乙醇生产中。

4. 发明申请

WO2012033324A3 NOVEL BIOLOGICAL DETECTION METHOD FOR DIOXINS IN SERUM, AND A DIAGNOSTIC USE THEREFOR IN METABOLIC SYNDROME AND RELATED CONDITIONS 审中-公开
标题翻译：血清中二氧化物的新生物检测方法及其代谢综合征及相关情况的诊断用途
公开(公告)号：WO2012033324A3
公开(公告)日：2012-06-14
申请号：PCT/KR2011006583
申请日：2011-09-06
申请人： UNIV KYUNG HEE UNIV IND COOP GROUP , LEE HONG KYU , KIM YOUNGMI
发明人： LEE HONG KYU , KIM YOUNGMI
IPC分类号： C12Q1/68 , C12N15/85 , C12Q1/66
CPC分类号： C12Q1/6897 , C12Q1/66 , G01N33/5308 , G01N2800/04
摘要： The present invention relates to a novel biological detection method for dioxins in serum, and to a diagnostic use therefor in metabolic syndrome and related conditions. More specifically, by measuring luciferase activity through the use of serum as a whole and cells that have been genetically transformed by means of a recombinant vector comprising a gene construct in which a dioxin response element (dioxin-responsive element), a promoter and a reporter gene have been operably linked, a significant correlation has been confirmed between physical variables and the content of dioxins in serum, and there is an improvement over existing methods which require a pre-processing step in order to purify dioxins from the blood, and a plurality of samples can be analysed both easily and accurately even in very small amounts because of the use of serum as a whole, and hence the detection system of the present invention, which involves total serum processing in a genetically transformed cell line comprising a recombinant reporter gene whose expression is modified by dioxin compounds, can be used to advantage in the biological detection of dioxins within serum, and this method can be used to research the correlation between specific POPs and patients' diseases by accurately detecting whether POPs such as dioxins are present in the serum, and this can be used to advantage in predicting the occurrence of diseases and determining treatability.
摘要翻译：本发明涉及血清中二恶英的新型生物检测方法及其代谢综合征及相关病症的诊断用途。更具体地，通过使用血清作为整体测量荧光素酶活性，以及通过包含二恶英应答元件（二恶英应答元件），启动子和报告基因的基因构建体的重组载体进行遗传转化的细胞基因已经可操作地连接，物理变量和血清中二恶英含量之间已经证实了显着的相关性，并且对于需要预处理步骤以从血液中纯化二恶英的现有方法有改进，并且多个由于使用血清作为整体，因此可以容易且精确地分析样品，因此本发明的检测系统涉及在包含重组报告基因的遗传转化细胞系中的总血清加工其表达被二恶英化合物修饰，可用于生物检测血清中二恶英的有效性该方法可用于通过准确检测血清中是否存在二恶英类POPs来研究特异性POPs与患者疾病之间的相关性，可用于预测疾病的发生和确定可治疗性。

5. 发明申请

WO2005073338A3 FLUORESCENT, SEMI-CONDUCTIVE POLYMERS, AND DEVICES COMPRISING THEM 审中-公开
标题翻译：氟化物，半导体聚合物和包含它们的装置
公开(公告)号：WO2005073338A3
公开(公告)日：2005-12-08
申请号：PCT/US2004040729
申请日：2004-12-06
申请人： MASSACHUSETTS INST TECHNOLOGY , SWAGER TIMOTHY M , KIM YOUNGMI
发明人： SWAGER TIMOTHY M , KIM YOUNGMI
IPC分类号： C08G61/02 , C08G61/06 , C08L27/12 , C09K11/06 , C12Q1/68 , G01N33/00 , G01N33/53 , G01N33/58 , H01J1/62 , H01L51/30 , H01L51/50 , H05B33/14 , H01L31/00
CPC分类号： C09K11/06 , C08G61/02 , C08G61/06 , C09K2211/1425 , G01N33/582 , H01L51/0035 , H01L51/0038 , H01L51/5012 , H05B33/14 , Y02E10/549
摘要： The present invention relates to fluorescent, semiconductive polymers comprising electron withdrawing groups bonded to the polymer. The invetion also relates to a method of detecting analytes comprising contacting the analyte with the fluorescent, semiconductive polymers of the present invention. The invention also relates to light emitting devices, photovoltaic devices, and sensors comprising the fluorescent, semiconductive polymers of the present invention.
摘要翻译：本发明涉及包含与聚合物键合的吸电子基团的荧光半导体聚合物。所述检测还涉及检测分析物的方法，包括使分析物与本发明的荧光半导体聚合物接触。本发明还涉及包含本发明的荧光半导体聚合物的发光器件，光伏器件和传感器。

6. 发明申请

WO2012112546A3 METHODS AND SYSTEMS USEFUL FOR DRYING ETHANOL 审中-公开
标题翻译：用于干燥乙醇的方法和系统
公开(公告)号：WO2012112546A3
公开(公告)日：2014-04-17
申请号：PCT/US2012025042
申请日：2012-02-14
申请人： PURDUE RESEARCH FOUNDATION , ARCHER DANIELS MIDLAND CO , KIM YOUNGMI , HENDRICKSON RICHARD L , MOSIER NATHAN , LADISCH MICHAEL R , HILALY AHMAD K
发明人： KIM YOUNGMI , HENDRICKSON RICHARD L , MOSIER NATHAN , LADISCH MICHAEL R , HILALY AHMAD K
IPC分类号： C07C29/76 , B01J20/24
CPC分类号： C07C29/76 , B01J20/28004 , B01J20/28019 , B01J20/28059 , B01J20/3433 , B01J20/3458 , B01J2220/4825 , C08L3/02 , C12P7/06 , Y02E50/17 , C07C31/08
摘要： Mixtures of ethanol and water are dehydrated using starch pearls to adsorb and remove water. Vapor-phase adsorption equilibrium capacities of cassava starch pellets (tapioca pearls) having different particle sizes are disclosed, and tapioca pearl particles are shown to be surprisingly more effective for dehydrating 88 to 97% w/w feed ethanol than corn grits. The adsorption equilibrium curve and BET surface area measurement show that the adsorption capacity of tapioca pearls is a function of surface area available to water molecules. SEM images demonstrate that the particle architecture required for the adsorption and dehydration properties is that of a core- shell configuration with pre-gel starch acting as a central scaffold holding together other particles to the outer layer of the particle. The outer surface area of the pearls, populated with dry starch granules, is the main factor determining the adsorption capacity of the pearls. Tapioca pearls are shown to possess a surprisingly higher adsorption capacity than corn grits of the same particle size. Pearls of 2 mm size in diameter gave 34% higher linear adsorption equilibrium constant ( K ) than grits of 1.7 mm.
摘要翻译：用淀粉珍珠脱水乙醇和水的混合物，吸附去除水分。公开了具有不同粒度的木薯淀粉颗粒（木薯珍珠）的气相吸附平衡能力，并且显示木薯珍珠颗粒比玉米砂粒脱水88至97％w / w的进料乙醇更有效。吸附平衡曲线和BET表面积测量显示，木薯珍珠的吸附能力是水分子可用表面积的函数。 SEM图像表明，吸附和脱水性质所需的颗粒结构是核 - 壳结构的结构，其中预凝胶淀粉作为将其它颗粒保持在颗粒的外层的中心支架。珍珠的外表面积为干淀粉颗粒，是决定珍珠吸附能力的主要因素。木薯珍珠与具有相同粒度的玉米砂粒相比具有惊人的更高的吸附能力。直径2毫米的珍珠比1.7毫米的砂粒提高了34％的线性吸附平衡常数（K）。

7. 发明申请

WO2009131327A3 UNIVERSAL STAND FOR MULTIVISION 审中-公开
标题翻译：通用的多功能立场
公开(公告)号：WO2009131327A3
公开(公告)日：2010-01-07
申请号：PCT/KR2009001915
申请日：2009-04-14
申请人： ORION PDP CO LTD , KIM KUNYOUNG , JEON WON WOO , KIM YOUNGMI
发明人： KIM KUNYOUNG , JEON WON WOO , KIM YOUNGMI
IPC分类号： H04N5/645
CPC分类号： H04N9/12 , G09F9/3026
摘要： Provided is a universal stand for multivision for forming the multivision using a plurality of display devices. The universal stands includes: a plurality of base frames arranged horizontally and vertically in lines; and a support frame which is mounted on each of the base frames to move vertically or horizontally and supports the display device.
摘要翻译：提供了一种用于使用多个显示装置形成多视点的多分辨率的通用支架。通用支架包括：沿水平方向和垂直方向排列的多个基架; 以及支撑框架，其安装在每个基架上以垂直或水平移动并支撑显示装置。

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